WO2020073050A1 - Prosthetic cardiac valve devices, systems, and methods - Google Patents

Prosthetic cardiac valve devices, systems, and methods

Info

Publication number
WO2020073050A1
WO2020073050A1 PCT/US2019/055049 US2019055049W WO2020073050A1 WO 2020073050 A1 WO2020073050 A1 WO 2020073050A1 US 2019055049 W US2019055049 W US 2019055049W WO 2020073050 A1 WO2020073050 A1 WO 2020073050A1
Authority
WO
WIPO (PCT)
Prior art keywords
valve
anchor
frame structure
native valve
native
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2019/055049
Other languages
English (en)
French (fr)
Inventor
Claudio Argento
Andrew Backus
Alice Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shifamed Holdings LLC
Original Assignee
Shifamed Holdings LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shifamed Holdings LLC filed Critical Shifamed Holdings LLC
Priority to CN201980079729.3A priority Critical patent/CN113260337A/zh
Priority to JP2021518574A priority patent/JP7528068B2/ja
Priority to CA3115270A priority patent/CA3115270A1/en
Priority to AU2019353156A priority patent/AU2019353156B2/en
Priority to EP19869666.8A priority patent/EP3860519A4/en
Publication of WO2020073050A1 publication Critical patent/WO2020073050A1/en
Anticipated expiration legal-status Critical
Priority to AU2025220804A priority patent/AU2025220804A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427—Devices for manipulating or deploying heart valves during implantation
    • A61F2/243—Deployment by mechanical expansion
    • A61F2/2433—Deployment by mechanical expansion using balloon catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2409—Support rings therefor, e.g. for connecting valves to tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427—Devices for manipulating or deploying heart valves during implantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2454—Means for preventing inversion of the valve leaflets, e.g. chordae tendineae prostheses
    • A61F2/2457—Chordae tendineae prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2466—Delivery devices therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008—Fixation appliances for connecting prostheses to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0091—Three-dimensional shapes helically-coiled or spirally-coiled, i.e. having a 2-D spiral cross-section
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/006—Additional features; Implant or prostheses properties not otherwise provided for modular
    • A61F2250/0063—Nested prosthetic parts

Definitions

  • Provisional Application No. 62/820,570 filed March 19, 2019, entitled“Prosthetic Cardiac Valve Delivery Devices, Systems, and Methods”
  • Blood flow between and out of heart chambers is regulated by native valves - the mitral valve, the aortic valve, the pulmonary valve, and the tricuspid valve.
  • Each of these valves are passive one-way valves which open and close in response to differential pressures.
  • Patients with valvular disease have abnormal anatomy and/or function of at least one valve.
  • a valve may suffer from insufficiency, also referred to as regurgitation, when the valve does not fully close and allows blood to flow retrograde.
  • Valve stenosis can cause a valve to fail to open properly.
  • Other diseases may also lead to dysfunction of the valves.
  • While medications may be used to treat the disease, in many cases the defective valve may need to be repaired or replaced at some point during the patient’s lifetime.
  • the heart 2 includes four chambers connected by four valves.
  • the upper part of the heart 2 includes the left atrium 25 and right atrium 5.
  • the lower part includes the left ventricle 26 and right ventricle 6.
  • the heart 2 and cardiovascular system operates like a closed circuit.
  • the right side of the heart 2 receives de-oxygenated blood from the body and delivers the blood through the pulmonary artery 7 to the lungs where it becomes re- oxygenated.
  • the oxygenated blood is returned to the left side of the heart 2, referred to as the systemic side, which delivers the oxygenated blood throughout the body.
  • Heart chambers Blood flow between the heart chambers is regulated by the valves.
  • the mitral valve 4 is located between the left atrium 25 and the left ventricle 26 and the aortic valve 9 is located between the left ventricle 26 and the aorta 1.
  • the pulmonary valve 3 is located between the right ventricle 6 and the pulmonary artery 7 and the tricuspid valve 8 is located between the right ventricle 6 and the right atrium 5.
  • All four of heart valves are passive one-way valves with“leaflets” which open and close in response to differential pressures.
  • the left ventricle 26 contracts and pushes blood out the aortic valve 9.
  • the pressure in the left ventricle 26 causes the mitral valve 4 to close thereby preventing blood from going back into the left atrium 25 during systole.
  • Congenital heart disease is also a significant problem. Patients with valvular disease have abnormal anatomy and/or function of at least one valve. Congenital valve abnormalities may be tolerated and/or treated palliatively for some years before developing into a life-threatening problem in later years. However, congenital heart disease may present life-threatening risk without notice.
  • Patients may acquire valvular disease from rheumatic fever, heart failure, degenerative leaflet tissue, bacterial infection, and more.
  • FIG. 3 shows a healthy mitral valve 4.
  • FIGS. 4 to 5 show a diseased mitral valve 4.
  • the valve 4 in FIG. 4 suffers from insufficiency, also referred to as regurgitation.
  • Such a valve 4 does not fully close and allows blood to flow retrograde. In this case, blood will flow back into the left atrium 25 during systole.
  • FIG. 5 shows a mitral valve 4 with stenosis.
  • Such a valve 4 does not open properly.
  • Some valves 4 can have concomitant insufficiency and stenosis.
  • Other diseases may also be present, such as Barlow’s disease, which prevent the valve 4 from functioning properly. These diseases reduce cardiac output and force the heart 2 to work harder, thus increasing the risk of heart failure and chordae failures.
  • While medications may be used to treat the disease, in many cases the defective valve may need to be repaired or replaced at some point during the patient’s lifetime.
  • the native valve can be replaced with a mechanical valve or tissue valve.
  • Mechanical valves have a disc or other member which opens and closes. Although mechanical valves are formed of biocompatible materials, they carry an increased risk of clotting. Thus, patients usually need to take
  • Tissue valves can be formed of human or animal tissue, as well as polymeric materials. Tissue valves, unlike mechanical valves, do not typically require long-term use of anti-coagulants, but because they are formed of a living tissue they are not as widely available nor do they last as long as mechanical valves. Common tissue valves include porcine aortic valves mounted within a stent like structure.
  • the mitral valve anatomy presents more complexities to transcatheter procedures than the aortic valve.
  • the mitral valve 4 includes two asymmetrical leaflets 4a, 4b and an irregularly-shaped annulus 4c.
  • the mitral valve 4 also varies far more considerably patient-to-patient than the aortic valve. For these and other reasons, surgical replacement and percutaneous repair thus far are the only widely- available commercial treatments for mitral valve disease.
  • the present disclosure relates generally to treatment of heart disease, and more particularly, implantable valve prostheses and treatments for heart valve diseases.
  • the present disclosure generally relates to treating a diseased native valve in a patient and more particularly relates to prosthetic heart valves.
  • the present disclosure relates prosthetic cardiac devices, and in some embodiments, prosthetic heart valves such as catheter-based mitral valves.
  • An aspect of the present disclosure provides a method for treating a diseased native valve in a patient.
  • the method comprises advancing a distal end of a delivery device to a first side of a native valve, wherein the distal end of the delivery device is detachably coupled to an anchor and a frame structure; deploying the anchor from a delivery configuration to a deployed configuration on the first side of the native valve; advancing the anchor in the deployed configuration from the first side of the native valve to a second side of the native valve; rotating a free end of the anchor in the deployed configuration around one or more structures on the second side of the native valve; releasing the anchor from the distal end of the delivery device; expanding the frame structure within the native valve from a compressed configuration to an expanded configuration; releasing the frame structure from the distal end of the delivery device; and retracting the delivery device from the native valve.
  • the method may further comprise positioning the anchor such that it is located only on the second side of the native valve after advancing the distal end of the delivery device from the
  • the method may further comprise steering the distal end of the delivery device such that the distal end of the delivery device points towards the first side of the native valve.
  • advancing the anchor may comprise pushing the anchor through the native valve.
  • advancing the anchor may comprise rotating the anchor through the native valve.
  • advancing the anchor may comprise positioning the anchor such that it is located only on the second side of the native valve.
  • expanding the frame structure may comprise expanding at least a portion the frame structure within at least a portion of the deployed anchor to anchor the frame structure to the native valve.
  • expanding the frame structure and releasing the frame structure may occur simultaneously.
  • the frame structure may be balloon-expandable. Expanding the frame structure may comprise inflating a balloon disposed within the frame structure. Inflation of the balloon may cause expansion of the frame structure.
  • the frame structure may be self-expanding. Expanding the frame structure may comprise releasing the frame structure from radial constriction by the delivery device.
  • the one or more structures may comprise one or more valve leaflets of the native valve. Alternatively, or in combination, the one or more structures may comprise one or more chordae of the left ventricle.
  • the free end may be disposed radially outward from a main body of the anchor in the deployed configuration in order to facilitate rotation of the free end around the one or more structures.
  • the free end of the wire may comprise an atraumatic tip.
  • the free end may comprise a ball tip.
  • the free end of the wire may be configured for piercing tissue.
  • the anchor may comprise a curved wire.
  • the curved wire may comprise a helical wire.
  • the anchor may comprise a first portion comprising the helical wire and another portion.
  • the anchor may comprise a plurality of helical wires.
  • the anchor may comprise at least two helical wires having the same or different diameters.
  • the anchor may comprise at least two helical wires having the same or different winding pitches.
  • the helical wire may have a generally tubular shape.
  • the free end of the helical wire may extend radially outward from the tubular shape.
  • the helical wire may have a generally frustoconical shape.
  • the free end of the helical wire may extend radially outward from the frustoconical shape.
  • the helical wire may have a generally cylindrical shape.
  • the free end of the helical wire may extend radially outward from the cylindrical shape.
  • the frame structure may further comprise a valve segment within the frame structure comprising a biocompatible one-way valve.
  • the native valve may be in a heart of a patient.
  • the method may further comprise transseptally inserting the distal end of the delivery device into a left atrium of the heart.
  • the native valve may comprise a mitral valve, the first side of the native valve may comprise a left atrium, and the second side of the native valve may comprise a left ventricle.
  • the native valve may be in a heart of a patient.
  • the native valve may comprise an aortic valve, the first side of the native valve may comprise a left ventricle, and the second side of the native valve may comprise an aorta.
  • the native valve may be in a heart of a patient.
  • the native valve may comprise a tricuspid valve, the first side of the native valve may comprise a right atrium, and the second side of the native valve may comprise a right ventricle.
  • a system for treating a diseased native valve in a patient comprises a frame structure having a compressed configuration and an expanded configuration and an anchor comprising a main body having a curved shape and a free end disposed radially outward from the curved shape of the main body when the anchor is in a deployed configuration.
  • the anchor is configured to be fully advanced from a first side of a native valve in a patient into a second side of the native valve and anchor the frame structure to the native valve when the frame structure is in the expanded configuration adjacent the native valve.
  • the curved shape may be a generally tubular shape.
  • the curved shape may be a generally frustoconical shape. [0026] In some embodiments, the curved shape may be a generally cylindrical shape.
  • the free end may be configured to be rotated around one or more structures on the second side of the native valve when the anchor in the deployed configuration is rotated.
  • the free end may have a larger radius of curvature than a radius of curvature of the main body.
  • a system for treating a diseased native valve in a patient comprises a frame structure having a compressed configuration and an expanded configuration and an anchor comprising a wire having a free end.
  • the anchor is configured to be fully advanced from an atrial side of a native valve in a patient into a ventricle of the heart and anchor the frame structure to the native valve when the frame structure is in the expanded configuration adjacent the native valve.
  • the system further comprises a delivery device.
  • the delivery device may comprise an outer sheath, an inner shaft disposed within a lumen of the outer sheath, and a guidewire disposed within a lumen of the inner shaft.
  • a proximal end of the anchor may be detachably coupled to the inner shaft during delivery to the native valve.
  • the outer sheath may be steerable.
  • the anchor may comprise an elongated configuration and a deployed configuration.
  • the anchor may be configured to be actuated from the elongated configuration to the deployed configuration adjacent the native valve. Retraction of the guidewire into the lumen of the inner shaft may actuate the anchor into the deployed
  • the anchor may be maintained in the elongated configuration by radial constriction from the outer sheath and advancement of the inner shaft out of the lumen of the outer sheath may actuate the anchor into the deployed configuration.
  • the proximal end of the anchor may be detachably coupled to the inner shaft of the delivery device by radial constriction from the outer sheath. Retraction of the outer sheath away from the proximal end of the anchor may detach the anchor from the delivery device.
  • the proximal end of the anchor may be detachably coupled to the inner shaft of the delivery device by an attachment element.
  • the proximal end of the anchor may be detachably coupled to the inner shaft of the delivery device by a weak adhesive.
  • the frame structure may be detachably coupled to the delivery device in the compressed configuration during delivery to the native valve. Expansion of the frame structure to the expanded configuration may detach the frame structure from the delivery device.
  • the free end may comprise an atraumatic tip.
  • the free end may comprise a ball tip.
  • the free end may be configured for piercing tissue.
  • the wire may comprise a helical wire.
  • the anchor may comprise a first portion comprising the helical wire and another portion.
  • the anchor may comprise a plurality of helical wires.
  • the anchor may comprise at least two helical wires having the same or different diameters.
  • the anchor may comprise at least two helical wires having the same or different winding pitches.
  • the helical wire may have a generally tubular shape.
  • the free end of the helical wire may extend radially outward from the tubular shape.
  • the helical wire may have a generally frustoconical shape.
  • the free end of the helical wire may extend radially outward from the frustoconical shape.
  • the helical wire may have a generally cylindrical shape.
  • the free end of the helical wire may extend radially outward from the cylindrical shape.
  • the frame structure may be configured for expanding within the native valve of the patient.
  • the compressed configuration may be sized and dimensioned for percutaneous insertion and the expanded configuration may be sized and dimensioned for implantation in the native valve of the patient.
  • the frame structure may comprise a first and second opposite ends, the first end extending above a native valve and the second end extending below the native valve when the frame structure is anchored to the native valve.
  • the frame structure may sit below the native valve when the frame structure is anchored to the native valve.
  • the frame structure may comprise an expandable stent.
  • the expanded configuration may have a generally tubular expanded shape.
  • the frame structure may comprise an expanded outer periphery in the expanded configuration and a compressed outer periphery when subject to an external radial force in the compressed configuration.
  • the compressed outer periphery may be smaller in diameter than the expanded outer periphery.
  • the frame structure may be balloon-expandable.
  • the frame structure may be self-expanding.
  • the frame structure may be maintained in the compressed configuration by radial constriction from the outer sheath of the delivery device. Advancement of the inner shaft out of the lumen of the outer sheath may actuate the frame structure into the expanded configuration.
  • the system may further comprise a valve segment within the frame structure comprising a biocompatible one-way valve. At least a portion of the valve segment may be positioned within at least a portion of the frame structure.
  • the valve segment may comprise at least one leaflet having an inner layer and an outer layer.
  • the frame structure may be attached to the outer layer at one or more ends of the frame structure.
  • the valve segment may comprise a plurality of leaflets.
  • a method for treating a diseased native valve in a patient comprises advancing a distal end of a delivery device from a first side of a native valve to a second side of the native valve, wherein the distal end of the delivery device is detachably coupled to an anchor and a frame structure, fully deploying the anchor on the second side of the native valve, releasing the anchor from the distal end of the delivery device, expanding the frame structure within the native valve from a compressed configuration to an expanded configuration, releasing the frame structure from the distal end of the delivery device, and retracting the delivery device from the native valve.
  • the method may further comprise steering the distal end of the delivery device such that the distal end of the delivery device points towards the first side of the native valve.
  • fully deploying the anchor may comprise actuating the anchor from an elongated configuration to a deployed configuration.
  • fully deploying the anchor may comprise actuating the anchor from an elongated configuration to a deployed configuration on the first side of the native valve and advancing the anchor in the deployed configuration through the native valve to the second side of the native valve.
  • Advancing the anchor may comprise pushing the anchor through the native valve.
  • Advancing the anchor may further comprise rotating the anchor through the native valve.
  • fully deploying the anchor may comprise positioning the anchor such that it is located only on the second side of the native valve.
  • the frame structure may comprise a first and second opposite ends. Expanding the frame structure may comprise expanding the frame structure such that the first end extends above the first side of the native valve and the second end extends below second side of the native valve. [0057] In some embodiments, expanding the frame structure may comprise expanding at least a portion the frame structure within at least a portion of the deployed anchor to anchor the frame structure to the native valve.
  • expanding the frame structure and releasing the frame structure may occur simultaneously.
  • the frame structure may be balloon-expandable. Expanding the frame structure may comprise inflating a balloon disposed within the frame structure. Inflation of the balloon may cause expansion of the frame structure.
  • the frame structure may be self-expanding. Expanding the frame structure may comprise releasing the frame structure from radial constriction by the delivery device.
  • the anchor may comprise a wire having a free end.
  • the method may further comprise rotating the free end of the deployed anchor around one or more structures on the second side of the native valve.
  • the one or more structures may comprise one or more valve leaflets of the native valve.
  • the one or more structures may comprise one or more chordae of the left ventricle.
  • the free end of the wire may comprise an atraumatic tip.
  • the free end may comprise a ball tip.
  • the free end of the wire may be configured for piercing tissue.
  • the wire may comprise a helical wire.
  • the anchor may comprise a first portion comprising the helical wire and another portion.
  • the anchor may comprise a plurality of helical wires.
  • the anchor may comprise at least two helical wires having the same or different diameters.
