KR900014309A - 신규 기관지진경제 및 그의 제조방법 - Google Patents

신규 기관지진경제 및 그의 제조방법 Download PDF

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Publication number
KR900014309A
KR900014309A KR1019900004099A KR900004099A KR900014309A KR 900014309 A KR900014309 A KR 900014309A KR 1019900004099 A KR1019900004099 A KR 1019900004099A KR 900004099 A KR900004099 A KR 900004099A KR 900014309 A KR900014309 A KR 900014309A
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KR
South Korea
Prior art keywords
compound
formula
pharmaceutically acceptable
general formula
methoxybenzylamino
Prior art date
Application number
KR1019900004099A
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English (en)
Inventor
아그네 토르스텐 올손 오토
주한 페다자 페터
에케 스벤손 라이프
베르틸 발데크 칼
잉바르 레오폴트 베테를린 크젤
Original Assignee
원본미기재
악티에볼라게트 드라코
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 원본미기재, 악티에볼라게트 드라코 filed Critical 원본미기재
Publication of KR900014309A publication Critical patent/KR900014309A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms

Abstract

내용 없음

Description

신규 기관지진경제 및 그의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. 다음 일반식(X)의 화합물 및 제약상 허용되는 이들의 염.
    식중, R1및 R2는 서로 동일하거나 또는 상이한 것으로서 각각 H, OH, OCH3, OC2H5, 할로겐 원자이거나 또는 R1및 R2는 함께 사슬 -O-CH2-O- 또는 -O-CF2-O-를 형성하고, R3는 H 또는 CH3이며, R5는 H 또는 -CO-R7이고, R3는 H, OH, OCH3, OC2H5또는 할로겐 원자이며, R7은 1-16의 탄소 원자수를 갖는 직쇄 또는 분지쇄 알킬기, 아릴기, -NH-CH3또는 N(CH3)2이다.
  2. 제1항에 있어서, 할로겐을 나타내는 R6가 불소, 염소 또는 브롬원자이고, 아릴기를 나타내는 R7이 3-8개의 탄소 원자수, 바람직하기로는 6개의 탄소 원자수를 갖는 화합물.
  3. 제1항에 있어서, 실질적으로 순수 광학 이성질체 형의 화합물.
  4. 제1항에 있어서, R1및 R2가 함께 사슬-O-CH2-O-를 형성하고, R3및 R5가 H이고, R6가 OCH3인 화합물.
  5. 제1항에 있어서, 1-(4-히드록시)-3-(p-메톡시벤질아미노)페닐-2-〔(1-메틸-2(3,4-메틸렌디옥시페닐)에틸)아미노〕에틴올의 R,S 및 S,S 이성질체의 혼합물인 화합물 또는 제약상 허용되는 이들의 염.
  6. 제1항에 있어서, 2-(4-히드록시)-3-(p-메톡시벤질아미노)페닐-2-〔(1-메틸-2-(3,4-메틸렌디옥시페닐)에틸)아미노〕에탄올의 R,S 및 S,R 이성질체의 라세미체인 화합물 또는 제약상 허용되는 이들의 염.
  7. 제1항에 있어서, 1-(R)-(4-히드록시)-3-(p-메톡시벤질아미노)페닐-2-〔(1-메틸-2-(S)-(3,4-메틸렌디옥시페닐)에틸)아미노〕에틴올의 이성질체인 화합물 또는 제약상 허용되는 이들의 염.
  8. 제7항에 의한 화합물의 염산염.
  9. 다음 일반식(Ⅴ)의 4-벤질옥시-3-니트로-스티렌옥시드를 다음 일반식(Ⅵ)의 화합물과 반응시켜 다음 일반식(Ⅶ)의 화합물을 얻은 후, 일반식(Ⅶ)의 화합물을 수소 및 적합한 촉매 및 다음 일반식(A)의 화합물과 반응시켜 수소첨가반응시킨 후 일반식(X)의 화합물을 순수 이성질체, 라세미체 또는 이성질체들의 혼합물로서 얻는 것을 특징으로 하는 제1항 기재의 일반식(X)의 화합물의 제조방법.
    위 각 식에서 R1,R2,R3및 R6는 제1항에서 정의한 바와 같고 R4는 수소원자이거나 또는 일반식의 기이다.
  10. 제1항 기재의 화합물과 제약상 허용되는 담체로 된 제약 조성물.
  11. 연장된 진경 작용을 갖는 제1항에 의한 화합물을 유효 성분으로 하는 기관지 진경제.
  12. 약리학상 유효량의 제1항 기재의 화합물을 기관지계통 질환의 치료를 요하는 환자에게 투여함으로써 기관지성 질환을 치료하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900004099A 1989-03-28 1990-03-27 신규 기관지진경제 및 그의 제조방법 KR900014309A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8901060-7 1989-03-28
SE8901060A SE8901060D0 (sv) 1989-03-28 1989-03-28 New compounds

