AR013004A1 - Derivados de aminospiropiperidina quinazolina, composicion farmaceutica, uso de dichos derivados en la preparacion de medicamentos, proceso para lapreparacion de dichos derivados y compuestos intermediarios para su exclusivo uso en dicho proceso. - Google Patents
Derivados de aminospiropiperidina quinazolina, composicion farmaceutica, uso de dichos derivados en la preparacion de medicamentos, proceso para lapreparacion de dichos derivados y compuestos intermediarios para su exclusivo uso en dicho proceso.Info
- Publication number
- AR013004A1 AR013004A1 ARP980102919A ARP980102919A AR013004A1 AR 013004 A1 AR013004 A1 AR 013004A1 AR P980102919 A ARP980102919 A AR P980102919A AR P980102919 A ARP980102919 A AR P980102919A AR 013004 A1 AR013004 A1 AR 013004A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- preparation
- halogen
- phenyl
- alkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Derivados de aminospiroperidina quinazolina que comprende la formula I en la cual R1 y R2 representan independientemente hidrogeno, alquilo C1-6,alquenilo C2-6, alquinilo C2-6, alcoxi C1-6, alquiltio C1-6, halogeno, hidroxi, trifluorometilo o amino; R3 representa uno o más sustituyentesindependientemente seleccionados entre hidrogeno, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, alcoxi C1-6, alquiltio C1-6, halogeno, trifluorometilo, amino,ciano, nitro, trifluorometoxi, metansulfonilo, sulfamoilo, -NR4R5, -COOR6, -CONR7R8, benciloxi, fenilo, o un anillo aromático heterocíclico de 5 miembrosque contiene de 1 a 3 heteroátomos que pueden ser iguales o diferentes y que se seleccionan entre O, N y S, cuyo fenilo o anillo aromático heterocíclico de 5miembros es optativamente sustituido, siendo los sustituyentes optativos alquilo C1-6, halogeno, ciano, nitro, hidroxi, alcoxi C1-6, trifluorometilo ytrifluorometoxi; R4, R5 y R6 representan independientemente hidrogeno o alquilo C1-6; R7 y R8 representan independientemente hidrogeno, alquilo C1-6 o fenilo,cuyo fenilo es optativamente sustituido por uno o más grupos independientemente seleccionados entre alquilo C1-6, halogeno, ciano, nitro, hidroxi, alcoxi C1-6trifluorometilo y trifluorometoxi; X representa -(CH2)n-, en donde n representa cero o 1; y A representa un anillo carbocíclico aromático o unanillo aromático heterocíclico de 5 o 6 miembros que contiene de 1 a 3 heteroátomos que pueden ser iguales o diferentes y se seleccionan entre O, Ny S; o una sal, enantiomero, racemato o tautomero farmacéuticamente aceptable de los mismos; procesos para su preparacion, las composiciones que loscontienen y su uso en la preparacion de medicamentosutiles como inhibidores de la sintasa de oxido níntrico y por ende son especialmente utiles en el
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9702534A SE9702534D0 (sv) | 1997-07-01 | 1997-07-01 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR013004A1 true AR013004A1 (es) | 2000-11-22 |
Family
ID=20407595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980102919A AR013004A1 (es) | 1997-07-01 | 1998-06-18 | Derivados de aminospiropiperidina quinazolina, composicion farmaceutica, uso de dichos derivados en la preparacion de medicamentos, proceso para lapreparacion de dichos derivados y compuestos intermediarios para su exclusivo uso en dicho proceso. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US6083952A (es) |
| EP (1) | EP1000064A1 (es) |
| JP (1) | JP2002507987A (es) |
| KR (1) | KR20010014367A (es) |
| CN (1) | CN1268138A (es) |
| AR (1) | AR013004A1 (es) |
| AU (1) | AU729792B2 (es) |
| BR (1) | BR9810214A (es) |
| CA (1) | CA2294734A1 (es) |
| EE (1) | EE9900602A (es) |
| HU (1) | HUP0003104A3 (es) |
| ID (1) | ID25585A (es) |