  • the anchor may comprise at least two helical wires having the same or different winding pitches.
  • the helical wire may have a generally tubular shape.
  • the free end of the helical wire may extend radially outward from the tubular shape.
  • the helical wire may have a generally frustoconical shape.
  • the free end of the helical wire may extend radially outward from the frustoconical shape.
  • the helical wire may have a generally cylindrical shape.
  • the free end of the helical wire may extend radially outward from the cylindrical shape.
  • the frame structure may further comprise a valve segment within the frame structure comprising a biocompatible one-way valve.
  • the native valve may be in a heart of a patient.
  • the method may further comprise transseptally inserting the distal end of the delivery device into a left atrium of the heart.
  • the native valve may comprise a mitral valve, the first side of the native valve may comprise a left atrium, and the second side of the native valve may comprise a left ventricle.
  • a method for treating a diseased native valve in a patient comprises advancing a distal end of a delivery device from a first side of a native valve to a second side of the native valve, wherein the distal end of the delivery device is detachably coupled to an anchor and a frame structure, wherein the anchor comprises the free end adjacent a proximal portion of the frame structure and a second end coupled to a distal portion of the frame structure, and wherein advancing the distal end of the delivery device advances the anchor from the first side of the native valve to the second side of the native valve and positions the free end of the anchor on the second side of the native valve; deploying the anchor from a delivery configuration to a deployed configuration; rotating the free end of the anchor in the deployed configuration around one or more structures on the second side of the native valve; releasing the anchor from the distal end of the delivery device; expanding the frame structure within the native valve from a compressed configuration to an expanded configuration; releasing the frame structure from the distal end of
  • the anchor may be deployed from the delivery configuration to the deployed configuration on the first side of the native valve.
  • the method may further comprise positioning the anchor such that it is located only on the second side of the native valve after advancing the distal end of the delivery device from the first side of the native valve to the second side of the native valve.
  • rotating the free end of the anchor around the one or more structures may comprise rotating the anchor upwards towards the native valve.
  • a method for treating a diseased native valve in a patient comprises advancing a distal end of a delivery device from a first side of a native valve to a second side of the native valve, wherein the distal end of the delivery device is detachably coupled to an anchor and a frame structure; deploying the anchor from a delivery configuration to a deployed configuration; positioning the anchor such that it is located only on the second side of the native valve after advancing the distal end of the delivery device from the first side of the native valve to the second side of the native valve; releasing the anchor from the distal end of the delivery device; expanding the frame structure within the native valve from a compressed configuration to an expanded configuration; releasing the frame structure from the distal end of the delivery device; and retracting the delivery device from the native valve.
  • the anchor may be deployed from the delivery configuration to the deployed configuration on the first side of the native valve.
  • the method may further comprise, after the anchor has been deployed into the deployed configuration, rotating a free end of the anchor in the deployed configuration around one or more structures on the second side of the native valve.
  • a heart valve prosthesis for replacing a diseased native valve in a heart of a patient.
  • the valve prosthesis comprises a compressible and expandable frame structure, a valve segment disposed within the frame structure, the valve segment comprising a biocompatible one-way valve, and an anchor connected to an outer periphery of the frame structure, wherein the anchor comprises a helical wire having a free end.
  • the free end of the helical wire may be configured to guide the helical wire through a commissure of a native valve of a patient.
  • the free end may comprise an atraumatic tip.
  • the free end may comprise a ball tip.
  • the free end may be configured for piercing tissue.
  • the anchor may comprise a first portion comprising the helical wire and another portion.
  • the anchor may comprise a plurality of anchors.
  • the plurality of anchors may comprise at least two helical wires having different diameters.
  • the plurality of anchors may comprise at least two helical wires having different winding pitches.
  • the helical wire may have a generally tubular shape.
  • the free end of the helical wire may extend radially outward from the tubular shape.
  • the helical wire may have a generally frustoconical shape.
  • the free end of the helical wire may extend radially outward from the frustoconical shape.
  • the frame structure may be configured for expanding within a native valve of a patient.
  • the frame structure may have a compressed state sized and dimensioned for percutaneous insertion and an expanded state sized and dimensioned for implantation in a native valve of a patient.
  • the frame structure may comprise first and second opposite ends, the first end extending above a native valve and the second end extending below the native valve when the valve prosthesis is positioned across the native valve.
  • the frame structure may comprise an expandable stent.
  • the frame structure may comprise a generally tubular expanded shape.
  • the frame structure may comprise an expanded outer periphery and a compressed outer periphery when subject to an external radial force.
  • the compressed outer periphery may be slightly smaller in diameter than the expanded outer periphery.
  • the frame structure may be balloon-expandable.
  • the frame structure may be self-expanding.
  • At least a portion of the valve segment may be positioned within at least a portion of the frame structure.
  • the valve segment may comprise at least one leaflet having an inner layer and an outer layer.
  • the frame structure may be attached to the outer layer at one or more ends of the frame structure.
  • the valve segment may comprise a plurality of leaflets.
  • the valve segment may comprise two leaflets.
  • a method of replacing a diseased native valve of a patient comprises loading a valve prosthesis into a delivery catheter, the valve prosthesis comprising an expandable frame structure carrying a biocompatible valve segment and an anchor attached to an outer periphery of the frame structure, the anchor comprising a wire having a free end; delivering the valve prosthesis to a target location above a native valve;
  • valve prosthesis inserting the valve prosthesis through the native valve to a position posterior the native valve; rotating the wire such that the free end wraps around at least a portion of chordae tendineae below the valve; and expanding the frame structure including the valve segment within the native valve.
  • the method may further comprise anchoring the valve prosthesis by rotating the wire until the frame structure is positioned within leaflets of the native valve.
  • the method may further comprise anchoring the valve prosthesis by rotating the wire until the wire tightens around the chordae tendineae.
  • the frame structure may be balloon-expandable. Expanding the frame structure may comprise expanding a balloon within the frame structure.
  • the frame structure may be self-expanding. Expanding the frame structure may comprise removing a sheath of the delivery device from the frame structure.
  • a method of replacing a diseased native valve of a patient comprises loading a valve prosthesis into a delivery catheter, the valve prosthesis comprising an expandable frame structure carrying a biocompatible valve segment and an anchor attached to an outer periphery of the frame structure; delivering the valve prosthesis to a target location above a native valve; inserting the valve prosthesis through the native valve to a position posterior the native valve; anchoring the valve prosthesis to native leaflets and/or chordae; and expanding the frame structure including the valve segment within the native valve.
  • anchoring may comprise rotating the anchor to engage the native valve leaflets and/or chordae.
  • the anchor may comprise a helical wire and anchoring may comprise rotating helical wire such that the wire wraps around the native valve leaflets and/or chordae tendineae.
  • a heart valve prosthesis for replacing a diseased native valve in a patient.
  • the valve includes a compressible and expandable frame structure and an anchor connected to an outer periphery of the frame structure.
  • the anchor comprises a helical wire having a free end.
  • the valve may further include a valve segment within the frame structure.
  • the valve segment may include a biocompatible one-way valve.
  • a method of implanting a prosthetic valve to treat a diseased native valve is provided.
  • valve comprising any of the features described herein in any combination thereof is provided.
  • FIG. 1 is a schematic of a human heart illustrating the path of blood flow through the heart.
  • FIG. 2 is a cross-sectional view of a heart looking down through the mitral valve, aortic valve, and aorta.
  • FIG. 3 is a schematic of a healthy mitral valve.
  • FIGS. 4 and 5 are schematics of diseased mitral valves.
  • FIGS. 6-10 are several views of a percutaneous valve for replacement of a diseased native valve, in accordance with embodiments.
  • FIG. 11 is a perspective view of the prosthetic valve leaflet of the valve of FIG. 6, in accordance with embodiments.
  • FIGS. 12-18 are several views of the frame structure of the valve of FIG. 6, in accordance with embodiments.
  • FIGS. 19-26 are several views of the method of implanting the valve of FIG. 6, in accordance with embodiments.
  • FIGS. 27 and 28 illustrate expanding of the frame structure using a balloon, in accordance with embodiments.
  • FIG. 29 is a front view of another percutaneous valve similar to the one of FIG. 6, in accordance with embodiments.
  • FIGS. 30A-30F are front views of other percutaneous valves similar to the one of FIG. 6, in accordance with embodiments.
  • FIGS. 31-35 illustrate another valve device similar to the one of FIG. 6, in accordance with embodiments.
  • FIG. 31 is a perspective view.
  • FIG. 32 is a front view.
  • FIG. 33 is a back view.
  • FIG. 34 is a top view.
  • FIG. 35 is an enlarged view of a bottom portion of the device, showing attachment of the anchor to the frame structure.
  • FIGS. 36-39 illustrate another valve device similar to the one of FIG. 6, in accordance with embodiments.
  • FIGS. 36 and 37 are perspective views.
  • FIG. 38 is a front view.
  • FIG. 39 is a top view.
  • FIGS. 40-42 are front views of valve devices similar to the one of FIG. 6, illustrating different anchors, in accordance with embodiments.
  • FIGS. 43 A-43 AF are sequential views of a method of implanting a device similar to the one of FIGS. 6 and 31, in accordance with embodiments.
  • FIGS. 44-49 show a valve device similar to the one of FIG. 6, except that the frame structure is self-expanding, in accordance with embodiments.
  • FIG. 44 is a front view of the device.
  • FIG. 45 is a perspective top view.
  • FIG. 46 is a bottom view.
  • FIG. 47 is a perspective view.
  • FIG. 48 is a perspective view of the valve device loaded on a delivery catheter.
  • FIG. 49 is a bottom view of the device loaded on a delivery catheter.
  • FIG. 50 shows a side view of a valve prosthesis system comprising a frame structure and an anchor loaded on a delivery device with the anchor in an elongated configuration, in accordance with embodiments.
  • FIG. 51 shows a side view of the valve prosthesis system of FIG. 50 with the anchor in a deployed configuration, in accordance with embodiments.
  • FIG. 1 shows a human heart 2 and the blood flow pathways through the four chambers of the heart.
  • FIG. 2 is a human heart 2 showing the mitral valve 4, aortic valve 9, and aorta 1.
  • the mitral valve 4 includes two leaflets 4a, 4b.
  • the anterior (aortic) leaflet 4a is adjacent the aorta 1.
  • the posterior (mural) leaflet 4b is remote from the aorta 1.
  • the aortic valve 9 includes three leaflets.
  • the heart 2 is in systole with the aortic valve 9 open and the mitral valve 4 closed.
  • FIGS. 2-5 illustrate exemplary mitral valve 4 disease states which may be addressed by the prosthetic valve in accordance with the present disclosure.
  • the prosthetic valve may also be used to treat functional regurgitation such as functional mitral regurgitation (FMR).
  • FMR functional mitral regurgitation
  • FIGS. 6-18 show an exemplary valve prosthesis 10 (also referred to herein as“valve device”) for replacement of a diseased mitral valve in accordance with the present disclosure.
  • the illustrated valve prosthesis 10 comprises a frame structure 12, a valve segment 14, and an anchor 15.
  • FIGS. 6-10 show the valve prosthesis 10 in an expanded, deployed state.
  • FIGS. 12-18 show the frame structure 12 without the valve segment 14.
  • the frame structure 12 is in a collapsed state in FIGS. 12-15 and an expanded state in FIGS. 16-18.
  • the anchor 15 is shown in a deployed state.
  • valve prosthesis 10 is configured for replacement of a native mitral valve.
  • Valve 10 includes a frame structure 12, valve segment 14, and anchor 15.
  • the anchor 15 includes a wire 20 formed in a helical or spiral shape around the frame structure.
  • the exemplary frame structure 12 is configured like a stent.
  • the frame structure 12 has an expanded state and an unexpanded (e.g., collapsed or compressed) state.
  • the compressed state is sized and dimensioned for percutaneous insertion and the expanded state sized and dimensioned for implantation in a native valve of a patient.
  • the frame structure 12 comprises an expanded outer periphery and a compressed outer periphery when subject to an external radial force, the compressed outer periphery being slightly smaller in diameter than the expanded outer periphery.
  • the frame structure 12 is shown in the expanded, deployed state in FIG. 6.
  • the frame structure 12 is shown in the collapsed, delivery state in FIG. 12
  • the exemplary frame structure 12 is a scaffold in a diamond pattern formed from a shape memory material (e.g. NiTi).
  • a shape memory material e.g. NiTi
  • the frame structure 12 may be formed of a polymer of sufficient elasticity.
  • the frame structure 12 may be formed of a combination of a metal and polymer, such as a metal (e.g., shape memory material) covered in polymer.
  • the frame structure 12 may include a variety of patterns besides diamond shapes.
  • Valve prosthesis 10 includes a valve segment 14 within the frame structure 12.
  • the exemplary valve segment 14 is expandable and collapsible.
  • the valve segment 14 is affixed within the frame structure 12 and expands and collapses with the frame structure 12.
  • Valve segment is used somewhat interchangeably with prosthetic valve leaflet and generally refers to the prosthetic leaflets and frame.
  • “prosthetic valve” may refer to all manner of prosthetic and artificial replacement valves including tissue (biological) valves, tissue-engineered valves, polymer valves (e.g. biodegradable polymer valves), and even certain mechanical valves.
  • frame structure 12 is a closed frame such that blood flow is forced through valve segment 14 therein.
  • One or more skirts and/or seals may help force blood through valve segment 14.
  • Valve segment 14 can be configured as would be understood by one of skill from the description herein.
  • the valve segment 14 can be similar to existing transcatheter valves.
  • the valve segment 14 can be similar to existing surgical tissue valves, and mechanical valves.
  • the valve segment 14 includes leaflets 16 formed of multi-layered materials for preferential function. At least one leaflet 16 may have an inner layer and an outer layer.
  • the leaflet 16 is connected to a valve structure which in turn is connected to the frame structure 12.
  • the valve structure may be connected to the frame structure 12 before or after the frame structure 12 has been deployed adjacent a native valve.
  • the leaflet 16 is attached to the frame structure 12 directly.
  • the leaflet 16 may have an inner layer and an outer layer, with the outer layer attached to the frame structure 12.
  • the leaflet 16 may be attached to an end of the frame structure 12.
  • the leaflet 16 may be attached to an intermediate portion of the frame structure 12.
  • the valve segment 14 includes a plurality of leaflets 16, such as two, three, or more leaflets.
  • the valve segment 14 includes three leaflets 16 which are attached to frame structure 12.
  • An exemplary leaflet 16 is shown in FIG. 11.
  • the leaflet 16 is concave to permit flow in one direction. In particular, flow in one direction causes the leaflet(s) 16 to deflect open and flow in the opposite direction causes the leaflet(s) 16 to close.
  • an exemplary anchor 15 comprises a helical member, such as wire 20, having a free end 22.
  • the other end of the wire 20 is attached to a top end of frame structure 12.
  • one end of the wire 20 is fixed to a strut of the frame structure 12.
  • This end can be attached by suitable means as would be understood by one of skill in the art from the description herein including, but not limited to, a weld, an adhesive, and a mechanical fastener.
  • the helical wire 20 is attached to the frame structure only at the location of the second end.
  • anchor 15 does not require performing an anchor function in the traditional sense. As will be described in more detail below, the anchor guides valve prosthesis 10 into a desired position within a native valve. The anchor 15 may also mitigate against undesired entanglement and disturbances to the chordae tendineae and valve leaflets of the mitral valve.
  • Wire 20 is formed of a material having sufficient rigidity to hold a predetermined shape.
  • the wire 20 is formed of a shape memory material (e.g. NiTi). It may be desirable for at least an end portion to be relatively rigid such that it can exert a force to move chordae tendineae, while still retaining flexibility to be collapsed within a catheter.
  • the end portion (including free end 22) only needs sufficient rigidity to hold its shape and will deform under a load.
  • the end portion may be configured with similar rigidity to a guidewire, or slightly stiffer.
  • the anchor 15 comprises a helical member.
  • the helical member may comprise a helical wire or flat ribbon.
  • the helical member may comprise a three- dimensional surface as described herein.
  • the anchor 15 may comprise a first portion comprising the helical wire 20 and another portion. Alternatively, or in combination, the anchor 15 may comprise a plurality of helical wires 20. For example, the anchor 15 may comprise at least two helical wires 20 having the same or different diameters. Alternatively, or in combination, the anchor 15 may comprise at least two helical wires 20 having the same or different winding pitches.
  • the anchor 15 may comprise a plurality of anchors, for example a plurality of helical wires 20 as described herein.
  • valve prosthesis 10 is configured for replacing a mitral valve and free end 22 is configured for insertion through a commissure.
  • FIG. l is a schematic of a human heart 2 having a mitral valve 4.
  • FIGS. 2 and 4 show an exemplary mitral valve 4. As can be seen in the figures, several commissure points (anterolateral commissure 4d and posteromedial commissure 4e) are presented at the ends of the valve leaflets 4a, 4b.
  • the exemplary free end 22 is sized and dimensioned for insertion through one of the commissures.
  • the free end 22 is configured to be atraumatic to avoid risk of injury to the valve tissue and leaflets.
  • the free end 22 may be in the form of a blunt end, a ball tip, a curved tip (e.g., J-tip or pigtail), and other atraumatic shapes.
  • the free end 22 is configured with a sharp end to pierce tissue.
  • wire 20 has varying stiffness along its length.
  • the wire 20 may have two or more segments of differing stiffness and/or the stiffness may transition over its length.
