ZA200208674B - Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by the NP Y5 receptor. - Google Patents
Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by the NP Y5 receptor. Download PDFInfo
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- ZA200208674B ZA200208674B ZA200208674A ZA200208674A ZA200208674B ZA 200208674 B ZA200208674 B ZA 200208674B ZA 200208674 A ZA200208674 A ZA 200208674A ZA 200208674 A ZA200208674 A ZA 200208674A ZA 200208674 B ZA200208674 B ZA 200208674B
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- ZA
- South Africa
- Prior art keywords
- amino
- alkyl
- carbamoyl
- formula
- methyl
- Prior art date
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- -1 Amino substituted dibenzothiophene derivatives Chemical class 0.000 title claims description 538
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 9
- 208000035475 disorder Diseases 0.000 title claims description 9
- 230000001404 mediated effect Effects 0.000 title claims description 5
- 102100029549 Neuropeptide Y receptor type 5 Human genes 0.000 title description 2
- 101710198055 Neuropeptide Y receptor type 5 Proteins 0.000 title description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 138
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 83
- 125000000623 heterocyclic group Chemical group 0.000 claims description 74
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 67
- 150000001875 compounds Chemical class 0.000 claims description 60
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 56
- 229910052757 nitrogen Inorganic materials 0.000 claims description 48
- 125000004452 carbocyclyl group Chemical group 0.000 claims description 44
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 40
- 229910052799 carbon Inorganic materials 0.000 claims description 39
- 125000005843 halogen group Chemical group 0.000 claims description 37
- 150000003839 salts Chemical class 0.000 claims description 37
- 229940002612 prodrug Drugs 0.000 claims description 33
- 239000000651 prodrug Substances 0.000 claims description 33
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 31
- 239000012453 solvate Substances 0.000 claims description 28
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 22
- 125000003545 alkoxy group Chemical group 0.000 claims description 21
- 125000006517 heterocyclyl carbonyl group Chemical group 0.000 claims description 21
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 19
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 19
- 125000000304 alkynyl group Chemical group 0.000 claims description 18
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 18
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- 125000005844 heterocyclyloxy group Chemical group 0.000 claims description 17
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- 125000005236 alkanoylamino group Chemical group 0.000 claims description 7
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 claims description 7
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 claims description 7
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- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 claims description 6
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- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 5
- IYYZUPMFVPLQIF-ALWQSETLSA-N dibenzothiophene Chemical group C1=CC=CC=2[34S]C3=C(C=21)C=CC=C3 IYYZUPMFVPLQIF-ALWQSETLSA-N 0.000 claims description 5
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- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
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- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
- 230000006870 function Effects 0.000 description 1
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- 125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 description 1
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- VDBNYAPERZTOOF-UHFFFAOYSA-N isoquinolin-1(2H)-one Chemical compound C1=CC=C2C(=O)NC=CC2=C1 VDBNYAPERZTOOF-UHFFFAOYSA-N 0.000 description 1
- 125000001786 isothiazolyl group Chemical group 0.000 description 1
- 125000000842 isoxazolyl group Chemical group 0.000 description 1
- 238000011005 laboratory method Methods 0.000 description 1
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- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
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- 125000004458 methylaminocarbonyl group Chemical group [H]N(C(*)=O)C([H])([H])[H] 0.000 description 1
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- BPGXUIVWLQTVLZ-OFGSCBOVSA-N neuropeptide y(npy) Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 BPGXUIVWLQTVLZ-OFGSCBOVSA-N 0.000 description 1
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- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/76—Dibenzothiophenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Anesthesiology (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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GBGB0010757.3A GB0010757D0 (en) | 2000-05-05 | 2000-05-05 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
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ZA200208674B true ZA200208674B (en) | 2004-02-10 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ZA200208674A ZA200208674B (en) | 2000-05-05 | 2002-10-25 | Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by the NP Y5 receptor. |
Country Status (16)
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US (2) | US6967216B2 (ko) |
EP (1) | EP1278739A1 (ko) |
JP (1) | JP2003532723A (ko) |
KR (1) | KR20020093975A (ko) |
CN (1) | CN1440401A (ko) |
AR (1) | AR028414A1 (ko) |
AU (1) | AU2001252372A1 (ko) |
BR (1) | BR0110548A (ko) |
CA (1) | CA2406634A1 (ko) |
GB (1) | GB0010757D0 (ko) |
IL (1) | IL152230A0 (ko) |
MX (1) | MXPA02010563A (ko) |
NO (1) | NO20025286L (ko) |
NZ (1) | NZ522188A (ko) |
WO (1) | WO2001085714A1 (ko) |
ZA (1) | ZA200208674B (ko) |
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2001
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- 2001-05-01 MX MXPA02010563A patent/MXPA02010563A/es unknown
- 2001-05-01 WO PCT/GB2001/001899 patent/WO2001085714A1/en active IP Right Grant
- 2001-05-01 BR BR0110548-5A patent/BR0110548A/pt not_active IP Right Cessation
- 2001-05-01 KR KR1020027014772A patent/KR20020093975A/ko not_active Application Discontinuation
- 2001-05-01 EP EP01925687A patent/EP1278739A1/en not_active Withdrawn
- 2001-05-01 AU AU2001252372A patent/AU2001252372A1/en not_active Abandoned
- 2001-05-01 CA CA002406634A patent/CA2406634A1/en not_active Abandoned
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EP1278739A1 (en) | 2003-01-29 |
US20030225097A1 (en) | 2003-12-04 |
IL152230A0 (en) | 2003-05-29 |
AU2001252372A1 (en) | 2001-11-20 |
MXPA02010563A (es) | 2003-03-10 |
US6967216B2 (en) | 2005-11-22 |
US7332492B2 (en) | 2008-02-19 |
CN1440401A (zh) | 2003-09-03 |
WO2001085714A1 (en) | 2001-11-15 |
AR028414A1 (es) | 2003-05-07 |
US20050209233A1 (en) | 2005-09-22 |
NZ522188A (en) | 2004-04-30 |
BR0110548A (pt) | 2003-04-01 |
NO20025286D0 (no) | 2002-11-04 |
KR20020093975A (ko) | 2002-12-16 |
GB0010757D0 (en) | 2000-06-28 |
NO20025286L (no) | 2002-11-04 |
JP2003532723A (ja) | 2003-11-05 |
CA2406634A1 (en) | 2001-11-15 |
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