PE20001482A1 - 2-aminopiridinas que contienen sustituyentes de tipo anillo condensado - Google Patents
2-aminopiridinas que contienen sustituyentes de tipo anillo condensadoInfo
- Publication number
- PE20001482A1 PE20001482A1 PE2000000146A PE0001462000A PE20001482A1 PE 20001482 A1 PE20001482 A1 PE 20001482A1 PE 2000000146 A PE2000000146 A PE 2000000146A PE 0001462000 A PE0001462000 A PE 0001462000A PE 20001482 A1 PE20001482 A1 PE 20001482A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- naphthalen
- pyridin
- ilamine
- etoxy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Psychology (AREA)
- Otolaryngology (AREA)
- Anesthesiology (AREA)
Abstract
SE REFIERE A 2-AMINOPIRIDINAS DE FORMULA I, DONDE: A Y B SON H, O JUNTOS FORMAN UN ANILLO CONDENSADO AL ANILLO DE FENILO CON 5-7 MIEMBROS CON 1-2 N, O, S, LOS MIEMBROS ADYACENTES DE DOS ANILLOS ADYACENTES NO SON HETEROATOMOS; X ES O, UN ENLACE; Y ES ALQUILO C1-C6; R1 ES H, ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON NR2R3; R2 Y R3 SON H, ALQUILO, ARILO, ARALQUILO, TETRAHIDRONAFTALENO O JUNTO CON N FORMAN UN HETEROCICLO, ANILLO CICLICO, BICICLICO, 6-AMINO-3-AZABICICLO[3.1.0]HEX-3-ILO SUSTITUIDO CON NR4R5; R4 Y R5 SON H, ALQUILO C1-C6, FENILO, NAFTILO, ALQUILO C1-C6-CO, CHO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS 1-[4-(6-AMINO-PIRIDIN-2-IL)-NAFTALEN-1-ILOXIMETIL]-CICLOHEXANOL, 6-[4-(2-(2-DIMETILAMINOETOXI)-ETOXI-NAFTALEN-1-IL]-PIRIDIN-2-ILAMINA, 6-[4-(2-HIDROXI-ETOXI)-5,6,7,8-TETRAHIDRO-NAFTALEN-1-IL]-PIRIDIN-2-ILAMINA, 6-[4-(2-(2-DIETILAMINOETOXI)ETOXI)NAFTALEN-1-IL]-PIRIDIN-2-ILAMINA. EL COMPUESTO I INHIBE LA ACTIVIDAD DE LA OXIDO NITRICO SINTASA NOS Y PUEDE SER UTIL PARA EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL, TRASTORNOS INFLAMATORIOS, CHOQUE SEPTICO, OBESIDAD, LESION AGUDA DE LA MEDULA ESPINAL, TRASTORNOS DE LA ANSIEDAD, TRASTORNOS POR ESTRESS, CANCER
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12159799P | 1999-02-25 | 1999-02-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001482A1 true PE20001482A1 (es) | 2001-01-03 |
Family
ID=22397690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000146A PE20001482A1 (es) | 1999-02-25 | 2000-02-23 | 2-aminopiridinas que contienen sustituyentes de tipo anillo condensado |
Country Status (44)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010049379A1 (en) * | 1997-08-27 | 2001-12-06 | Lowe John Adams | 2-aminopyridines containing fused ring substituents |
| TR200102481T2 (tr) * | 1999-02-25 | 2002-01-21 | Pfizer Products Inc. | Fazlı zincir muadili içeren 2-aminopiridinler. |
| KR20020084278A (ko) | 2000-03-31 | 2002-11-04 | 코센시스 인크 | 항경련제 및 나트륨 통로 차단제로서의 아미노피리딘과이의 용도 |
| US20040092741A1 (en) * | 2002-11-08 | 2004-05-13 | Pfizer Inc | Substituted pyridines via boronic acid coupling |
| US8729107B2 (en) * | 2002-12-06 | 2014-05-20 | Purdue Research Foundation | Pyridines for treating injured mammalian nerve tissue |
| EP1567497B1 (en) * | 2002-12-06 | 2009-09-23 | Purdue Research Foundation | Pyridines for treating injured mammalian nerve tissue |
| US20050192321A1 (en) * | 2003-09-15 | 2005-09-01 | Meythaler Jay M. | Treatment of neuropathy with rapid release aminopyridine |
| WO2014138460A1 (en) * | 2013-03-07 | 2014-09-12 | Northwestern University | 2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors |
| US9951014B2 (en) | 2014-11-04 | 2018-04-24 | Northwestern University | Mammalian and bacterial nitric oxide synthase inhibitors |
| US10759791B2 (en) | 2014-11-04 | 2020-09-01 | Northwestern University | Mammalian and bacterial nitric oxide synthase inhibitors |
| US9585867B2 (en) | 2015-08-06 | 2017-03-07 | Charles Everett Ankner | Cannabinod formulation for the sedation of a human or animal |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4515696A (en) * | 1994-12-12 | 1996-07-03 | Merck & Co., Inc. | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase |
| JPH101435A (ja) * | 1995-09-14 | 1998-01-06 | Nippon Kayaku Co Ltd | ２−アミノピリジン類を有効成分とする一酸化窒素合成酵素阻害剤 |