  • wire 20 is attached to frame 12 at multiple points such that free end 22 is relatively flexible and the wire 20 is more rigid along portions where it is attached to the frame structure 12.
  • free end 22 extends radially outward from frame structure 12, and in particular the remainder of wire 20.
  • the free end 22 is configured to encircle a larger radius than the main coils of the wire 20.
  • the main coils of wire 20 have a generally curved shape (e.g., helical, tubular, frustoconoical, etc.)
  • the free end 22 may extend radially outward from the curved shape.
  • the main coils of wire 20 have a generally tubular shape
  • the free end 22 may extend radially outward from the tubular shape.
  • the free end 22 may extend radially outward from the helical shape.
  • the free end 22 may extend radially outward from the frustoconical shape.
  • the larger diameter facilitates capturing of the valve leaflets and/or chordae tendineae within the sweep of the free end 22 during rotation as will be described in more detail below.
  • FIGS. 19-28 A method of implanting valve prosthesis 10 in accordance with the present disclosure will now be described with reference to FIGS. 19-28. Although shown and described with respect to a mitral valve, one of ordinary skill in the art will understand that the principles described herein may be applied equally to other atrioventricular valves. Aspects of the procedure, delivery tool, and implanted valve prosthesis are similar to those described in U.S. Pat. Nos. 9,034,032; 9,005,273; 8,323,336; 8,075,615; 7,621,948; and 7,175,656 and U.S. Pub. No. 2011/0288637, which are incorporated herein for all purposes in their entirety.
  • valve prosthesis 10 Prior to implantation, valve prosthesis 10 may be collapsed and loaded into a delivery device 30, for example, a delivery catheter.
  • the valve system may optionally be primed before or after loading into the delivery catheter 30.
  • FIG. 19 shows a cross-sectional side view of a heart 2 with a transseptal puncture 27 in the atrial septum thereof. The leaflets 42 of valve 4 do not fully prolapse and the patient is experiencing regurgitation.
  • the delivery catheter 30 is inserted through an introducer into a vessel.
  • the delivery catheter 30 can be guided over a guidewire to a target location using the Seldinger technique.
  • the delivery catheter 30 is guided to the left atrium 25 through a transseptal puncture 27 in conventional fasion as shown in FIG. 20.
  • valve prosthesis 10 is then pushed out of the distal end of delivery catheter 30.
  • the delivery device 30 may comprise an outer catheter 50 and an inner catheter or shaft 52.
  • the delivery tube 52 extends out of the outer catheter 50 to move valve device 10 distally towards the native valve 4.
  • an anchor 15, such as wire 20 is deployed (e.g., from a straightened shape within the delivery device 30) to its pre-formed deployed shape and wraps around frame 12, which remains in its collapsed state as shown in FIG. 22.
  • the valve prosthesis 10 is then aligned with the target native valve 4 so the axis of the prosthetic valve 10 is aligned with a central axis of the native valve 4.
  • valve 10 is anchored to the native valve 4 using exemplary helical wire 20.
  • the valve prosthesis 10 frame 12, wire 20, and valve segment 14— are slowly rotated into the native mitral valve 4.
  • a torquer is provided in the delivery catheter 30 for rotating valve 10.
  • Free end 22 of wire 20 is rotated through a commissure and extends below the native valve 4 annulus.
  • the valve prosthesis 4 is further rotated so the free end 22 captures the chordae tendineae (also referred to as“papillary muscles”) 40 and/or native valve leaflets 42.
  • the chordae tendineae 40 are gathered and pulled radially inward.
  • Free end 22 has a larger radius than the main body of the helical coil (e.g., is disposed radially outward of the main body of the helical coil) in order to facilitate capture of the chordae tendineae 40 during rotation of the valve prosthesis 10.
  • Frame structure 12 also moves into the native valve 4 as the wire 20 is rotated.
  • Valve prosthesis 10 is in the correct position when the chordae tendineae 40 have been captured to a sufficient degree and/or frame structure 12 is in the desired location in the native valve 40. Insertion of the device through the native valve may be facilitated by the natural opening and closing of the native valve during the cardiac cycle.
  • the chordae tendineae 40 are pulled inwardly into a bunches (best seen in FIG. 25).
  • the native valve leaflets 42 are also in communication with the helical coil 20. At this stage valve device 10 is rigidly anchored adjacent the native valve 40 annulus.
  • the helical wire 20 can be counter-rotated to back out the device 10 from the native valve 4. The implant rotation procedure can then be repeated.
  • Frame structure 12 is expanded once valve 10 is in the desired location as shown in FIG. 25.
  • the frame structure 12 may comprise a first and second opposite ends, the first end extending above a native valve and the second end extending below the native valve when the frame structure 12 is anchored to the native valve 4.
  • the frame structure 12 is expanded with a balloon 48 as shown in FIGS. 27-28.
  • the frame structure 12 is self-expanding.
  • the self-expanding exemplary frame structure 12 is formed of a shape memory material or any material having superelastic properties.
  • the self expanding frame structure 12 is configured and expands in a similar manner to a self-expanding stent or scaffold. Expanding the frame structure 12 comprises removing a sheath (for example, outer sheath 50) of the delivery device 30 from the frame structure 12.
  • the entire valve assembly 10 is released from the delivery catheter 30 and the delivery catheter 30 is removed as shown in FIG. 26.
  • expansion of the frame structure 12 may occur simultaneously with release of the frame structure 12 from the delivery catheter 30.
  • valve structure 14 and frame structure 12 are deployed together.
  • the frame structure 12 can be deployed first and then receive the prosthetic valve segment 14.
  • valve prosthesis 10 does not include a valve segment 14. Instead, the frame structure 12 and anchor 15 are positioned within the native valve 4.
  • the frame structure 12 is configured to receive a valve segment 14 delivered separately.
  • the frame structure 12 can be configured to receive one of several valve sizes and types. In this manner, a clinician can choose the proper valve for the individual patient.
  • the helical wire 20 of anchor 15 guides the valve system 10 along a desired axis into position adjacent the native valve 4.
  • the wire 20 also provides an initial anchoring.
  • the valve prosthesis 10 is finally anchored when the frame structure 12 is expanded within the native valve 4.
  • the frame structure 12 dilates the valve leaflets 14 and the compressive force fixes the valve prosthesis 10 into position. Thereafter tissue ingrowth ensures the valve prosthesis 10 remains seated and does not migrate.
  • valve devices described herein in accordance with the present disclosure provides several advantages over conventional valve systems.
  • Embodiments described herein provide an easy-to-use, repositionable device.
  • the valve prosthesis described herein reduces the risk of injuring or tearing chordae.
  • Typical mitral valve replacement systems involve implanting a prosthetic annulus or ring around the valve. The ring increases the circumference of the valve and risks occluding the entry to the aortic valve.
  • the valve device described herein overcomes these and other problems.
  • FIG. 29 illustrates another embodiment in accordance with the present disclosure.
  • a valve prosthesis 10’ includes a helical wire 20’ and frame structure 12’.
  • Valve structure 10’ is similar to valve 10 except that valve segment 14’ is fixed within a separate end of frame structure 12’.
  • Wire 20’ is wrapped around a lower portion of the frame structure 12 having a smaller diameter than the upper portion of the frame structure 12 to which the valve segment 14’ is fixed.
  • FIGS. 30A to 3 OF illustrate several other embodiments in accordance with the present disclosure.
  • Each of valves 10a to lOf includes a helical wire and frame.
  • Each can optionally include a valve segment within the frame.
  • FIG. 30A shows a valve prosthesis 10a which is similar to valve prosthesis 10 except that free end 22a includes an atraumatic ball tip. Also, wire 20a has a tubular shape at one end and a frustoconical shape at another end. Frame structure 12a is substantially similar to frame structure 12.
  • FIG. 30B shows a valve prosthesis 10b which is similar to valve prosthesis 10 except that free end 22 has a pigtail tip. Also, wire 20b is attached to an intermediate portion of frame structure 12b instead of an end of the frame structure 12b. Frame structure 12b is substantially similar to frame structure 12.
  • FIG. 30C shows a valve prosthesis 10c which is similar to valve prosthesis 10 except that frame structure 12c is a tubular structure instead of a scaffold or stent-like structure.
  • the frame structure 12c can be formed of expandable materials such as polyurethane or
  • the wire 20c is substantially similar to wire 20.
  • the free end 22c is substantially similar to free end 22.
  • FIG. 30D shows a valve prosthesis lOd which is similar to valve prosthesis 10 except that the anchor 15 is formed of a three-dimensional surface 20d instead of a wire 20.
  • Three- dimensional surface 20d comprises a free end 22d, which may be substantially similar to any of the free ends described herein.
  • Frame structure 12d is substantially similar to frame structure 12.
  • FIG. 30E shows a valve prosthesis lOe which is similar to valve prosthesis 10 except that frame structure 12e has a conical shape instead of a tubular shape.
  • the wire 20e is substantially similar to wire 20.
  • the free end 22e is substantially similar to free end 22.
  • FIG. 30F shows a valve prosthesis lOf which is similar to valve prosthesis 10 except that the valve device lOf includes a plurality of wires 20f and 20F.
  • the use of a plurality of wires 20f and 20P provides increased anchoring security. Because it may be difficult to insert both free ends 22f and 22P, one or both free ends 22f and 22P may include a sharp point for piercing tissue. In this manner, the sharp end can pierce the valve annulus or leaflets. Barbs or other mechanisms may be employed to increase anchoring of the wire.
  • one or both of the wires 20f and 20G may include a braided surface or barbs to prevent axial dislocation once it is screwed into place.
  • FIGS. 31-35 illustrate another valve prosthesis lOg embodiment which is similar to valve prosthesis 10 except that the valve prosthesis lOg is configured for anchoring from the bottom (i.e., ventricular side) of the native mitral valve annulus.
  • valve prosthesis lOg includes a helical anchor 15g in a frustoconical (or conical) shape with a narrow section at the bottom of the frame structure 12g and a wider section along a central portion of the device lOg.
  • the widest section of the anchor 15g is near a top of the coil 15g.
  • the coiled anchor 15g extends from a bottom of the frame structure 12g to a top section of the frame structure 12g in the collapsed (e.g., unexpanded) configuration.
  • the frame structure 12g, anchor 15g, and valve segment are otherwise generally similar to those of valve 10 or any of the frame structures, anchors, or valve segments described herein.
  • the anchor 15g is inverted compared to anchor 15 in FIG. 6.
  • a free end 22g is positioned along a central section of the valve prosthesis lOg.
  • the valve prosthesis device lOg may be configured to be inserted through the native valve (e.g. mitral valve) and anchored from below.
  • the anchor 15g may be configured to capture the chordae and/or native valve leaflets from below the valve annulus. This inverted design provides a simple transcatheter approach to the diseased native valve while providing a long-term and clinically useful anchoring mechanism.
  • the exemplary anchor 15g is attached to the frame structure 12g at one end 57.
  • the end is fixed to a strut of the frame structure 12g.
  • This attached end can be attached by suitable means as would be understood by one of skill in the art from the description herein including, but not limited to, a weld, an adhesive, and a mechanical fastener.
  • the valve prosthesis lOg includes optional eyelets 55 for supplemental securement of the coil anchor 15g.
  • the exemplary anchor 15g is formed in the shape of a coil wire similar to the other anchor wires described herein and with a section extending through the eyelets 55. The coil 15g is slidably held within the eyelets 55.
  • the coil 15g may be configured to retain its shape after deployment. As the frame structure 12g is subsequently expanded, the coil wire anchor 15g slides through the eyelets 55 to allow the frame structure 12g to expand within the larger diameter of the anchor 15g. The eyelets 55 hold the coil wire anchor 15g in a radial position relative to the frame structure 12g. This may mitigate against the risk of the coil 15g bending away from the frame structure 12g and/or fracture failure.
  • the anchor 15g has a radius of curvature (R) is between about l5mm and about 50m.
  • R radius of curvature
  • R is about 35mm.
  • the height of the anchor (H a ) is between about lOmm and about 60mm. In various embodiments, the height of the anchor (H a ) is between about 3mm and about 60mm. In various embodiments, the height of the anchor (H ) is between about 3mm and about 6mm. In various embodiments, the height of the anchor (H ) is between about 3mm and about 50mm. In various embodiments, H is about 30mm. In various embodiments, the height of the frame structure (Hf) is between about 20mm and about 55mm. In various embodiments, Hf is about 30mm. In various embodiments, the width of the frame structure in a collapsed configuration (W c ) is between about 4mm and about 8mm.
  • W c is about 6mm. In various embodiments, the width of the frame structure 12g in an expanded configuration (W e ) is between about 25mm and about 35mm. In various embodiments, W c is about 30mm. In various embodiments, the anchor 15g is formed as a coil with varying widths and the minimum width (or radius) is about lOmm and the maximum radius is about 30mm.
  • FIGS. 36-39 illustrate another valve prosthesis lOh embodiment which is similar to valve proshtesis lOg except that the anchor 15h has a generally symmetrical tubular profile.
  • a proximal end 57h of anchor 15h extends inwardly from the coil body to an attachment point on the frame structure 12h.
  • the end 57h wraps around the frame structure 12h and is fixed to the frame structure 12h as described herein.
  • the coil 20h can have a portion of a turn around the collapsed frame structure 12h.
  • the coil 20h can have one or more turns around the collapsed frame structure 12h.
  • a portion of the coil 20h may extend through eyelets 55h as described herein.
  • the frame structure 12g may be allowed to expand by the coil anchor 15g sliding through the eyelets 55h. At the same time, the eyelets 55h may maintain a relative radial position of the respective portion of the coil anchor 15g.
  • eyelets 55g one of ordinary skill in the art will appreciate from the description herein that other mechanisms may be suitable for guiding the anchor 15g including, but not limited to, hooks and guiderails or the like, or any combination thereof.
  • FIGS. 40-42 illustrate exemplary valve prosthesis embodiments lOi, lOj, and 10k which are similar to valve prosthesis lOg and having anchors 15i, 15j, and 15k of varying configurations.
  • the exemplary anchors include an atraumatic tip 60 as described herein.
  • the atraumatic tip may be formed as a ball, rounded edge, J-tip, or any other suitable means as would be understood by one of skill in the art from the description herein.
  • FIG. 40 illustrates a valve prosthesis lOi which is similar to valve prosthesis lOg except that the anchor 15i does not have a linear or symmetrical shape. At least a portion of anchor 15i has a tapered shape. In the illustrated embodiment, the anchor 15i is formed as a coil and at least one turn of the windings has a curvilinear shape. Whereas at least some of the turns in the windings of anchor lOg are generally flat in a plane, the respective turns in the valve prosthesis lOi are configured to extend out of the plane in a three-dimensional, degenerate surface.
  • the curvilinear shape is more pronounced, and the radius of curvature is greater, on the turn at the top than the turns at the bottom.
  • the overall shape of anchor 15i is generally conical. This shape may promote insertion of the anchor through the native valve leaflets as will be described in more detail below.
  • FIG. 41 illustrates a valve prosthesis lOj which is similar to valve prostheses lOg, lOh, lOi, and lOj.
  • Anchor 15j is formed as a coil with a complex, tapered shape.
  • FIG. 41 illustrates a valve prosthesis 10k which is similar to valve prostheses lOg, lOh, lOi, and lOj except that the anchor 15k is configured for facilitating easier insertion through the native valve.
  • the anchor 15k is formed as a coil with a relatively smaller form factor than the other anchors. The smaller radial width of the coil may promote insertion through the native valve while still having sufficient width to capture a necessary number of chordae and/or the native valve leaflets.
  • any of the anchor embodiments described herein may have windings with varying shapes and curvatures.
  • a lower portion of the anchor has windings which curve in a first direction and an upper portion has windings which curve in a second direction (in planes generally perpendicular to a major axis of the frame structure and/or anchor).
  • the second direction is opposite the first direction.
  • the anchor includes a first portion having a first radius of curvature (in a plane generally perpendicular the major axis of the frame structure and/or anchor), and a second portion having a second radius of curvature.
  • the anchor includes a third portion having a third radius of curvature.
  • the anchor includes a fourth portion having a fourth radius of curvature.
  • the anchor includes a plurality of portions each having a unique radius of curvature.
  • the respective radii of curvature are all different.
  • the second radius of curvature is greater than the first, and the third radius of curvature is greater than the second.
  • the radius of curvature of the upper windings is greater than 30mm. In various embodiments, the radius of curvature of the lower windings is greater than lOmm.
  • FIG. 42 illustrates an exemplary modality for attachment of the anchor 15j to a frame structure 12j.
  • the anchor 15j is welded to the frame structure 12j, for example, to one of the struts of the frame structure 12j .
  • one end of the anchor 15j is configured to extend inside the frame structure 12j where it is mechanically fastened.
  • the anchor 15j is fixed to a bottom-most (inferior) end of the frame structure 12j .
  • valve device similar to valve devices lOg, lOh, lOi, lOj, 10k, 101, 10m, etc. will now be described with reference to FIGS. 43A to 43 AF.
  • FIGS. 43 A-43 AF show sequential views of a method of implanting a valve prosthesis 10 using a delivery device 30’.
  • the valve prosthesis 10 may be similar to any of the valve prostheses described herein or understood by one of ordinary skill in the art from the description herein.
  • valve prosthesis 10 may be substantially similar to the valve prosthesis lOg shown in FIGS. 31-35 and may comprise a frame structure 12g and anchor 15g as described herein.
