HRP20030378A2 - Novel medicament compositions based on tiotropiumsalts and on salmeterol salts - Google Patents

Novel medicament compositions based on tiotropiumsalts and on salmeterol salts Download PDF

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Publication number
HRP20030378A2
HRP20030378A2 HR20030378A HRP20030378A HRP20030378A2 HR P20030378 A2 HRP20030378 A2 HR P20030378A2 HR 20030378 A HR20030378 A HR 20030378A HR P20030378 A HRP20030378 A HR P20030378A HR P20030378 A2 HRP20030378 A2 HR P20030378A2
Authority
HR
Croatia
Prior art keywords
acid
compound
inhalation
salts
active substances
Prior art date
Application number
HR20030378A
Other languages
English (en)
Croatian (hr)
Inventor
Schmelzer Christel
Nagel Juergen
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co. Kg.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg. filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg.
Publication of HRP20030378A2 publication Critical patent/HRP20030378A2/hr

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/468-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HR20030378A 2000-11-13 2003-05-12 Novel medicament compositions based on tiotropiumsalts and on salmeterol salts HRP20030378A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10056104A DE10056104A1 (de) 2000-11-13 2000-11-13 Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols
PCT/EP2001/012962 WO2002038154A1 (fr) 2000-11-13 2001-11-09 Nouvelles compositions de medicaments a base de sels de tiotropium et de sels de salmeterol

Publications (1)

Publication Number Publication Date
HRP20030378A2 true HRP20030378A2 (en) 2005-04-30

Family

ID=7663071

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20030378A HRP20030378A2 (en) 2000-11-13 2003-05-12 Novel medicament compositions based on tiotropiumsalts and on salmeterol salts

Country Status (32)

