AR018979A1 - 2-aminopiridinas que contienen sustituyentes de tipo anillo condensado - Google Patents

2-aminopiridinas que contienen sustituyentes de tipo anillo condensado

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Publication number
AR018979A1
AR018979A1 ARP000100767A ARP000100767A AR018979A1 AR 018979 A1 AR018979 A1 AR 018979A1 AR P000100767 A ARP000100767 A AR P000100767A AR P000100767 A ARP000100767 A AR P000100767A AR 018979 A1 AR018979 A1 AR 018979A1
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AR
Argentina
Prior art keywords
group
alkyl
ring
aralkyl
aryl
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ARP000100767A
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English (en)
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Pfizer Prod Inc
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Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR018979A1 publication Critical patent/AR018979A1/es

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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/73Unsubstituted amino or imino radicals
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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Abstract

La presente invencion se refiere a derivados de 2-aminopiridina de la formula I o sales farmacéuticamente aceptables de los mismos, en la que A y B soncada uno independientemente H, o juntos, A y B forman un anillo condensado al anillo de fenilo, siendo dicho anillo saturado o insaturado y conteniendo de 5 a7 átomos en el anillo, donde dichos átomos en el anillo pueden opcionalmente comprender de 1 a 2 heteroátomos seleccionados independientemente del grupoconstituido por N, O o S, siempre que los miembros de dos anillos adyacentes no sean heteroátomos; X es oxígeno o un enlace sencillo; Y es alquilo (C1-6); R1es hidrogeno, alquilo (C1-6) o un grupo (alquilo C1-6) sustituido con -NR2R3 en el que R2 y R3 se seleccionan bien independientemente del grupo constituido porH; alquilo, arilo, aralquilo o tetrahidronaftaleno, siendo dicho grupo arilo o dicho resto arilo de dicho grupo aralquilo fenilo o naftilo, conteniendo dichogrupo alquilo o dicho resto alquilo de dicho grupo aralquilo de uno a seis átomos de carbono y siendo una cadena lineal o ramificada, y estando dicho grupoarilo, dicho tetrahidronaftaleno o dicho resto arilo de dicho grupo aralquilo, opcionalmente sustituido con uno o tres restos de halogeno, nitro, ciano, amino,alcoxi (C1-4) y alquilamino (C1-4) o bien R2 y R3 forman, junto con el nitrogeno al que están unidos, un anillo heterocíclico, o un anillo cíclico o bicíclicoque está saturado o insaturado. Los compuestos de la invencion tienen la capacidad de inhibirla actividad de la síntasas de oxido n'trico (NOS), y por lotanto , son utiles en el tratamiento de enfermedades, estados y trastornos del sistema nervioso central entre otros.
ARP000100767A 1999-02-25 2000-02-23 2-aminopiridinas que contienen sustituyentes de tipo anillo condensado AR018979A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12159799P 1999-02-25 1999-02-25

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AR018979A1 true AR018979A1 (es) 2001-12-12

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ARP000100767A AR018979A1 (es) 1999-02-25 2000-02-23 2-aminopiridinas que contienen sustituyentes de tipo anillo condensado

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US (2) US6211208B1 (es)
EP (1) EP1155000B1 (es)
JP (1) JP3825636B2 (es)
KR (1) KR20010114213A (es)
CN (1) CN1341099A (es)
AP (1) AP2001002251A0 (es)
AR (1) AR018979A1 (es)
AT (1) ATE245143T1 (es)
AU (1) AU767593B2 (es)
BG (1) BG105855A (es)
BR (1) BR0008569A (es)
CA (1) CA2364719C (es)
CO (1) CO5160241A1 (es)
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EA (1) EA003941B1 (es)
EE (1) EE200100454A (es)
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US20010049379A1 (en) * 1997-08-27 2001-12-06 Lowe John Adams 2-aminopyridines containing fused ring substituents
PT1155000E (pt) * 1999-02-25 2003-10-31 Pfizer Prod Inc 2-aminopiridinas contendo aneis fundidos substituintes
NZ521870A (en) 2000-03-31 2004-08-27 Euro Celtique S Aminopyridines and their use as anticonvulsants and sodium channel blockers
US20040092741A1 (en) * 2002-11-08 2004-05-13 Pfizer Inc Substituted pyridines via boronic acid coupling
US8729107B2 (en) * 2002-12-06 2014-05-20 Purdue Research Foundation Pyridines for treating injured mammalian nerve tissue
EP1567497B1 (en) * 2002-12-06 2009-09-23 Purdue Research Foundation Pyridines for treating injured mammalian nerve tissue
US20050192321A1 (en) * 2003-09-15 2005-09-01 Meythaler Jay M. Treatment of neuropathy with rapid release aminopyridine
US9120750B2 (en) 2013-03-07 2015-09-01 Northwestern University 2-Aminopyridine-based selective neuronal nitric oxide synthase inhibitors
US10759791B2 (en) 2014-11-04 2020-09-01 Northwestern University Mammalian and bacterial nitric oxide synthase inhibitors
US9951014B2 (en) 2014-11-04 2018-04-24 Northwestern University Mammalian and bacterial nitric oxide synthase inhibitors
US9585867B2 (en) 2015-08-06 2017-03-07 Charles Everett Ankner Cannabinod formulation for the sedation of a human or animal

