CO5160241A1 - 2-aminopiridinas que contienen sustituyentes de tipo anillo condensado - Google Patents
2-aminopiridinas que contienen sustituyentes de tipo anillo condensadoInfo
- Publication number
- CO5160241A1 CO5160241A1 CO00012733A CO00012733A CO5160241A1 CO 5160241 A1 CO5160241 A1 CO 5160241A1 CO 00012733 A CO00012733 A CO 00012733A CO 00012733 A CO00012733 A CO 00012733A CO 5160241 A1 CO5160241 A1 CO 5160241A1
- Authority
- CO
- Colombia
- Prior art keywords
- group
- ring
- alkyl
- aryl
- aralkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
Abstract
La presente invención se refiere a derivados de 2-aminopiridina de la fórmula I:<EMI FILE="00012733_1" ID="1" IMF=JPEG >o sales farmacéuticamente aceptables de los mismos, en la que A y B son cada uno independientemente H, o juntos, A y B forman un anillo condensado al anillo de fenilo, siendo dicho anillo saturado o insaturado y contenido de 5 a 7 átomos en el anillo, donde dichos átomos en el anillo pueden opcionalmente comprender de 1 a 2 heteroátomos seleccionados independientemente del grupo constituido por N, O o S, siempre que los mismos de dos anillos adyacentes no sean heteroátomos; X es oxigeno o un enlace sencillo; Y es alquilo (C1-C6); R1 es hidrógeno, alquilo (C1-C6) o un grupo (alquilo C1-C6) sustituido con -NR2R3 en el que R2 y R3 se seleccionan bien independientemente del grupo constituido por H, alquilo, arilo, aralquilo o tetrahidronaftaleno, siendo dicho grupo arilo o dicho resto arilo de dicho grupo aralquilo fenilo o naftilo, conteniendo dicho grupo alquilo o dicho resto alquilo de dicho grupo aralquilo de uno a seis átomos de carbono y siendo una cadena lineal o ramificada, y estando dicho grupo arilo, dicho tetrahidronaftaleno o dicho resto arilo de dicho grupo aralquilo opcionalmente sustituido con uno a tres restos de halógeno, nitro, ciano, amino, alcoxi (C1-C4) y alquilamino (C1-C4), o bien R2 y R3 forman, junto con un nitrógeno al que están unidos, un anillo heterocíclíco, o un anillo cíclico o bicíclico que está saturado o insaturado. Los compuestos de la invención tienen la capacidad de inhibir la actividad de las síntasas de óxido nítrico (NOS), y por lo tanto, son útiles en el tratamiento de enfermedades, estados y trastornos del sistema nervioso central, entre otros.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12159799P | 1999-02-25 | 1999-02-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5160241A1 true CO5160241A1 (es) | 2002-05-30 |
Family
ID=22397690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00012733A CO5160241A1 (es) | 1999-02-25 | 2000-02-23 | 2-aminopiridinas que contienen sustituyentes de tipo anillo condensado |
Country Status (44)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010049379A1 (en) * | 1997-08-27 | 2001-12-06 | Lowe John Adams | 2-aminopyridines containing fused ring substituents |
| TR200102481T2 (tr) * | 1999-02-25 | 2002-01-21 | Pfizer Products Inc. | Fazlı zincir muadili içeren 2-aminopiridinler. |
| KR20020084278A (ko) | 2000-03-31 | 2002-11-04 | 코센시스 인크 | 항경련제 및 나트륨 통로 차단제로서의 아미노피리딘과이의 용도 |
| US20040092741A1 (en) * | 2002-11-08 | 2004-05-13 | Pfizer Inc | Substituted pyridines via boronic acid coupling |
| US8729107B2 (en) * | 2002-12-06 | 2014-05-20 | Purdue Research Foundation | Pyridines for treating injured mammalian nerve tissue |
| EP1567497B1 (en) * | 2002-12-06 | 2009-09-23 | Purdue Research Foundation | Pyridines for treating injured mammalian nerve tissue |
| US20050192321A1 (en) * | 2003-09-15 | 2005-09-01 | Meythaler Jay M. | Treatment of neuropathy with rapid release aminopyridine |
| WO2014138460A1 (en) * | 2013-03-07 | 2014-09-12 | Northwestern University | 2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors |
