YU48249B - POSTUPAK ZA IZRADU N-METIL-3-(p-TRIFLUORMETILFENOKSI)-3-FENIL-PROPILAMINA I NJEGOVIH SOLI - Google Patents
POSTUPAK ZA IZRADU N-METIL-3-(p-TRIFLUORMETILFENOKSI)-3-FENIL-PROPILAMINA I NJEGOVIH SOLIInfo
- Publication number
- YU48249B YU48249B YU1590A YU1590A YU48249B YU 48249 B YU48249 B YU 48249B YU 1590 A YU1590 A YU 1590A YU 1590 A YU1590 A YU 1590A YU 48249 B YU48249 B YU 48249B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- phenyl
- propylamine
- chem
- methyl
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Indexing, Searching, Synchronizing, And The Amount Of Synchronization Travel Of Record Carriers (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Jib Cranes (AREA)
Abstract
POSTUPAK ZA IZRADU N-METIL-3-(p-TRIFLUORMETILFENOKSI)-3-FENIL-PROPILAMINA I NJEGOVIH SOLI - Naznačen time, što se 2-benzoil-N-benzil-N-metiletilamin baza formule (II), kaalitički hidrogenuje, pri čemu se stvara 1-fenil-3-(N-metilamino)-propan-1-ol formule (III) koji se posle toga selektivno eterifikuje pomoću 1-hlor-4-tri-fluormetil benzola formule (IV) u prisustvu baze, pri čemu se stvara N-metil-3-(p-trifluormetil-fenoksi)-3-fenil-propilamin, koji se po želji prevodi na poznat način u adicionu so kiseline fluoksetina, na pr. fluoksetin hidrohlorid. - Prijava sadrži još 5 zavisnih zahteva.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI9010015A SI9010015B (sl) | 1989-03-03 | 1990-01-04 | Postopek za pridobivanje N-metil-3-(p-trifluorometilfenoksi)-3-fenil-propilamin hidroklorida |
HRP-15/90A HRP921278B1 (en) | 1989-03-03 | 1992-11-16 | An improved process for the preparation of a valuable drug |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI891015A FI81083C (fi) | 1989-03-03 | 1989-03-03 | Ett foerbaettrat foerfarande foer framstaellning av n-metyl-3-(p-trifluormetylfenoxi)-3-fenylpropylamin hydroklorid. |
Publications (2)
Publication Number | Publication Date |
---|---|
YU1590A YU1590A (en) | 1991-10-31 |
YU48249B true YU48249B (sh) | 1997-09-30 |
Family
ID=8527991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU1590A YU48249B (sh) | 1989-03-03 | 1990-01-04 | POSTUPAK ZA IZRADU N-METIL-3-(p-TRIFLUORMETILFENOKSI)-3-FENIL-PROPILAMINA I NJEGOVIH SOLI |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP0391070B1 (sh) |
JP (1) | JPH0791244B2 (sh) |
AT (1) | ATE100440T1 (sh) |
AU (1) | AU620497B2 (sh) |
BG (1) | BG51156A3 (sh) |
CA (1) | CA2010410C (sh) |
CS (1) | CS276782B6 (sh) |
DD (1) | DD297806A5 (sh) |
DE (1) | DE69006072T2 (sh) |
DK (2) | DK172360B1 (sh) |
ES (1) | ES2062131T3 (sh) |
FI (1) | FI81083C (sh) |
HR (1) | HRP921278B1 (sh) |
HU (1) | HU204769B (sh) |
IE (1) | IE63650B1 (sh) |
IL (1) | IL92802A (sh) |
NO (1) | NO172284C (sh) |
PL (1) | PL163884B1 (sh) |
PT (1) | PT93302A (sh) |
RO (1) | RO105802B1 (sh) |
RU (1) | RU1779244C (sh) |
SI (1) | SI9010015B (sh) |
YU (1) | YU48249B (sh) |
ZA (1) | ZA90739B (sh) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL99316A (en) | 1991-08-27 | 1995-03-15 | Teva Pharma | Production of fluoxetine and new intermediates |
HU9202128D0 (en) * | 1992-06-26 | 1992-10-28 | Richter Gedeon Vegyeszet | Method for producing n-methyl-(3-phenyl-3-(4-[trifluoro-methyl])-phenooxi-)-amine |
US5618968A (en) * | 1993-02-05 | 1997-04-08 | Pliva Farmaceutska Kemijska, Prehrambena I Kozmeticka Industrija, Dionicko Drustvo | N-substituted derivatives of N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine and the procedure for their preparation |
US5362886A (en) * | 1993-10-12 | 1994-11-08 | Eli Lilly And Company | Asymmetric synthesis |
ES2101650B1 (es) * | 1995-06-29 | 1998-01-16 | Lilly Sa | Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometilfenoxi) propilamina. |
ES2101654B1 (es) * | 1995-07-24 | 1998-01-16 | Lilly Sa | Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometilfe noxi) propilamina. |
