YU48249B - POSTUPAK ZA IZRADU N-METIL-3-(p-TRIFLUORMETILFENOKSI)-3-FENIL-PROPILAMINA I NJEGOVIH SOLI - Google Patents

POSTUPAK ZA IZRADU N-METIL-3-(p-TRIFLUORMETILFENOKSI)-3-FENIL-PROPILAMINA I NJEGOVIH SOLI

Info

Publication number
YU48249B
YU48249B YU1590A YU1590A YU48249B YU 48249 B YU48249 B YU 48249B YU 1590 A YU1590 A YU 1590A YU 1590 A YU1590 A YU 1590A YU 48249 B YU48249 B YU 48249B
Authority
YU
Yugoslavia
Prior art keywords
phenyl
propylamine
chem
methyl
preparation
Prior art date
Application number
YU1590A
Other languages
English (en)
Other versions
YU1590A (en
Inventor
P.J. Kairisalo
P.J. Hukka
A.H. Järvinen
Original Assignee
Orion Corporation Fermion
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8527991&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU48249(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Orion Corporation Fermion filed Critical Orion Corporation Fermion
Priority to SI9010015A priority Critical patent/SI9010015B/sl
Publication of YU1590A publication Critical patent/YU1590A/xx
Priority to HRP-15/90A priority patent/HRP921278B1/xx
Publication of YU48249B publication Critical patent/YU48249B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Indexing, Searching, Synchronizing, And The Amount Of Synchronization Travel Of Record Carriers (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Jib Cranes (AREA)

Abstract

POSTUPAK ZA IZRADU N-METIL-3-(p-TRIFLUORMETILFENOKSI)-3-FENIL-PROPILAMINA I NJEGOVIH SOLI - Naznačen time, što se 2-benzoil-N-benzil-N-metiletilamin baza formule (II), kaalitički hidrogenuje, pri čemu se stvara 1-fenil-3-(N-metilamino)-propan-1-ol formule (III) koji se posle toga selektivno eterifikuje pomoću 1-hlor-4-tri-fluormetil benzola formule (IV) u prisustvu baze, pri čemu se stvara N-metil-3-(p-trifluormetil-fenoksi)-3-fenil-propilamin, koji se po želji prevodi na poznat način u adicionu so kiseline fluoksetina, na pr. fluoksetin hidrohlorid. - Prijava sadrži još 5 zavisnih zahteva.
YU1590A 1989-03-03 1990-01-04 POSTUPAK ZA IZRADU N-METIL-3-(p-TRIFLUORMETILFENOKSI)-3-FENIL-PROPILAMINA I NJEGOVIH SOLI YU48249B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI9010015A SI9010015B (sl) 1989-03-03 1990-01-04 Postopek za pridobivanje N-metil-3-(p-trifluorometilfenoksi)-3-fenil-propilamin hidroklorida
HRP-15/90A HRP921278B1 (en) 1989-03-03 1992-11-16 An improved process for the preparation of a valuable drug

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI891015A FI81083C (fi) 1989-03-03 1989-03-03 Ett foerbaettrat foerfarande foer framstaellning av n-metyl-3-(p-trifluormetylfenoxi)-3-fenylpropylamin hydroklorid.

Publications (2)

Publication Number Publication Date
YU1590A YU1590A (en) 1991-10-31
YU48249B true YU48249B (sh) 1997-09-30

Family

ID=8527991

Family Applications (1)

Application Number Title Priority Date Filing Date
YU1590A YU48249B (sh) 1989-03-03 1990-01-04 POSTUPAK ZA IZRADU N-METIL-3-(p-TRIFLUORMETILFENOKSI)-3-FENIL-PROPILAMINA I NJEGOVIH SOLI

Country Status (24)

