EG20202A - Benzopyran and related LTB4 antagonists - Google Patents

Benzopyran and related LTB4 antagonists

Info

Publication number
EG20202A
EG20202A EG3293A EG3293A EG20202A EG 20202 A EG20202 A EG 20202A EG 3293 A EG3293 A EG 3293A EG 3293 A EG3293 A EG 3293A EG 20202 A EG20202 A EG 20202A
Authority
EG
Egypt
Prior art keywords
benzopyran
ltb4 antagonists
related ltb4
antagonists
ltb4
Prior art date
Application number
EG3293A
Other languages
English (en)
Inventor
Kevin Koch
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of EG20202A publication Critical patent/EG20202A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
EG3293A 1992-01-23 1993-01-02 Benzopyran and related LTB4 antagonists EG20202A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82441292A 1992-01-23 1992-01-23

Publications (1)

Publication Number Publication Date
EG20202A true EG20202A (en) 1997-10-30

Family

ID=25241346

Family Applications (1)

Application Number Title Priority Date Filing Date
EG3293A EG20202A (en) 1992-01-23 1993-01-02 Benzopyran and related LTB4 antagonists

Country Status (37)

Country Link
US (2) US5552435A (xx)
EP (1) EP0623123B1 (xx)
JP (1) JP2765757B2 (xx)
KR (2) KR0124802B1 (xx)
CN (1) CN1041311C (xx)
AP (1) AP352A (xx)
AT (1) ATE152108T1 (xx)
AU (1) AU666896B2 (xx)
BG (1) BG62331B1 (xx)
BR (1) BR9207061A (xx)
CA (1) CA2126752C (xx)
CZ (1) CZ282400B6 (xx)
DE (1) DE69219364T2 (xx)
DK (1) DK0623123T3 (xx)
EG (1) EG20202A (xx)
FI (1) FI943474A0 (xx)
GR (1) GR3023657T3 (xx)
HK (1) HK1000245A1 (xx)
HU (1) HU221194B1 (xx)
IL (1) IL104386A (xx)
IS (1) IS1795B (xx)
MX (1) MX9300312A (xx)
MY (1) MY109144A (xx)
NO (1) NO306508B1 (xx)
NZ (1) NZ245735A (xx)
OA (1) OA11456A (xx)
PH (1) PH30346A (xx)
PL (1) PL171003B1 (xx)
PT (1) PT101183B (xx)
RO (1) RO112031B1 (xx)
RU (1) RU2114110C1 (xx)
SG (1) SG49813A1 (xx)
SK (1) SK280451B6 (xx)
TW (1) TW213907B (xx)
WO (1) WO1993015067A1 (xx)
YU (1) YU48949B (xx)
ZA (1) ZA93486B (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2084547B1 (es) * 1993-07-12 1997-01-16 Pfizer Antagonistas benzopiranicos y relacionados de leucotrieno b4.
CN1160399A (zh) * 1994-10-13 1997-09-24 美国辉瑞有限公司 苯并吡喃和苯并稠合化合物、其制备方法和它们作为白三烯b4(ltb4)拮抗剂的用途
JP3012339B2 (ja) * 1994-10-13 2000-02-21 ファイザー・インコーポレーテッド ベンゾピランおよびベンゾ縮合化合物、それらの製造、並びにロイコトリエンｂ▲下４▼（ｌｔｂ▲下４▼）アンタゴニストとしてのそれらの用途
CA2265043C (en) * 1996-09-16 2003-01-14 Pfizer Inc. Processes and intermediates for preparing substituted chromanol derivatives
US6416733B1 (en) 1996-10-07 2002-07-09 Bristol-Myers Squibb Pharma Company Radiopharmaceuticals for imaging infection and inflammation
EP0836850A3 (en) * 1996-10-17 2000-11-29 Pfizer Inc. Method of preventing allograft rejection
EP0963755A3 (en) * 1998-04-16 2001-03-14 Pfizer Products Inc. Use of benzopyranes for preventing allograft rejection
US6436987B1 (en) * 2000-06-08 2002-08-20 Pfizer Inc. Crystalline forms of (3S-trans)-2-[3,4-dihydro-4-hydroxy-3-(phenylmethyl)-2H-1-benzopyran-7-yl]-4-(trifluoromethyl)-benzoic acid
WO2002036173A2 (en) 2000-11-03 2002-05-10 Bristol-Myers Squibb Pharma Company Simultaneous dual isotope imaging of cardiac perfusion and cardiac inflammation
CA2433516A1 (en) * 2001-01-30 2002-08-08 Keith Michael Devries Processes for preparing chromanylbenzoic acids
AU4239302A (en) * 2001-06-28 2003-01-02 Pfizer Products Inc. Benzoic acid substituted benzopyrans for the treatment of atherosclerosis
RU2007101510A (ru) * 2004-07-22 2008-08-27 Фармаци Корпорейшн (US) Композиции для лечения воспаления и боли с использованием комбинации селективного ингибитора сох-2 и антагониста рецептора ltb4
EP3383389B1 (en) * 2015-11-30 2021-04-28 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as blt1 antagonists
EP3383388B1 (en) 2015-11-30 2021-04-14 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as blt1 antagonists
WO2017095725A1 (en) 2015-11-30 2017-06-08 Merck Sharp & Dohme Corp. Aryl sulfonamides as blt1 antagonists
EP3383868B1 (en) 2015-11-30 2022-10-05 Merck Sharp & Dohme LLC Aryl sulfonamides as blt1 antagonists