ES2101655B1 (es) * | 1995-07-28 | 1998-01-16 | Lilly Sa | Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometilfe noxi) propilamina. |
ES2103680B1 (es) * | 1995-08-03 | 1998-04-01 | Lilly Sa | Procedimiento de preparacion de n-metil-3-fenil-3- (p-trifluorometilfenoxi)propilamina. |
ES2103681B1 (es) * | 1995-09-19 | 1998-04-01 | Lilly Sa | Procedimiento de preparacion de n-metil-3-fenil - (p-trifluorometilfenoxi) propilamina. |
ES2120368B1 (es) * | 1996-06-14 | 1999-07-01 | Almirall Prodesfarma Sa | Procedimiento de obtencion de n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina y sus sales farmaceuticamente aceptables. |
US6008412A (en) * | 1997-10-14 | 1999-12-28 | Eli Lilly And Company | Process to make chiral compounds |
TW514634B (en) * | 1997-10-14 | 2002-12-21 | Lilly Co Eli | Process to make chiral compounds |
US6025517A (en) * | 1998-08-03 | 2000-02-15 | Sepracor Inc. | Fluoxetine process from benzoylacetonitrile |
US6541668B1 (en) * | 1999-04-09 | 2003-04-01 | Eli Lilly And Company | Methods for preparing 3-arloxy-3-arylpropylamines and intermediates thereof |
US6313350B1 (en) | 2001-01-31 | 2001-11-06 | Grayson Walker Stowell | Form a of fluoxetine hydrochloride |
US6310251B1 (en) | 2001-01-31 | 2001-10-30 | Grayson Walker Stowell | Form a of fluoxetine hydrochloride |
US6316672B1 (en) | 2001-01-31 | 2001-11-13 | Grayson Walker Stowell | Form a of fluoxetine hydrochloride |
US6258853B1 (en) | 2001-01-31 | 2001-07-10 | Grayson Walker Stowell | Form a of fluoxetine hydrochloride |
US6310250B1 (en) | 2001-01-31 | 2001-10-30 | Grayson Walker Stowell | Form A of fluoxetine hydrochloride |
JP4769464B2 (ja) * | 2005-01-12 | 2011-09-07 | 広栄化学工業株式会社 | アルコール化合物の製造方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4314081A (en) * | 1974-01-10 | 1982-02-02 | Eli Lilly And Company | Arloxyphenylpropylamines |
GB2060618A (en) * | 1979-09-14 | 1981-05-07 | Wyeth John & Brother Ltd | 3-Aryl-3-Aryloxypropylamines |
JPS6172736A (ja) * | 1984-09-18 | 1986-04-14 | Toyo Soda Mfg Co Ltd | エフエドリン誘導体およびその製造方法 |
GB8500482D0 (en) * | 1985-01-09 | 1985-02-13 | Shell Int Research | Substituted phenyl ethers |
-
1989
- 1989-03-03 FI FI891015A patent/FI81083C/fi not_active IP Right Cessation
- 1989-12-19 IL IL9280289A patent/IL92802A/en unknown
- 1989-12-20 IE IE411889A patent/IE63650B1/en not_active IP Right Cessation
-
1990
- 1990-01-04 SI SI9010015A patent/SI9010015B/sl unknown
- 1990-01-04 YU YU1590A patent/YU48249B/sh unknown
- 1990-01-31 ZA ZA90739A patent/ZA90739B/xx unknown
- 1990-02-20 CA CA002010410A patent/CA2010410C/en not_active Expired - Fee Related
- 1990-02-20 AU AU49969/90A patent/AU620497B2/en not_active Ceased
- 1990-02-20 BG BG091247A patent/BG51156A3/xx unknown
- 1990-02-26 DK DK049790A patent/DK172360B1/da not_active IP Right Cessation
- 1990-02-26 DD DD90338155A patent/DD297806A5/de unknown
- 1990-03-01 AT AT90104018T patent/ATE100440T1/de not_active IP Right Cessation
- 1990-03-01 DK DK90104018.8T patent/DK0391070T3/da active
- 1990-03-01 PT PT93302A patent/PT93302A/pt not_active Application Discontinuation
- 1990-03-01 EP EP90104018A patent/EP0391070B1/en not_active Revoked
- 1990-03-01 ES ES90104018T patent/ES2062131T3/es not_active Expired - Lifetime
- 1990-03-01 DE DE69006072T patent/DE69006072T2/de not_active Revoked
- 1990-03-01 CS CS901003A patent/CS276782B6/cs not_active IP Right Cessation
- 1990-03-02 RU SU904743358A patent/RU1779244C/ru active
- 1990-03-02 RO RO144334A patent/RO105802B1/ro unknown
- 1990-03-02 JP JP2052564A patent/JPH0791244B2/ja not_active Expired - Fee Related
- 1990-03-02 HU HU901276A patent/HU204769B/hu not_active IP Right Cessation
- 1990-03-02 NO NO901013A patent/NO172284C/no not_active IP Right Cessation
- 1990-03-02 PL PL90284147A patent/PL163884B1/pl unknown
-
1992
- 1992-11-16 HR HRP-15/90A patent/HRP921278B1/xx not_active IP Right Cessation
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