YU48949B - Benzopiran i srodni ltb-antagonisti - Google Patents
Benzopiran i srodni ltb-antagonistiInfo
- Publication number
- YU48949B YU48949B YU3393A YU3393A YU48949B YU 48949 B YU48949 B YU 48949B YU 3393 A YU3393 A YU 3393A YU 3393 A YU3393 A YU 3393A YU 48949 B YU48949 B YU 48949B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- alkyl
- phenyl
- hydrogen
- formula
- substituted
- Prior art date
Links
- KYNSBQPICQTCGU-UHFFFAOYSA-N Benzopyrane Chemical compound C1=CC=C2C=CCOC2=C1 KYNSBQPICQTCGU-UHFFFAOYSA-N 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 150000002148 esters Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 229920001774 Perfluoroether Polymers 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- -1 carboxy, tetrazolyl Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000005493 quinolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
Abstract
Benzopiran i srodni LTB antagonisti, formule u kojoj A predstavlja O, CH2, S NH ili N(C1-C6)alkil, n je 0, 1 ili 2; R1 je supstituent na poziciji b ili c formule R2, R8, R9 i R10 su vodonik ili svaki nezavisno predstavlja jedan ili bilo koja dva od sledećih: fluoro, hloro, C1-C6 alkil, C1-C6 alkoksi, C1-C4 perfluoroalkil, C1-C4 perfluoroalkoksi, C1-C6 alkiltio, C1-C6 alkilsulfinil ili C1-C6 alkilsulfonil; R3 je -(CH2)qCHR11R12, -(CH2)qR12,-O(CH2)pCHR11R12, ili -O(CH2)pR12, pri čemu je p 0, 1 ili 2, a q je 0, 1, 2 ili 3; R4 je karboksi, tetrazolil ili R13SO2NHCO; R11 je vodonik, C1-C6 alkil ili R8-supstituisani fenil pri čemu je R8 prethodno definisan; R12 i R13 su vodonik ili su svaki nezavisno C1-C6 alkil ili C3-C8 sikloalkil; ili fenil, tienil, piridil, furil, naftil, hinolil, pirimidinil, ili pirazinil, od kojih je svaki po izboru supstituisan fenilom, R9, ili R9-supstituisani fenil pri čemu je R9 kao što je prethodno definisano; i soli i estri tih jedinjenja formule I koji sadrže karboksi grupu, pri čemu estri sadrže grupe estara odabrane iz grupe koja se sastoji od C1-C6 alkila, fenil(C1-C6) alkila, C3-C7 cikloalkila i fenila i benzil supstituisan sa fluoro, hloro, C1-C6 alkilom ili C1-C6 alkoksi. Prijava sadrži još 2 nezavisna i 12 zavisnih zahteva.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82441292A | 1992-01-23 | 1992-01-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU3393A YU3393A (sh) | 1996-07-24 |
| YU48949B true YU48949B (sh) | 2003-01-31 |
Family
ID=25241346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU3393A YU48949B (sh) | 1992-01-23 | 1993-01-22 | Benzopiran i srodni ltb-antagonisti |
Country Status (37)
| Country | Link |
|---|---|
| US (2) | US5552435A (sh) |
| EP (1) | EP0623123B1 (sh) |
| JP (1) | JP2765757B2 (sh) |
| KR (2) | KR0124802B1 (sh) |
| CN (1) | CN1041311C (sh) |
| AP (1) | AP352A (sh) |
| AT (1) | ATE152108T1 (sh) |
| AU (1) | AU666896B2 (sh) |
| BG (1) | BG62331B1 (sh) |
| BR (1) | BR9207061A (sh) |
| CA (1) | CA2126752C (sh) |
| CZ (1) | CZ282400B6 (sh) |
| DE (1) | DE69219364T2 (sh) |
| DK (1) | DK0623123T3 (sh) |
| EG (1) | EG20202A (sh) |
| FI (1) | FI943474A (sh) |
| GR (1) | GR3023657T3 (sh) |
| HK (1) | HK1000245A1 (sh) |
| HU (1) | HU221194B1 (sh) |
| IL (1) | IL104386A (sh) |
| IS (1) | IS1795B (sh) |
| MX (1) | MX9300312A (sh) |
| MY (1) | MY109144A (sh) |
| NO (1) | NO306508B1 (sh) |
| NZ (1) | NZ245735A (sh) |
| OA (1) | OA11456A (sh) |
| PH (1) | PH30346A (sh) |
| PL (1) | PL171003B1 (sh) |
| PT (1) | PT101183B (sh) |
| RO (1) | RO112031B1 (sh) |