| US9951014B2 (en) | 2014-11-04 | 2018-04-24 | Northwestern University | Mammalian and bacterial nitric oxide synthase inhibitors |
| US10759791B2 (en) | 2014-11-04 | 2020-09-01 | Northwestern University | Mammalian and bacterial nitric oxide synthase inhibitors |
| US9585867B2 (en) | 2015-08-06 | 2017-03-07 | Charles Everett Ankner | Cannabinod formulation for the sedation of a human or animal |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4515696A (en) * | 1994-12-12 | 1996-07-03 | Merck & Co., Inc. | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase |
| JPH101435A (ja) * | 1995-09-14 | 1998-01-06 | Nippon Kayaku Co Ltd | ２−アミノピリジン類を有効成分とする一酸化窒素合成酵素阻害剤 |
| DK0891332T3 (da) * | 1996-03-29 | 2004-07-05 | Pfizer | 6-phenylpyridyl-2-aminderivater |
| HN1997000027A (es) | 1996-12-06 | 1997-06-05 | Pfizer Prod Inc | Derivados de 6-fenil piridil - 2 amina |
| JP3505189B2 (ja) * | 1997-02-10 | 2004-03-08 | ファイザー・プロダクツ・インク | ２−アミノ−６−（２−置換−４−フェノキシ）−置換ピリジン |
| HN1998000118A (es) * | 1997-08-27 | 1999-02-09 | Pfizer Prod Inc | 2 - aminopiridinas que contienen sustituyentes de anillos condensados. |
| HN1998000125A (es) * | 1997-08-28 | 1999-02-09 | Pfizer Prod Inc | 2-aminopiridinas con sustituyentes alcoxi ramificados |
| SK17912000A3 (sk) * | 1998-06-03 | 2001-09-11 | Pfizer Products Inc. | 2-aminopyridny obsahujce kondenzovan cyklick substituenty ako inhibtory syntzy oxidu dusnatho |
| TR200102481T2 (tr) * | 1999-02-25 | 2002-01-21 | Pfizer Products Inc. | Fazlı zincir muadili içeren 2-aminopiridinler. |
-
2000
- 2000-02-02 TR TR2001/02481T patent/TR200102481T2/xx unknown
- 2000-02-02 KR KR1020017010899A patent/KR20010114213A/ko not_active Application Discontinuation
- 2000-02-02 SK SK1202-2001A patent/SK12022001A3/sk unknown
- 2000-02-02 ID IDW00200101819A patent/ID29892A/id unknown
- 2000-02-02 WO PCT/IB2000/000109 patent/WO2000050400A1/en not_active Application Discontinuation
- 2000-02-02 CA CA002364719A patent/CA2364719C/en not_active Expired - Fee Related
- 2000-02-02 CN CN00804126A patent/CN1341099A/zh active Pending
- 2000-02-02 MX MXPA01008671A patent/MXPA01008671A/es active IP Right Grant
- 2000-02-02 HU HU0200163A patent/HUP0200163A3/hu unknown
- 2000-02-02 BR BR0008569-3A patent/BR0008569A/pt not_active IP Right Cessation
- 2000-02-02 AT AT00901285T patent/ATE245143T1/de not_active IP Right Cessation
- 2000-02-02 JP JP2000600983A patent/JP3825636B2/ja not_active Expired - Fee Related
- 2000-02-02 NZ NZ512912A patent/NZ512912A/en unknown
- 2000-02-02 AP APAP/P/2001/002251A patent/AP2001002251A0/en unknown
- 2000-02-02 ES ES00901285T patent/ES2200813T3/es not_active Expired - Lifetime
- 2000-02-02 DK DK00901285T patent/DK1155000T3/da active
- 2000-02-02 DE DE60003893T patent/DE60003893T2/de not_active Expired - Fee Related
- 2000-02-02 OA OA1200100224A patent/OA11841A/en unknown
- 2000-02-02 EP EP00901285A patent/EP1155000B1/en not_active Expired - Lifetime
- 2000-02-02 IL IL14430800A patent/IL144308A0/xx unknown
- 2000-02-02 CZ CZ20013036A patent/CZ20013036A3/cs unknown
- 2000-02-02 EE EEP200100454A patent/EE200100454A/xx unknown
- 2000-02-02 YU YU58301A patent/YU58301A/sh unknown
- 2000-02-02 EA EA200100816A patent/EA003941B1/ru not_active IP Right Cessation
- 2000-02-02 PT PT00901285T patent/PT1155000E/pt unknown
- 2000-02-02 PL PL00350219A patent/PL350219A1/xx not_active Application Discontinuation
- 2000-02-02 AU AU21243/00A patent/AU767593B2/en not_active Ceased
- 2000-02-03 HN HN2000000016A patent/HN2000000016A/es unknown
- 2000-02-15 US US09/504,989 patent/US6211208B1/en not_active Expired - Fee Related
- 2000-02-17 PA PA20008490901A patent/PA8490901A1/es unknown
- 2000-02-23 CO CO00012733A patent/CO5160241A1/es unknown
- 2000-02-23 DZ DZ000036A patent/DZ3017A1/xx active
