ZA200301465B - Vaccine composition comprising an antigen and a peptide having adjuvant properties. - Google Patents
Vaccine composition comprising an antigen and a peptide having adjuvant properties. Download PDFInfo
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- ZA200301465B ZA200301465B ZA200301465A ZA200301465A ZA200301465B ZA 200301465 B ZA200301465 B ZA 200301465B ZA 200301465 A ZA200301465 A ZA 200301465A ZA 200301465 A ZA200301465 A ZA 200301465A ZA 200301465 B ZA200301465 B ZA 200301465B
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- ZA
- South Africa
- Prior art keywords
- peptide
- amino acid
- vaccine according
- acid residues
- antigen
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
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- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Microbiology (AREA)
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- Communicable Diseases (AREA)
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- Pulmonology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0178900A AT410635B (de) | 2000-10-18 | 2000-10-18 | Vakzin-zusammensetzung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200301465B true ZA200301465B (en) | 2004-02-24 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| ZA200301465A ZA200301465B (en) | 2000-10-18 | 2003-02-24 | Vaccine composition comprising an antigen and a peptide having adjuvant properties. |
Country Status (27)
| Country | Link |
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| US (3) | US8361476B2 (ja) |
| EP (1) | EP1326634B1 (ja) |
| JP (2) | JP4227407B2 (ja) |
| KR (1) | KR100598302B1 (ja) |
| CN (1) | CN1248736C (ja) |
| AT (2) | AT410635B (ja) |
| AU (2) | AU2002212326B2 (ja) |
| BR (1) | BRPI0114994B8 (ja) |
| CA (1) | CA2426490C (ja) |
| CZ (1) | CZ303303B6 (ja) |
| DE (1) | DE60119145T2 (ja) |
| DK (1) | DK1326634T3 (ja) |
| ES (1) | ES2263668T3 (ja) |
| HK (1) | HK1055899A1 (ja) |
| HU (1) | HU228382B1 (ja) |
| IL (2) | IL154605A0 (ja) |
| IS (1) | IS2608B (ja) |
| MX (1) | MXPA03002828A (ja) |
| NO (1) | NO330274B1 (ja) |
| NZ (1) | NZ524532A (ja) |
| PL (1) | PL209016B1 (ja) |
| PT (1) | PT1326634E (ja) |
| RU (2) | RU2328305C2 (ja) |
| SI (1) | SI1326634T1 (ja) |
| SK (1) | SK287618B6 (ja) |
| WO (1) | WO2002032451A1 (ja) |
| ZA (1) | ZA200301465B (ja) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
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| AT410635B (de) * | 2000-10-18 | 2003-06-25 | Cistem Biotechnologies Gmbh | Vakzin-zusammensetzung |
| WO2002053184A2 (en) * | 2001-01-05 | 2002-07-11 | Intercell Ag | Uses for polycationic compounds as vaccine adjuvants |
| US7244438B2 (en) | 2001-01-05 | 2007-07-17 | Intercell Ag | Uses for polycationic compounds |
| AT410798B (de) | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
| EP1279404A1 (en) | 2001-07-26 | 2003-01-29 | Istituto Superiore di Sanità | Use of HIV-1 tat, fragments or derivatives thereof, to target or to activate antigen-presenting cells, to deliver cargo molecules for vaccination or to treat other diseases |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| EP1523557A2 (en) | 2002-07-24 | 2005-04-20 | Intercell AG | Antigens encoded by alternative reading frame from pathogenic viruses |