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2309282A1 (de) * 1973-02-24 1974-08-29 Hoechst Ag Verfahren zur herstellung von 4-hydroxy-thiochromanen
DE2745305A1 (de) * 1977-10-07 1979-04-19 Bayer Ag Insektizide und akarizide mittel
US4565882A (en) * 1984-01-06 1986-01-21 G. D. Searle & Co. Substituted dihydrobenzopyran-2-carboxylates
CA1320490C (en) * 1987-01-12 1993-07-20 Darrel M. Gapinski Anti-inflammatory agents
JPS63292977A (ja) * 1987-05-25 1988-11-30 片山　晋 スキ−用のビンディング固定板
US5059609A (en) * 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
MX13485A (es) * 1987-10-19 1993-05-01 Pfizer Procedimiento para obtener tetralinas, cromados y compuestos relacionados, sustituidos
US5298512A (en) * 1989-04-07 1994-03-29 Pfizer Inc. Substituted chromans and their use in the treatment of asthma, arthritis and related diseases
WO1990015801A1 (en) * 1989-06-22 1990-12-27 Pfizer Inc. Substituted sulfonamides and related compounds in the treatment of asthma, arthritis and related diseases
WO1991012253A1 (en) * 1990-02-07 1991-08-22 Pfizer Inc. Tetralin and chroman derivatives useful in the treatment of asthma, arthritis, and related diseases
WO1993015066A1 (en) * 1992-01-23 1993-08-05 Pfizer Inc. Benzopyran and related ltb4 antagonists
EP0558245A1 (en) * 1992-02-25 1993-09-01 RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors
FR2693196B1 (fr) * 1992-07-03 1994-12-23 Lipha Dérivés de benzopyranone ou de benzothiopyranone, procédé de préparation et composition pharmaceutique les contenant.

Also Published As

Publication number Publication date
GR3023657T3 (en) 1997-09-30
JP2765757B2 (ja) 1998-06-18
SK280451B6 (sk) 2000-02-14
SG49813A1 (en) 1998-06-15
RU94035964A (ru) 1997-05-27
NO942759L (no) 1994-07-22
MY109144A (en) 1996-12-31
CZ176294A3 (en) 1995-02-15
TW213907B (xx) 1993-10-01
YU48949B (sh) 2003-01-31
DE69219364D1 (de) 1997-05-28
AU3065092A (en) 1993-09-01
PH30346A (en) 1997-04-02
OA11456A (en) 2003-11-18
CZ282400B6 (cs) 1997-07-16
BR9207061A (pt) 1995-12-26
RU2114110C1 (ru) 1998-06-27
CN1041311C (zh) 1998-12-23
HUT68790A (en) 1995-07-28
DK0623123T3 (da) 1997-10-13
HU221194B1 (en) 2002-08-28
US5552435A (en) 1996-09-03
PL171003B1 (pl) 1997-02-28
CA2126752A1 (en) 1993-08-05
PT101183A (pt) 1994-03-31
FI943474A (fi) 1994-07-22
NZ245735A (en) 1995-04-27
PT101183B (pt) 1999-09-30
EP0623123A1 (en) 1994-11-09
EP0623123B1 (en) 1997-04-23
NO942759D0 (no) 1994-07-22
YU3393A (sh) 1996-07-24
AP352A (en) 1994-08-10
ATE152108T1 (de) 1997-05-15
KR0124802B1 (ko) 1997-11-25
AU666896B2 (en) 1996-02-29
WO1993015067A1 (en) 1993-08-05
RO112031B1 (ro) 1997-04-30
IL104386A (en) 2001-05-20
CA2126752C (en) 2000-05-16
AP9200449A0 (en) 1993-01-31
SK84494A3 (en) 1995-05-10
NO306508B1 (no) 1999-11-15
US5684046A (en) 1997-11-04
BG62331B1 (bg) 1999-08-31
HK1000245A1 (en) 1998-02-13
ZA93486B (en) 1994-07-22
IS3969A (is) 1993-07-24
IL104386A0 (en) 1993-05-13
CN1075318A (zh) 1993-08-18
HU9401979D0 (en) 1994-09-28
KR950700273A (ko) 1995-01-16
MX9300312A (es) 1993-07-31
BG98867A (bg) 1995-03-31
FI943474A0 (fi) 1994-07-22
DE69219364T2 (de) 1997-08-07
JPH07502536A (ja) 1995-03-16
IS1795B (is) 2001-12-18

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