  • the delivery device 30’ may be substantially similar to any of the delivery devices described herein or understood by one of ordinary skill in the art from the description herein.
  • the delivery device 30’ may comprise an inner shaft or delivery tube 52 as described herein.
  • the delivery device 30’ may optionally comprise an outer shaft or outer catheter 50, a guidewire 54, and/or an inflatable balloon 48, in any combination thereof as desired by one of ordinary skill in the art. Not all elements are labeled in each of FIGS. 43 A-43 AF in order to make the illustrations less cluttered and easier to see. [0186] While the method shown in FIGS. 43A-43AF is described in relation to a mitral valve replacement procedure, it will be understood by one of ordinary skill in the art that the methods described herein may be applied to a variety of procedures or anatomical areas, for example other atrioventricular valves of the heart or the like. For example, the methods described herein may be applied to replacement of a diseased aortic valve or tricuspid valve.
  • FIGS. 43A-43C shows various cross-section views of a heart 2 having a diseased mitral valve 4 which may be treated using the devices, systems, and methods described herein.
  • the mitral valve 4 sits between the left atrium 25 and the left ventricle 26 and, when functioning properly, allows blood to flow from the left atrium 25 to the left ventricle 26 while preventing backflow or regurgitation in the reverse direction.
  • FIG. 43 A shows that the native valve leaflets 42 of the diseased mitral valve 4 do not fully prolapse and the patient experiences regurgitation.
  • FIG. 43B shows a cross-sectional view of the heart 2 taken along line A-A, shown in FIG.
  • FIG. 43 A which shows the native valve leaflets 42 of the mitral valve 4 from the viewpoint of the left atrium 25.
  • FIG. 43C shows a cross-sectional view of the heart 2 taken along line B-B, shown in FIG. 43 A, which shows the chordae tendineae 40 of the left ventricle 26.
  • a distal end of the delivery device 30’ may be inserted into the left atrium 25 of the heart 2 via a transseptal puncture as described herein.
  • the distal ends of inner shaft 52 and/or outer sheath 50 may be advanced into the left atrium 25 of the heart 2.
  • the inner shaft 52 may optionally be advanced distally into the left atrium 25 away from the distal end of the outer sheath 50.
  • advancing the inner shaft 52 relative to the outer sheath 50 may aid in deployment and/or placement of the valve prosthesis lOg as described herein.
  • both the inner shaft 52 and the outer sheath 50 may be advanced distally into the left atrium 25 through the transseptal puncture.
  • FIGS. 43E-43H show deployment of the anchor 15g from the distal end of the delivery device 30’.
  • the valve prosthesis lOg may be deployed from an undeployed (for example, compressed) configuration to an expanded configuration within the left atrium 25.
  • At least a portion of the anchor 15g may be deployed from a delivery and/or elongated configuration to a deployed configuration within the heart.
  • anchor 15g may be actuated from an elongated configuration (e.g., from a straightened shape) to a deployed configuration (e.g., a pre-formed shape for implantation, such as a helical or conical shape as illustrated) within the left atrium 25 as described herein.
  • a deployed configuration e.g., a pre-formed shape for implantation, such as a helical or conical shape as illustrated
  • the anchor 15g may be deployed from the inner shaft 52 by pushing the anchor 15g out of the inner shaft 52, releasing the anchor 15g from radial constraint by retracting the outer sheath 50, or the like as described herein.
  • the anchor 15g may be pushed out the inner shaft 52 using a pusher on a proximal handle (not shown) located outside the body.
  • the frame structure 12g may be at least partially deployed from the delivery device 30’ as shown in FIG. 43H so as to place the frame structure 12g within the anchor 15g.
  • the frame structure 12g may be deployed from the delivery device 30’ in either the unexpanded configuration or the expanded configuration, depending on the location of deployment, as will be understood by one of ordinary skill in the art.
  • FIGS. 43I-43K show advancement of the valve prosthesis lOg, with anchor 15g deployed around the unexpanded frame structure 12g, towards the native valve 4 requiring treatment.
  • the distal end of the delivery device 30’ (for example, the distal end of the inner shaft 52 and/or the outer sheath 50) may be steered such that the distal end of the delivery device 30’ points toward the atrial side of the native valve 4 Such steering may occur prior to, during, or after deployment of at least a portion (for example deployment of an anchor 15g) of the valve prosthesis lOg.
  • the distal end of the outer sheath 50 may be steerable.
  • the inner shaft 52 may comprise a joint configured to change an angle of the distal portion of the inner shaft 52 relative to a proximal portion of the inner shaft 52.
  • the inner shaft 52 may be steered by changing the angle of the distal portion of the inner shaft 52 relative to the proximal portion of the inner shaft 52.
  • the angle of the joint may be changed passively or actively.
  • the angle may be selectively controlled by a proximal handle. For example, pull wires or other mechanisms may connect to the joint to controls on the handle.
  • FIGS. 43L-43P show the valve prosthesis lOg being advanced through the native valve 4 by the delivery device 30’ from the left atrium 25 to the left ventricle 26. Advancement of the valve prosthesis lOg and optionally delivery device 30’ through the mitral valve 4 may be facilitated by the natural opening and closing of the valve 4 during the cardiac cycle.
  • the distal end of the delivery device 30’ and/or valve prosthesis lOg may be configured to be advanced from a first side of a native valve to a second side of the native valve.
  • the distal end of the delivery device 30’ and/or valve prosthesis lOg may be advanced from a left atrial side of a mitral valve 4 to a left ventricular side of a mitral valve 4
  • Advancing the anchor 15g may comprise pushing the anchor 15g through the native valve 4
  • advancing the anchor 15g may comprise rotating the anchor 15g through the native valve 4
  • the combination of rotational motion and pushing may facilitate advancement of the device from the first side of the native valve 4 to the second side of the native valve 4
  • FIG. 43M may cause the anchor 15g to be stretched or elongated as shown in FIG. 43M.
  • Rotation of the anchor 15g during advancement may assist with the stretching process by aiding in unwinding the anchor 15g. Additionally, the rotational motion may reduce the risk of the free end 22g of the anchor 15g undesirably engaging other anatomy during insertion through the native leaflets 43.
  • the anchor 15g may be sufficiently elastic so as to enable relatively easy insertion through the native valve 4 and/or reduce the risk of injury to the native leaflets 43.
  • FIGS. 430-43P show the position of the valve prosthesis lOg within the ventricle 26 and, in particular, the position of the anchor 15g relative to the native chordae tendineae 40 and native valve annulus.
  • the anchor 15g may be advanced into the ventricle after being fully deployed from the delivery (e.g., elongated) configuration to the deployed configuration.
  • the anchor 15g may be advanced into the ventricle before being deployed from the delivery (e.g., elongated) configuration to the deployed configuration.
  • FIGS. 43Q-43T show rotation of the valve prosthesis lOg around one or more structures on the ventricular side of the mitral valve 4.
  • the one or more structures may comprise one or more valve leaflets 43 and/or one or more chordae tendineae 40.
  • the valve prosthesis lOg may be rotated to capture and anchor the native chordae 40 and/or native leaflets 43.
  • the free end 22g of the anchor 15g may extend radially outward from the rest of the anchor 15g to facilitate capture of the native structures.
  • the free end 22g of the coil 15g may be rotated around one or more of the chordae tendineae 40 as shown in FIGS. 43Q-43R. Additional rotation of the valve coil 15g may gradually capture additional chordae tendineae 40 as shown in FIGS. 43S-43T.
  • Rotation of the valve prosthesis lOg may be facilitated by the delivery device 30’ described herein.
  • the inner shaft 52 may be rotated and rotational motion may be transmitted from the inner shaft 52 to the valve prosthesis lOg in order to rotate the valve prosthesis lOg around one or more of the structures on the ventricle side of the mitral valve 4 as described herein.
  • FIGS. 43U-43 V show the valve prosthesis lOg wrapped around the captured chordae tendineae 40.
  • the valve prosthesis lOg may be rotated around the chordae tendineae 40 such that the chordae tendineae 40 are pulled inwardly into bunches.
  • the native valve leaflets 43 may also be in communication with the valve prosthesis lOg.
  • the valve prosthesis lOg may be rotated to capture enough chordae tendineae 40 and/or valve leaflets 43 to rigidly anchor the anchor 15g adjacent the native valve annulus.
  • the valve prosthesis lOg may be anchored by wrapping around only a portion of the chordae 40.
  • the prosthesis may be further anchored by expansion of the frame structure 12g within the native valve and against the anchor
  • the frame structure 12g and prosthetic valve segment 14 may be expanded at least partially within the anchor 15g as described herein.
  • the frame structure 12g and the valve segment 14g may be deployed (e.g., expanded) simultaneously.
  • the frame structure 12g and the valve segment 14g may be deployed sequentially, for example by first expanding the frame structure 12g and then receiving the prosthetic valve segment 14g therein.
  • FIGS. 43W-43 AA show expansion of the frame structure 12g within the native valve 4.
  • the frame structure 12g may be expanded within the native valve 4 from an unexpanded configuration to an expanded configuration.
  • at least a portion the frame structure 12g may be expanded within at least a portion of the deployed anchor 15g to anchor the frame structure 12g to the native valve 4.
  • the frame structure 12g may comprise an expandable stent.
  • the frame structure 12 of valve prosthesis lOg may be self-expandable.
  • the frame structure 12 of valve prosthesis lOg may be balloon-expandable.
  • the delivery device 30’ may comprise a balloon 48g which may be disposed within the valve prosthesis lOg in order to expand the valve prosthesis lOg.
  • the balloon 48g may be positioned within at least a portion of the valve prosthesis lOg, for example within at least a portion of frame structure 12 in an uninflated configuration, as shown in FIG. 43W, prior to being inflated.
  • the inflatable balloon 48g may, for example, be disposed within the inner shaft 52 or outer sheath 50 while the anchor 15g is being positioned adjacent the native valve 4 and then advanced therefrom (or the inner shaft 52 or outer sheath 50 is retracted therefrom) to be positioned within the frame structure 12g.
  • FIGS. 43X-43 Y show the frame structure 12g partially expanded by partially-inflated balloon 48g.
  • the frame structure 12g may be partially expanded towards the anchor 15g in order to capture the chordae tendineae 40 therebetween.
  • the chordae tendineae 40 may be sandwiched between the anchor 15g and the frame structure 12g. The frame structure 12g and anchor 15g may thus be anchored to the chordae tendineae 40.
  • the valve prosthesis lOg may then be released from the delivery device 30’.
  • releasing the valve prosthesis lOg may comprise releasing the anchor 15g and/or the frame structure 12g.
  • Releasing the valve prosthesis lOg from the delivery device 30’ may comprise expanding the valve prosthesis lOg from the unexpanded configuration to the expanded configuration.
  • expanding the frame structure 12g and releasing the frame structure 12g may occur simultaneously as described herein.
  • the frame structure 12g may be released prior to or after being expanded.
  • FIGS. 43AB-43AD show deflation of the balloon 48g (FIG. 43 AB), retraction of the balloon 48g into inner shaft 52 (FIG. 43 AC), and removal of the delivery device 30’ from the heart 2 (FIG. 43 AD).
  • the inflatable balloon 48g may be deflated.
  • the balloon 48g may be retracted back into the delivery device 30’, for example into inner shaft 52.
  • the delivery device 30’ may then be removed from the heart 2.
  • FIGS. 43AE-43AF show the valve prosthesis lOg fully expanded with the native valve leaflets 42 and chordae tendineae 40 captured between the frame structure 12g and the anchor 15g.
  • the valve prosthesis lOg may comprise one or more valve segments 14g disposed therein to replace the native valve leaflets 42.
  • steps above show a method of deploying a valve prosthesis 10 within a native valve 4 in accordance with embodiments
  • a person of ordinary skill in the art will recognize many variations based on the teaching described herein.
  • the steps may be completed in a different order. Steps may be added or deleted. Some of the steps may comprise sub-steps. Many of the steps may be repeated as often as necessary to assemble at least a part of an article.
  • deploying the valve prosthesis 10 may occur in multiple steps such that a portion of the valve prosthesis 10 (e.g., anchor 15) may be deployed before another portion the valve prosthesis 10 (e.g., frame structure 12).
  • deploying the anchor 15 may occur in multiple steps such that a portion of the anchor 15 may be deployed before being advanced through the native valve 4 and another portion of the anchor 15 may be deployed after being advanced through the native valve 4.
  • the delivery device 30 may be advanced from the left atrium 25 to the left ventricle 26 with the valve prosthesis 10 undeployed.
  • the frame structure may 12 be self-expanding and the balloon 48 may not be necessary for expansion of the frame structure 12.
  • the anchor 15 may be released after the frame structure 12 has been expanded within it.
  • any of the valve prostheses described herein may be deployed to replace a diseased mitral valve.
  • the first side of the native valve may comprise a left atrium and the second side of the native valve may comprise a left ventricle.
  • any of the valve prostheses described herein may be deployed to replace a diseased tricuspid valve.
  • the first side of the native valve may comprise a right atrium and the second side of the native valve may comprise a right ventricle.
  • any of the valve prostheses described herein may be deployed to replace a diseased aortic valve.
  • the first side of the native valve may comprise a left ventricle and the second side of the native valve may comprise an aorta.
  • FIGS. 43 A-43AF refer to delivery of valve prosthesis lOg, similar steps may be used for delivery of any of the valve prosthesis described herein.
  • FIGS. 44-49 show another exemplary valve prosthesis device 101 which is similar to valve prosthesis devices 10 and lOg-lOj except that the frame structure 121 is self-expanding.
  • the valve prosthesis 101 includes a helical coil 201 similar to helical coils 20 and 20g.
  • Frame structure 121 is similar frame structures 12 and 12g-12j except that it is configured to expand to the deployed shape upon removal of the sheath of the delivery device.
  • the frame structure 121 is shown in the drawings in both the collapsed and deployed shapes for ease of understanding.
  • the exemplary frame structure 121 may be formed of a shape memory material or any material having superelastic properties.
  • the exemplary frame structure 121 is formed with a diamond pattern, but one of ordinary skill in the art will appreciate from the description herein that many other patterns and configurations will be suitable.
  • the exemplary frame structure 121 is configured to expand in a similar manner to a self-expanding stent or scaffold.
  • FIGS. 48 and 49 show the exemplary valve prosthesis device 101 loaded on an exemplary delivery tool or catheter 301.
  • the manner of implanting the valve prosthesis device 101 is similar to the method described herein with respect to valve device lOg except that the frame structure 121 is configured to expand on its own rather than under the force of a balloon.
  • the frame structure 121 and prosthetic valve segment can be easily deployed in one shot after the coil 151 has been anchored to one or more structures adjacent the native valve. This may reduce the time of the implantation procedure and may eliminate complications like a system for deploying, inflating, and deflating the balloon used in a balloon-expandable embodiment.
  • the valve prosthesis device and implant method described herein in accordance with the present disclosure may provide many advantages as will be understood by one of ordinary skill in the art.
  • the overall device and method may provide a simpler way to approach the native valve compared to existing devices.
  • the system may enable a transcatheter approach through the septal wall compared to more invasive transapical approaches.
  • the device may provide a consistent and relatively easy mechanism for anchoring to the native valve. Clinicians need only use the common technique of inserting the device through the valve and then rotating the anchor.
  • the coil may provide preliminary anchoring in the native valve. If desired, the clinician can readjust the anchor and/or retrieve the anchor (e.g. by counterrotation). The device is then easily set by expanding within the native valve leaflets.
  • the device and methods in accordance with the present disclosure may also address unmet clinical needs with atrioventricular repair and replacement.
  • Existing devices face challenges with the complex anatomy of the mitral and tricuspid valves, for example.
  • the present disclosures address these complications by reshaping the native valve annulus to a conventional round shape and providing a robust, yet simple, anchoring mechanism.
  • FIG. 50 shows a side view of a valve prosthesis system 100m comprising a frame structure l2m and an anchor 15m loaded on a distal end of a delivery device 30m with the anchor 15m in an elongated delivery configuration.
  • FIG. 51 shows a side view of the valve prosthesis system 100m of FIG. 50 with the anchor 15m in a deployed configuration.
  • the valve prosthesis may be substantially similar to any of the valve prostheses described herein except that the anchor may be detachably coupled to the delivery device during delivery as described herein instead of the frame structure.
  • the frame structure may be expanded inside the anchor without altering the shape or position of the deployed anchor during expansion, which may lead to a better connection between the anchor and the frame structure adjacent the native valve than may have been possible if expansion of the frame structure caused deflection or movement of the deployed anchor.
  • the frame structure 12m may have an unexpanded (for example, a compressed configuration) and an expanded configuration (not shown).
  • the frame structure l2m is shown in the unexpanded configuration.
  • the anchor 15m may comprise a wire 20m having a free end 22m.
  • the anchor 15m may be configured to be fully advanced from a first side of a native valve in a patient (e.g. an atrial side) to a second side of the native valve (e.g., into a ventricle of the heart) and anchor the frame structure 12m to the native valve when the frame structure 12m is in the expanded configuration adjacent the native valve.
  • the delivery device 30m may comprise an outer sheath (e.g.
  • an outer catheter not shown
  • an inner shaft 52 e.g., a delivery tube
  • a guidewire 54 disposed within a lumen of the inner shaft 52.
  • a proximal end 57 of the anchor 15m may be detachably coupled to the inner shaft 52 during delivery to the native valve.
  • the outer sheath may be steerable.
