YU42332B - Process for obtaining 3-(methylthio, methylsulfinyl or methylsulfonyl)-4-quinolone - Google Patents

Process for obtaining 3-(methylthio, methylsulfinyl or methylsulfonyl)-4-quinolone

Info

Publication number
YU42332B
YU42332B YU849/80A YU84980A YU42332B YU 42332 B YU42332 B YU 42332B YU 849/80 A YU849/80 A YU 849/80A YU 84980 A YU84980 A YU 84980A YU 42332 B YU42332 B YU 42332B
Authority
YU
Yugoslavia
Prior art keywords
quinolone
methylsulfinyl
methylsulfonyl
methylthio
obtaining
Prior art date
Application number
YU849/80A
Other languages
English (en)
Other versions
YU84980A (en
Inventor
R V Davies
J Fraser
K J Nichol
R Parkinson
D B Yates
M F Sim
Original Assignee
Boots Co Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Co Plc filed Critical Boots Co Plc
Priority to SI8010849A priority Critical patent/SI8010849A8/sl
Publication of YU84980A publication Critical patent/YU84980A/xx
Publication of YU42332B publication Critical patent/YU42332B/xx
Priority to HRP-849/80A priority patent/HRP930742B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
YU849/80A 1979-03-27 1980-03-26 Process for obtaining 3-(methylthio, methylsulfinyl or methylsulfonyl)-4-quinolone YU42332B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI8010849A SI8010849A8 (sl) 1979-03-27 1980-03-26 Postopek za pridobivanje 3-(metiltio, metilsulfinil ali metilsulfonil)-4-kinolonov
HRP-849/80A HRP930742B1 (en) 1979-03-27 1993-04-02 Process for the preparation of 3-(methylthio, methylsulphinyl or methylsulphonyl)-4-cinolone

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7910558 1979-03-27
GB7939505 1979-11-15

Publications (2)

Publication Number Publication Date
YU84980A YU84980A (en) 1983-09-30
YU42332B true YU42332B (en) 1988-08-31

Family

ID=26271029

Family Applications (1)

Application Number Title Priority Date Filing Date
YU849/80A YU42332B (en) 1979-03-27 1980-03-26 Process for obtaining 3-(methylthio, methylsulfinyl or methylsulfonyl)-4-quinolone

Country Status (34)