| DK0891332T3 (da) * | 1996-03-29 | 2004-07-05 | Pfizer | 6-phenylpyridyl-2-aminderivater |
| HN1997000027A (es) | 1996-12-06 | 1997-06-05 | Pfizer Prod Inc | Derivados de 6-fenil piridil - 2 amina |
| JP3505189B2 (ja) * | 1997-02-10 | 2004-03-08 | ファイザー・プロダクツ・インク | ２−アミノ−６−（２−置換−４−フェノキシ）−置換ピリジン |
| HN1998000118A (es) * | 1997-08-27 | 1999-02-09 | Pfizer Prod Inc | 2 - aminopiridinas que contienen sustituyentes de anillos condensados. |
| HN1998000125A (es) * | 1997-08-28 | 1999-02-09 | Pfizer Prod Inc | 2-aminopiridinas con sustituyentes alcoxi ramificados |
| SK17912000A3 (sk) * | 1998-06-03 | 2001-09-11 | Pfizer Products Inc. | 2-aminopyridny obsahujce kondenzovan cyklick substituenty ako inhibtory syntzy oxidu dusnatho |
| TR200102481T2 (tr) * | 1999-02-25 | 2002-01-21 | Pfizer Products Inc. | Fazlı zincir muadili içeren 2-aminopiridinler. |
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2000
- 2000-02-02 TR TR2001/02481T patent/TR200102481T2/xx unknown
- 2000-02-02 KR KR1020017010899A patent/KR20010114213A/ko not_active Application Discontinuation
- 2000-02-02 SK SK1202-2001A patent/SK12022001A3/sk unknown
- 2000-02-02 ID IDW00200101819A patent/ID29892A/id unknown
- 2000-02-02 WO PCT/IB2000/000109 patent/WO2000050400A1/en not_active Application Discontinuation
- 2000-02-02 CA CA002364719A patent/CA2364719C/en not_active Expired - Fee Related
- 2000-02-02 CN CN00804126A patent/CN1341099A/zh active Pending
- 2000-02-02 MX MXPA01008671A patent/MXPA01008671A/es active IP Right Grant
- 2000-02-02 HU HU0200163A patent/HUP0200163A3/hu unknown
- 2000-02-02 BR BR0008569-3A patent/BR0008569A/pt not_active IP Right Cessation
- 2000-02-02 AT AT00901285T patent/ATE245143T1/de not_active IP Right Cessation
- 2000-02-02 JP JP2000600983A patent/JP3825636B2/ja not_active Expired - Fee Related
- 2000-02-02 NZ NZ512912A patent/NZ512912A/en unknown
- 2000-02-02 AP APAP/P/2001/002251A patent/AP2001002251A0/en unknown
- 2000-02-02 ES ES00901285T patent/ES2200813T3/es not_active Expired - Lifetime
- 2000-02-02 DK DK00901285T patent/DK1155000T3/da active
- 2000-02-02 DE DE60003893T patent/DE60003893T2/de not_active Expired - Fee Related
- 2000-02-02 OA OA1200100224A patent/OA11841A/en unknown
- 2000-02-02 EP EP00901285A patent/EP1155000B1/en not_active Expired - Lifetime
- 2000-02-02 IL IL14430800A patent/IL144308A0/xx unknown
- 2000-02-02 CZ CZ20013036A patent/CZ20013036A3/cs unknown
- 2000-02-02 EE EEP200100454A patent/EE200100454A/xx unknown
- 2000-02-02 YU YU58301A patent/YU58301A/sh unknown
- 2000-02-02 EA EA200100816A patent/EA003941B1/ru not_active IP Right Cessation
- 2000-02-02 PT PT00901285T patent/PT1155000E/pt unknown
- 2000-02-02 PL PL00350219A patent/PL350219A1/xx not_active Application Discontinuation
- 2000-02-02 AU AU21243/00A patent/AU767593B2/en not_active Ceased
- 2000-02-03 HN HN2000000016A patent/HN2000000016A/es unknown
- 2000-02-15 US US09/504,989 patent/US6211208B1/en not_active Expired - Fee Related
- 2000-02-17 PA PA20008490901A patent/PA8490901A1/es unknown
- 2000-02-23 CO CO00012733A patent/CO5160241A1/es unknown
- 2000-02-23 DZ DZ000036A patent/DZ3017A1/xx active
- 2000-02-23 PE PE2000000146A patent/PE20001482A1/es not_active Application Discontinuation
- 2000-02-23 MA MA25912A patent/MA26721A1/fr unknown
- 2000-02-23 AR ARP000100767A patent/AR018979A1/es unknown
- 2000-02-23 TN TNTNSN00034A patent/TNSN00034A1/fr unknown
- 2000-02-24 GT GT200000021A patent/GT200000021A/es unknown
- 2000-02-24 SV SV2000000026A patent/SV2002000026A/es not_active Application Discontinuation
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2001
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- 2001-08-10 HR HR20010597A patent/HRP20010597A2/hr not_active Application Discontinuation
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- 2001-08-23 NO NO20014095A patent/NO20014095L/no not_active Application Discontinuation
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