Publications (1)

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KR900014309A true KR900014309A (ko) 1990-10-23

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Country Status (30)

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EP (1) EP0390762B1 (ko)
JP (1) JPH02286650A (ko)
KR (1) KR900014309A (ko)
CN (1) CN1045968A (ko)
AR (1) AR247197A1 (ko)
AT (1) ATE100437T1 (ko)
AU (1) AU618171B2 (ko)
CA (1) CA2013114A1 (ko)
CZ (1) CZ280747B6 (ko)
DD (1) DD297805A5 (ko)
DE (1) DE69006071T2 (ko)
DK (1) DK0390762T3 (ko)
EG (1) EG18954A (ko)
ES (1) ES2062495T3 (ko)
FI (1) FI901528A0 (ko)
HK (1) HK123396A (ko)
HR (1) HRP920765A2 (ko)
HU (1) HUT58043A (ko)
IE (1) IE64851B1 (ko)
IL (1) IL93799A (ko)
IS (1) IS1581B (ko)
LT (1) LT3979B (ko)
LV (1) LV10708B (ko)
NO (1) NO172115C (ko)
NZ (1) NZ232765A (ko)
PL (1) PL163566B1 (ko)
PT (1) PT93576B (ko)
SE (1) SE8901060D0 (ko)
YU (1) YU47508B (ko)
ZA (1) ZA901716B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6040344A (en) 1996-11-11 2000-03-21 Sepracor Inc. Formoterol process
ZA994264B (en) 1998-07-01 2000-01-25 Warner Lambert Co Stereoisomers with high affinity for adrenergic receptors.
US7232837B2 (en) 1999-06-29 2007-06-19 Mcneil-Ppc, Inc. Stereoisomers with high affinity for adrenergic receptors
US6472563B1 (en) 2001-11-09 2002-10-29 Sepracor Inc. Formoterol tartrate process and polymorph
US7169907B2 (en) * 2002-03-01 2007-01-30 Roche Diagnostics Operations, Inc. Derivatives, immunogens, and antibodies for detecting ecstasy-class drugs
EP2348013A1 (en) * 2010-01-25 2011-07-27 Inke, S.A. Process for preparation of intermediates of arformoterol

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4072720A (en) * 1971-01-19 1978-02-07 Mobil Oil Corporation Production of alcohol
US3700692A (en) * 1971-06-04 1972-10-24 Colgate Palmolive Co 1-(4{40 -hydroxy-3{40 -(hydroxy methyl)-phenyl)-1-hydroxy-2-aralkylaminoethanes
GB1531718A (en) * 1974-11-20 1978-11-08 Pharmacia As Phenylethanolamines

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EG18954A (en) 1994-03-30
HRP920765A2 (en) 1995-02-28
NO900982L (no) 1990-10-01
JPH02286650A (ja) 1990-11-26
IS1581B (is) 1996-03-01
LV10708B (en) 1996-02-20
EP0390762B1 (en) 1994-01-19
LTIP1719A (en) 1995-07-25
HU901854D0 (en) 1990-08-28
DE69006071D1 (de) 1994-03-03
NZ232765A (en) 1992-12-23
AR247197A1 (es) 1994-11-30
EP0390762A1 (en) 1990-10-03
CN1045968A (zh) 1990-10-10
LV10708A (lv) 1995-06-20
SE8901060D0 (sv) 1989-03-28
LT3979B (en) 1996-06-25
ZA901716B (en) 1990-12-28
DK0390762T3 (da) 1994-05-24
IE901104L (en) 1990-09-28
PL163566B1 (pl) 1994-04-29
ES2062495T3 (es) 1994-12-16
CZ151890A3 (en) 1995-12-13
AU618171B2 (en) 1991-12-12
YU46490A (en) 1992-05-28
FI901528A0 (fi) 1990-03-27
IL93799A (en) 1994-12-29
IS3567A7 (is) 1990-09-29
PT93576A (pt) 1990-11-07
DD297805A5 (de) 1992-01-23
NO900982D0 (no) 1990-03-01
HUT58043A (en) 1992-01-28
IE64851B1 (en) 1995-09-06
HK123396A (en) 1996-07-19
PT93576B (pt) 1996-03-29
YU47508B (sh) 1995-10-03
NO172115C (no) 1993-06-09
AU5067590A (en) 1990-10-04
CA2013114A1 (en) 1990-09-28
CZ280747B6 (cs) 1996-04-17
ATE100437T1 (de) 1994-02-15
DE69006071T2 (de) 1994-05-19
NO172115B (no) 1993-03-01

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