| US7785608B2 (en) | 2002-08-30 | 2010-08-31 | Wyeth Holdings Corporation | Immunogenic compositions for the prevention and treatment of meningococcal disease |
| EP1537418A2 (en) | 2002-09-13 | 2005-06-08 | Intercell AG | Method for isolating hepatitis c virus peptides |
| CN102174533A (zh) | 2002-10-15 | 2011-09-07 | 英特塞尔股份公司 | 编码b族链球菌粘着因子的核酸、b族链球菌的粘着因子和它们的用途 |
| PT1601770E (pt) | 2003-03-04 | 2009-12-07 | Intercell Ag | Antigénios de streptococcus pyogenes |
| WO2004084937A1 (en) * | 2003-03-24 | 2004-10-07 | Intercell Ag | Use of alum and a th1 immune response inducing adjuvant for enhancing immune responses |
| WO2004084938A1 (en) * | 2003-03-24 | 2004-10-07 | Intercell Ag | Improved vaccines |
| JP2007523609A (ja) | 2003-03-31 | 2007-08-23 | インターツェル・アクチェンゲゼルシャフト | 表皮ブドウ球菌抗原 |
| CA2522238A1 (en) | 2003-04-15 | 2004-10-28 | Intercell Ag | S. pneumoniae antigens |
| US8076059B2 (en) * | 2003-04-16 | 2011-12-13 | Duke University | Adjuvant capable of specifically activating the adaptive immune response |
| EP2287177A3 (en) | 2003-05-07 | 2011-08-31 | Intercell AG | Streptococcus agalactiae antigens I + II |
| EP2327720A1 (en) | 2003-05-30 | 2011-06-01 | Intercell AG | Enterococcus antigens |
| PL1648502T3 (pl) * | 2003-07-11 | 2011-05-31 | Intercell Ag | Szczepionki przeciwko HCV |
| DE602005004014T2 (de) | 2004-03-12 | 2008-12-11 | Intercell Ag | Verfahren zur solubilisierung von peptid-mischungen |
| PT1791858E (pt) | 2004-09-24 | 2010-07-26 | Intercell Ag | PROTENA DE CáPSIDE VP1 MODIFICADA DO PARVOVRUS B19 |
| EP1931379B1 (en) | 2005-10-07 | 2013-05-29 | Health Protection Agency | Proteins with improved solubility and methods for producing and using same |
| TW200806315A (en) | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| ES2400531T3 (es) | 2006-06-28 | 2013-04-10 | Statens Serum Institut | Expansión del repertorio de los linfocitos T para incluir epítopos subdominantes mediante vacunación con antígenos administrados en forma de fragmentos proteicos o cócteles peptídicos |
| CN101490083A (zh) | 2006-07-07 | 2009-07-22 | 英特塞尔股份公司 | 小化脓性链球菌抗原及其用途 |
| EP2275434A1 (en) | 2006-09-15 | 2011-01-19 | Intercell AG | Borrelia antigens |
| EP1923069A1 (en) | 2006-11-20 | 2008-05-21 | Intercell AG | Peptides protective against S. pneumoniae and compositions, methods and uses relating thereto |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| US8343510B2 (en) | 2007-01-12 | 2013-01-01 | Intercell Ag | Protective proteins of S. agalactiae, combinations thereof and methods of using the same |
| JP2010532657A (ja) | 2007-05-02 | 2010-10-14 | インターセル アーゲー | クレブシエラ属の抗原 |
| EP2012122A1 (en) | 2007-07-06 | 2009-01-07 | Medigene AG | Mutated parvovirus structural proteins as vaccines |
| US20100203083A1 (en) | 2007-05-31 | 2010-08-12 | Medigene Ag | Mutated structural protein of a parvovirus |
| AU2008265218A1 (en) | 2007-06-18 | 2008-12-24 | Intercell Ag | Chlamydia antigens |
| EP2265634A2 (en) | 2008-03-17 | 2010-12-29 | Intercell AG | Peptides protective against s. pneumoniae and compositions, methods and uses relating thereto |