  • the anchor 15m may comprise an elongated delivery configuration (shown in FIG.
  • the anchor 15m may be configured to be actuated from the delivery configuration to the deployed configuration adjacent the native valve.
  • the anchor 15m may be self-expanding and may move to the deployed configuration as it is removed from the delivery sheath.
  • the anchor may be configured to self-assemble when it is deployed in the heart cavity (e.g. in a left atrium). Retraction of the guidewire 54 into the lumen of the inner shaft 52 may actuate the anchor l5m into the deployed configuration.
  • the anchor 15m may be maintained in the elongated configuration by radial constriction from the outer sheath.
  • Advancement of the inner shaft 52 out of the lumen of the outer sheath may actuate the anchor 15m into the deployed configuration.
  • a proximal end 57 of the anchor 15m may be detachably coupled to the inner shaft 52 of the delivery device 30m.
  • the proximal end 57 may be configured to remain engaged with the inner shaft 52 after being actuated from the elongated configuration to the deployed
  • the frame structure 12m may be configured to remain in its unexpanded configuration while the anchor 15m is in the deployed configuration.
  • the proximal end 57 of the anchor 15m may be detachably coupled to the inner shaft 52 of the delivery device 30m by radial constriction from the outer sheath. Retraction of the outer sheath away from the proximal end 57 of the anchor 15m may detach the anchor 15m from the delivery device 30 Alternatively, or in combination, the proximal end 57 of the anchor may be detachably coupled to the inner shaft 52 of the delivery device 30m by an attachment element 58. Alternatively, or in combination, the proximal end 57 of the anchor 15m may be detachably coupled to the inner shaft 52 of the delivery device 30m by a weak adhesive.
  • the anchor 15m may be configured to rotate when the inner shaft 52 is rotated.
  • Rotation of the anchor may aid in advancement of the anchor to the second side of the native valve.
  • rotation of the anchor for example a wire 20m comprising a free end 22m, may aid in capture of one or more structures on the second side of the native valve by the free end 22m as described herein.
  • the anchor 15m may maintain its position relative to the native valve and provide an anchor point for the frame structure 12m when in the expanded configuration.
  • the frame structure 12m may comprise an unexpanded configuration and an expanded configuration as described herein.
  • the expanded configuration may have a generally tubular expanded shape.
  • the frame structure 12m may be configured for expanding within the native valve of the patient.
  • the unexpanded configuration may be sized and dimensioned for percutaneous insertion and the expanded configuration may be sized and dimensioned for implantation in the native valve of the patient.
  • the frame structure 12m may comprise a first and second opposite ends, the first end extending above a native valve and the second end extending below the native valve when the frame structure 12m is anchored to the native valve.
  • the frame structure 12m may be configured to sit entirely below the native valve when the frame structure 12m is anchored to the native valve.
  • the frame structure may comprise an expanded outer periphery in the expanded configuration and a compressed outer periphery when subject to an external radial force in the unexpanded configuration.
  • the compressed outer periphery may be smaller in diameter than the expanded outer periphery.
  • the frame structure 12m may be balloon-expandable, self-expanding, or otherwise expansible as will be understood by one of ordinary skill in the art from the description herein.
  • the delivery system 30m may comprise an inflatable balloon (not shown) disposed within the frame structure 12m. Inflation of the balloon may cause expansion of the frame structure 12m as described herein.
  • the frame structure 12m may be maintained in the unexpanded configuration by radial constriction from the outer sheath of the delivery device 30m. Advancement of the inner shaft out of the lumen of the outer sheath may actuate the frame structure into the expanded configuration.
  • the frame structure 12m may be detachably coupled to the delivery device 30m in the unexpanded configuration during delivery to the native valve. Expansion of the frame structure 12m to the expanded configuration may detach the frame structure from the delivery device.
  • the frame structure 12m may be expanded within at least a portion of the deployed anchor 15m to anchor the frame structure 12m to the native valve.
  • the anchor 15m may be deployed such that it captures one or more structures therein, for example one or more chordae tendineae and/or one or more valve leaflets. Expansion of the frame structure 12m, or a portion thereof, within the anchor 15m may compress the capture structures between the frame structure 12m and the anchor 15m to anchor the frame structure 12m in place.
  • the guidewire 54 may comprise a nosecone 54a configured to facilitate guidance of the guidewire to the native valve.
  • the wire 20m may comprise a helical wire in the deployed configuration.
  • the free end 22m of the helical wire 20m may extend radially outward from the frame structure 12m, and in particular from the remainder of the wire 20m.
  • the helical wire 20m may have a generally tubular shape.
  • the free end 22m of the helical wire 20m may extend radially outward from the tubular shape.
  • the helical wire 20m may have a generally frustoconical shape.
  • the free end 22m of the helical wire 20m may extend radially outward from the frustoconical shape.
  • the helical wire 20m may have a generally cylindrical shape.
  • the free end 22m of the helical wire 20m may extend radially outward from the cylindrical shape.
  • the free end 22m may be configured to encircle a larger radius than the main coils of the helical wire 20m. The larger diameter may facilitate capturing of one or more structures, for example the valve leaflets of the chordal tendineae within the sweep of the free end 22m when rotated as described herein.
  • the anchor 15m may comprise a first portion comprising the helical wire 20m and another portion.
  • the anchor 15m may comprise a first portion comprising the helical wire 20m and another portion.
  • the anchor 15m may comprise a plurality of helical wires 20m.
  • the anchor l5m may comprise at least two helical wires 20m having the same or different diameters.
  • the anchor 15m may comprise at least two helical wires 20m having the same or different winding pitches.
  • the free end 22m of the wire 20m may be sized and dimensioned for insertion through the native valve, for example through tissue at or near a commissure of the native valve or through the valve opening itself.
  • the free end 22m of the wire 20m may comprise an atraumatic tip to avoid reduce risk of injury to the native valve tissue and leaflets.
  • the free end may comprise a blunt end, a ball tip, a curved tip (e.g. J-tip or pigtail), or other atraumatic shapes.
  • the free end 22m of the wire 20m may be configured for piercing tissue.
  • Wire 20m may be formed of a material having sufficient rigidity to hold a predetermined shape.
  • the wire may, for example, be formed of a shape memory material (e.g. NiTi).
  • NiTi shape memory material
  • the end portion only needs sufficient rigidity to hold its shape and will deform under a load.
  • the end portion may be configured with a similar rigidity to a guidewire, or slightly stiff er.
  • the frame structure 12m may be configured like a stent.
  • the frame structure 12m may, for example, comprise a scaffold in a diamond pattern formed from a shape memory material (e.g. NiTi).
  • a shape memory material e.g. NiTi
  • the frame structure 12m may be formed of a polymer of sufficient elasticity.
  • the frame structure 12m may be formed of a combination of metal and polymer, such as metal (e.g. shape memory material) covered in polymer.
  • the frame structure 12m may include a variety of patterns besides diamond shapes.
  • the frame structure 12m may comprise a valve segment (not shown) disposed therein.
  • valve segment is used somewhat interchangeably with prosthetic valve leaftlet and generally refers to the prosthetic leaflets and frame.
  • “prosthetic valve” may refer to all manner of prosthetic and artificial replacement valves including tissue (biological valves), tissue- engineered valves, polymer valves (e.g. biodegradable polymer valves), and even certain mechanical valves.
  • the valve segment can be similar to existing transcatheter valves.
  • the valve segment can be similar to existing surgical tissue valves, and mechanical valves. At least a portion of the valve segment may be positioned within at least a portion of the frame structure.
  • the valve segment may include leaflets formed of multi-layered materials for preferential function.
  • the valve segment may comprise at least one leaflet having an inner layer and an outer layer.
  • the valve segment may be attached to a valve structure which is in turn connected to the frame structure 12m.
  • the valve structure may be connected to the frame structure 12m before or after the frame structure l2m has been deployed adjacent a native valve.
  • the valve segment may be attached directly to the frame structure 12m.
  • the frame structure 12m may be attached to a leaflet, for example an outer layer of a leaflet, at one or more ends of the frame structure 12m.
  • the frame structure 12m may be attached to a leaflet, for example an outer layer of a leaflet, at one or more intermediate portions of the frame structure 12m.
  • the valve segment may comprise a plurality of leaflets.
  • the valve segment may comprise a biocompatible one-way valve. Flow in one direction may cause the leaflet(s) to deflect open and flow in the opposite direction may cause the leaflet(s)
  • any of the valve prostheses described herein may comprise any of the frame structure shapes, frame structure designs, frame structure materials, anchor shapes, anchor windings, anchor materials, free end tips, leaflet(s) configurations, or any other of the variable features described herein in any combination thereof as desired.
  • the distal end of the delivery device 30m may be configured to be advanced from a first side of a native valve to a second side of the native valve.
  • the distal end of the delivery device 30m may be advanced from a left atrial side of a mitral valve to a left ventricular side of a mitral valve.
  • the distal end of the delivery device 30m may be transseptally inserted into the left atrium of the heart prior to advancement into the left ventricle.
  • the distal end of the delivery device 30m may be steerable such that it is positionable to point towards the first side of the native valve before being advanced to the second side of the native valve.
  • the anchor 15m may be fully deployed on the second side of the native valve.
  • Fully deploying the anchor 15m may comprise actuating the anchor 15m from an elongated configuration to a deployed configuration as shown in FIG. 51
  • fully deploying the anchor 15m may comprise actuating the anchor 15m from an elongated configuration to a deployed configuration on the first side of the native valve (e.g., in the left atrium) and advancing the anchor 15m, in the deployed
  • Advancing the anchor 15m may comprise pushing the anchor 15m through the native valve as described herein. Advancing the anchor 15m may further comprise rotating the anchor 15m through the native valve.
  • fully deploying the anchor 15m may comprise positioning the anchor 15m such that it is located only on the second side of the native valve.
  • the anchor 15m may be actuated from the delivery
  • the anchor 15m may be fully deployed in a left atrium of a heart prior to being advanced to a left ventricle of the heart as described herein.
  • the free end 22m of the deployed anchor 15m may optionally be rotated around one or more structures on the second side of the native valve.
  • the one or more structures may comprise one or more valve leaflets of the native valve.
  • the one or more structures may comprise one or more chordae of the left ventricle.
  • the anchor 15m may then be released from the distal end of the delivery device 30m.
  • the anchor 15m may be released from the distal end of the delivery device 30m on the second side of the native valve.
  • the frame structure 12m may be expanded within the native valve from an
  • the frame structure 12m may be released from the distal end of the delivery device 30m. In some embodiments, at least a portion the frame structure 12m may be expanded within at least a portion of the deployed anchor to anchor 15m the frame structure 12m to the native valve.
  • expanding the frame structure and releasing the frame structure may occur simultaneously.
  • the delivery device 30m may be retracted from the native valve.
  • Additional information about the frame structure may be found in U.S. Provisional Applications No. 62/720,853, 16/546,901, 62/748,162, 62/784,280, 62/813,963, 62/815,791, 62/820,570, 62/828,835, 62/833,425, 62/833,430, 62/851,245, 62/872,016, 62/873,454,
  • valve prosthesis may be substantially similar to any of the valve prostheses described in U.S. Provisional Applications No. 62/720,853, 16/546,901, 62/748,162,
  • references to a structure or feature that is disposed“adjacent” another feature may have portions that overlap or underlie the adjacent feature.
  • Terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
  • the singular fonns“a”,“an” and“the” are intended to include the plural forms as well, unless the context clearly indicates otherwise.
  • the terms“comprises” and/or “comprising,” when used in this specification, specify the presence of stated features, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, steps, operations, elements, components, and/or groups thereof.
  • the term“and/or” includes any and all combinations of one or more of the associated listed items and may be abbreviated as“/”.
  • spatially relative terms such as“under”,“below”,“lower”,“over”,“upper” and the like, may be used herein for ease of description to describe one element or feature’s relationship to another element(s) or feature(s) as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if a device in the figures is inverted, elements described as“under” or“beneath” other elements or features would then be oriented“over” the other elements or features. Thus, the exemplary term“under” can encompass both an orientation of over and under.
  • the device may be otherwise oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.
  • the terms“upwardly”,“downwardly”,“vertical”,“horizontal” and the like are used herein for the purpose of explanation only unless specifically indicated otherwise.
  • first feature/element discussed below could be termed a second feature/element, and similarly, a second feature/element discussed below could be termed a first feature/element without departing from the teachings of the present disclosure.
  • the word“comprise”, and variations such as“comprises” and“comprising” means various components can be co-jointly employed in the methods and articles (e.g., compositions and apparatuses including device and methods).
  • the term“comprising” will be understood to imply the inclusion of any stated elements or steps but not the exclusion of any other elements or steps.
  • a numeric value may have a value that is +/- 0.1% of the stated value (or range of values), +/- 1% of the stated value (or range of values), +/- 2% of the stated value (or range of values), +/- 5% of the stated value (or range of values), +/- 10% of the stated value (or range of values), etc.
  • Any numerical values given herein should also be understood to include about or approximately that value, unless the context indicates otherwise. For example, if the value“10” is disclosed, then“about 10” is also disclosed. Any numerical range recited herein is intended to include all sub-ranges subsumed therein.