| RU (1) | RU2114110C1 (sh) |
| SG (1) | SG49813A1 (sh) |
| SK (1) | SK280451B6 (sh) |
| TW (1) | TW213907B (sh) |
| WO (1) | WO1993015067A1 (sh) |
| YU (1) | YU48949B (sh) |
| ZA (1) | ZA93486B (sh) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2084547B1 (es) * | 1993-07-12 | 1997-01-16 | Pfizer | Antagonistas benzopiranicos y relacionados de leucotrieno b4. |
| MX9702731A (es) * | 1994-10-13 | 1997-06-28 | Pfizer | Compuestos de benzopirano y benzo fusionados, composiciones que los contienen y uso de los mismos. |
| CA2202056A1 (en) * | 1994-10-13 | 1996-04-25 | Mark A. Dombroski | Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene b4' (ltb4) antagonists |
| SK31399A3 (en) * | 1996-09-16 | 2000-05-16 | Pfizer | Processes and intermediates for preparing substituted chromanol derivatives |
| US6416733B1 (en) | 1996-10-07 | 2002-07-09 | Bristol-Myers Squibb Pharma Company | Radiopharmaceuticals for imaging infection and inflammation |
| EP0836850A3 (en) * | 1996-10-17 | 2000-11-29 | Pfizer Inc. | Method of preventing allograft rejection |
| EP0963755A3 (en) * | 1998-04-16 | 2001-03-14 | Pfizer Products Inc. | Use of benzopyranes for preventing allograft rejection |
| US6436987B1 (en) * | 2000-06-08 | 2002-08-20 | Pfizer Inc. | Crystalline forms of (3S-trans)-2-[3,4-dihydro-4-hydroxy-3-(phenylmethyl)-2H-1-benzopyran-7-yl]-4-(trifluoromethyl)-benzoic acid |
| JP2004512382A (ja) | 2000-11-03 | 2004-04-22 | ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー | 心臓灌流および心臓炎症の２核種同時イメージング |
| CA2433516A1 (en) * | 2001-01-30 | 2002-08-08 | Keith Michael Devries | Processes for preparing chromanylbenzoic acids |
| AU4239302A (en) * | 2001-06-28 | 2003-01-02 | Pfizer Products Inc. | Benzoic acid substituted benzopyrans for the treatment of atherosclerosis |
| CA2574627A1 (en) * | 2004-07-22 | 2006-02-02 | Pharmacia Corporation | Compositions for treatment of inflammation and pain using a combination of a cox-2 selective inhibitor and a ltb4 receptor antagonist |
| EP3383389B1 (en) * | 2015-11-30 | 2021-04-28 | Merck Sharp & Dohme Corp. | Aryl acylsulfonamides as blt1 antagonists |
| US20190382363A1 (en) | 2015-11-30 | 2019-12-19 | Merck Sharp & Dohme Corp. | Aryl sulfonamides as blt1 antagonists |
| US10336733B2 (en) | 2015-11-30 | 2019-07-02 | Merk Sharp & Dohme Corp. | Aryl acylsulfonamides as BLT1 antagonists |
| US10450309B2 (en) | 2015-11-30 | 2019-10-22 | Merch Sharp & Dohme Corp. | Aryl sulfonamides as BLT1 antagonists |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2309282A1 (de) * | 1973-02-24 | 1974-08-29 | Hoechst Ag | Verfahren zur herstellung von 4-hydroxy-thiochromanen |
| DE2745305A1 (de) * | 1977-10-07 | 1979-04-19 | Bayer Ag | Insektizide und akarizide mittel |
| US4565882A (en) * | 1984-01-06 | 1986-01-21 | G. D. Searle & Co. | Substituted dihydrobenzopyran-2-carboxylates |
| CA1320490C (en) * | 1987-01-12 | 1993-07-20 | Darrel M. Gapinski | Anti-inflammatory agents |
| JPS63292977A (ja) * | 1987-05-25 | 1988-11-30 | 片山 晋 | スキ−用のビンディング固定板 |
| US5059609A (en) * | 1987-10-19 | 1991-10-22 | Pfizer Inc. | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases |
| MX13485A (es) * | 1987-10-19 | 1993-05-01 | Pfizer | Procedimiento para obtener tetralinas, cromados y compuestos relacionados, sustituidos |
| WO1990012010A1 (en) * | 1989-04-07 | 1990-10-18 | Pfizer Inc. | Substituted chromans in the treatment of asthma, arthritis and related diseases |