Country Link
EP (3) EP1514546B1 (fr)
JP (2) JP4282322B2 (fr)
KR (2) KR100940752B1 (fr)
CN (1) CN1678318A (fr)
AT (2) ATE362761T1 (fr)
AU (3) AU2002227910B2 (fr)
BG (1) BG107781A (fr)
BR (1) BR0115226A (fr)
CA (1) CA2429012A1 (fr)
CY (1) CY1106774T1 (fr)
CZ (1) CZ20031444A3 (fr)
DE (3) DE10056104A1 (fr)
DK (2) DK1335728T3 (fr)
EA (1) EA007904B1 (fr)
EC (1) ECSP034571A (fr)
EE (1) EE200300228A (fr)
ES (2) ES2240549T3 (fr)
HR (1) HRP20030378A2 (fr)
HU (1) HUP0301447A3 (fr)
IL (2) IL155718A0 (fr)
MX (1) MXPA03004164A (fr)
NO (1) NO20032111L (fr)
NZ (1) NZ526400A (fr)
PL (1) PL205330B1 (fr)
PT (2) PT1335728E (fr)
RS (2) RS20090105A (fr)
SG (1) SG167657A1 (fr)
SI (2) SI1335728T1 (fr)
SK (2) SK286939B6 (fr)
UA (1) UA74853C2 (fr)
WO (1) WO2002038154A1 (fr)
ZA (1) ZA200302921B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
US7214687B2 (en) 1999-07-14 2007-05-08 Almirall Ag Quinuclidine derivatives and medicinal compositions containing the same
JP2003514841A (ja) * 1999-11-23 2003-04-22 グラクソ グループ リミテッド サルメテロールの医薬製剤
MXPA04002401A (es) * 2001-09-14 2004-05-31 Boehringer Ingelheim Pharma Nuevos medicamentos para inhalacion.
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
DE10214263A1 (de) * 2002-03-28 2003-10-16 Boehringer Ingelheim Pharma HFA-Suspensionsformulierungen enthaltend ein Anticholinergikum
US7311894B2 (en) 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
US7250426B2 (en) 2002-11-29 2007-07-31 Boehringer Ingelheim Pharma Gmbh & Co Kg Tiotropium-containing pharmaceutical combination for inhalation
DE10256080A1 (de) * 2002-11-29 2004-06-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropiumhaltige Arzneimittelkombination für die Inhalation
MXPA05006383A (es) * 2002-12-16 2005-08-29 Boehringer Ingelheim Pharma Formulaciones de soluciones de hidrofluorocarburo que contienen tiotropio.
DE10351663A1 (de) * 2002-12-20 2004-07-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverförmige Arzneimittel enthaltend ein Tiotropiumsalz und Salmeterolxinafoat
DE10345065A1 (de) * 2003-09-26 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
WO2005042528A1 (fr) * 2003-11-03 2005-05-12 Boehringer Ingelheim International Gmbh Nouveaux sels de tiotropium, procedes permettant de les produire et formulations medicamenteuses les contenant
JP5165244B2 (ja) * 2003-11-03 2013-03-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング チオトロピウム塩の製法、チオトロピウム塩及びそれを含有する医薬組成物
ES2257152B1 (es) * 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
PL1891974T3 (pl) * 2004-05-31 2010-12-31 Almirall Sa Kombinacje zawierające środki przeciwmuskarynowe i inhibitory PDE4
NZ563596A (en) 2005-05-02 2011-01-28 Boehringer Ingelheim Int Crystalline form of tiotropium bromide anhydrate
CA2617897A1 (fr) * 2005-08-06 2007-02-15 Boehringer Ingelheim International Gmbh Procede pour le traitement de la dyspnee comprenant l'administration combinee de sels de tiotropium et de sels de salmeterol
ES2298049B1 (es) 2006-07-21 2009-10-20 Laboratorios Almirall S.A. Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.
EP2100598A1 (fr) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Composition à inhaler comprenant aclidinium pour le traitement de l'asthme et de maladies respiratoires obstructives chroniques
EP2100599A1 (fr) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Composition à inhaler comprenant aclidinium pour le traitement de l'asthme et de maladies respiratoires obstructives chroniques
US20120220557A1 (en) * 2011-02-17 2012-08-30 Chiesi Farmaceutici S.P.A. Liquid propellant-free formulation comprising an antimuscarinic drug
EP2510928A1 (fr) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium pour l'amélioration du sommeil des patients avec des maldadies respiratoires
EP2819669B1 (fr) * 2012-02-28 2021-04-21 Boehringer Ingelheim International GmbH Nouvelle formulation de tiotropium contenant un gaz propulseur
WO2015065222A1 (fr) * 2013-10-28 2015-05-07 Шолекс Девелопмент Гмбх Préparation pharmaceutique inhalable pour le traitement de l'asthme bronchial et de maladies à obstruction chronique des poumons contenant du bromure de tiotropium micronisé en qualité de substance active, et procédé de production
TW201835041A (zh) 2017-02-17 2018-10-01 印度商托仁特生技有限公司 具β-腎上腺素促效劑及抗蕈毒活性化合物
WO2019142214A1 (fr) * 2018-01-19 2019-07-25 Cipla Limited Composition pharmaceutique comprenant du tiotropium destinée à être inhalée
CN116196298A (zh) * 2018-07-26 2023-06-02 四川海思科制药有限公司 一种含格隆铵盐的气雾剂药物组合物及其制备方法与应用
CN111936124A (zh) * 2018-07-26 2020-11-13 四川海思科制药有限公司 一种含格隆铵盐及茚达特罗盐的气雾剂药物组合物及其制备方法与应用
WO2022119661A1 (fr) * 2020-12-04 2022-06-09 Tygrus, LLC Matériau thérapeutique à faible ph et faible toxicité, actif contre au moins un pathogène pour la prise en charge de patients atteints de maladies respiratoires
US12042514B2 (en) 2020-05-01 2024-07-23 Tygrus, LLC Therapeutic material with low pH and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses
US11826382B2 (en) 2020-05-01 2023-11-28 Tygrus, LLC Therapeutic material with low pH and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses
US11642372B2 (en) 2020-05-01 2023-05-09 Tygrus, LLC Therapeutic material with low pH and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000006121A1 (fr) * 1998-07-24 2000-02-10 Jago Research Ag Formulations pour aerosols a usage medical
DE19835346A1 (de) * 1998-08-05 2000-02-10 Boehringer Ingelheim Pharma Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren
DE19847971A1 (de) * 1998-10-17 1999-09-02 Schiering Verfahren und Einrichtung zur Verhinderung von Filterbränden (Staubfilter)
DE19847970A1 (de) * 1998-10-17 2000-04-20 Boehringer Ingelheim Pharma Lagerfähige Wirkstoff-Formulierung
DE19921693A1 (de) * 1999-05-12 2000-11-16 Boehringer Ingelheim Pharma Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika
DE19961300A1 (de) * 1999-12-18 2001-06-21 Asta Medica Ag Vorratssystem für Arzneimittel in Pulverform und damit ausgestatteter Inhalator

