IL83661A0 - Dihydropyridine compounds,their preparation and pharmaceutical compositions containing them - Google Patents
Dihydropyridine compounds,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL83661A0 IL83661A0 IL83661A IL8366187A IL83661A0 IL 83661 A0 IL83661 A0 IL 83661A0 IL 83661 A IL83661 A IL 83661A IL 8366187 A IL8366187 A IL 8366187A IL 83661 A0 IL83661 A0 IL 83661A0
- Authority
- IL
- Israel
- Prior art keywords
- carbon atoms
- alkyl
- chain
- halogen
- hydroxyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Blood-sugar-lowering dihydropyridines of the formula <IMAGE> in which R1 represents phenyl, naphthyl, thienyl, pyridyl, chromenyl or thiochromenyl, it being possible for the radicals mentioned each to carry up to 2 identical or different substituents from the series comprising halogen, alkyl, alkoxy and alkylthio with in each case up to 6 carbon atoms, fluoroalkyl and fluoroalkoxy with in each case up to 3 carbon atoms and 3 fluorine atoms, nitro and cyano, R2 represents straight-chain, branched or cyclic alkyl which has up to 8 carbon atoms, can be interrupted in the alkyl chain by an oxygen or a sulphur atom and can be substituted by halogen, phenyl, cyano, hydroxyl, amino, alkylamino or dialkylamino with in each case up to 3 carbon atoms per alkyl group or by N-benzylmethylamino, R3 represents straight-chain, branched or cyclic alkyl which has up to 6 carbon atoms, can be interrupted in the alkyl chain by an oxygen atom and can be substituted by halogen, hydroxyl, amino, phenyl, morpholino, carboxy or alkoxycarbonyl with up to 4 carbon atoms and R4 and R5 each represent hydroxyl, or R4 and R5 together represent -O-, or a physiologically acceptable salt thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19863629545 DE3629545A1 (en) | 1986-08-30 | 1986-08-30 | DIHYDROPYRIDINE COMPOUNDS, METHOD FOR THEIR PRODUCTION AND THEIR USE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL83661A0 true IL83661A0 (en) | 1988-01-31 |
Family
ID=6308550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL83661A IL83661A0 (en) | 1986-08-30 | 1987-08-27 | Dihydropyridine compounds,their preparation and pharmaceutical compositions containing them |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4786641A (en) |
| EP (1) | EP0258729B1 (en) |
| JP (1) | JPH0832685B2 (en) |
| KR (1) | KR880002874A (en) |
| CN (1) | CN87105876A (en) |
| AT (1) | ATE52250T1 (en) |
| AU (1) | AU602529B2 (en) |
| CA (1) | CA1300626C (en) |
| DD (1) | DD263985A5 (en) |
| DE (2) | DE3629545A1 (en) |
| DK (1) | DK452687A (en) |
| ES (1) | ES2014456B3 (en) |
| FI (1) | FI873726A (en) |
| GR (1) | GR3000447T3 (en) |
| HU (1) | HU199120B (en) |
| IL (1) | IL83661A0 (en) |
| PT (1) | PT85622B (en) |
| ZA (1) | ZA876434B (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT657432E (en) | 1993-12-10 | 2003-07-31 | Bayer Ag | PHENYL-SUBSTITUTED 1,4-DIHYDROPYRIDINES WITH CEREBRAL ACTIVITY |
| DE4430092A1 (en) * | 1994-08-25 | 1996-02-29 | Bayer Ag | 2,3-Cyclically condensed 1,4-dihydropyridines, process for their preparation and their use as medicaments |
| JPH11106375A (en) * | 1997-08-18 | 1999-04-20 | Pfizer Pharmaceut Inc | Optically active 1,4-dihydropyridine compound as bradykinin antagonist |
| US6711297B1 (en) * | 1998-07-03 | 2004-03-23 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods and apparatus for dynamic transfer of image data |
| CO5271699A1 (en) | 2000-01-24 | 2003-04-30 | Pfizer Prod Inc | PROCEDURE FOR THE TREATMENT OF CARDIOMIOPATIA USING INHIBITORS OF THE GLUCOGENO FOSFORILASA |
| GB0021831D0 (en) * | 2000-09-06 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
| GB0205166D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| GB0205175D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| GB0205176D0 (en) * | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| GB0205162D0 (en) * | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| GB0205165D0 (en) * | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| GB0205170D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| GB0318464D0 (en) * | 2003-08-07 | 2003-09-10 | Astrazeneca Ab | Chemical compounds |
| GB0318463D0 (en) * | 2003-08-07 | 2003-09-10 | Astrazeneca Ab | Chemical compounds |
