ES2101650B1 - Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometilfenoxi) propilamina. - Google Patents

Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometilfenoxi) propilamina.

Info

Publication number
ES2101650B1
ES2101650B1 ES9501304A ES9501304A ES2101650B1 ES 2101650 B1 ES2101650 B1 ES 2101650B1 ES 9501304 A ES9501304 A ES 9501304A ES 9501304 A ES9501304 A ES 9501304A ES 2101650 B1 ES2101650 B1 ES 2101650B1
Authority
ES
Spain
Prior art keywords
methyl
preparation
product
trifluoromethylphenoxy
propylamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9501304A
Other languages
English (en)
Other versions
ES2101650A1 (es
Inventor
Tercero Concepcion Pedregal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lilly SA
Original Assignee
Lilly SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly SA filed Critical Lilly SA
Priority to ES9501304A priority Critical patent/ES2101650B1/es
Publication of ES2101650A1 publication Critical patent/ES2101650A1/es
Application granted granted Critical
Publication of ES2101650B1 publication Critical patent/ES2101650B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Abstract

PROCEDIMIENTO DE PREPARACION DE N-METIL-3-FENIL-3-(P-TRIFLUOROMETILFENOXI) PROPILAMINA. ESTA BASADO EN UNA NUEVA REACCION DE TIPO MICHAEL Y CONSTA DE LAS SIGUIENTES ETAPAS: A) HACER REACCIONAR FENILVINILCETONA CON N-METILBENCILAMINA EN TOLUENO; B) REDUCIR LA 3-(N-METIL-N-BENCILAMINO)PROPIOFENONA A [2-(METILAMINO)ETIL]-BENCENOMETANOL MEDIANTE HIDROGENACION CATALITICA CON NEGRO DE PALADIO; C) HACER REACCIONAR EN DIMETILACETAMIDA, CANTIDADES APROXIMADAMENTE EQUIMOLARES DEL PRODUCTO ANTERIOR, HIDRURO SODICO Y 1-CLORO-4-(TRIFLUOROMETIL)BENCENO, OBTENIENDOSE ASI EL PRODUCTO (I) DEL TITULO; Y D) OPCIONALMENTE, CONVERTIR EL PRODUCTO (I) ASI FORMADO EN HIDROCLORURO MEDIANTE LA ADICION DE CLORURO DE HIDROGENO. LA FENILVINILCETONA DE PARTIDA SE PREPARA A PARTIR DE ACETOFENONA Y PARAFORMALDEHIDO EN PRESENCIA DE TRIFLUOROACETATO DE N-METILANILINIO. LA INVENCION TIENE UTILIDAD PARA LA PREPARACION INDUSTRIALMENTE VENTAJOSA DE (I).
ES9501304A 1995-06-29 1995-06-29 Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometilfenoxi) propilamina. Expired - Fee Related ES2101650B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9501304A ES2101650B1 (es) 1995-06-29 1995-06-29 Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometilfenoxi) propilamina.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9501304A ES2101650B1 (es) 1995-06-29 1995-06-29 Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometilfenoxi) propilamina.

Publications (2)

Publication Number Publication Date
ES2101650A1 ES2101650A1 (es) 1997-07-01
ES2101650B1 true ES2101650B1 (es) 1998-01-16

Family

ID=8290891

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9501304A Expired - Fee Related ES2101650B1 (es) 1995-06-29 1995-06-29 Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometilfenoxi) propilamina.

Country Status (1)

Country Link
ES (1) ES2101650B1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110194719A (zh) * 2019-06-12 2019-09-03 山东大学 一种r-(-)-盐酸阿托莫西汀的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4314081A (en) * 1974-01-10 1982-02-02 Eli Lilly And Company Arloxyphenylpropylamines
ES8707175A1 (es) * 1986-06-13 1987-07-16 Inke Sa Procedimiento para la obtencion de la n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina
ZA898513B (en) * 1988-11-14 1991-07-31 Lilly Co Eli Fluoxetine analog
IT1228209B (it) * 1989-01-10 1991-06-05 Grato Magnone Procedimento per la preparazione di fluoxetina cloridrato.
FI81083C (fi) * 1989-03-03 1990-09-10 Orion Yhtymae Oy Ett foerbaettrat foerfarande foer framstaellning av n-metyl-3-(p-trifluormetylfenoxi)-3-fenylpropylamin hydroklorid.
HU9202128D0 (en) * 1992-06-26 1992-10-28 Richter Gedeon Vegyeszet Method for producing n-methyl-(3-phenyl-3-(4-[trifluoro-methyl])-phenooxi-)-amine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110194719A (zh) * 2019-06-12 2019-09-03 山东大学 一种r-(-)-盐酸阿托莫西汀的制备方法
CN110194719B (zh) * 2019-06-12 2020-05-15 山东大学 一种r-(-)-盐酸阿托莫西汀的制备方法

Also Published As

Publication number Publication date
ES2101650A1 (es) 1997-07-01

Similar Documents

Publication Publication Date Title
MY139475A (en) Process for the preparation of (1s)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane, acid addition salts thereof and its use for the synthesis of ivabradine and for its pharmaceutically acceptable acid addition salts
AP2003002755A0 (en) Guanidinobenzamides as mc4-r agonists
CR11283A (es) "composicion de liberacion sostenida y proceso para producirla"
WO2003103603A3 (en) NEW FORMIATE-TYPE SALT OF O-DESMETHYLVENLAFAXINE
AU2576202A (en) Preparation of polymerization catalysts
ES2160534B1 (es) Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo.
ES2191203T3 (es) Procedimiento para la obtencion de peroxido de hidrogeno.
ES2194840T3 (es) Produccion de metanol para reducir los gases de efecto invernadero.
BR9912029A (pt) Compostos reacionais de amina compreendendo um ou mais ingredientes ativos
HRP20080117A2 (en) Pharmaceutical composition for modified release insulin sensitiser
ES2101650B1 (es) Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometilfenoxi) propilamina.
FR2818552B1 (fr) Compositions pharmaceutique solide thermoformable pour la liberation controlee d'ivabradine
CA2397270A1 (en) Method for the preparation of 5-cyanophthalide
GB2342352B (en) Pure cis-tramadol hydrochloride production
DE50101838D1 (de) Verbessertes Verfahren zur Herstellung von 2-(4-Trifluormethoxyphenyl)ethylamin
ES2162419T3 (es) Procedimiento para la hidrogenacion de compuestos del grupo de las iminas o de las enaminas.
ES2131374T3 (es) Procedimiento para la preparacion de canfeno por transposicion de alfa-pineno.
ES2103681B1 (es) Procedimiento de preparacion de n-metil-3-fenil - (p-trifluorometilfenoxi) propilamina.
HUP0103017A2 (hu) Kognitív funkciók károsodásával járó kórképek kezelésére szolgáló gyógyászati készítmény és alkalmazása
AU2001269184A1 (en) Toaster with reinforced walls
AU4246701A (en) Flap accessory
AU2001281756A1 (en) Purification process for improving total yield of curcuminoid colouring agent
HUP0003988A2 (hu) A 3-karbometoxi-4,5-dimetil-tiofén előállítása
ES1031097U (es) Gorra de visera perfeccionada.
WO2003099322A3 (en) Il-11 derivatives and therapeutic uses thereof

Legal Events

Date Code Title Description
EC2A Search report published

Date of ref document: 19970701

Kind code of ref document: A1

Effective date: 19970701

FD1A Patent lapsed

Effective date: 20070630