Also Published As

Publication number Publication date
EP1514546B1 (fr) 2007-05-23
JP2005068163A (ja) 2005-03-17
RS50286B (sr) 2009-09-08
RS20090105A (en) 2009-07-15
DE10056104A1 (de) 2002-05-23
PL205330B1 (pl) 2010-04-30
IL155718A0 (en) 2003-11-23
MXPA03004164A (es) 2005-08-16
HUP0301447A3 (en) 2007-10-29
EP1335728B1 (fr) 2005-03-23
YU35503A (sh) 2006-05-25
NZ526400A (en) 2005-09-30
HUP0301447A2 (hu) 2003-10-28
KR100886094B1 (ko) 2009-02-27
PT1335728E (pt) 2005-05-31
JP4282322B2 (ja) 2009-06-17
PT1514546E (pt) 2007-06-15
KR100940752B1 (ko) 2010-02-11
JP4282594B2 (ja) 2009-06-24
EE200300228A (et) 2003-10-15
AU2007202303B2 (en) 2010-01-21
KR20030065509A (ko) 2003-08-06
SK286939B6 (sk) 2009-07-06
SK7412003A3 (en) 2003-10-07
UA74853C2 (en) 2006-02-15
ECSP034571A (es) 2003-06-25
ATE362761T1 (de) 2007-06-15
AU2791002A (en) 2002-05-21
KR20080079701A (ko) 2008-09-01
EA200300503A1 (ru) 2004-12-30
SG167657A1 (en) 2011-01-28
SI1335728T1 (en) 2005-08-31
DK1335728T3 (da) 2005-04-18
EP1514546A1 (fr) 2005-03-16
BR0115226A (pt) 2003-10-07
SI1514546T1 (sl) 2007-10-31
CZ20031444A3 (cs) 2003-08-13
CY1106774T1 (el) 2012-05-23
NO20032111L (no) 2003-07-08
DE50112535D1 (de) 2007-07-05
IL155718A (en) 2010-06-30
ES2240549T3 (es) 2005-10-16
DK1514546T3 (da) 2007-09-24
DE50105729D1 (de) 2005-04-28
WO2002038154A1 (fr) 2002-05-16
EA007904B1 (ru) 2007-02-27
EP1808174A1 (fr) 2007-07-18
NO20032111D0 (no) 2003-05-12
PL365989A1 (en) 2005-01-24
EP1335728A1 (fr) 2003-08-20
ES2287629T3 (es) 2007-12-16
SK286950B6 (sk) 2009-08-06
CA2429012A1 (fr) 2002-05-16
BG107781A (bg) 2004-06-30
CN1678318A (zh) 2005-10-05
ATE291428T1 (de) 2005-04-15
ZA200302921B (en) 2004-04-19
AU2002227910B2 (en) 2007-03-01
AU2007202303A1 (en) 2007-06-14
JP2004513146A (ja) 2004-04-30

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