ZA200300647B - Composition comprising substained-release fine particles for quick-disintegrating tablets in the buccal cavity and manufacturing method thereof. - Google Patents
Composition comprising substained-release fine particles for quick-disintegrating tablets in the buccal cavity and manufacturing method thereof. Download PDFInfo
- Publication number
- ZA200300647B ZA200300647B ZA200300647A ZA200300647A ZA200300647B ZA 200300647 B ZA200300647 B ZA 200300647B ZA 200300647 A ZA200300647 A ZA 200300647A ZA 200300647 A ZA200300647 A ZA 200300647A ZA 200300647 B ZA200300647 B ZA 200300647B
- Authority
- ZA
- South Africa
- Prior art keywords
- sustained
- fine particles
- quick
- release fine
- buccal cavity
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30830301P | 2001-07-27 | 2001-07-27 |
Publications (1)
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|---|---|
| ZA200300647B true ZA200300647B (en) | 2004-07-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200300647A ZA200300647B (en) | 2001-07-27 | 2003-01-23 | Composition comprising substained-release fine particles for quick-disintegrating tablets in the buccal cavity and manufacturing method thereof. |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7255876B2 (de) |
| EP (1) | EP1413294B1 (de) |
| JP (3) | JP4019374B2 (de) |
| KR (1) | KR100530546B1 (de) |
| CN (1) | CN1473035B (de) |
| AT (1) | ATE482692T1 (de) |
| AU (1) | AU2002355222B2 (de) |
| BR (1) | BR0205509A (de) |
| CA (1) | CA2419089A1 (de) |
| CZ (1) | CZ14921U1 (de) |
| DE (2) | DE20220604U1 (de) |
| ES (1) | ES2351249T3 (de) |
| HU (1) | HUP0302351A3 (de) |
| MX (1) | MXPA03000985A (de) |
| PL (1) | PL361452A1 (de) |
| RU (1) | RU2245136C2 (de) |
| WO (1) | WO2003009831A1 (de) |
| ZA (1) | ZA200300647B (de) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7815937B2 (en) * | 1998-10-27 | 2010-10-19 | Biovail Laboratories International Srl | Quick dissolve compositions and tablets based thereon |
| AU1323400A (en) * | 1998-10-27 | 2000-05-15 | Fuisz Technologies Ltd. | Microparticles containing peg and/or peg glyceryl esters |
| ES2351249T3 (es) * | 2001-07-27 | 2011-02-02 | Astellas Pharma Inc. | Composición que comprende partículas finas, de liberación sostenida, para comprimidos de disgregación rápida en la cavidad bucal. |
| ATE321544T1 (de) * | 2001-11-07 | 2006-04-15 | Synthon Bv | Tamsulosin tabletten |
| JP4173670B2 (ja) * | 2002-03-08 | 2008-10-29 | 旭化成ファーマ株式会社 | 口腔内崩壊製剤 |
| DE10232113A1 (de) | 2002-07-16 | 2004-01-29 | Bayer Ag | Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel |
| DE10244504A1 (de) * | 2002-09-25 | 2004-04-08 | Capsulution Nanoscience Ag | Schnellfreisetzende Darreichungsform mit schwerlöslichem Wirkstoff |
| JP4523265B2 (ja) * | 2002-11-13 | 2010-08-11 | 旭化成ファーマ株式会社 | 排尿障害治療用口腔内崩壊製剤 |
| CN1758903A (zh) * | 2003-01-27 | 2006-04-12 | 安斯泰来制药有限公司 | 坦洛新或其盐的肠缓释微粒及其制造方法 |
