ES2009209A6 - Procedimiento para la obtencion de dihidropiridinlactoles. - Google Patents

Procedimiento para la obtencion de dihidropiridinlactoles.

Info

Publication number
ES2009209A6
ES2009209A6 ES8601187A ES8601187A ES2009209A6 ES 2009209 A6 ES2009209 A6 ES 2009209A6 ES 8601187 A ES8601187 A ES 8601187A ES 8601187 A ES8601187 A ES 8601187A ES 2009209 A6 ES2009209 A6 ES 2009209A6
Authority
ES
Spain
Prior art keywords
carbon atoms
chain
fluorine
alkyl
atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601187A
Other languages
English (en)
Inventor
Siegfried Goldmann
Friedrich Bossert
Hans J Ahr
Hilmar Bischoff
Walter Puls
Dieter Petzinna
Klaus Schlossmann
Joachim Bender
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES2009209A6 publication Critical patent/ES2009209A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DIHIDROPIRIDINLACTOLES DE FORMULA (I), DONDE R1 ES FENILO, NAFTILO, TIENILO, PIRIDILO, CROMONILO, TIOCROMONILO, TIOCROMENILO, BENZOXADIAZOLILO O BENZOTIADIAZOLILO OPCIONALMENTE SUSTITUIDOS; R2 ALQUILO C1-12 LINEAL, RAMIFICADO O CICLICO, OPCIONALMENTE CONTENIENDO 1 O 2 ATOMOS DE O O S Y OPCIONALMENTE SUSTITUIDO; R3 ES CIANO, ALQUILO C1-4 LINEAL O RAMIFICADO, CONTENIENDO OPCIONALMENTE UN RESTO N-ALQUILO CON 1 A 3 ATOMOS DE C U O; Y R4 ES H, ALQUILO C1-6, LINEAL, RAMIFICADO O CICLICO, OPCIONALMENTE CONTENIENDO 1 O 2 ATOMOS DE OXIGENO, Y OPCIONALMENTE SUSTITUIDO. EL PROCEDIMIENTO CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UNA BASE Y POSTERIORMENTE CON UN ACIDO. ALTERNATIVAMENTE LOS COMPUESTOS (I) PUEDEN OBTENERSE POR BROMACION DE UN COMPUESTO (III) Y POSTERIOR HIDROLISIS DEL INTERMEDIO OBTENIDO. ESTOS COMPUESTOS (I) REBAJAN EL AZUCAR EN SANGRE Y SON ADECUADOS PARA EL TRATAMIENTO DE LA DIABETES.
ES8601187A 1986-01-17 1986-08-19 Procedimiento para la obtencion de dihidropiridinlactoles. Expired ES2009209A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863601226 DE3601226A1 (de) 1986-01-17 1986-01-17 Dihydropyridinlactole, verfahren zur herstellung und ihre verwendung in arzneimitteln

Publications (1)

Publication Number Publication Date
ES2009209A6 true ES2009209A6 (es) 1989-09-16

Family

ID=6292033

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601187A Expired ES2009209A6 (es) 1986-01-17 1986-08-19 Procedimiento para la obtencion de dihidropiridinlactoles.

Country Status (25)

Country Link
US (1) US4721719A (es)
EP (1) EP0235347B1 (es)
JP (1) JPH0762018B2 (es)
KR (1) KR870007179A (es)
CN (2) CN1061528A (es)
AT (1) ATE68184T1 (es)
AU (1) AU587068B2 (es)
CA (1) CA1293508C (es)
CS (1) CS258492B2 (es)
DD (1) DD268945A5 (es)
DE (2) DE3601226A1 (es)
DK (1) DK161252C (es)
EG (1) EG18031A (es)
ES (1) ES2009209A6 (es)
FI (1) FI870151A (es)
GR (1) GR862107B (es)
HU (1) HU196804B (es)
IL (1) IL81258A (es)
NO (1) NO164597C (es)
NZ (1) NZ217308A (es)
PH (1) PH23676A (es)
PL (2) PL149694B1 (es)
PT (1) PT84120B (es)
SU (1) SU1440345A3 (es)
ZA (1) ZA865968B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3410645A1 (de) * 1984-03-23 1985-09-26 Bayer Ag, 5090 Leverkusen L-alkylsubstituierte 1,4-dihydropyridinlactone, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
JP2594809B2 (ja) * 1988-04-02 1997-03-26 日本ゼオン株式会社 タイヤトレッド用ゴム組成物
JP4860050B2 (ja) * 2001-04-23 2012-01-25 富士重工業株式会社 溶断装置による穿孔方法及び溶断装置
JP2007505137A (ja) * 2003-09-10 2007-03-08 シンタ ファーマシューティカルズ コーポレイション 代謝性障害を処置または予防するためのジヒドロピリジン化合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0080220B1 (en) * 1981-11-17 1986-02-19 FISONS plc Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals
EP0111455A3 (de) * 1982-12-10 1984-07-25 Ciba-Geigy Ag Ungesättigte Lactone
DE3343658A1 (de) * 1983-12-02 1985-06-13 Bayer Ag, 5090 Leverkusen Hydroxy-tetrahydropyridinlactone, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln