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  • Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Prostheses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
PCT/US2019/055049 2018-10-05 2019-10-07 Prosthetic cardiac valve devices, systems, and methods Ceased WO2020073050A1 (en)

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CN201980079729.3A CN113260337A (zh) 2018-10-05 2019-10-07 人工心脏瓣膜装置、系统和方法
JP2021518574A JP7528068B2 (ja) 2018-10-05 2019-10-07 人工心弁デバイス、システム、および方法
CA3115270A CA3115270A1 (en) 2018-10-05 2019-10-07 Prosthetic cardiac valve devices, systems, and methods
AU2019353156A AU2019353156B2 (en) 2018-10-05 2019-10-07 Prosthetic cardiac valve devices, systems, and methods
EP19869666.8A EP3860519A4 (en) 2018-10-05 2019-10-07 HEART VALVE PROSTHESIS, SYSTEMS AND PROCEDURES
AU2025220804A AU2025220804A1 (en) 2018-10-05 2025-08-22 Prosthetic cardiac valve devices, systems, and methods

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US201862742043P 2018-10-05 2018-10-05
US62/742,043 2018-10-05
US201862755996P 2018-11-05 2018-11-05
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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021183610A1 (en) 2020-03-13 2021-09-16 Shifamed Holdings, Llc Prosthetic cardiac valve devices, systems, and methods
WO2021207545A1 (en) 2020-04-08 2021-10-14 Shifamed Holdings, Llc Valve delivery system
US11471282B2 (en) 2019-03-19 2022-10-18 Shifamed Holdings, Llc Prosthetic cardiac valve devices, systems, and methods
WO2022262117A1 (zh) * 2021-06-17 2022-12-22 上海臻亿医疗科技有限公司 一种心脏瓣膜的锚固装置
US11672657B2 (en) 2018-10-05 2023-06-13 Shifamed Holdings, Llc Prosthetic cardiac valve devices, systems, and methods
US11833034B2 (en) 2016-01-13 2023-12-05 Shifamed Holdings, Llc Prosthetic cardiac valve devices, systems, and methods
US12053371B2 (en) 2020-08-31 2024-08-06 Shifamed Holdings, Llc Prosthetic valve delivery system
US12201521B2 (en) 2021-03-22 2025-01-21 Shifamed Holdings, Llc Anchor position verification for prosthetic cardiac valve devices
US12290456B2 (en) 2018-08-21 2025-05-06 Shifamed Holdings, Llc Prosthetic cardiac valve devices, systems, and methods
US12329635B2 (en) 2020-12-04 2025-06-17 Shifamed Holdings, Llc Flared prosthetic cardiac valve delivery devices and systems
US12403008B2 (en) 2018-10-19 2025-09-02 Shifamed Holdings, Llc Adjustable medical device

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2741711B1 (en) 2011-08-11 2018-05-30 Tendyne Holdings, Inc. Improvements for prosthetic valves and related inventions
JP6329570B2 (ja) * 2013-03-14 2018-05-23 ４テック インコーポレイテッド テザーインターフェースを有するステント
WO2015124631A2 (en) * 2014-02-18 2015-08-27 Medtentia International Ltd Oy Medical device for a cardiac valve implant
WO2020163031A1 (en) * 2019-02-04 2020-08-13 Edwards Lifesciences Corporation Guide wire apparatuses and methods
US20220054261A1 (en) * 2019-04-12 2022-02-24 Shifamed Holdings, Llc Minimal frame prosthetic cardiac valve delivery devices, systems, and methods
EP3972534A4 (en) 2019-05-22 2023-08-02 Triflo Cardiovascular Inc. HEART VALVE RETENTION DEVICE
EP4114313B1 (en) * 2020-03-03 2025-10-01 Shifamed Holdings, LLC Prosthetic cardiac valve devices, systems
AU2021306283A1 (en) * 2020-07-07 2023-02-09 Shifamed Holdings, Llc Valve delivery system
WO2022047095A1 (en) * 2020-08-31 2022-03-03 Shifamed Holdings, Llc Anchor for prosthetic cardiac valve devices
WO2022047274A1 (en) * 2020-08-31 2022-03-03 Shifamed Holdings, Llc Prosthetic cardiac valve delivery systems and methods
WO2022066720A1 (en) * 2020-09-22 2022-03-31 Shifamed Holdings, Llc Prosthetic cardiac valve sensor devices, systems, and methods with imaging
EP4395866A4 (en) * 2021-09-01 2025-07-16 Shifamed Holdings Llc GUIDE CATHETER FOR PROSTHETIC HEART VALVE DELIVERY SYSTEMS
JP2024538089A (ja) 2021-10-14 2024-10-18 シファメド・ホールディングス・エルエルシー 人工心臓弁送達システムおよび使用方法
CN114869545A (zh) * 2022-03-31 2022-08-09 上海纽脉医疗科技股份有限公司 一种瓣叶捕获装置、系统及人工心脏瓣膜
CN115501000B (zh) * 2022-08-24 2026-01-23 上海汇禾医疗科技有限公司 导引装置及人工瓣膜锚定方法
WO2024187023A2 (en) * 2023-03-07 2024-09-12 Shifamed Holdings, Llc Prosthetic cardiac valve device, systems, and methods

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8449599B2 (en) * 2009-12-04 2013-05-28 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
WO2015023579A1 (en) 2013-08-12 2015-02-19 Mitral Valve Technologies Sa Apparatus and methods for implanting a replacement heart valve
WO2015127264A1 (en) * 2014-02-20 2015-08-27 Mitral Valve Technologies Sarl Coiled anchor for supporting prosthetic heart valve, prosthetic heart valve, and deployment device
US20170128203A1 (en) * 2015-11-06 2017-05-11 Micor Limited Mitral valve prosthesis
US20180228610A1 (en) * 2017-02-10 2018-08-16 Millipede, Inc. Implantable device and delivery system for reshaping a heart valve annulus

Family Cites Families (660)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3230858C2 (de) 1982-08-19 1985-01-24 Ahmadi, Ali, Dr. med., 7809 Denzlingen Ringprothese
US4725274A (en) 1986-10-24 1988-02-16 Baxter Travenol Laboratories, Inc. Prosthetic heart valve
US5002563A (en) 1990-02-22 1991-03-26 Raychem Corporation Sutures utilizing shape memory alloys
US5370685A (en) 1991-07-16 1994-12-06 Stanford Surgical Technologies, Inc. Endovascular aortic valve replacement
US5327905A (en) 1992-02-14 1994-07-12 Boaz Avitall Biplanar deflectable catheter for arrhythmogenic tissue ablation
US5356424A (en) 1993-02-05 1994-10-18 American Cyanamid Co. Laparoscopic suturing device
US5873835A (en) 1993-04-29 1999-02-23 Scimed Life Systems, Inc. Intravascular pressure and flow sensor
US5582616A (en) 1994-08-05 1996-12-10 Origin Medsystems, Inc. Surgical helical fastener with applicator
JPH08131551A (ja) 1994-11-04 1996-05-28 Yoshimasa Obayashi 血栓除去用カテーテル
US5997526A (en) 1996-03-25 1999-12-07 The Uab Research Foundation Shape memory catheter
US7238197B2 (en) 2000-05-30 2007-07-03 Devax, Inc. Endoprosthesis deployment system for treating vascular bifurcations
US5779669A (en) 1996-10-28 1998-07-14 C. R. Bard, Inc. Steerable catheter with fixed curve
US5716397A (en) 1996-12-06 1998-02-10 Medtronic, Inc. Annuloplasty device with removable stiffening element
EP0850607A1 (en) 1996-12-31 1998-07-01 Cordis Corporation Valve prosthesis for implantation in body channels
WO1998029030A1 (en) 1997-01-03 1998-07-09 Biosense Inc. Pressure-sensing stent
US5944690A (en) 1997-03-17 1999-08-31 C.R. Bard, Inc. Slidable control mechanism for steerable catheter
US5755601A (en) 1997-03-17 1998-05-26 Brunswick Corporation Brake system for personal watercraft
US6530952B2 (en) 1997-12-29 2003-03-11 The Cleveland Clinic Foundation Bioprosthetic cardiovascular valve system
US6048339A (en) 1998-06-29 2000-04-11 Endius Incorporated Flexible surgical instruments with suction
DE69914609T2 (de) 1998-08-19 2005-01-05 Cook Inc., Bloomington Vorgeformter Führungsdraht
DE19857887B4 (de) 1998-12-15 2005-05-04 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verankerungsstütze für eine Herzklappenprothese
US6425916B1 (en) 1999-02-10 2002-07-30 Michi E. Garrison Methods and devices for implanting cardiac valves
US20040044350A1 (en) 1999-04-09 2004-03-04 Evalve, Inc. Steerable access sheath and methods of use
US7811296B2 (en) 1999-04-09 2010-10-12 Evalve, Inc. Fixation devices for variation in engagement of tissue
US8216256B2 (en) 1999-04-09 2012-07-10 Evalve, Inc. Detachment mechanism for implantable fixation devices
US10327743B2 (en) 1999-04-09 2019-06-25 Evalve, Inc. Device and methods for endoscopic annuloplasty
US7666204B2 (en) 1999-04-09 2010-02-23 Evalve, Inc. Multi-catheter steerable guiding system and methods of use
ATE484241T1 (de) 1999-04-09 2010-10-15 Evalve Inc Verfahren und vorrichtung zur herzklappenreperation
US6752813B2 (en) 1999-04-09 2004-06-22 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
US6790229B1 (en) 1999-05-25 2004-09-14 Eric Berreklouw Fixing device, in particular for fixing to vascular wall tissue
ATE342089T1 (de) 1999-06-02 2006-11-15 Boston Scient Ltd Arzneimittelabgabevorrichtungen
DE19933278C2 (de) 1999-07-14 2001-11-29 Biotronik Mess & Therapieg Steuerbarer Katheter
US8579966B2 (en) 1999-11-17 2013-11-12 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US6458153B1 (en) 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US6797002B2 (en) 2000-02-02 2004-09-28 Paul A. Spence Heart valve repair apparatus and methods
US6419695B1 (en) 2000-05-22 2002-07-16 Shlomo Gabbay Cardiac prosthesis for helping improve operation of a heart valve
US6869444B2 (en) 2000-05-22 2005-03-22 Shlomo Gabbay Low invasive implantable cardiac prosthesis and method for helping improve operation of a heart valve
US6419696B1 (en) 2000-07-06 2002-07-16 Paul A. Spence Annuloplasty devices and related heart valve repair methods
US7077861B2 (en) 2000-07-06 2006-07-18 Medtentia Ab Annuloplasty instrument
US6974476B2 (en) * 2003-05-05 2005-12-13 Rex Medical, L.P. Percutaneous aortic valve
US8202315B2 (en) 2001-04-24 2012-06-19 Mitralign, Inc. Catheter-based annuloplasty using ventricularly positioned catheter
FR2826863B1 (fr) 2001-07-04 2003-09-26 Jacques Seguin Ensemble permettant la mise en place d'une valve prothetique dans un conduit corporel
EP1432369B1 (en) 2001-08-31 2008-02-27 Mitral Interventions Apparatus for valve repair
US20060052821A1 (en) 2001-09-06 2006-03-09 Ovalis, Inc. Systems and methods for treating septal defects
US6893460B2 (en) 2001-10-11 2005-05-17 Percutaneous Valve Technologies Inc. Implantable prosthetic valve
US6908478B2 (en) 2001-12-05 2005-06-21 Cardiac Dimensions, Inc. Anchor and pull mitral valve device and method
US7201771B2 (en) 2001-12-27 2007-04-10 Arbor Surgical Technologies, Inc. Bioprosthetic heart valve
US8308797B2 (en) 2002-01-04 2012-11-13 Colibri Heart Valve, LLC Percutaneously implantable replacement heart valve device and method of making same
WO2003105670A2 (en) 2002-01-10 2003-12-24 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
AU2003225766A1 (en) 2002-03-11 2003-09-29 Wardle, John, L. Surgical coils and methods of deploying
AU2003247526A1 (en) 2002-06-12 2003-12-31 Mitral Interventions, Inc. Method and apparatus for tissue connection
US7753924B2 (en) 2003-09-04 2010-07-13 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
US8641727B2 (en) 2002-06-13 2014-02-04 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US7594903B2 (en) 2002-09-25 2009-09-29 Abbott Cardiovascular Systems Inc. Controlling shaft bending moment and whipping in a tendon deflection or other tendon system
US20050119735A1 (en) 2002-10-21 2005-06-02 Spence Paul A. Tissue fastening systems and methods utilizing magnetic guidance
JP2004154177A (ja) 2002-11-01 2004-06-03 Olympus Corp 内視鏡
US8551162B2 (en) 2002-12-20 2013-10-08 Medtronic, Inc. Biologically implantable prosthesis
US7175656B2 (en) 2003-04-18 2007-02-13 Alexander Khairkhahan Percutaneous transcatheter heart valve replacement
US10631871B2 (en) 2003-05-19 2020-04-28 Evalve, Inc. Fixation devices, systems and methods for engaging tissue
US20070255396A1 (en) 2003-06-20 2007-11-01 Medtronic Vascular, Inc. Chrodae Tendinae Girdle
JP2007524460A (ja) 2003-06-25 2007-08-30 ジョージア テック リサーチ コーポレイション 弁輪形成チェーン
AU2004258942B2 (en) 2003-07-21 2009-12-03 The Trustees Of The University Of Pennsylvania Percutaneous heart valve
US7160322B2 (en) 2003-08-13 2007-01-09 Shlomo Gabbay Implantable cardiac prosthesis for mitigating prolapse of a heart valve
US8021421B2 (en) 2003-08-22 2011-09-20 Medtronic, Inc. Prosthesis heart valve fixturing device
EP1689329A2 (en) 2003-11-12 2006-08-16 Medtronic Vascular, Inc. Cardiac valve annulus reduction system
US20050165344A1 (en) 2003-11-26 2005-07-28 Dobak John D.Iii Method and apparatus for treating heart failure
US8343213B2 (en) 2003-12-23 2013-01-01 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US8603160B2 (en) 2003-12-23 2013-12-10 Sadra Medical, Inc. Method of using a retrievable heart valve anchor with a sheath
US7381219B2 (en) 2003-12-23 2008-06-03 Sadra Medical, Inc. Low profile heart valve and delivery system
US8579962B2 (en) 2003-12-23 2013-11-12 Sadra Medical, Inc. Methods and apparatus for performing valvuloplasty
US7329279B2 (en) 2003-12-23 2008-02-12 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US7166127B2 (en) 2003-12-23 2007-01-23 Mitralign, Inc. Tissue fastening systems and methods utilizing magnetic guidance
US9005273B2 (en) 2003-12-23 2015-04-14 Sadra Medical, Inc. Assessing the location and performance of replacement heart valves
US20050137696A1 (en) 2003-12-23 2005-06-23 Sadra Medical Apparatus and methods for protecting against embolization during endovascular heart valve replacement
US7959666B2 (en) 2003-12-23 2011-06-14 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US7824442B2 (en) 2003-12-23 2010-11-02 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US7445631B2 (en) 2003-12-23 2008-11-04 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US8840663B2 (en) 2003-12-23 2014-09-23 Sadra Medical, Inc. Repositionable heart valve method
US8287584B2 (en) 2005-11-14 2012-10-16 Sadra Medical, Inc. Medical implant deployment tool
US20050137691A1 (en) 2003-12-23 2005-06-23 Sadra Medical Two piece heart valve and anchor
US20050137686A1 (en) 2003-12-23 2005-06-23 Sadra Medical, A Delaware Corporation Externally expandable heart valve anchor and method
US20050137694A1 (en) 2003-12-23 2005-06-23 Haug Ulrich R. Methods and apparatus for endovascularly replacing a patient's heart valve
US7780725B2 (en) 2004-06-16 2010-08-24 Sadra Medical, Inc. Everting heart valve
US7748389B2 (en) 2003-12-23 2010-07-06 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US20050137687A1 (en) 2003-12-23 2005-06-23 Sadra Medical Heart valve anchor and method
US8828078B2 (en) 2003-12-23 2014-09-09 Sadra Medical, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US7824443B2 (en) 2003-12-23 2010-11-02 Sadra Medical, Inc. Medical implant delivery and deployment tool
US9526609B2 (en) 2003-12-23 2016-12-27 Boston Scientific Scimed, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US8182528B2 (en) 2003-12-23 2012-05-22 Sadra Medical, Inc. Locking heart valve anchor
US8500774B2 (en) 2004-01-22 2013-08-06 Rex Medical, L.P. Vein filter
US7597711B2 (en) 2004-01-26 2009-10-06 Arbor Surgical Technologies, Inc. Heart valve assembly with slidable coupling connections
EP1718246A4 (en) 2004-02-05 2009-11-18 Childrens Medical Center TRANSCATHETER DELIVERY OF A HEARTLAPPROTHESIS
WO2005087139A1 (en) 2004-03-15 2005-09-22 Baker Medical Research Institute Treating valve failure
US20050240202A1 (en) 2004-04-21 2005-10-27 Hani Shennib Devices and methods of repairing cardiac valves
EP1750592B1 (en) 2004-05-14 2016-12-28 Evalve, Inc. Locking mechanisms for fixation devices
US7678135B2 (en) 2004-06-09 2010-03-16 Usgi Medical, Inc. Compressible tissue anchor assemblies
US20050277839A1 (en) 2004-06-10 2005-12-15 Honeywell International, Inc. Wireless flow measurement in arterial stent
US20050278023A1 (en) 2004-06-10 2005-12-15 Zwirkoski Paul A Method and apparatus for filling a cavity
US20070135913A1 (en) 2004-06-29 2007-06-14 Micardia Corporation Adjustable annuloplasty ring activation system
US8012202B2 (en) 2004-07-27 2011-09-06 Alameddine Abdallah K Mitral valve ring for treatment of mitral valve regurgitation
US9061120B2 (en) 2004-08-05 2015-06-23 Oscor Inc. Catheter control mechanism and steerable catheter
JP2008513060A (ja) 2004-09-14 2008-05-01 エドワーズ ライフサイエンシーズ アーゲー 心臓弁逆流の処置のためのデバイスおよび方法
AU2004324043A1 (en) 2004-10-02 2006-04-20 Christoph Hans Huber Methods and devices for repair or replacement of heart valves or adjacent tissue without the need for full cardiopulmonary support
EP1841383A1 (en) 2004-12-15 2007-10-10 Mednua Limited A medical device suitable for use in treatment of a valve
WO2009053952A2 (en) 2007-10-26 2009-04-30 Mednua Limited A medical device for use in treatment of a valve
US7731705B2 (en) 2005-01-10 2010-06-08 Wardle John L Eluting coils and methods of deploying and retrieving
US10064540B2 (en) 2005-02-02 2018-09-04 Intuitive Surgical Operations, Inc. Visualization apparatus for transseptal access
AU2006212750B2 (en) 2005-02-07 2011-11-17 Evalve, Inc. Methods, systems and devices for cardiac valve repair
US20100312333A1 (en) 2009-04-29 2010-12-09 The Cleveland Clinic Foundation Apparatus and method for replacing a diseased cardiac valve
CN101340861B (zh) 2005-02-28 2011-08-10 梅德坦提亚国际有限公司 用于改善心脏瓣膜功能的装置和成套工具
US7955385B2 (en) 2005-02-28 2011-06-07 Medtronic Vascular, Inc. Device, system, and method for aiding valve annuloplasty
EP1861045B1 (en) 2005-03-25 2015-03-04 St. Jude Medical, Cardiology Division, Inc. Apparatus for controlling the internal circumference of an anatomic orifice or lumen
US7914569B2 (en) 2005-05-13 2011-03-29 Medtronics Corevalve Llc Heart valve prosthesis and methods of manufacture and use
US20060293698A1 (en) 2005-06-28 2006-12-28 Medtronic Vascular, Inc. Retainer device for mitral valve leaflets
JP2007020797A (ja) 2005-07-14 2007-02-01 Olympus Medical Systems Corp 内視鏡
US20070027533A1 (en) 2005-07-28 2007-02-01 Medtronic Vascular, Inc. Cardiac valve annulus restraining device
US20070038292A1 (en) 2005-08-09 2007-02-15 Moise Danielpour Bio-absorbable stent
US20070055206A1 (en) 2005-08-10 2007-03-08 Guided Delivery Systems, Inc. Methods and devices for deployment of tissue anchors
MX2008002552A (es) 2005-09-07 2008-04-21 Medtentia Ab Un dispositivo y un metodo para mejorar la funcion de una valvula cardiaca.