| ZA200409537B (en) * | 2003-01-31 | 2006-10-25 | Yamanouchi Pharma Co Ltd | Stable solid medicinal composition for oral administration |
| DK1473029T3 (da) * | 2003-04-30 | 2005-04-18 | Ferring Bv | Farmaceutisk præparat som fast dosisform og fremgangsmåde til fremstilling deraf |
| ES2272914T3 (es) * | 2003-05-20 | 2007-05-01 | Ethypharm | Composicion farmaceutica oral de liberacion sostenida. |
| WO2005013960A1 (en) * | 2003-08-12 | 2005-02-17 | Kyungdong Pharm. Co., Ltd. | Preparing method for controlled released type tablet tamsulosin hcl and the tablet thereof |
| WO2005030179A1 (en) * | 2003-09-29 | 2005-04-07 | Cj Corporation | Sustained-release formulations |
| CN100438914C (zh) * | 2003-10-15 | 2008-12-03 | 富士化学工业株式会社 | 用于口腔内快速崩解的片剂的组合物 |
| ES2688193T3 (es) | 2003-10-15 | 2018-10-31 | Fuji Chemical Industry Co., Ltd. | Comprimido de disgregación rápida en la cavidad oral |
| DE10350322A1 (de) * | 2003-10-23 | 2005-06-09 | Coty B.V. | Klimabeständiger kosmetischer Komplex |
| WO2005039542A1 (ja) * | 2003-10-27 | 2005-05-06 | Yamanouchi Pharmaceutical Co., Ltd. | 口腔内崩壊錠用の薬物含有被覆微粒子 |
| US8128958B2 (en) | 2003-11-10 | 2012-03-06 | Astellas Pharma Inc. | Sustained release pharmaceutical composition |
| US8197846B2 (en) * | 2003-11-10 | 2012-06-12 | Astellas Pharma Inc. | Sustained release pharmaceutical composition |
| WO2005053659A1 (en) * | 2003-12-03 | 2005-06-16 | Natco Pharma Limited | An improved pharmaceutical formulation containing tamsulosin salt and a process for its preparation |
| SI21637A (sl) * | 2003-12-23 | 2005-06-30 | LEK farmacevtska dru�ba d.d. | Farmacevtska oblika z nadzorovanim sproščanjem |
| KR100582350B1 (ko) * | 2004-02-17 | 2006-05-22 | 한미약품 주식회사 | 탐수로신 염산염의 경구투여용 조성물 및 이의 서방성과립 제제 |
| PL1753398T3 (pl) * | 2004-06-10 | 2019-04-30 | Glatt Air Techniques Inc | Macierz o kontrolowanym uwalnianiu farmaceutycznej formulacji dawkowania |
| DE102004028940A1 (de) * | 2004-06-15 | 2006-01-12 | Krka Tovarna Zdravil, D.D. | Oral zerfallende pharmazeutische Zusammensetzung, die Risperidon enthält |
| ES2287613T3 (es) * | 2004-07-14 | 2007-12-16 | Siegfried Generics International Ag | Granulado para la liberacion controlada de tamsulosina, que contiene alginato. |
| PL204079B1 (pl) * | 2004-08-12 | 2009-12-31 | Inst Farmaceutyczny | Stały doustny preparat chlorowodorku tamsulozyny o przedłużonym uwalnianiu i sposób jego wytwarzania |
| WO2006090845A1 (ja) * | 2005-02-25 | 2006-08-31 | Takeda Pharmaceutical Company Limited | 顆粒の製造方法 |
| DE102005009241A1 (de) * | 2005-03-01 | 2006-09-07 | Bayer Healthcare Ag | Arzneiformen mit kontrollierter Bioverfügbarkeit |
| DE102005009240A1 (de) | 2005-03-01 | 2006-09-07 | Bayer Healthcare Ag | Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften |
| ITBO20050123A1 (it) * | 2005-03-07 | 2005-06-06 | Alfa Wassermann Spa | Formulazioni farmaceutiche gastroresistenti contenenti rifaximina |