- 2000-02-23 PE PE2000000146A patent/PE20001482A1/es not_active Application Discontinuation
- 2000-02-23 MA MA25912A patent/MA26721A1/fr unknown
- 2000-02-23 AR ARP000100767A patent/AR018979A1/es unknown
- 2000-02-23 TN TNTNSN00034A patent/TNSN00034A1/fr unknown
- 2000-02-24 GT GT200000021A patent/GT200000021A/es unknown
- 2000-02-24 SV SV2000000026A patent/SV2002000026A/es not_active Application Discontinuation
-
2001
- 2001-02-08 US US09/779,318 patent/US6372768B2/en not_active Expired - Fee Related
- 2001-07-13 IS IS6005A patent/IS6005A/is unknown
- 2001-08-08 CR CR6438A patent/CR6438A/es unknown
- 2001-08-10 HR HR20010597A patent/HRP20010597A2/hr not_active Application Discontinuation
- 2001-08-23 ZA ZA200106974A patent/ZA200106974B/en unknown
- 2001-08-23 NO NO20014095A patent/NO20014095L/no not_active Application Discontinuation
- 2001-08-30 BG BG105855A patent/BG105855A/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO5080782A1 (es) | Compuestos heterociclicos como inhibidores de enzimas de rotamasa | |
| DE69835430D1 (de) | Sulfonamidderivate, ihre herstellung und verwendung | |
| AR025735A1 (es) | Compuestos terapeuticos | |
| CO4650042A1 (es) | Derivados de 6-fenilpiridil-2-amina | |
| HUP0202263A2 (hu) | Benzimidazol-, indol- és imidazo-piridin-származékok és ezeket tartalmazó gyógyszerkészítmények | |
| AR067443A1 (es) | Derivados heterociclicos de n-benziloxazolidinonas potenciadores de receptores de glutamato mglur2, composiciones farmaceuticas que los contienen y usos de los mismos en el tratamiento de trastornos del sistema nervioso central | |
| AR029301A1 (es) | Compuestos derivados de biarilo, metodos para su preparacion composiciones que los contienen, su uso como agonistas en receptores beta-adreno-receptores atipicos | |
| PA8456901A1 (es) | 2-aminopiridinas que contienen sustituyentes de anillos condensados | |
| BRPI0014526C1 (pt) | compostos cíclicos de seis elementos contendo nitrogênio aromático, composição farmacêutica e uso do mesmo | |
| CO5160241A1 (es) | 2-aminopiridinas que contienen sustituyentes de tipo anillo condensado | |
| HUP0301249A2 (hu) | APO B termelődés gátló benzamid-vegyületek ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| CY1108403T1 (el) | Κυκλικης αμινης ενωση ως ανταγωνιστης ccr5 | |
| EA200100970A1 (ru) | Аминопроизводные как ингибиторы протеазы | |
| UY26048A1 (es) | Derivados de piridopiranoacepinas, su preparacion y su aplicacion terapeutica | |
| AR016644A1 (es) | Compuestos de 2-aminopiridinas con sustituyentes alcoxi ramificados, composicion farmaceutica y uso para la manufactura de medicamentos | |
| AR035514A1 (es) | Sales farmaceuticamente aceptables de inhibidores de fosfodiesterasa-4 de 8-arilquinolina sustituida, composiciones farmaceuticas y su uso en la preparacion de medicamentos | |
| FR2632639B1 (fr) | Derives d'amino-4 carboxy-3 naphtyridines, leur preparation et compositions pharmaceutiques qui les contiennent | |
| AR045125A1 (es) | Compuestos de oxima heterociclicos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen | |
| AR026222A1 (es) | Compuestos derivados de acido antranilico | |
| AR016594A1 (es) | DERIVADOS DE 3,4,5,7-TETRAHIDRO-PIRROLO[3',4':4,5]TIENO[2,3-d]PIRIMIDINA 3-SUSTITUIDOS Y SU USO PARA LA PREPARACION DE COMPOSICIONES FARMACEUTICAS | |
| ECSP003346A (es) | 2 aminopiridinas que contienen sustituyentes de tipo anillo condensado | |
| AR046027A1 (es) | Derivados de benzofurano de tipo carbamoilo | |
| ES2061868T3 (es) | Derivados ariloxi-, ariltio-, heteroariloxi-, heteroariltio-alquenilen-aminas. | |
| CO5180634A1 (es) | Sulfonamidas sustituidas con naftilo | |
| ES2190426T3 (es) | Derivados de acidos arilo o heteroarilo quinolinil-fosfonicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. |