| CA2720277C (en) | 2008-04-02 | 2017-01-17 | The University Of Tokushima | Antigen-and-drug vehicle comprising synthetic peptide, and mucosal vaccine using the same |
| CA2728308A1 (en) | 2008-06-20 | 2009-12-23 | Wyeth Llc | Compositions and methods of use of orf1358 from beta-hemolytic streptococcal strains |
| US20100015171A1 (en) * | 2008-07-15 | 2010-01-21 | Statens Serum Institute | Vaccines comprising tb 10.4 |
| EP2424882A2 (en) | 2009-02-05 | 2012-03-07 | Intercell AG | Peptides protective against e. faecalis, methods and uses relating thereto |
| EP2405938A2 (en) | 2009-02-13 | 2012-01-18 | Intercell AG | Nontypable haemophilus influenzae antigens |
| RU2536981C9 (ru) | 2009-06-22 | 2015-05-10 | ВАЙЕТ ЭлЭлСи | Иммуногенные композиции антигенов staphylococcus aureus |
| SA114350400B1 (ar) | 2009-06-22 | 2016-05-26 | ويث ال ال سي | تركيبات وطرق لتحضير تركيبات مولدة للمناعة لمقترن بولي سكاريد كبسولي للنمط المصلي 5 و 8 من المكورات العنقودية الذهبية |
| WO2011024071A1 (en) | 2009-08-27 | 2011-03-03 | Novartis Ag | Adjuvant comprising aluminium, oligonucleotide and polycation |
| EP2308896A1 (en) | 2009-10-09 | 2011-04-13 | Sanofi-aventis | Polypeptides for binding to the "receptor for advanced glycation endproducts" as well as compositions and methods involving the same |
| EP2319871A1 (en) | 2009-11-05 | 2011-05-11 | Sanofi-aventis | Polypeptides for binding to the "receptor for advanced glycation endproducts" as well as compositions and methods involving the same |
| BR112012007821A2 (pt) | 2009-10-09 | 2017-05-30 | Sanofi Sa | polipeptídeos para ligação ao "receptor de produtos finais de glicação avançada" bem como composições e métodos envolvendo os mesmos |
| WO2011101465A1 (en) | 2010-02-19 | 2011-08-25 | Intercell Ag | Ic31 nanoparticles |
| CN102802662A (zh) | 2010-03-18 | 2012-11-28 | 诺华有限公司 | 用于脑膜炎球菌血清组b的含佐剂疫苗 |
| EP3626263A1 (en) | 2010-06-04 | 2020-03-25 | Wyeth LLC | Vaccine formulations |
| PL3246044T5 (pl) | 2010-08-23 | 2024-06-17 | Wyeth Llc | Stabilne preparaty antygenów rLP2086 Neisseria meningitidis |
| EP2753352B2 (en) | 2010-09-03 | 2022-08-10 | Valneva Austria GmbH | Isolated polypeptide of the toxin a and toxin b proteins of c. difficile and uses thereof |
| WO2012031760A1 (en) | 2010-09-08 | 2012-03-15 | Medigene Ag | Parvovirus mutated structural proteins comprising cross - protective b - cell epitopes of a hpv l2 protein as well as products and methods relating thereto |
| MY166172A (en) | 2010-09-10 | 2018-06-07 | Wyeth Llc | Non-lipidated variants of neisseria meningitidis orf2086 antigens |
| PL3150222T3 (pl) | 2010-12-22 | 2020-05-18 | Wyeth Llc | Stabilne immunogenne kompozycje antygenów staphylococcus aureus |
| BRPI1100857A2 (pt) * | 2011-03-18 | 2013-05-21 | Alexandre Eduardo Nowill | agente imunomodulador e suas combinaÇÕes, seu uso e mÉtodo imunoterÁpico para a recontextualizaÇço, reprogramaÇço e reconduÇço do sistema imune em tempo real |
| ITMI20111182A1 (it) | 2011-06-28 | 2012-12-29 | Canio Buonavoglia | Vaccino per coronavirus canino |