| WO2006115285A1 (ja) * | 2005-04-21 | 2006-11-02 | Takeda Pharmaceutical Company Limited | 医薬組成物 |
| KR101213345B1 (ko) * | 2005-04-28 | 2012-12-17 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 항치매약을 함유하는 조성물 |
| US20070048369A1 (en) * | 2005-08-26 | 2007-03-01 | National Starch And Chemical Investment Holding Corporation | Mucosal delivery tablet |
| CA2620738C (en) * | 2005-08-31 | 2010-10-12 | Ezaki Glico Co., Ltd. | Tablet for removing tongue coating |
| US7811604B1 (en) | 2005-11-14 | 2010-10-12 | Barr Laboratories, Inc. | Non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising clozapine and methods of making and using the same |
| CN101516367A (zh) | 2006-09-15 | 2009-08-26 | 安斯泰来制药有限公司 | 对光稳定的雷莫司琼的固态医药组合物 |
| EP2180882B2 (de) * | 2007-10-19 | 2017-06-28 | Otsuka Pharmaceutical Co., Ltd. | Pharmazeutisches präparat mit fester matrix |
| EP2252261A2 (de) * | 2008-02-13 | 2010-11-24 | Bayer Schering Pharma Aktiengesellschaft | Medikamentenausgabesystem mit stabilisierungseffekt |
| CA2714340A1 (en) * | 2008-02-13 | 2009-08-20 | Bayer Schering Pharma Aktiengesellschaft | Estradiol-containing drug delivery system |
| JP5572321B2 (ja) * | 2008-03-07 | 2014-08-13 | 沢井製薬株式会社 | 被覆微粒子含有口腔内崩壊錠 |
| ES2332168B1 (es) * | 2008-04-30 | 2010-10-27 | Consejo Superior De Investigaciones Cientificas (Csic) (75%) | Forma pseudopolimorfica de hidrocloruro de nicardipina, procedimiento para su preparacion y formulacion que la contiene. |
| JP5511663B2 (ja) * | 2008-07-01 | 2014-06-04 | 沢井製薬株式会社 | タムスロシン塩酸塩を含有する球形微粒子の製造方法 |
| CN101639340B (zh) * | 2008-08-01 | 2011-01-12 | 广东省计量科学研究院 | 读数显微镜检定装置 |
| EP2341899B1 (de) * | 2008-09-24 | 2014-12-17 | Evonik Röhm GmbH | Opioidhaltige pharmazeutische zusammensetzung mit ph-abhängiger freisetzung, die resistent ist gegen den einfluss von ethanol |
| EP2177215A1 (de) | 2008-10-17 | 2010-04-21 | Laboratorios Del. Dr. Esteve, S.A. | Co-Kristalle von Tramadol und NSARs |
| US9284307B2 (en) | 2009-08-05 | 2016-03-15 | Idenix Pharmaceuticals Llc | Macrocyclic serine protease inhibitors |
| UY32836A (es) | 2009-08-12 | 2011-03-31 | Bayer Schering Pharma Ag | Partículas estabilizadas que comprenden 5-metil-(6s)-tetrahidrofolato |
| CA2771358A1 (en) | 2009-08-19 | 2011-02-24 | Sascha General | Drug delivery systems (wafer) for pediatric use |
| TWI491395B (zh) | 2009-09-30 | 2015-07-11 | Ct Lab Inc | 一種內含用以治療神經退化性疾病之立即釋出與長效釋出藥物的口服劑量配方 |
| WO2011056764A1 (en) | 2009-11-05 | 2011-05-12 | Ambit Biosciences Corp. | Isotopically enriched or fluorinated imidazo[2,1-b][1,3]benzothiazoles |
| MX2012006877A (es) | 2009-12-18 | 2012-08-31 | Idenix Pharmaceuticals Inc | Inhibidores de virus de hepatitis c de arileno o heteroarileno 5, 5 - fusionado. |
| WO2011094890A1 (en) | 2010-02-02 | 2011-08-11 | Argusina Inc. | Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators |
| SG10201504529WA (en) * | 2010-03-09 | 2015-07-30 | Alkermes Pharma Ireland Ltd | Alcohol Resistant Enteric Pharmaceutical Compositions |