DE102005052628B4 (de) 2005-11-04 2014-06-05 Jenavalve Technology Inc. Selbstexpandierendes, flexibles Drahtgeflecht mit integrierter Klappenprothese für den transvaskulären Herzklappenersatz und ein System mit einer solchen Vorrichtung und einem Einführkatheter
US20080275540A1 (en) 2005-11-09 2008-11-06 Ning Wen Artificial Heart Valve Stent and Weaving Method Thereof
US20070118151A1 (en) 2005-11-21 2007-05-24 The Brigham And Women's Hospital, Inc. Percutaneous cardiac valve repair with adjustable artificial chordae
WO2007100410A2 (en) 2005-12-15 2007-09-07 Georgia Tech Research Corporation Systems and methods for enabling heart valve replacement
US20070142907A1 (en) 2005-12-16 2007-06-21 Micardia Corporation Adjustable prosthetic valve implant
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
WO2007081820A1 (en) 2006-01-09 2007-07-19 Children's Medical Center Corporation Transcatheter delivery of a replacement heart valve
US8562645B2 (en) 2006-09-29 2013-10-22 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US7637946B2 (en) 2006-02-09 2009-12-29 Edwards Lifesciences Corporation Coiled implant for mitral valve repair
EP1988851A2 (en) 2006-02-14 2008-11-12 Sadra Medical, Inc. Systems and methods for delivering a medical implant
EP2583640B1 (en) 2006-02-16 2022-06-22 Venus MedTech (HangZhou), Inc. Minimally invasive replacement heart valve
US8147541B2 (en) 2006-02-27 2012-04-03 Aortx, Inc. Methods and devices for delivery of prosthetic heart valves and other prosthetics
US8403981B2 (en) 2006-02-27 2013-03-26 CardiacMC, Inc. Methods and devices for delivery of prosthetic heart valves and other prosthetics
US9402633B2 (en) 2006-03-13 2016-08-02 Pneumrx, Inc. Torque alleviating intra-airway lung volume reduction compressive implant structures
US8075615B2 (en) 2006-03-28 2011-12-13 Medtronic, Inc. Prosthetic cardiac valve formed from pericardium material and methods of making same
US8070800B2 (en) 2006-05-05 2011-12-06 Children's Medical Center Corporation Transcatheter heart valve prostheses
IE20070428A1 (en) 2006-06-15 2007-12-21 Mednua Ltd A medical device suitable for use in treatment of a valve
US8449605B2 (en) 2006-06-28 2013-05-28 Kardium Inc. Method for anchoring a mitral valve
US20080004696A1 (en) 2006-06-29 2008-01-03 Valvexchange Inc. Cardiovascular valve assembly with resizable docking station
US8870916B2 (en) 2006-07-07 2014-10-28 USGI Medical, Inc Low profile tissue anchors, tissue anchor systems, and methods for their delivery and use
JP2008018139A (ja) 2006-07-14 2008-01-31 Terumo Corp 骨補填材及び骨補填材組立体
FR2905260B1 (fr) 2006-09-04 2010-06-04 Univ Paris Curie Endoprothese et procede de fabrication d'une endoprothese.
US8834564B2 (en) 2006-09-19 2014-09-16 Medtronic, Inc. Sinus-engaging valve fixation member
US8876894B2 (en) 2006-09-19 2014-11-04 Medtronic Ventor Technologies Ltd. Leaflet-sensitive valve fixation member
US7534261B2 (en) 2006-10-02 2009-05-19 Edwards Lifesciences Corporation Sutureless heart valve attachment
US7935144B2 (en) 2006-10-19 2011-05-03 Direct Flow Medical, Inc. Profile reduction of valve implant
SE530568C2 (sv) 2006-11-13 2008-07-08 Medtentia Ab Anordning och metod för förbättring av funktionen hos en hjärtklaff
AU2012261727B2 (en) 2006-11-13 2015-10-29 Medtentia International Ltd Oy Device and Method for Improving Function of Heart Valve
AU2007231733B2 (en) 2006-11-28 2014-03-13 Cathrx Ltd A catheter steering system
US20080208327A1 (en) 2007-02-27 2008-08-28 Rowe Stanton J Method and apparatus for replacing a prosthetic valve
US11660190B2 (en) 2007-03-13 2023-05-30 Edwards Lifesciences Corporation Tissue anchors, systems and methods, and devices
FR2915087B1 (fr) 2007-04-20 2021-11-26 Corevalve Inc Implant de traitement d'une valve cardiaque, en particulier d'une valve mitrale, materiel inculant cet implant et materiel de mise en place de cet implant.
US20090030504A1 (en) 2007-07-27 2009-01-29 Boston Scientific Scimed, Inc. Medical devices comprising porous inorganic fibers for the release of therapeutic agents
US9814611B2 (en) 2007-07-31 2017-11-14 Edwards Lifesciences Cardiaq Llc Actively controllable stent, stent graft, heart valve and method of controlling same
EP2219558B8 (en) 2007-08-21 2015-09-23 Symetis SA Stent-valves for valve replacement and associated systems for surgery
AU2008288796B2 (en) 2007-08-23 2014-03-20 Dfm, Llc Cardiovascular prosthetic valve
BRPI0817708A2 (pt) 2007-09-26 2017-05-16 St Jude Medical válvula cardíaca protética, e, estrutura de lamela para a mesma.
US9532868B2 (en) 2007-09-28 2017-01-03 St. Jude Medical, Inc. Collapsible-expandable prosthetic heart valves with structures for clamping native tissue
US8454686B2 (en) 2007-09-28 2013-06-04 St. Jude Medical, Inc. Two-stage collapsible/expandable prosthetic heart valves and anchoring systems
US20090093826A1 (en) 2007-10-05 2009-04-09 Cardica, Inc. Patent Foramen Ovale Closure System
US10856970B2 (en) 2007-10-10 2020-12-08 Medtronic Ventor Technologies Ltd. Prosthetic heart valve for transfemoral delivery
US20090138079A1 (en) 2007-10-10 2009-05-28 Vector Technologies Ltd. Prosthetic heart valve for transfemoral delivery
US8313526B2 (en) 2007-11-19 2012-11-20 Cook Medical Technologies Llc Valve frame
US9526487B2 (en) 2007-12-05 2016-12-27 Indiana University Research & Technology Corporation Methods and apparatuses for delivering anchoring devices into body passage walls
EP2231070B1 (en) 2007-12-14 2013-05-22 Edwards Lifesciences Corporation Leaflet attachment frame for a prosthetic valve
EP2072027B1 (en) 2007-12-21 2020-06-17 Medtentia International Ltd Oy pre-annuloplasty device and method
US8157853B2 (en) 2008-01-24 2012-04-17 Medtronic, Inc. Delivery systems and methods of implantation for prosthetic heart valves
AU2009206340B2 (en) 2008-01-24 2012-06-14 Medtronic Vascular Inc. Infundibular reducer device delivery system and related methods
AU2009212393B2 (en) 2008-02-06 2014-07-24 Ancora Heart, Inc. Multi-window guide tunnel
US20090209950A1 (en) 2008-02-20 2009-08-20 Guided Delivery Systems Inc. Electrophysiology catheter system
US8968393B2 (en) 2008-02-28 2015-03-03 Medtronic, Inc. System and method for percutaneous mitral valve repair
US8998933B2 (en) 2008-02-28 2015-04-07 Medtronic, Inc. Surgical fastening clips, systems and methods for proximating tissue
DE102008012113A1 (de) 2008-03-02 2009-09-03 Transcatheter Technologies Gmbh Stent, welcher vom expandierten Zustand erneut im Durchmesser kontrolliert verringerbar ist
US8382829B1 (en) 2008-03-10 2013-02-26 Mitralign, Inc. Method to reduce mitral regurgitation by cinching the commissure of the mitral valve
FR2930137B1 (fr) 2008-04-18 2010-04-23 Corevalve Inc Materiel de traitement d'une valve cardiaque, en particulier d'une valve mitrale.
BRPI0911351B8 (pt) 2008-04-23 2021-06-22 Medtronic Inc estrutura de stent para uma válvula cardíaca protética, e, prótese de válvula cardíaca
DK3967274T4 (da) 2008-04-23 2025-08-25 Medtronic Inc Hjerteklapanordninger med stent
US20090276040A1 (en) 2008-05-01 2009-11-05 Edwards Lifesciences Corporation Device and method for replacing mitral valve
US8096985B2 (en) 2008-05-07 2012-01-17 Guided Delivery Systems Inc. Deflectable guide
US20090287304A1 (en) 2008-05-13 2009-11-19 Kardium Inc. Medical Device for Constricting Tissue or a Bodily Orifice, for example a mitral valve
US8323335B2 (en) 2008-06-20 2012-12-04 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves and methods for using
US20100010520A1 (en) 2008-07-11 2010-01-14 Olympus Medical Systems Corp. Tissue fastener
US8337390B2 (en) 2008-07-30 2012-12-25 Cube S.R.L. Intracardiac device for restoring the functional elasticity of the cardiac structures, holding tool for the intracardiac device, and method for implantation of the intracardiac device in the heart
US8652202B2 (en) 2008-08-22 2014-02-18 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
US8287591B2 (en) 2008-09-19 2012-10-16 Edwards Lifesciences Corporation Transformable annuloplasty ring configured to receive a percutaneous prosthetic heart valve implantation
US9314335B2 (en) 2008-09-19 2016-04-19 Edwards Lifesciences Corporation Prosthetic heart valve configured to receive a percutaneous prosthetic heart valve implantation
CN102292053A (zh) 2008-09-29 2011-12-21 卡迪尔克阀门技术公司 心脏瓣膜
JP5607639B2 (ja) 2008-10-10 2014-10-15 サドラ メディカル インコーポレイテッド 医療用デバイス・システム
US20110046600A1 (en) 2008-12-05 2011-02-24 Crank Justin M Devices, systems, and related methods for delivery of fluid to tissue
US9011530B2 (en) 2008-12-22 2015-04-21 Valtech Cardio, Ltd. Partially-adjustable annuloplasty structure
US8940044B2 (en) 2011-06-23 2015-01-27 Valtech Cardio, Ltd. Closure element for use with an annuloplasty structure
US8545553B2 (en) 2009-05-04 2013-10-01 Valtech Cardio, Ltd. Over-wire rotation tool
US8808368B2 (en) 2008-12-22 2014-08-19 Valtech Cardio, Ltd. Implantation of repair chords in the heart
EP3848002A1 (en) 2008-12-22 2021-07-14 Valtech Cardio, Ltd. Adjustable annuloplasty devices and adjustment mechanisms therefor
US10517719B2 (en) 2008-12-22 2019-12-31 Valtech Cardio, Ltd. Implantation of repair devices in the heart
US8926697B2 (en) 2011-06-23 2015-01-06 Valtech Cardio, Ltd. Closed band for percutaneous annuloplasty
US8147542B2 (en) 2008-12-22 2012-04-03 Valtech Cardio, Ltd. Adjustable repair chords and spool mechanism therefor
US8241351B2 (en) 2008-12-22 2012-08-14 Valtech Cardio, Ltd. Adjustable partial annuloplasty ring and mechanism therefor
US8715342B2 (en) 2009-05-07 2014-05-06 Valtech Cardio, Ltd. Annuloplasty ring with intra-ring anchoring
US20100198208A1 (en) 2009-01-20 2010-08-05 Napp Malte I Diagnostic catheters, guide catheters, visualization devices and chord manipulation devices, and related kits and methods
WO2010085456A1 (en) 2009-01-20 2010-07-29 Guided Delivery Systems Inc. Anchor deployment devices and related methods
WO2010093837A2 (en) 2009-02-11 2010-08-19 Tendyne Medical, Inc. Percutaneous mitral annular stitch to decrease mitral regurgitation
US8348997B2 (en) 2009-02-24 2013-01-08 Medtronic Vascular, Inc. One-way replacement valve
WO2010098857A1 (en) 2009-02-27 2010-09-02 St. Jude Medical, Inc. Stent features for collapsible prosthetic heart valves
CN101919753A (zh) 2009-03-30 2010-12-22 卡迪万蒂奇医药公司 人工主动脉瓣膜或二尖瓣膜的无缝合移植方法和装置
AU2010236288A1 (en) 2009-04-15 2011-10-20 Cardiaq Valve Technologies, Inc. Vascular implant and delivery system
US9968452B2 (en) 2009-05-04 2018-05-15 Valtech Cardio, Ltd. Annuloplasty ring delivery cathethers
US8523881B2 (en) 2010-07-26 2013-09-03 Valtech Cardio, Ltd. Multiple anchor delivery tool
WO2010141847A1 (en) 2009-06-05 2010-12-09 Ats Medical, Inc. Flexible commissure structure for attaching valve bioprosthesis
EP2445568B1 (en) 2009-06-24 2020-09-23 Kalila Medical, Inc. Steerable medical delivery devices
CA2767035C (en) 2009-07-02 2015-07-21 The Cleveland Clinic Foundation Apparatus and method for replacing a diseased cardiac valve
JP5744028B2 (ja) 2009-08-27 2015-07-01 メドトロニック，インコーポレイテッド 経カテーテル弁搬送システムおよび方法
CN102548508B (zh) 2009-09-21 2015-06-03 麦德托尼克公司 带支架的经导管假体心脏瓣膜输送系统及方法
US9730790B2 (en) 2009-09-29 2017-08-15 Edwards Lifesciences Cardiaq Llc Replacement valve and method
US8652203B2 (en) 2010-09-23 2014-02-18 Cardiaq Valve Technologies, Inc. Replacement heart valves, delivery devices and methods
US9180007B2 (en) 2009-10-29 2015-11-10 Valtech Cardio, Ltd. Apparatus and method for guide-wire based advancement of an adjustable implant
WO2011154942A2 (en) 2010-06-07 2011-12-15 Valtech Cardio, Ltd. Apparatus and method for guide-wire based advancement of a rotation assembly
DE102009055969A1 (de) 2009-11-27 2011-06-01 Transcatheter Technologies Gmbh Vorrichtung und Set zum Falten oder Entfalten eines medizinischen Implantats und Verfahren
WO2011069154A2 (en) 2009-12-05 2011-06-09 Integrated Sensing Systems, Inc. Delivery system, method, and anchor for medical implant placement
US8715300B2 (en) 2009-12-05 2014-05-06 Integrated Sensing Systems, Inc. Delivery system, method, and anchor for medical implant placement
US8870950B2 (en) 2009-12-08 2014-10-28 Mitral Tech Ltd. Rotation-based anchoring of an implant
EP3300695B1 (en) 2009-12-08 2023-05-24 Avalon Medical Ltd. Device and system for transcatheter mitral valve replacement
CN102113921A (zh) 2009-12-30 2011-07-06 微创医疗器械(上海)有限公司 一种介入式心脏瓣膜
EP2536364A1 (en) 2010-02-16 2012-12-26 NLT Spine Ltd. Locking between levels of a multi-level helix device
US9072603B2 (en) 2010-02-24 2015-07-07 Medtronic Ventor Technologies, Ltd. Mitral prosthesis and methods for implantation
CN102869321B (zh) 2010-03-05 2015-05-06 爱德华兹生命科学公司 人工瓣膜锁紧机构
US8795354B2 (en) 2010-03-05 2014-08-05 Edwards Lifesciences Corporation Low-profile heart valve and delivery system
US20110224785A1 (en) 2010-03-10 2011-09-15 Hacohen Gil Prosthetic mitral valve with tissue anchors
US9320597B2 (en) 2010-03-30 2016-04-26 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with recapturing feature and method
US8652204B2 (en) 2010-04-01 2014-02-18 Medtronic, Inc. Transcatheter valve with torsion spring fixation and related systems and methods
US8998980B2 (en) 2010-04-09 2015-04-07 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with recapturing feature and method
US8512401B2 (en) 2010-04-12 2013-08-20 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with funnel recapturing feature and method
US8465541B2 (en) 2010-04-19 2013-06-18 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system and method with expandable stability tube
US8740976B2 (en) 2010-04-21 2014-06-03 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with flush report
US8623075B2 (en) 2010-04-21 2014-01-07 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system and method with controlled expansion of prosthetic heart valve
WO2011139746A1 (en) 2010-04-27 2011-11-10 Medtronic Inc. Transcatheter prosthetic heart valve delivery device with passive trigger release
AU2011248658B2 (en) 2010-04-27 2014-09-11 Medtronic Inc. Transcatheter prosthetic heart valve delivery device with biased release features
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
CN103002833B (zh) 2010-05-25 2016-05-11 耶拿阀门科技公司 人工心脏瓣及包括人工心脏瓣和支架的经导管输送的内假体
US9561102B2 (en) 2010-06-02 2017-02-07 Medtronic, Inc. Transcatheter delivery system and method with controlled expansion and contraction of prosthetic heart valve
EP3061422B1 (en) 2010-06-21 2021-11-03 Edwards Lifesciences CardiAQ LLC Replacement heart valve
EP2962664B1 (en) 2010-07-09 2022-05-11 Highlife SAS Transcatheter atrio-ventricular valve prosthesis
US8657872B2 (en) * 2010-07-19 2014-02-25 Jacques Seguin Cardiac valve repair system and methods of use
US9132009B2 (en) 2010-07-21 2015-09-15 Mitraltech Ltd. Guide wires with commissural anchors to advance a prosthetic valve
WO2012012761A2 (en) 2010-07-23 2012-01-26 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves
US8518107B2 (en) 2010-08-04 2013-08-27 Valcare, Inc. Percutaneous transcatheter repair of heart valves