| IL (1) | IL133729A0 (es) |
| IS (1) | IS5323A (es) |
| NO (1) | NO996544L (es) |
| PL (1) | PL337536A1 (es) |
| SE (1) | SE9702534D0 (es) |
| SK (1) | SK170299A3 (es) |
| TR (1) | TR199903296T2 (es) |
| WO (1) | WO1999001455A1 (es) |
| ZA (1) | ZA985326B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002073760A (ja) * | 2000-08-28 | 2002-03-12 | Tadakatsu Yoshida | 貿易統合システム |
| WO2003076440A1 (en) * | 2002-03-06 | 2003-09-18 | Smithkline Beecham Corporation | Condensed heterocyclic compounds as calcitonin agonists |
| US20040063751A1 (en) * | 2002-05-31 | 2004-04-01 | Pharmacia Corporation | Combination therapy for the treatment of amyotrophic lateral sclerosis (ALS) with cyclooxygenase-2 (COX-2) inhibitor(s) and a second drug |
| CN112225662A (zh) * | 2020-11-16 | 2021-01-15 | 苏州华鑫医药科技有限公司 | 一种邻碘苯甲酸的制备方法 |
| CA3209491A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease |
| CN114773316B (zh) * | 2022-06-17 | 2022-10-25 | 上海睿跃生物科技有限公司 | 2-(2,6-二氧代-哌啶-3-基)-5-氟-异吲哚-1,3-二酮的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3761480A (en) * | 1968-07-10 | 1973-09-25 | Pennwalt Corp | Process for the preparation of 3-aryl-6-sulfamyl-7-halo-1,2,3,4-tetrahydro-4-quinazolinones |
| US5883102A (en) * | 1995-10-17 | 1999-03-16 | Astra Pharmaceuticals Limited | Pharmaceutically active compounds |
-
1997
- 1997-07-01 SE SE9702534A patent/SE9702534D0/xx unknown
-
1998
- 1998-06-18 AR ARP980102919A patent/AR013004A1/es unknown
- 1998-06-18 ZA ZA985326A patent/ZA985326B/xx unknown
- 1998-06-22 IL IL13372998A patent/IL133729A0/xx unknown
- 1998-06-22 AU AU81356/98A patent/AU729792B2/en not_active Ceased
- 1998-06-22 CN CN98808429A patent/CN1268138A/zh active Pending
- 1998-06-22 EE EEP199900602A patent/EE9900602A/xx unknown
- 1998-06-22 HU HU0003104A patent/HUP0003104A3/hu unknown
- 1998-06-22 JP JP50700699A patent/JP2002507987A/ja active Pending
- 1998-06-22 BR BR9810214-1A patent/BR9810214A/pt not_active IP Right Cessation
- 1998-06-22 PL PL98337536A patent/PL337536A1/xx unknown
- 1998-06-22 US US09/125,174 patent/US6083952A/en not_active Expired - Fee Related
- 1998-06-22 CA CA002294734A patent/CA2294734A1/en not_active Abandoned
- 1998-06-22 WO PCT/SE1998/001206 patent/WO1999001455A1/en not_active Application Discontinuation
- 1998-06-22 EP EP98931170A patent/EP1000064A1/en not_active Ceased
- 1998-06-22 ID IDW991642A patent/ID25585A/id unknown
- 1998-06-22 KR KR1019997012524A patent/KR20010014367A/ko not_active Application Discontinuation
- 1998-06-22 SK SK1702-99A patent/SK170299A3/sk unknown
- 1998-06-22 TR TR1999/03296T patent/TR199903296T2/xx unknown
-
1999
- 1999-12-28 IS IS5323A patent/IS5323A/is unknown
- 1999-12-29 NO NO996544A patent/NO996544L/no not_active Application Discontinuation
-
2000
- 2000-05-31 US US09/583,775 patent/US6211189B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0003104A2 (hu) | 2001-02-28 |
| IS5323A (is) | 1999-12-28 |
| ZA985326B (en) | 1999-03-23 |
| CA2294734A1 (en) | 1999-01-14 |
| US6083952A (en) | 2000-07-04 |
| EP1000064A1 (en) | 2000-05-17 |
| SK170299A3 (en) | 2000-08-14 |
| NO996544L (no) | 2000-02-29 |
| BR9810214A (pt) | 2000-08-08 |
| PL337536A1 (en) | 2000-08-28 |
| WO1999001455A1 (en) | 1999-01-14 |
| NO996544D0 (no) | 1999-12-29 |
| ID25585A (id) | 2000-10-19 |
| CN1268138A (zh) | 2000-09-27 |
| KR20010014367A (ko) | 2001-02-26 |
| EE9900602A (et) | 2000-08-15 |
| JP2002507987A (ja) | 2002-03-12 |
| HUP0003104A3 (en) | 2002-01-28 |
| AU729792B2 (en) | 2001-02-08 |
| TR199903296T2 (en) | 2000-07-21 |
| IL133729A0 (en) | 2001-04-30 |
| SE9702534D0 (sv) | 1997-07-01 |
| AU8135698A (en) | 1999-01-25 |
| US6211189B1 (en) | 2001-04-03 |
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