Also Published As

Publication number Publication date
NO164597B (no) 1990-07-16
PT84120A (en) 1987-02-01
IL81258A (en) 1991-06-10
AU587068B2 (en) 1989-08-03
ZA865968B (en) 1987-03-25
CN86106735A (zh) 1987-07-29
EP0235347A2 (de) 1987-09-09
EG18031A (en) 1991-11-30
PL271190A1 (en) 1989-01-23
DD268945A5 (de) 1989-06-14
NO164597C (no) 1990-10-24
US4721719A (en) 1988-01-26
ATE68184T1 (de) 1991-10-15
JPS62169790A (ja) 1987-07-25
PL261050A1 (en) 1988-07-07
AU6323386A (en) 1987-07-23
EP0235347B1 (de) 1991-10-09
DK372586A (da) 1987-07-18
DK161252B (da) 1991-06-17
CN1061528A (zh) 1992-06-03
CS258492B2 (en) 1988-08-16
FI870151A (fi) 1987-07-18
HU196804B (en) 1989-01-30
GR862107B (en) 1986-12-30
PL149184B1 (en) 1990-01-31
CA1293508C (en) 1991-12-24
CS792386A2 (en) 1988-01-15
DE3601226A1 (de) 1987-07-23
SU1440345A3 (ru) 1988-11-23
CN1019488B (zh) 1992-12-16
PH23676A (en) 1989-09-27
DK372586D0 (da) 1986-08-05
NZ217308A (en) 1988-11-29
PL149694B1 (en) 1990-03-31
HUT45255A (en) 1988-06-28
DK161252C (da) 1992-01-06
JPH0762018B2 (ja) 1995-07-05
KR870007179A (ko) 1987-08-17
IL81258A0 (en) 1987-08-31
NO865324L (no) 1987-07-20
EP0235347A3 (en) 1987-11-19
PT84120B (pt) 1989-07-31
FI870151A0 (fi) 1987-01-15
DE3681913D1 (de) 1991-11-14

Similar Documents

Publication Publication Date Title
TR200000713T2 (tr) Mantar öldürücü ilaç olarak yeni pirimidin-4-on ve piridin-4-tiyon.
ES2008941A6 (es) Un procedimiento de produccion de nuevos derivados de oxa(tia) diazol>
IL83661A0 (en) Dihydropyridine compounds,their preparation and pharmaceutical compositions containing them
ATE69807T1 (de) Phenoxyessigsaeure-verbindungen, ihre herstellung, pharmazeutische zusammensetzungen und deren verwendung.
ES8504718A1 (es) Un metodo para preparar derivados de 4-hidroxi-2-quinolona.
ES507003A0 (es) Procedimiento de preparar derivados aminicos.
ES2009209A6 (es) Procedimiento para la obtencion de dihidropiridinlactoles.
MY101864A (en) Barbituric acid derivatives
DE3877036D1 (de) Biologisch aktive verbindungen.
IL68032A0 (en) Substituted 4-phenyl-4,5,6,7-tetrahydro-thieno(2,3-c)pyridines and salts thereof,their preparation and pharmaceutical compositions containing them
EP0132914A3 (en) Imidazolinone derivatives as histamine h2-antagonists
IT1197841B (it) Derivati pirido-benzotiazinici ad attivita' antibatterica ed a lunga durata di azione
ES8201541A1 (es) Un procedimiento para la preparacion de nuevas guanilamidi- nas
MY100957A (en) Quinazolinone compounds and processes for the preparation thereof.
CA2013960A1 (en) Substituted dibenzofurans and methods of using same
DK0413278T3 (da) Anvendelse af xanthinderivater mod mavesår
IT1205114B (it) 2-selenometil-1,4-diidropiridine,procedimento per la loro preparazione e composizioni farmaceutiche che le contengono
ES8600271A1 (es) Procedimiento para la obtencion de derivados de benzodioxol
TH6272EX (th) สารผสมเคมีภัณฑ์การเกษตรที่ทำให้เสถียรที่มีอนุพันธ์พิริมิดีน
MY104164A (en) Heterocyclic compounds.

Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-08-19