| NZ628449A (en) | 2012-03-09 | 2016-04-29 | Pfizer | Neisseria meningitidis compositions and methods thereof |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| JP6445427B2 (ja) * | 2012-05-08 | 2018-12-26 | ウエスタン ユニバーシティ オブ ヘルス サイエンシズ | ＣＤ４＋Ｔ細胞集団の抗原特異的な拡大のために標準化されたｅｘｖｉｖｏプラットフォーム |
| CA2889841C (en) * | 2012-10-29 | 2021-12-28 | The Board Of Trustees Of The University Of Arkansas | Novel mucosal adjuvants and delivery systems |
| EP3363806B1 (en) | 2012-12-20 | 2022-11-16 | Pfizer Inc. | Glycoconjugation process |
| ES2685894T3 (es) | 2013-03-08 | 2018-10-15 | Pfizer Inc. | Polipéptidos de fusión inmunogénicos |
| US20140271723A1 (en) * | 2013-03-15 | 2014-09-18 | Saint Louis University | Adjuvant compositions and methods of using thereof |
| KR101905278B1 (ko) | 2013-09-08 | 2018-10-08 | 화이자 인코포레이티드 | 나이세리아 메닌지티디스 조성물 및 그의 방법 |
| WO2016130569A1 (en) | 2015-02-09 | 2016-08-18 | Mj Biologics, Inc. | A composition comprising pedv antigens and methods for making and using the composition |
| EP3270959A1 (en) | 2015-02-19 | 2018-01-24 | Pfizer Inc | Neisseria meningitidis compositions and methods thereof |
| IL297740A (en) | 2015-05-04 | 2022-12-01 | Pfizer | Protein-polysaccharide conjugates of group b streptococcus, methods for preparing the conjugates, immunogenic preparations containing conjugates and their uses |
| CN113521007B (zh) * | 2016-07-01 | 2022-11-18 | 四川大学 | 抗菌肽衍生物在制备免疫佐剂中的用途 |
| US10751402B2 (en) | 2016-11-09 | 2020-08-25 | Pfizer Inc. | Immunogenic compositions and uses thereof |
| SG11201906519RA (en) | 2017-01-31 | 2019-08-27 | Pfizer | Neisseria meningitidis compositions and methods thereof |
| CN107266585B (zh) * | 2017-07-13 | 2019-08-06 | 陕西科技大学 | 一种mlh融合抗菌肽及其制备方法和应用 |
| EP3527223A1 (en) | 2018-02-16 | 2019-08-21 | 2A Pharma AB | Mutated parvovirus structural protein |
| EP3752184A1 (en) | 2018-02-16 | 2020-12-23 | 2A Pharma AB | Parvovirus structural protein for the treatment of autoimmune diseases |
| CN109745556A (zh) * | 2019-03-01 | 2019-05-14 | 龙阔（苏州）生物工程有限公司 | 一种疫苗佐剂及其应用及猪繁殖与呼吸综合征疫苗 |
| CN114127101A (zh) | 2019-05-20 | 2022-03-01 | 瓦尔尼瓦公司 | 用于治疗或预防呼吸道感染的亚单位疫苗 |
| WO2021202456A1 (en) * | 2020-03-30 | 2021-10-07 | The Wistar Institute Of Anatomy And Biology | Synthetic soluble receptor mimics and methods of use for treatment of covid-19 |
| EP4136095A1 (en) | 2020-04-17 | 2023-02-22 | Regents of the University of Minnesota | Sars-cov-2 spike receptor binding domain and compositions and methods thereof |
| US20230321212A1 (en) | 2020-08-26 | 2023-10-12 | Pfizer Inc. | Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof |
| MX2023010370A (es) | 2021-04-09 | 2023-09-12 | Valneva Se | Vacuna del metapneumovirus humano. |
| WO2023083964A1 (en) | 2021-11-11 | 2023-05-19 | 2A Pharma Ab | Parvovirus structural protein against beta- and gamma-hpv |
| WO2024069420A2 (en) | 2022-09-29 | 2024-04-04 | Pfizer Inc. | Immunogenic compositions comprising an rsv f protein trimer |
Family Cites Families (11)
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| WO1995004542A1 (en) * | 1993-08-06 | 1995-02-16 | Cytel Corporation | Cloning and characterization of the complete mage-1 gene |
| JP3442824B2 (ja) * | 1993-08-30 | 2003-09-02 | 理化学研究所 | 抗菌性ペプチド類 |