| WO2011112689A2 (en) | 2010-03-11 | 2011-09-15 | Ambit Biosciences Corp. | Saltz of an indazolylpyrrolotriazine |
| JP5648303B2 (ja) * | 2010-03-19 | 2015-01-07 | 味の素株式会社 | 耐吸湿固結性を有する粉体造粒物の製造方法および粉体造粒物 |
| KR101423237B1 (ko) * | 2010-05-04 | 2014-07-30 | 주식회사 삼양바이오팜 | 탐스로신 또는 이의 약학적으로 허용 가능한 염을 포함하는 방출 제어용 약학 조성물, 및 이를 포함하는 경구용 제제 |
| JP5933554B2 (ja) | 2010-09-01 | 2016-06-15 | アムビト ビオスシエンセス コルポラチオン | 光学活性のあるピラゾリルアミノキナゾリン及びその医薬組成物及び使用方法 |
| AU2011296046B2 (en) | 2010-09-01 | 2015-05-14 | Ambit Biosciences Corporation | Hydrobromide salts of a pyrazolylaminoquinazoline |
| BR112013014021A8 (pt) | 2010-12-06 | 2017-10-03 | Follica Inc | Métodos para tratamento de calvície e promoção de crescimento de cabelos |
| WO2012080050A1 (en) | 2010-12-14 | 2012-06-21 | F. Hoffmann-La Roche Ag | Solid forms of a phenoxybenzenesulfonyl compound |
| KR101111534B1 (ko) * | 2010-12-24 | 2012-02-15 | (주)비씨월드제약 | 구강 속붕해성 조성물 및 이의 제조방법 |
| CN103338753A (zh) | 2011-01-31 | 2013-10-02 | 细胞基因公司 | 胞苷类似物的药物组合物及其使用方法 |
| AR085352A1 (es) | 2011-02-10 | 2013-09-25 | Idenix Pharmaceuticals Inc | Inhibidores macrociclicos de serina proteasa, sus composiciones farmaceuticas y su uso para tratar infecciones por hcv |
| US20120252721A1 (en) | 2011-03-31 | 2012-10-04 | Idenix Pharmaceuticals, Inc. | Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor |
| WO2013019056A1 (en) * | 2011-08-01 | 2013-02-07 | Sam-A Pharm. Co., Ltd. | Novel granule formulation containing sildenafil or pharmaceutically acceptable salts thereof as an active ingredient |
| EP2807177B1 (de) | 2012-01-27 | 2019-11-13 | The Regents of The University of California | Stabilisierung von biomolekülen anhand von zuckerpolymeren |
| RU2014141674A (ru) | 2012-03-16 | 2016-05-10 | Аксикин Фармасьютикалз, Инк. | 3,5-диаминопиразоловые ингибиторы киназы |
| TW201427720A (zh) * | 2012-10-12 | 2014-07-16 | Ajinomoto Kk | 含有鈣拮抗劑及血管張力素ｉｉ受體拮抗劑之醫藥製劑之製造方法 |
| CN113842362A (zh) | 2012-11-14 | 2021-12-28 | 格雷斯公司 | 含有生物活性材料与无序无机氧化物的组合物 |
| CN103230379A (zh) * | 2013-04-02 | 2013-08-07 | 万特制药(海南)有限公司 | 一种含有盐酸坦索罗辛的口崩缓释制剂及其制备方法 |
| NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
| EP3046924A1 (de) | 2013-09-20 | 2016-07-27 | IDENIX Pharmaceuticals, Inc. | Inhibitoren des hepatitis-c-virus |
| WO2015134560A1 (en) | 2014-03-05 | 2015-09-11 | Idenix Pharmaceuticals, Inc. | Solid forms of a flaviviridae virus inhibitor compound and salts thereof |
| KR102663309B1 (ko) | 2014-03-20 | 2024-05-03 | 카펠라 테라퓨틱스, 인크. | 암 치료용의 ｅｒｂｂ 티로신 키나제 억제제로서의 벤즈이미다졸 유도체 |
| JP6568926B2 (ja) | 2014-03-20 | 2019-08-28 | カペラ セラピューティクス，インコーポレーテッド | 癌の治療のためのｅｒｂｂチロシンキナーゼ阻害剤としてのベンゾイミダゾール誘導体 |
| US10335374B2 (en) * | 2014-12-04 | 2019-07-02 | University System of Georgia, Valdosta State University | Tablet composition for anti-tuberculosis antibiotics |