Country Link
US (1) US4302460A (it)
KR (1) KR840001612B1 (it)
AT (1) AT379390B (it)
AU (1) AU536616B2 (it)
BG (2) BG37836A3 (it)
CA (1) CA1151652A (it)
CH (1) CH644366A5 (it)
CS (1) CS221906B2 (it)
DD (1) DD149608A5 (it)
DE (2) DE3051205C2 (it)
DK (1) DK151252C (it)
EG (1) EG16606A (it)
FI (1) FI77026C (it)
FR (2) FR2452484A1 (it)
GR (1) GR68007B (it)
HK (1) HK94986A (it)
HU (1) HU179845B (it)
IE (1) IE49562B1 (it)
IL (1) IL59710A (it)
IT (1) IT1188916B (it)
KE (1) KE3649D (it)
LU (1) LU82295A1 (it)
MX (1) MX6816E (it)
MY (1) MY8600668A (it)
NL (1) NL191306C (it)
NO (1) NO156787C (it)
NZ (1) NZ193167A (it)
PH (1) PH16758A (it)
PL (1) PL124037B1 (it)
PT (1) PT71006A (it)
RO (1) RO79397A (it)
SE (1) SE455422B (it)
SG (1) SG60886G (it)
YU (1) YU42332B (it)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE51542B1 (en) * 1980-09-26 1987-01-07 Boots Co Ltd Therapeutic agents
PT79031B (en) * 1983-08-20 1986-08-22 Boots Co Plc Therapeutic agents
DE3578374D1 (de) * 1984-01-13 1990-08-02 Boots Co Ltd Verwendung von chinolonen fuer die herstellung eines arzneimittels zur behandlung von herzerkrankungen.
DE3576686D1 (de) * 1984-08-15 1990-04-26 Boots Co Ltd Chinolinone, verfahren zu ihrer herstellung und die sie enthaltenden pharmazeutischen praeparate.
GB8515207D0 (en) * 1985-06-15 1985-07-17 Boots Co Plc Therapeutic agents
GB8515209D0 (en) * 1985-06-15 1985-07-17 Boots Co Plc Therapeutic agents
GB8627698D0 (en) * 1986-11-20 1986-12-17 Boots Co Plc Therapeutic agents
GB8726950D0 (en) * 1987-11-18 1987-12-23 Boots Co Plc Chemical process
GB8804016D0 (en) * 1988-02-22 1988-03-23 Boots Co Plc Therapeutic agents
GB8918952D0 (en) * 1989-08-19 1989-10-04 Boots Co Plc Therapeutic agents
FR2684671B1 (fr) * 1991-11-20 1995-05-19 Roussel Uclaf Nouveaux derives de la quinoleine, leur procede de preparation et intermediaires et leur application a titre de medicaments.
FR2672597B1 (fr) * 1991-02-07 1995-05-19 Roussel Uclaf Nouveaux derives n-substitues de la quinoleine, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
IL100555A (en) * 1991-02-07 2000-08-31 Hoechst Marion Roussel Inc N-substituted quinoline derivatives their preparation their use for the preparation of medicaments and the pharmaceutical compositions containing them
FR2680511B1 (fr) * 1991-08-20 1995-05-19 Roussel Uclaf Derives n-substitues de la quinoleine, leur procede de preparation, intermediaires obtenus, leur application comme medicaments et les compositions les renfermant.
CA2339484A1 (en) * 1998-08-03 2000-02-17 Robert A. O'brien Pyridinones for the treatment of sexual dysfunction
US6307050B1 (en) * 2000-08-29 2001-10-23 R. T. Alamo Venture I Llc Method of synthesizing flosequinan from 4-fluoroanthranilic acid
US6562838B2 (en) 2001-01-26 2003-05-13 R. T. Alamo Ventures I, L.L.C. Treatment of cardiovascular disease with quinolinone enantiomers
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
US6458804B1 (en) * 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US6649764B2 (en) * 2001-10-25 2003-11-18 R. T. Alamo Ventures I, Llc Stereospecific enrichment of heterocyclic enantiomers
US6730790B2 (en) * 2002-03-01 2004-05-04 R.T. Alamo Ventures I. Llc Chlorinated heterocyclic compounds and methods of synthesis

