YU35501A - STABILNA FARMACEUTSKA FORMULACIJA KOJA UKLJUČUJE INHIBITOR HMG-CoA REDUKTAZE - Google Patents

STABILNA FARMACEUTSKA FORMULACIJA KOJA UKLJUČUJE INHIBITOR HMG-CoA REDUKTAZE

Info

Publication number
YU35501A
YU35501A YU35501A YU35501A YU35501A YU 35501 A YU35501 A YU 35501A YU 35501 A YU35501 A YU 35501A YU 35501 A YU35501 A YU 35501A YU 35501 A YU35501 A YU 35501A
Authority
YU
Yugoslavia
Prior art keywords
pharmaceutical formulation
hmg
coa reductase
reductase inhibitor
pravastatin
Prior art date
Application number
YU35501A
Other languages
English (en)
Inventor
Janez Kerč
Original Assignee
Lek Pharmaceutical And Chemical Company D.D.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Pharmaceutical And Chemical Company D.D. filed Critical Lek Pharmaceutical And Chemical Company D.D.
Publication of YU35501A publication Critical patent/YU35501A/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin, i njihovi derivati i analozi poznati su kao inhibitori HMG-CoA reduktaze i koriste se kao antihiperholesterolemijska sredstva. Vecina njih proizvodi se fermentacljom uz koriscenje mikroorganizama razlicitih vrsta identifikovanih kao vrste koje pripadaju rodovima Aspergillus, Monascus, Nocardia, Amycolatopsis, Mucor ili Penicillium, a neki se dobijaju obradjivanjem proizvoda fermentacije uz koriscenje metoda hemijske sinteze ili su proizvodi potpune hemijske sinteze. Gore pomenute aktivne supstance mogu biti destabilisane sredinskim faktorima, njihova degradacija moze takodje biti ubrzana interakcijama sa drugim farmaceutskim sastojcima, kao sto su potporne supstance, povezivaci, lubrikanti, glidansi i dezintegrisuca sredstva, tako da farmaceutski sastojci i postupak za pripremanje farmaceutske formulacije treba da budu precizno odabrani kako bi se izbegle gore pomenute nezeljene interakcije i reakcije. Predmetni pronalazak se odnosi na stabilnu cvrstu farmaceutsku formulaciju za lecenje hiperholesterolemije i hiperlipidemije. Preciznije predmetni pronalazak se odnosi na novu cvrstu stabilnu farmaceutsku formulaciju koja, kao aktivni sastojak, sadrzi jedan od inhibitora HMG-CoA reduktaze, kao sto su atorvastatin, pravastatin, fluvastatin i cerivastatin ili njihove farmaceutski prihvatljive soli.
YU35501A 1998-12-16 1999-10-29 STABILNA FARMACEUTSKA FORMULACIJA KOJA UKLJUČUJE INHIBITOR HMG-CoA REDUKTAZE YU35501A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI9800309A SI20109A (sl) 1998-12-16 1998-12-16 Stabilna farmacevtska formulacija

Publications (1)

Publication Number Publication Date
YU35501A true YU35501A (sh) 2005-07-19

Family

ID=20432372

Family Applications (1)

Application Number Title Priority Date Filing Date
YU35501A YU35501A (sh) 1998-12-16 1999-10-29 STABILNA FARMACEUTSKA FORMULACIJA KOJA UKLJUČUJE INHIBITOR HMG-CoA REDUKTAZE

Country Status (25)

Country Link
US (3) US6680341B1 (sh)
EP (2) EP1911445A3 (sh)
JP (1) JP2002532409A (sh)
KR (1) KR100638307B1 (sh)
CN (1) CN1198597C (sh)
AT (1) ATE380020T1 (sh)
AU (1) AU775946B2 (sh)
BG (1) BG105559A (sh)
CA (1) CA2348988C (sh)
CZ (1) CZ302562B6 (sh)
DE (1) DE69937691T2 (sh)
ES (1) ES2299265T3 (sh)
HR (1) HRP20010325A2 (sh)
HU (1) HUP0104258A3 (sh)
IL (2) IL143759A0 (sh)
IS (1) IS5939A (sh)
NZ (1) NZ511260A (sh)
PL (1) PL347686A1 (sh)
RU (1) RU2227019C2 (sh)
SI (2) SI20109A (sh)
SK (1) SK8092001A3 (sh)
TR (1) TR200101235T2 (sh)
WO (1) WO2000035425A1 (sh)
YU (1) YU35501A (sh)
ZA (1) ZA200103802B (sh)

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Also Published As

Publication number Publication date
EP1911445A3 (en) 2011-04-27
AU775946B2 (en) 2004-08-19
DE69937691D1 (de) 2008-01-17
PL347686A1 (en) 2002-04-22
IS5939A (is) 2001-05-15
EP1911445A2 (en) 2008-04-16
SI20109A (sl) 2000-06-30
WO2000035425A1 (en) 2000-06-22
TR200101235T2 (tr) 2001-10-22
DE69937691T2 (de) 2008-11-20
KR20010101105A (ko) 2001-11-14
SI1148872T1 (sl) 2008-04-30
AU6360899A (en) 2000-07-03
CA2348988A1 (en) 2000-06-22
US6680341B1 (en) 2004-01-20
CA2348988C (en) 2009-07-21
RU2227019C2 (ru) 2004-04-20
CN1198597C (zh) 2005-04-27
HUP0104258A2 (hu) 2002-03-28
IL143759A0 (en) 2002-04-21
CZ20011727A3 (cs) 2001-09-12
US20090264497A1 (en) 2009-10-22
HRP20010325A2 (en) 2002-06-30
CN1330538A (zh) 2002-01-09
EP1148872A1 (en) 2001-10-31
US20040072894A1 (en) 2004-04-15
ES2299265T3 (es) 2008-05-16
NZ511260A (en) 2004-01-30
SK8092001A3 (en) 2001-10-08
HUP0104258A3 (en) 2002-11-28
ZA200103802B (en) 2002-06-10
KR100638307B1 (ko) 2006-10-25
ATE380020T1 (de) 2007-12-15
BG105559A (en) 2001-12-29
JP2002532409A (ja) 2002-10-02
EP1148872B1 (en) 2007-12-05
IL143759A (en) 2006-08-01
CZ302562B6 (cs) 2011-07-13

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