| UA118312C2 (uk) | 2014-12-23 | 2018-12-26 | Ексікін Фармасутікалз, Інк. | 3,5-діамінопіразолові інгібітори кінази |
| CZ2015225A3 (cs) * | 2015-03-30 | 2016-10-12 | Zentiva, K.S. | Nový krok ve způsobu potahování pelet obsahujících Tamsulosin.HCI |
| JP2016193894A (ja) * | 2015-04-01 | 2016-11-17 | 京都薬品工業株式会社 | 生菌含有製剤 |
| JP6618736B2 (ja) * | 2015-09-01 | 2019-12-11 | 沢井製薬株式会社 | ミラベグロン含有錠剤、ミラベグロン含有製剤の製造方法及びミラベグロン含有造粒物の製造方法 |
| JP7418958B2 (ja) | 2016-03-17 | 2024-01-22 | チオジェネシス セラピューティクス， インコーポレイテッド | システアミンの制御放出のための組成物及びシステアミン感受性障害の全身治療 |
| CN108066304B (zh) * | 2016-11-16 | 2022-09-16 | 深圳万和制药有限公司 | 具有缓释性能的坦索罗辛口腔崩解片组合物 |
| CN108066347B (zh) * | 2016-11-16 | 2021-02-02 | 深圳万和制药有限公司 | 包含坦索罗辛和度他雄胺的口腔崩解片药物组合物 |
| CN108066305B (zh) * | 2016-11-16 | 2022-09-16 | 深圳万和制药有限公司 | 改善口崩片硬度和崩解的方法和定位释放口腔崩解片 |
| CN108066297B (zh) * | 2016-11-16 | 2022-09-16 | 深圳万和制药有限公司 | 治疗老年痴呆症的定位释放美金刚口腔崩解片组合物 |
| CN107616969B (zh) * | 2016-11-16 | 2020-09-18 | 杭州朱养心药业有限公司 | 迅速崩解的吡仑帕奈片剂药物组合物 |
| EP3673901A4 (de) | 2017-08-21 | 2021-05-19 | Nipro Corporation | Teilchen einer pharmazeutischen zusammensetzung, oral zerfallendes präparat damit und verfahren zur herstellung von teilchen einer pharmazeutischen zusammensetzung |
| JP7336388B2 (ja) * | 2018-02-02 | 2023-08-31 | ニプロ株式会社 | 錠剤及びその製造方法 |
| WO2019183142A1 (en) * | 2018-03-19 | 2019-09-26 | Cage Bio Inc. | Ionic liquid compositions for treatment of rosacea |
| GB202001237D0 (en) * | 2020-01-29 | 2020-03-11 | Sisteks D O O | Granular pharmaceutical product for oral administration from a pre-filled straw and method of manufacturing such pharmaceutical product |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4772475A (en) | 1985-03-08 | 1988-09-20 | Yamanouchi Pharmaceutical Co., Ltd. | Controlled-release multiple units pharmaceutical formulation |
| JPH0780754B2 (ja) | 1986-08-06 | 1995-08-30 | エーザイ株式会社 | 多顆粒型持続性錠剤 |
| JPH01135451A (ja) * | 1987-11-20 | 1989-05-29 | Mitsubishi Electric Corp | 搬送ロボット |
| AU652723B2 (en) * | 1989-08-25 | 1994-09-08 | Bioglan Laboratories Ltd. | Pharmaceutical compositions and a device for administering the same |
| EP0444441B1 (de) | 1990-03-01 | 1996-09-25 | Hewlett-Packard Company | Minimierung von Eluatbandbreiten in der Flüssigchromatographie |
| EP0447168A3 (en) * | 1990-03-16 | 1993-01-07 | Yamanouchi Pharmaceutical Co. Ltd. | Long acting granular pharmaceutical composition |
| JP2807346B2 (ja) * | 1991-12-24 | 1998-10-08 | 山之内製薬株式会社 | 口腔内崩壊製剤及びその製造法 |
| PL187160B1 (pl) | 1994-01-31 | 2004-05-31 | Yamanouchi Pharma Co Ltd | Sposób wytwarzania rozpuszczalnej wewnątrzustnie formowanej tłocznie wypraski |
| US5576014A (en) | 1994-01-31 | 1996-11-19 | Yamanouchi Pharmaceutical Co., Ltd | Intrabuccally dissolving compressed moldings and production process thereof |
| JPH1135451A (ja) | 1994-07-27 | 1999-02-09 | Yamanouchi Pharmaceut Co Ltd | 口腔内溶解型錠剤およびその製造方法 |
| US5824339A (en) * | 1995-09-08 | 1998-10-20 | Takeda Chemical Industries, Ltd | Effervescent composition and its production |