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3178348A (en) * 1961-02-08 1965-04-13 Norwich Pharma Co Hypotensive quinolines
GB1066919A (en) 1964-04-03 1967-04-26 Hoffmann La Roche Novel benzyl amine derivatives
DE1770482A1 (de) * 1968-05-22 1971-11-11 Basf Ag Verfahren zur Herstellung von 2,4-Dioxychinolinen
US3798219A (en) * 1971-10-18 1974-03-19 Warner Lambert Co 3-(methylsulfinyl)cinnolinones and their derivatives
US3772301A (en) * 1971-11-22 1973-11-13 Warner Lambert Co (4-substituted)4-(methylsulfinyl)methylcarbostyrils
CH607848A5 (it) * 1974-06-04 1978-11-30 Bayer Ag
GB1488411A (en) * 1975-01-16 1977-10-12 Wyeth John & Brother Ltd 3,4-dihydro-4-arylquinolin-4-ol derivatives
US4127574A (en) * 1976-03-01 1978-11-28 Sandoz, Inc. 4-Hydroxy-3-sulfonyl-quinolin-2(1H)-ones
US4124587A (en) * 1976-03-01 1978-11-07 Sandoz, Inc. 4-Hydroxy-3-sulfinyl-quinolin-2(1H)-ones
DE2616995A1 (de) 1976-04-17 1977-10-27 Bayer Ag 1.4-dihydropyridine mit schwefelhaltigen substituenten mehrere verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2616991A1 (de) 1976-04-17 1977-10-27 Bayer Ag Heterocyclisch-substituierte schwefelhaltige dihydropyridine, mehrere verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2639257A1 (de) 1976-09-01 1978-03-02 Bayer Ag Aminoalkylidenamino-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2639498A1 (de) 1976-09-02 1978-03-09 Bayer Ag Neue schwefelhaltige amino-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2641746C2 (de) 1976-09-16 1986-11-06 Bayer Ag, 5090 Leverkusen 1,4-Dihydropyridin-Zuckerderivate, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2658183A1 (de) * 1976-12-22 1978-07-06 Bayer Ag In 2-position substituierte 1,4- dihydropyridin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2658804A1 (de) 1976-12-24 1978-07-06 Bayer Ag Kreislaufbeeinflussende mittel
DE2715182A1 (de) 1977-04-05 1978-10-19 Bayer Ag 2-alkylenaminodihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4177278A (en) * 1977-04-05 1979-12-04 Bayer Aktiengesellschaft 2-Alkyleneaminodihydropyridines compounds, their production and their medicinal use
JPS5424882A (en) 1977-07-22 1979-02-24 Yamanouchi Pharmaceut Co Ltd Novel heterocyclic compounds and their preparation
DE2747513A1 (de) 1977-10-22 1979-05-03 Bayer Ag Dihydropyridine mit schwefelhaltigen estergruppierungen

Also Published As

Publication number Publication date
FI77026B (fi) 1988-09-30
DE3011994C2 (it) 1991-06-27
LU82295A1 (fr) 1981-04-17
DD149608A5 (de) 1981-07-22
FR2452484A1 (fr) 1980-10-24
FR2468367B1 (it) 1983-09-30
CH644366A5 (fr) 1984-07-31
IE800567L (en) 1980-09-27
IE49562B1 (en) 1985-10-30
RO79397A (ro) 1982-06-25
CA1151652A (en) 1983-08-09
HK94986A (en) 1986-12-12
PH16758A (en) 1984-02-15
FR2452484B1 (it) 1983-08-12
HU179845B (en) 1982-12-28
KR840001612B1 (ko) 1984-10-11
SE8002345L (sv) 1980-11-14
FR2468367A1 (fr) 1981-05-08
GR68007B (it) 1981-10-26
MX6816E (es) 1986-08-05
BG37993A3 (en) 1985-09-16
EG16606A (en) 1989-01-30
ATA161880A (de) 1985-05-15
IT8048262A0 (it) 1980-03-26
YU84980A (en) 1983-09-30
IT1188916B (it) 1988-01-28
SE455422B (sv) 1988-07-11
AU536616B2 (en) 1984-05-17
BG37836A3 (en) 1985-08-15
FI800923A (fi) 1980-09-28
DK130180A (da) 1980-09-28
IL59710A (en) 1984-01-31
MY8600668A (en) 1986-12-31
AT379390B (de) 1985-12-27
NO156787C (no) 1987-11-25
DE3011994A1 (de) 1980-10-16
FI77026C (fi) 1989-01-10
IT8048262A1 (it) 1981-09-26
NZ193167A (en) 1984-08-24
NO800881L (no) 1980-09-29
NL191306B (nl) 1994-12-16
NL191306C (nl) 1995-05-16
AU5670280A (en) 1980-10-02
NL8001771A (nl) 1980-09-30
DE3051205C2 (de) 1991-01-24
KR830001898A (ko) 1983-05-19
CS221906B2 (en) 1983-04-29
DK151252B (da) 1987-11-16
DK151252C (da) 1988-05-16
US4302460A (en) 1981-11-24
NO156787B (no) 1987-08-17
PL124037B1 (en) 1982-12-31
SG60886G (en) 1987-03-27
PL223050A1 (it) 1981-01-30
KE3649D (en) 1986-08-01
PT71006A (en) 1980-04-01

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