| WO1990015801A1 (en) * | 1989-06-22 | 1990-12-27 | Pfizer Inc. | Substituted sulfonamides and related compounds in the treatment of asthma, arthritis and related diseases |
| WO1991012253A1 (en) * | 1990-02-07 | 1991-08-22 | Pfizer Inc. | Tetralin and chroman derivatives useful in the treatment of asthma, arthritis, and related diseases |
| WO1993015066A1 (en) * | 1992-01-23 | 1993-08-05 | Pfizer Inc. | Benzopyran and related ltb4 antagonists |
| HRP930210A2 (en) * | 1992-02-25 | 1995-06-30 | Recordati Chem Pharm | Heterobicyclic compounds and pharmaceutical preparations containing them |
| FR2693196B1 (fr) * | 1992-07-03 | 1994-12-23 | Lipha | Dérivés de benzopyranone ou de benzothiopyranone, procédé de préparation et composition pharmaceutique les contenant. |
-
1992
- 1992-01-22 MX MX9300312A patent/MX9300312A/es not_active IP Right Cessation
- 1992-11-13 CA CA002126752A patent/CA2126752C/en not_active Expired - Lifetime
- 1992-11-13 EP EP92924284A patent/EP0623123B1/en not_active Expired - Lifetime
- 1992-11-13 KR KR1019940702518A patent/KR0124802B1/ko active
- 1992-11-13 CZ CZ941762A patent/CZ282400B6/cs not_active IP Right Cessation
- 1992-11-13 RO RO94-01220A patent/RO112031B1/ro unknown
- 1992-11-13 SK SK844-94A patent/SK280451B6/sk unknown
- 1992-11-13 AU AU30650/92A patent/AU666896B2/en not_active Ceased
- 1992-11-13 DE DE69219364T patent/DE69219364T2/de not_active Expired - Lifetime
- 1992-11-13 RU RU94035964/04A patent/RU2114110C1/ru not_active IP Right Cessation
- 1992-11-13 JP JP5513184A patent/JP2765757B2/ja not_active Expired - Lifetime
- 1992-11-13 BR BR9207061A patent/BR9207061A/pt not_active Application Discontinuation
- 1992-11-13 DK DK92924284.0T patent/DK0623123T3/da active
- 1992-11-13 WO PCT/US1992/009496 patent/WO1993015067A1/en active IP Right Grant
- 1992-11-13 PL PL92304689A patent/PL171003B1/pl unknown
- 1992-11-13 SG SG1996006699A patent/SG49813A1/en unknown
- 1992-11-13 AT AT92924284T patent/ATE152108T1/de not_active IP Right Cessation
- 1992-11-13 US US08/295,827 patent/US5552435A/en not_active Expired - Lifetime
- 1992-11-13 HU HU9401979A patent/HU221194B1/hu not_active IP Right Cessation
- 1992-11-17 TW TW081109200A patent/TW213907B/zh active
- 1992-11-20 AP APAP/P/1992/000449A patent/AP352A/en active
-
1993
- 1993-01-02 EG EG3293A patent/EG20202A/xx active
- 1993-01-13 PH PH45558D patent/PH30346A/en unknown
- 1993-01-14 IL IL10438693A patent/IL104386A/en not_active IP Right Cessation
- 1993-01-19 IS IS3969A patent/IS1795B/is unknown
- 1993-01-19 MY MYPI93000086A patent/MY109144A/en unknown
- 1993-01-21 CN CN93100769A patent/CN1041311C/zh not_active Expired - Fee Related
- 1993-01-22 NZ NZ245735A patent/NZ245735A/en unknown
- 1993-01-22 ZA ZA93486A patent/ZA93486B/xx unknown
- 1993-01-22 YU YU3393A patent/YU48949B/sh unknown
- 1993-01-22 PT PT101183A patent/PT101183B/pt not_active IP Right Cessation
-
1994
- 1994-06-21 BG BG98867A patent/BG62331B1/bg unknown
- 1994-07-22 NO NO942759A patent/NO306508B1/no not_active IP Right Cessation
- 1994-07-22 KR KR1019940702518A patent/KR950700273A/ko not_active IP Right Cessation
- 1994-07-22 FI FI943474A patent/FI943474A/fi not_active IP Right Cessation
- 1994-07-22 OA OA60543A patent/OA11456A/en unknown
-
1996
- 1996-05-03 US US08/642,711 patent/US5684046A/en not_active Expired - Lifetime
-
1997
- 1997-06-04 GR GR970401301T patent/GR3023657T3/el unknown
- 1997-09-16 HK HK97101786A patent/HK1000245A1/xx not_active IP Right Cessation
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