| AU713462B2 (en) | 1996-07-12 | 1999-12-02 | Daiichi Pharmaceutical Co., Ltd. | Quickly disintegrable compression-molded materials and process for producing the same |
| JPH10182436A (ja) | 1996-10-31 | 1998-07-07 | Takeda Chem Ind Ltd | 固形医薬製剤 |
| AU8977698A (en) * | 1997-07-25 | 1999-02-16 | Elan Corporation, Plc | A process for the preparation of a granulate suitable to the preparation of rapidly disintegrable mouth-soluble tablets |
| NZ505123A (en) * | 1997-12-19 | 2003-07-25 | Smithkline Beecham Corp | Process for manufacturing bite-dispersion tablets by compressing medicaments and other ingredients into granulates then compressing the granulates and other ingredients into tablets, and the tablets thereof |
| US6589554B1 (en) | 1998-03-16 | 2003-07-08 | Yamanouchi Pharmaceutical Co., Ltd. | Tablets quickly disintegrating in the oral cavity and process for producing the same |
| US6465009B1 (en) | 1998-03-18 | 2002-10-15 | Yamanouchi Pharmaceutical Co., Ltd. | Water soluble polymer-based rapidly dissolving tablets and production processes thereof |
| JP2000128774A (ja) * | 1998-10-26 | 2000-05-09 | Tanabe Seiyaku Co Ltd | 薬物を含有する球形微粒子の製法 |
| US6495177B1 (en) * | 1999-08-13 | 2002-12-17 | Warner Chilcott Laboratories Ireland Limited | Orally dissolvable nutritional supplement |
| CA2403594A1 (en) | 2000-03-27 | 2002-09-18 | Kyowa Hakko Kogyo Co., Ltd. | Granules having good taking property |
| US6872405B2 (en) * | 2001-05-10 | 2005-03-29 | Yamanouchi Pharmaceutical Co., Ltd. | Quick-disintegrating tablet in buccal cavity and manufacturing method thereof |
| ES2351249T3 (es) * | 2001-07-27 | 2011-02-02 | Astellas Pharma Inc. | Composición que comprende partículas finas, de liberación sostenida, para comprimidos de disgregación rápida en la cavidad bucal. |
-
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| DE60237826D1 (de) | 2010-11-11 |
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| CZ14921U1 (cs) | 2004-11-23 |
| JP4019374B2 (ja) | 2007-12-12 |
| KR20030036656A (ko) | 2003-05-09 |
| CN1473035A (zh) | 2004-02-04 |
| MXPA03000985A (es) | 2004-04-02 |
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| EP1413294B1 (de) | 2010-09-29 |
| ATE482692T1 (de) | 2010-10-15 |
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| WO2003009831A1 (en) | 2003-02-06 |
| EP1413294A1 (de) | 2004-04-28 |
| DE20220604U1 (de) | 2004-02-26 |
| BR0205509A (pt) | 2003-06-24 |
| US7575762B2 (en) | 2009-08-18 |
| EP1413294A4 (de) | 2006-06-07 |
| ES2351249T3 (es) | 2011-02-02 |
| CA2419089A1 (en) | 2003-03-05 |
| KR100530546B1 (ko) | 2005-11-23 |
| US20030147948A1 (en) | 2003-08-07 |
| PL361452A1 (en) | 2004-10-04 |
| JP2004196829A (ja) | 2004-07-15 |
| AU2002355222B2 (en) | 2007-07-26 |
| RU2245136C2 (ru) | 2005-01-27 |
| HUP0302351A3 (en) | 2007-03-28 |
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