| GB0319690D0 (en) * | 2003-08-22 | 2003-09-24 | Astrazeneca Ab | Chemical compounds |
| GB0319759D0 (en) * | 2003-08-22 | 2003-09-24 | Astrazeneca Ab | Chemical compounds |
| US20050203119A1 (en) * | 2003-09-10 | 2005-09-15 | Mitsunori Ono | Dihydropyridine compounds for treating or preventing metabolic disorders |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB125803A (en) * | 1918-05-29 | 1919-05-01 | Joseph Ernest Barrows | Improvements in Sparking Plugs for use with Internal Combustion Engines. |
| GB161221A (en) * | 1919-11-21 | 1921-03-21 | Edwin William Nick | Improved method of feed-water regulation for marine boilers and means therefor |
| GB158138A (en) * | 1919-11-25 | 1921-02-03 | Herman Schoener | Improvements in weed cutters or hoes |
| DE2248150A1 (en) * | 1972-09-30 | 1974-04-04 | Bayer Ag | DIHYDROPYRIDINE POLYESTER, METHOD FOR MANUFACTURING AND USING THEM AS A MEDICINAL PRODUCT |
| US3970662A (en) * | 1975-06-19 | 1976-07-20 | Sterling Drug Inc. | 4-(3-Nitrophenyl)-2,3,5,6-pyridinetetracarboxylic acid and intermediates |
| EP0125803A3 (en) * | 1983-04-27 | 1987-01-21 | FISONS plc | Pharmaceutically active dihydropyridines |
| DE3445356A1 (en) * | 1983-12-15 | 1985-06-27 | Ciba-Geigy Ag, Basel | Halogenated thiophene compounds |
| DE3410645A1 (en) * | 1984-03-23 | 1985-09-26 | Bayer Ag, 5090 Leverkusen | L-ALKYL-SUBSTITUTED 1,4-DIHYDROPYRIDINE LACTONE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS |
| US4748244A (en) * | 1984-05-11 | 1988-05-31 | Ciba-Geigy Corporation | Process for the preparation of pyridine-2-3-dicarboxylic acid derivatives, and novel 1-amino-1,4-dihydropyridine-2-3-diarboxylic acid derivatives |
-
1986
- 1986-08-30 DE DE19863629545 patent/DE3629545A1/en not_active Withdrawn
-
1987
- 1987-08-18 DE DE8787111924T patent/DE3762416D1/en not_active Expired - Lifetime
- 1987-08-18 ES ES87111924T patent/ES2014456B3/en not_active Expired - Lifetime
- 1987-08-18 AT AT87111924T patent/ATE52250T1/en not_active IP Right Cessation
- 1987-08-18 EP EP87111924A patent/EP0258729B1/en not_active Expired - Lifetime
- 1987-08-20 US US07/087,491 patent/US4786641A/en not_active Expired - Fee Related
- 1987-08-27 IL IL83661A patent/IL83661A0/en not_active IP Right Cessation
- 1987-08-27 FI FI873726A patent/FI873726A/en not_active Application Discontinuation
- 1987-08-28 PT PT85622A patent/PT85622B/en not_active IP Right Cessation
- 1987-08-28 CA CA000545604A patent/CA1300626C/en not_active Expired - Lifetime
- 1987-08-28 JP JP62213163A patent/JPH0832685B2/en not_active Expired - Lifetime
- 1987-08-28 ZA ZA876434A patent/ZA876434B/en unknown
- 1987-08-28 AU AU77695/87A patent/AU602529B2/en not_active Ceased
- 1987-08-28 DK DK452687A patent/DK452687A/en not_active Application Discontinuation
- 1987-08-28 CN CN198787105876A patent/CN87105876A/en active Pending
- 1987-08-28 DD DD87306465A patent/DD263985A5/en not_active IP Right Cessation
- 1987-08-28 HU HU873794A patent/HU199120B/en not_active IP Right Cessation
- 1987-08-29 KR KR1019870009512A patent/KR880002874A/en not_active Application Discontinuation
-
1990
- 1990-04-26 GR GR90400152T patent/GR3000447T3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0258729B1 (en) | 1990-04-25 |
| DD263985A5 (en) | 1989-01-18 |
| PT85622A (en) | 1987-09-01 |
| JPS6372674A (en) | 1988-04-02 |
| KR880002874A (en) | 1988-05-12 |
| ZA876434B (en) | 1988-05-25 |
| GR3000447T3 (en) | 1991-06-28 |
| HU199120B (en) | 1990-01-29 |
| PT85622B (en) | 1990-05-31 |
| ATE52250T1 (en) | 1990-05-15 |
| FI873726A (en) | 1988-03-01 |
| HUT45014A (en) | 1988-05-30 |
| AU7769587A (en) | 1988-03-03 |
| CN87105876A (en) | 1988-03-23 |
| AU602529B2 (en) | 1990-10-18 |
| EP0258729A3 (en) | 1988-06-15 |
| CA1300626C (en) | 1992-05-12 |
| EP0258729A2 (en) | 1988-03-09 |
| FI873726A0 (en) | 1987-08-27 |
| DK452687A (en) | 1988-03-01 |
| DE3629545A1 (en) | 1988-03-10 |
| DE3762416D1 (en) | 1990-05-31 |
| US4786641A (en) | 1988-11-22 |
| JPH0832685B2 (en) | 1996-03-29 |
| DK452687D0 (en) | 1987-08-28 |
| ES2014456B3 (en) | 1990-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM9K | Patent not in force due to non-payment of renewal fees |