| JP3547504B2 (ja) * | 1994-11-01 | 2004-07-28 | 独立行政法人理化学研究所 | 新規なポリペプチド及びその用途 |
| EP0991767A1 (en) * | 1997-06-11 | 2000-04-12 | Institut Pasteur | Attenuated recombinant mycobacteria useful as immunogens or as vaccine components |
| EP1009386B1 (en) * | 1997-08-29 | 2005-08-31 | Corixa Corporation | Rapid release encapsulated bioactive agents for inducing or potentiating an immune response and methods of using thereof |
| CU22700A1 (es) * | 1997-09-29 | 2001-07-31 | Ct Ingenieria Genetica Biotech | Formulación farmacéutica anti-viral que contiene un péptido de la proteína factor anti-lps de limulus y su uso |
| US20020072495A1 (en) * | 2000-09-21 | 2002-06-13 | Oleg Chertov | LL-37 is an immunostimulant |
| AT410635B (de) | 2000-10-18 | 2003-06-25 | Cistem Biotechnologies Gmbh | Vakzin-zusammensetzung |
| WO2004084937A1 (en) * | 2003-03-24 | 2004-10-07 | Intercell Ag | Use of alum and a th1 immune response inducing adjuvant for enhancing immune responses |
| WO2004084938A1 (en) | 2003-03-24 | 2004-10-07 | Intercell Ag | Improved vaccines |
| PL1648502T3 (pl) * | 2003-07-11 | 2011-05-31 | Intercell Ag | Szczepionki przeciwko HCV |
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- 2001-10-18 HU HU0302117A patent/HU228382B1/hu unknown
- 2001-10-18 AT AT01980496T patent/ATE324116T1/de not_active IP Right Cessation
- 2001-10-18 IL IL15460501A patent/IL154605A0/xx unknown
- 2001-10-18 AU AU1232602A patent/AU1232602A/xx active Pending
- 2001-10-18 KR KR1020037004977A patent/KR100598302B1/ko active IP Right Grant
- 2001-10-18 BR BRPI0114994-6 patent/BRPI0114994B8/pt not_active IP Right Cessation
- 2001-10-18 MX MXPA03002828A patent/MXPA03002828A/es active IP Right Grant
- 2001-10-18 DE DE60119145T patent/DE60119145T2/de not_active Expired - Lifetime
- 2001-10-18 JP JP2002535688A patent/JP4227407B2/ja not_active Expired - Lifetime
- 2001-10-18 PL PL362966A patent/PL209016B1/pl unknown
- 2001-10-18 SK SK575-2003A patent/SK287618B6/sk not_active IP Right Cessation
- 2001-10-18 CZ CZ20031299A patent/CZ303303B6/cs not_active IP Right Cessation
- 2001-10-18 DK DK01980496T patent/DK1326634T3/da active
- 2001-10-18 CN CNB018171168A patent/CN1248736C/zh not_active Expired - Lifetime
- 2001-10-18 EP EP01980496A patent/EP1326634B1/en not_active Expired - Lifetime
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2003
- 2003-02-20 IS IS6722A patent/IS2608B/is unknown
- 2003-02-24 IL IL154605A patent/IL154605A/en unknown
- 2003-02-24 ZA ZA200301465A patent/ZA200301465B/en unknown
- 2003-04-08 NO NO20031595A patent/NO330274B1/no not_active IP Right Cessation
- 2003-11-12 HK HK03108189A patent/HK1055899A1/xx not_active IP Right Cessation
-
2007
- 2007-12-13 RU RU2007146372/15A patent/RU2007146372A/ru not_active Application Discontinuation
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2008
- 2008-05-21 US US12/124,785 patent/US8900564B2/en active Active
- 2008-05-22 JP JP2008134215A patent/JP2008222721A/ja not_active Withdrawn
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2013
- 2013-01-16 US US13/742,500 patent/US20130216583A1/en not_active Abandoned
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