Country Link
EP (1) EP0391070B1 (sh)
JP (1) JPH0791244B2 (sh)
AT (1) ATE100440T1 (sh)
AU (1) AU620497B2 (sh)
BG (1) BG51156A3 (sh)
CA (1) CA2010410C (sh)
CS (1) CS276782B6 (sh)
DD (1) DD297806A5 (sh)
DE (1) DE69006072T2 (sh)
DK (2) DK172360B1 (sh)
ES (1) ES2062131T3 (sh)
FI (1) FI81083C (sh)
HR (1) HRP921278B1 (sh)
HU (1) HU204769B (sh)
IE (1) IE63650B1 (sh)
IL (1) IL92802A (sh)
NO (1) NO172284C (sh)
PL (1) PL163884B1 (sh)
PT (1) PT93302A (sh)
RO (1) RO105802B1 (sh)
RU (1) RU1779244C (sh)
SI (1) SI9010015B (sh)
YU (1) YU48249B (sh)
ZA (1) ZA90739B (sh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL99316A (en) 1991-08-27 1995-03-15 Teva Pharma Production of fluoxetine and new intermediates
HU9202128D0 (en) * 1992-06-26 1992-10-28 Richter Gedeon Vegyeszet Method for producing n-methyl-(3-phenyl-3-(4-[trifluoro-methyl])-phenooxi-)-amine
US5618968A (en) * 1993-02-05 1997-04-08 Pliva Farmaceutska Kemijska, Prehrambena I Kozmeticka Industrija, Dionicko Drustvo N-substituted derivatives of N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine and the procedure for their preparation
US5362886A (en) * 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis
ES2101650B1 (es) * 1995-06-29 1998-01-16 Lilly Sa Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometilfenoxi) propilamina.
ES2101654B1 (es) * 1995-07-24 1998-01-16 Lilly Sa Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometilfe noxi) propilamina.
ES2101655B1 (es) * 1995-07-28 1998-01-16 Lilly Sa Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometilfe noxi) propilamina.
ES2103680B1 (es) * 1995-08-03 1998-04-01 Lilly Sa Procedimiento de preparacion de n-metil-3-fenil-3- (p-trifluorometilfenoxi)propilamina.
ES2103681B1 (es) * 1995-09-19 1998-04-01 Lilly Sa Procedimiento de preparacion de n-metil-3-fenil - (p-trifluorometilfenoxi) propilamina.
ES2120368B1 (es) * 1996-06-14 1999-07-01 Almirall Prodesfarma Sa Procedimiento de obtencion de n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina y sus sales farmaceuticamente aceptables.
US6008412A (en) * 1997-10-14 1999-12-28 Eli Lilly And Company Process to make chiral compounds
TW514634B (en) * 1997-10-14 2002-12-21 Lilly Co Eli Process to make chiral compounds
US6025517A (en) * 1998-08-03 2000-02-15 Sepracor Inc. Fluoxetine process from benzoylacetonitrile
US6541668B1 (en) * 1999-04-09 2003-04-01 Eli Lilly And Company Methods for preparing 3-arloxy-3-arylpropylamines and intermediates thereof
US6313350B1 (en) 2001-01-31 2001-11-06 Grayson Walker Stowell Form a of fluoxetine hydrochloride
US6310251B1 (en) 2001-01-31 2001-10-30 Grayson Walker Stowell Form a of fluoxetine hydrochloride
US6316672B1 (en) 2001-01-31 2001-11-13 Grayson Walker Stowell Form a of fluoxetine hydrochloride
US6258853B1 (en) 2001-01-31 2001-07-10 Grayson Walker Stowell Form a of fluoxetine hydrochloride
US6310250B1 (en) 2001-01-31 2001-10-30 Grayson Walker Stowell Form A of fluoxetine hydrochloride
JP4769464B2 (ja) * 2005-01-12 2011-09-07 広栄化学工業株式会社 アルコール化合物の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4314081A (en) * 1974-01-10 1982-02-02 Eli Lilly And Company Arloxyphenylpropylamines
GB2060618A (en) * 1979-09-14 1981-05-07 Wyeth John & Brother Ltd 3-Aryl-3-Aryloxypropylamines
JPS6172736A (ja) * 1984-09-18 1986-04-14 Toyo Soda Mfg Co Ltd エフエドリン誘導体およびその製造方法
GB8500482D0 (en) * 1985-01-09 1985-02-13 Shell Int Research Substituted phenyl ethers

Also Published As

Publication number Publication date
SI9010015B (sl) 1999-06-30
NO901013L (no) 1990-09-04
IE63650B1 (en) 1995-05-31
IE894118L (en) 1990-09-03
DK49790A (da) 1990-09-04
CS9001003A2 (en) 1991-09-15
FI81083C (fi) 1990-09-10
AU4996990A (en) 1990-09-06
EP0391070A1 (en) 1990-10-10
HU901276D0 (en) 1990-05-28
HRP921278B1 (en) 2000-04-30
EP0391070B1 (en) 1994-01-19
CS276782B6 (en) 1992-08-12
DK49790D0 (da) 1990-02-26
NO172284C (no) 1993-06-30
BG51156A3 (en) 1993-02-15
DE69006072D1 (de) 1994-03-03
YU1590A (en) 1991-10-31
PL163884B1 (pl) 1994-05-31
FI81083B (fi) 1990-05-31
JPH02282352A (ja) 1990-11-19
AU620497B2 (en) 1992-02-20
DD297806A5 (de) 1992-01-23
ES2062131T3 (es) 1994-12-16
FI891015A0 (fi) 1989-03-03
HRP921278A2 (en) 1995-08-31
RU1779244C (ru) 1992-11-30
RO105802B1 (ro) 1992-12-30
ZA90739B (en) 1990-11-28
IL92802A (en) 1994-01-25
CA2010410C (en) 1997-03-18
CA2010410A1 (en) 1990-09-03
DK172360B1 (da) 1998-04-14
PT93302A (pt) 1990-11-07
ATE100440T1 (de) 1994-02-15
NO901013D0 (no) 1990-03-02
HUT54619A (en) 1991-03-28
JPH0791244B2 (ja) 1995-10-04
HU204769B (en) 1992-02-28
SI9010015A (sl) 1998-06-30
NO172284B (no) 1993-03-22
DE69006072T2 (de) 1994-06-30
DK0391070T3 (da) 1994-02-28

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