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AU4515696A (en) * 1994-12-12 1996-07-03 Merck & Co., Inc. Substituted 2-aminopyridines as inhibitors of nitric oxide synthase
JPH101435A (ja) * 1995-09-14 1998-01-06 Nippon Kayaku Co Ltd 2−アミノピリジン類を有効成分とする一酸化窒素合成酵素阻害剤
ATE261942T1 (de) * 1996-03-29 2004-04-15 Pfizer 6-phenylpyridinderivate
HN1997000027A (es) 1996-12-06 1997-06-05 Pfizer Prod Inc Derivados de 6-fenil piridil - 2 amina
UA64740C2 (uk) * 1997-02-10 2004-03-15 Пфайзер Продактс Інк. Похідні 2-амінопіридинів, фармацевтична композиція на їх основі (варіанти), спосіб лікування (варіанти), спосіб інгібування nos у ссавця та проміжні сполуки (варіанти)
HN1998000118A (es) * 1997-08-27 1999-02-09 Pfizer Prod Inc 2 - aminopiridinas que contienen sustituyentes de anillos condensados.
HN1998000125A (es) * 1997-08-28 1999-02-09 Pfizer Prod Inc 2-aminopiridinas con sustituyentes alcoxi ramificados
DE69923448T2 (de) * 1998-06-03 2005-12-29 Pfizer Products Inc., Groton 2-aminopyridine mit kondensierten ringsubstituenten als stickstoff-oxid-synthase inhibitoren
PT1155000E (pt) * 1999-02-25 2003-10-31 Pfizer Prod Inc 2-aminopiridinas contendo aneis fundidos substituintes

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DE60003893T2 (de) 2004-02-05
MXPA01008671A (es) 2002-03-14
NO20014095L (no) 2001-10-24
TR200102481T2 (tr) 2002-01-21
US20010014689A1 (en) 2001-08-16
CR6438A (es) 2004-02-23
EA003941B1 (ru) 2003-10-30
HRP20010597A2 (en) 2002-08-31
EP1155000A1 (en) 2001-11-21
TNSN00034A1 (fr) 2005-11-10
DK1155000T3 (da) 2003-10-13
DE60003893D1 (de) 2003-08-21
CA2364719A1 (en) 2000-08-31
EP1155000B1 (en) 2003-07-16
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ID29892A (id) 2001-10-18
ATE245143T1 (de) 2003-08-15
AU767593B2 (en) 2003-11-20
JP3825636B2 (ja) 2006-09-27
CZ20013036A3 (cs) 2002-03-13
OA11841A (en) 2005-08-22
PL350219A1 (en) 2002-11-18
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BG105855A (en) 2002-04-30
CA2364719C (en) 2006-07-04
AP2001002251A0 (en) 2001-09-30
EE200100454A (et) 2002-12-16
HUP0200163A2 (en) 2002-06-29
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KR20010114213A (ko) 2001-12-31
AU2124300A (en) 2000-09-14
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US6211208B1 (en) 2001-04-03
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IL144308A0 (en) 2002-05-23
MA26721A1 (fr) 2004-12-20
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ZA200106974B (en) 2002-10-14
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IS6005A (is) 2001-07-13
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