YU58301A - 2-aminopiridini koji sadrže supstituente sa kondenzovanim prstenom - Google Patents

2-aminopiridini koji sadrže supstituente sa kondenzovanim prstenom

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Publication number
YU58301A
YU58301A YU58301A YUP58301A YU58301A YU 58301 A YU58301 A YU 58301A YU 58301 A YU58301 A YU 58301A YU P58301 A YUP58301 A YU P58301A YU 58301 A YU58301 A YU 58301A
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Yugoslavia
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group
ring
alkyl
aryl
aralkyl
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YU58301A
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English (en)
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John Adams Lowe
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Pfizer Products Inc.
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Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of YU58301A publication Critical patent/YU58301A/sh

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Ovaj pronalazak se odnosi na derivate 2-aminopiridina formule (I) ili njihove farmaceutski prihvatljive soli, gde A i B su svaki nezavisno H, ili oba, A i B obrazuju prsten kondenzovan u fenil prsten, navedeni prsten je zasićen ili nezasićen i sadrži od 5 do 7 atoma članova prstena, gde navedeni atomi članovi prstena mogu opcionalno da sadrže od 1 do 2 heteroatoma nezavisno birana iz grupe koja se sastoji od N, O ili S, pod uslovom da nijedna dva susedna člana prstena nisu heteroatomi; X je kiseonik ili jednoguba veza; Y je (C1-C6)alkil; R1 je vodonik, (C1-C6)alkil ili (C1-C6)alkil grupa supstituisana sa -NR2R3 gde se R2 i R3 svaki nezavisno biraju iz grupe koju sačinjavaju H, alkil, aril, aralkil ili tetrahidronaftalen, gde je navedena aril grupa ili navedeni aril ostatak navedene aralkil grupe fenil ili naftil, navedena alkil grupa ili navedeni alkil ostatak navedene aralkil grupe sadrži od jednog do 6 atoma ugljenika i ravnog je lanca ili račvast, i navedena aril grupa, navedeni tetrahidronaftalen ili navedeni aril ostatak navedene aralkil grupe je opcionalno supstituisan sa jednim do tri halogen, nitro, ciano, amino, (C1-C4)alkoksi i (C1-C4)alkilamino ostatka, ili R2 i R3 obrazuju, zajedno sa azotom za koji su vezani, heterociklični prsten, ili ciklični ili biciklični prsten koji je zasićen iil nezasićen. Jedinjenja ovog pronalaska imaju svojstvo da inhibiraju aktivnost azotmonoksidsintaza (NOS) i zbog toga su korisna u tretiranju bolesti, poremećaja ili stanja centralnog nervnog sistema, izmedju ostalog.
YU58301A 1999-02-25 2000-02-02 2-aminopiridini koji sadrže supstituente sa kondenzovanim prstenom YU58301A (sh)

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YU58301A true YU58301A (sh) 2004-05-12

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Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010049379A1 (en) * 1997-08-27 2001-12-06 Lowe John Adams 2-aminopyridines containing fused ring substituents
DK1155000T3 (da) * 1999-02-25 2003-10-13 Pfizer Prod Inc 2-aminopyridiner som indeholder sammensluttede ringsubstituenser
CN1426397A (zh) 2000-03-31 2003-06-25 欧洲凯尔特股份有限公司 氨基吡啶类化合物及其作为抗惊厥剂和钠通道阻滞剂的应用
US20040092741A1 (en) * 2002-11-08 2004-05-13 Pfizer Inc Substituted pyridines via boronic acid coupling
US8729107B2 (en) * 2002-12-06 2014-05-20 Purdue Research Foundation Pyridines for treating injured mammalian nerve tissue
EP1567497B1 (en) * 2002-12-06 2009-09-23 Purdue Research Foundation Pyridines for treating injured mammalian nerve tissue
US20050192321A1 (en) * 2003-09-15 2005-09-01 Meythaler Jay M. Treatment of neuropathy with rapid release aminopyridine
WO2014138460A1 (en) 2013-03-07 2014-09-12 Northwestern University 2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors
US10759791B2 (en) 2014-11-04 2020-09-01 Northwestern University Mammalian and bacterial nitric oxide synthase inhibitors
WO2016073623A2 (en) 2014-11-04 2016-05-12 Northwestern University Mammalian and bacterial nitric oxide synthase inhibitors
US9585867B2 (en) 2015-08-06 2017-03-07 Charles Everett Ankner Cannabinod formulation for the sedation of a human or animal

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996018616A1 (en) * 1994-12-12 1996-06-20 Merck & Co., Inc. Substituted 2-aminopyridines as inhibitors of nitric oxide synthase
JPH101435A (ja) * 1995-09-14 1998-01-06 Nippon Kayaku Co Ltd ２−アミノピリジン類を有効成分とする一酸化窒素合成酵素阻害剤
DE69728138T2 (de) * 1996-03-29 2004-09-16 Pfizer Inc. 6-phenylpyridinderivate
HN1997000027A (es) 1996-12-06 1997-06-05 Pfizer Prod Inc Derivados de 6-fenil piridil - 2 amina
AU744313B2 (en) * 1997-02-10 2002-02-21 Pfizer Products Inc. 2-amino-6-(2-substituted-4-phenoxy)-substituted-pyridines
HN1998000118A (es) * 1997-08-27 1999-02-09 Pfizer Prod Inc 2 - aminopiridinas que contienen sustituyentes de anillos condensados.
HN1998000125A (es) * 1997-08-28 1999-02-09 Pfizer Prod Inc 2-aminopiridinas con sustituyentes alcoxi ramificados
DE69923448T2 (de) * 1998-06-03 2005-12-29 Pfizer Products Inc., Groton 2-aminopyridine mit kondensierten ringsubstituenten als stickstoff-oxid-synthase inhibitoren
DK1155000T3 (da) * 1999-02-25 2003-10-13 Pfizer Prod Inc 2-aminopyridiner som indeholder sammensluttede ringsubstituenser

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