US10130470B2 (en) 2010-08-17 2018-11-20 St. Jude Medical, Llc Sleeve for facilitating movement of a transfemoral catheter
US20120053680A1 (en) 2010-08-24 2012-03-01 Bolling Steven F Reconfiguring Heart Features
EP2611391B1 (en) 2010-09-01 2017-11-22 Mvalve Technologies Ltd. Cardiac valve support structure
US10105224B2 (en) 2010-09-01 2018-10-23 Mvalve Technologies Ltd. Cardiac valve support structure
WO2012030598A2 (en) 2010-09-01 2012-03-08 Medtronic Vascular Galway Limited Prosthetic valve support structure
AU2011300644B2 (en) 2010-09-10 2015-08-20 Symetis Sa Valve replacement devices and a system comprising the valve replacement device and a delivery device therefor
CN103118630B (zh) 2010-09-24 2016-05-04 西美蒂斯股份公司 支架瓣膜、输送设备和输送方法
US8940002B2 (en) 2010-09-30 2015-01-27 Kardium Inc. Tissue anchor system
PL3593762T3 (pl) 2010-10-05 2021-05-04 Edwards Lifesciences Corporation Zastawka protetyczna serca i urządzenie do wprowadzania
EP2629699B1 (en) 2010-10-21 2017-01-04 Medtronic, Inc. Mitral bioprosthesis with low ventricular profile
IT1402571B1 (it) 2010-11-12 2013-09-13 Ht Consultant Di Giovanni Righini Sistema protesico per valvola cardio-vascolare con struttura di ancoraggio separata
CA2822381C (en) 2010-12-23 2019-04-02 Foundry Newco Xii, Inc. System for mitral valve repair and replacement
EP2474287A1 (en) 2011-01-11 2012-07-11 Symetis Sa Delivery catheter for stent-valve, and sub-assembly therefor
EP2663258B1 (de) 2011-01-11 2018-11-21 Hans Reiner Figulla Klappenprothese zum ersatz einer artrioventrikularklappe des herzens
EP2478868A1 (en) 2011-01-25 2012-07-25 The Provost, Fellows, Foundation Scholars, and the other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth Implant device
US8888843B2 (en) 2011-01-28 2014-11-18 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valve regurgitation
US8845717B2 (en) 2011-01-28 2014-09-30 Middle Park Medical, Inc. Coaptation enhancement implant, system, and method
WO2012106185A1 (en) 2011-01-31 2012-08-09 Boston Scientific Scimed, Inc. Articulation section with locking
US9155619B2 (en) 2011-02-25 2015-10-13 Edwards Lifesciences Corporation Prosthetic heart valve delivery apparatus
US8454656B2 (en) 2011-03-01 2013-06-04 Medtronic Ventor Technologies Ltd. Self-suturing anchors
US9072511B2 (en) 2011-03-25 2015-07-07 Kardium Inc. Medical kit for constricting tissue or a bodily orifice, for example, a mitral valve
US8845588B2 (en) 2011-04-19 2014-09-30 Medtronic Vascular, Inc. Sheath introducer system with exchangeable hemostatic valves
AU2012250729B2 (en) 2011-05-03 2016-12-01 Shifamed Holdings, Llc Steerable delivery sheaths
EP2520250B1 (en) 2011-05-04 2014-02-19 Medtentia International Ltd Oy Medical device for a cardiac valve implant
EP2709520A4 (en) 2011-05-17 2014-12-10 Landy Aaron Toth DEVICES, SYSTEMS AND METHOD FOR THE ASSESSMENT OF IMPLANTS, ORGANS, TRANSPLANTS, TISSUE, SYNTHETIC CONSTRUCTS, TUBULAR RAPPLANTS AND THE SAME
US8945209B2 (en) 2011-05-20 2015-02-03 Edwards Lifesciences Corporation Encapsulated heart valve
US8840664B2 (en) 2011-06-15 2014-09-23 Edwards Lifesciences Corporation Heart valve prosthesis anchoring device and methods
WO2012175483A1 (en) 2011-06-20 2012-12-27 Jacques Seguin Prosthetic leaflet assembly for repairing a defective cardiac valve and methods of using the same
CA2840084C (en) 2011-06-21 2019-11-05 Foundry Newco Xii, Inc. Prosthetic heart valve devices and associated systems and methods
US9918840B2 (en) 2011-06-23 2018-03-20 Valtech Cardio, Ltd. Closed band for percutaneous annuloplasty
US10792152B2 (en) 2011-06-23 2020-10-06 Valtech Cardio, Ltd. Closed band for percutaneous annuloplasty
US9364326B2 (en) 2011-06-29 2016-06-14 Mitralix Ltd. Heart valve repair devices and methods
US9629715B2 (en) 2011-07-28 2017-04-25 V-Wave Ltd. Devices for reducing left atrial pressure having biodegradable constriction, and methods of making and using same
EP2741711B1 (en) 2011-08-11 2018-05-30 Tendyne Holdings, Inc. Improvements for prosthetic valves and related inventions
US9343224B2 (en) 2011-08-19 2016-05-17 Leviticus Cardio Ltd. Coplanar energy transfer
US20130053792A1 (en) 2011-08-24 2013-02-28 Ablative Solutions, Inc. Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation
EP2755602B1 (en) 2011-09-12 2017-08-09 Highlife SAS Transcatheter valve prosthesis
US8956404B2 (en) 2011-09-12 2015-02-17 Highlife Sas Transcatheter valve prosthesis
US8900295B2 (en) 2011-09-26 2014-12-02 Edwards Lifesciences Corporation Prosthetic valve with ventricular tethers
US9039757B2 (en) 2011-10-19 2015-05-26 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9655722B2 (en) 2011-10-19 2017-05-23 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
EA201400481A1 (ru) 2011-10-19 2014-10-30 Твелв, Инк. Искусственные сердечно-клапанные устройства, искусственные митральные клапаны и соответствующие системы и способы
US9763780B2 (en) 2011-10-19 2017-09-19 Twelve, Inc. Devices, systems and methods for heart valve replacement
EP3970627B1 (en) 2011-11-08 2023-12-20 Edwards Lifesciences Innovation (Israel) Ltd. Controlled steering functionality for implant-delivery tool
EP2591754B1 (en) 2011-11-10 2015-02-25 Medtentia International Ltd Oy A device and a method for improving the function of a heart valve
EP2591755A1 (en) 2011-11-12 2013-05-15 Medtentia International Ltd Oy Device and method for improving fixation of a medical device
US20130123912A1 (en) 2011-11-15 2013-05-16 Boston Scientific Scimed, Inc. Medical device with nosecone and nosecone tube extension
US20140350669A1 (en) 2011-12-01 2014-11-27 The Trustees if The University of Pennsylvania Percutaneous valve replacement devices
WO2013086132A1 (en) 2011-12-06 2013-06-13 Aortic Innovations Llc Device for endovascular aortic repair and method of using the same
PL2787926T3 (pl) 2011-12-09 2022-11-14 Edwards Lifesciences Corporation Usprawnione wsporniki spojeń zastawki protetycznej serca
US9078747B2 (en) 2011-12-21 2015-07-14 Edwards Lifesciences Corporation Anchoring device for replacing or repairing a heart valve
EP3581152B1 (en) 2011-12-21 2025-09-24 Majoro Cardiac Innovations, LLC Platforms for mitral valve replacement
EP2620125B1 (en) 2012-01-24 2017-10-11 Medtentia International Ltd Oy An arrangement, a loop-shaped support, a prosthetic heart valve and a method of repairing or replacing a native heart valve
WO2013112547A1 (en) 2012-01-25 2013-08-01 Boston Scientific Scimed, Inc. Valve assembly with a bioabsorbable gasket and a replaceable valve implant
EP2809263B1 (en) 2012-01-31 2017-08-23 Mitral Valve Technologies Sàrl Mitral valve docking devices, systems
US20150094802A1 (en) 2012-02-28 2015-04-02 Mvalve Technologies Ltd. Single-ring cardiac valve support
US9579198B2 (en) 2012-03-01 2017-02-28 Twelve, Inc. Hydraulic delivery systems for prosthetic heart valve devices and associated methods
US20130274873A1 (en) 2012-03-22 2013-10-17 Symetis Sa Transcatheter Stent-Valves and Methods, Systems and Devices for Addressing Para-Valve Leakage
ES2535295T3 (es) 2012-03-23 2015-05-08 Sorin Group Italia S.R.L. Prótesis de válvula plegable
US9295547B2 (en) 2012-03-28 2016-03-29 Medtronic Vascular Galway Prosthesis for transcatheter valve implantation
US9999501B2 (en) 2012-04-18 2018-06-19 Medtronic CV Luxembourg S.a.r.l. Valve prosthesis
US9427315B2 (en) 2012-04-19 2016-08-30 Caisson Interventional, LLC Valve replacement systems and methods
US9011515B2 (en) 2012-04-19 2015-04-21 Caisson Interventional, LLC Heart valve assembly systems and methods
DE102012207053A1 (de) 2012-04-27 2013-10-31 Abiomed Europe Gmbh Intravasale rotationsblutpumpe
CA2872611C (en) 2012-05-16 2020-09-15 Edwards Lifesciences Corporation Systems and methods for placing a coapting member between valvular leaflets
CN104684505B (zh) 2012-05-20 2017-07-07 戴尔马修墨医学研究内结构和服务有限公司 人造二尖瓣
US20130331931A1 (en) 2012-06-07 2013-12-12 Boston Scientific Scimed Inc. Apparatus for Replacing a Native Heart Valve and Method of Making the Same
US9883941B2 (en) 2012-06-19 2018-02-06 Boston Scientific Scimed, Inc. Replacement heart valve
EP2740400A4 (en) 2012-06-22 2016-01-27 Olympus Corp BITE EAR AND MEDICAL INSTRUMENT
US20140005776A1 (en) 2012-06-29 2014-01-02 St. Jude Medical, Cardiology Division, Inc. Leaflet attachment for function in various shapes and sizes
US10376360B2 (en) 2012-07-27 2019-08-13 W. L. Gore & Associates, Inc. Multi-frame prosthetic valve apparatus and methods
WO2014022124A1 (en) 2012-07-28 2014-02-06 Tendyne Holdings, Inc. Improved multi-component designs for heart valve retrieval device, sealing structures and stent assembly
WO2014021905A1 (en) 2012-07-30 2014-02-06 Tendyne Holdings, Inc. Improved delivery systems and methods for transcatheter prosthetic valves
US10206775B2 (en) 2012-08-13 2019-02-19 Medtronic, Inc. Heart valve prosthesis
US9232995B2 (en) 2013-01-08 2016-01-12 Medtronic, Inc. Valve prosthesis and method for delivery
US8926690B2 (en) 2012-08-13 2015-01-06 Medtronic, Inc. Heart valve prosthesis
US9468525B2 (en) 2012-08-13 2016-10-18 Medtronic, Inc. Heart valve prosthesis
US9636481B2 (en) 2012-09-27 2017-05-02 Boston Scientific Scimed, Inc. Steerable catheter with brake assembly
GB2507053A (en) 2012-10-16 2014-04-23 Jonathan Featherstone Nephroureterectomy apparatus
US9226823B2 (en) 2012-10-23 2016-01-05 Medtronic, Inc. Valve prosthesis
US10376266B2 (en) 2012-10-23 2019-08-13 Valtech Cardio, Ltd. Percutaneous tissue anchor techniques
WO2014064694A2 (en) 2012-10-23 2014-05-01 Valtech Cardio, Ltd. Controlled steering functionality for implant-delivery tool
EP2730252A1 (en) 2012-11-07 2014-05-14 Medtentia International Ltd Oy Medical device for a cardiac valve implant, and a metod of manufacturing the medical device
DK3158975T3 (da) 2012-11-20 2023-03-13 Innovheart S R L Protesesystem til hjerteklaperstatning
WO2014087402A1 (en) 2012-12-06 2014-06-12 Valtech Cardio, Ltd. Techniques for guide-wire based advancement of a tool
US9737398B2 (en) 2012-12-19 2017-08-22 W. L. Gore & Associates, Inc. Prosthetic valves, frames and leaflets and methods thereof
US11406498B2 (en) 2012-12-20 2022-08-09 Philips Image Guided Therapy Corporation Implant delivery system and implants
US9949692B2 (en) 2012-12-21 2018-04-24 Canary Medical Inc. Stent graft monitoring assembly and method of use thereof
WO2014102268A1 (en) 2012-12-27 2014-07-03 Transcatheter Technologies Gmbh Apparatus and set for folding or unfolding a medical implant comprising a clamping mechanism, implant and method
US9066801B2 (en) 2013-01-08 2015-06-30 Medtronic, Inc. Valve prosthesis and method for delivery
US8986371B2 (en) 2013-01-08 2015-03-24 Medtronic CV Luxembourg S.a.r.l. Method of treating paravalvular leakage after prosthetic valve implantation
US20150351906A1 (en) 2013-01-24 2015-12-10 Mitraltech Ltd. Ventricularly-anchored prosthetic valves
KR20150140634A (ko) 2013-01-25 2015-12-16 메드텐티아 인터내셔날 엘티디 오와이 판륜성형술 임플란트의 선택을 용이하게 위한 의료 디바이스 및 방법
CA2897907A1 (en) 2013-01-25 2014-07-31 Medtentia International Ltd Oy Temporary atrium support device
US10856983B2 (en) 2013-01-25 2020-12-08 Medtentia International Ltd. Oy System for cardiac valve repair
JP6600558B2 (ja) 2013-01-25 2019-10-30 メドテンシア インターナショナル エルティーディー オーワイ 腱索及び／又は弁尖の収集のための装置、医療システム、及び方法
CN104994812B (zh) 2013-01-25 2017-05-17 梅德坦提亚国际有限公司 用于接管和/或临时或部分支撑心脏中的天然瓣膜的短时间置换的瓣膜及其递送方法
US10413401B2 (en) 2013-02-01 2019-09-17 Medtronic CV Luxembourg S.a.r.l. Anti-paravalvular leakage component for a transcatheter valve prosthesis
US9439763B2 (en) 2013-02-04 2016-09-13 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US9168129B2 (en) 2013-02-12 2015-10-27 Edwards Lifesciences Corporation Artificial heart valve with scalloped frame design
US9844435B2 (en) 2013-03-01 2017-12-19 St. Jude Medical, Cardiology Division, Inc. Transapical mitral valve replacement
US9119713B2 (en) 2013-03-11 2015-09-01 St. Jude Medical, Cardiology Division, Inc. Transcatheter valve replacement
US10583002B2 (en) * 2013-03-11 2020-03-10 Neovasc Tiara Inc. Prosthetic valve with anti-pivoting mechanism
US20140277427A1 (en) 2013-03-14 2014-09-18 Cardiaq Valve Technologies, Inc. Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
CN106691630A (zh) 2013-03-14 2017-05-24 斯波瑞申有限公司 瓣膜装载方法、系统和装置
US11406497B2 (en) 2013-03-14 2022-08-09 Jc Medical, Inc. Heart valve prosthesis
US9173713B2 (en) 2013-03-14 2015-11-03 Hansen Medical, Inc. Torque-based catheter articulation
US11259923B2 (en) 2013-03-14 2022-03-01 Jc Medical, Inc. Methods and devices for delivery of a prosthetic valve
US10507104B2 (en) 2013-03-14 2019-12-17 Suzhou Jiecheng Medical Technology Co., Ltd. Sutureless valve prosthesis delivery device and methods of use thereof
EP2967938B1 (en) 2013-03-14 2017-03-01 Medtronic Vascular Inc. Method for manufacturing a stent and stent manufactured thereby
US9289297B2 (en) 2013-03-15 2016-03-22 Cardiosolutions, Inc. Mitral valve spacer and system and method for implanting the same
CN105377192A (zh) 2013-05-09 2016-03-02 米塔埃瑟斯医疗有限公司 心脏瓣膜辅助修复体
EP3326583B1 (en) 2013-05-20 2018-12-12 Edwards Lifesciences Corporation Prosthetic heart valve delivery apparatus
EP2805695A1 (en) 2013-05-21 2014-11-26 Medtentia International Ltd Oy Medical system for annuloplasty
US9610159B2 (en) 2013-05-30 2017-04-04 Tendyne Holdings, Inc. Structural members for prosthetic mitral valves
CN105451688A (zh) 2013-06-14 2016-03-30 哈祖有限公司 用于治疗瓣膜反流的方法和装置
US20150005874A1 (en) 2013-06-27 2015-01-01 Tendyne Holdings, Inc. Atrial Thrombogenic Sealing Pockets for Prosthetic Mitral Valves
CN105358084B (zh) 2013-07-01 2018-11-09 波士顿科学国际有限公司 用于肾神经消融的医疗器械
US10028832B2 (en) 2013-07-10 2018-07-24 Medtronic, Inc. Helical coil mitral valve annuloplasty systems and methods
EP2835112B1 (en) 2013-08-08 2021-01-27 Sorin Group Italia S.r.l. Heart valve prosthesis
CA2920865C (en) * 2013-08-14 2023-06-06 Mitral Valve Technologies Sarl Replacement heart valve apparatus and methods
US10195028B2 (en) 2013-09-10 2019-02-05 Edwards Lifesciences Corporation Magnetic retaining mechanisms for prosthetic valves
US9839511B2 (en) 2013-10-05 2017-12-12 Sino Medical Sciences Technology Inc. Device and method for mitral valve regurgitation treatment
US9662202B2 (en) 2013-10-24 2017-05-30 Medtronic, Inc. Heart valve prosthesis
US9889004B2 (en) 2013-11-19 2018-02-13 St. Jude Medical, Cardiology Division, Inc. Sealing structures for paravalvular leak protection
US9848880B2 (en) 2013-11-20 2017-12-26 James E. Coleman Adjustable heart valve implant
US10098734B2 (en) 2013-12-05 2018-10-16 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
US9901444B2 (en) 2013-12-17 2018-02-27 Edwards Lifesciences Corporation Inverted valve structure
KR102432831B1 (ko) 2014-02-04 2022-08-12 이노브하르트 에세.에레.엘레. 심장 판막용 인공 디바이스
WO2015124630A1 (en) 2014-02-18 2015-08-27 Medtentia International Ltd Oy Stapling device
WO2015124631A2 (en) 2014-02-18 2015-08-27 Medtentia International Ltd Oy Medical device for a cardiac valve implant
EP3107495B2 (en) 2014-02-18 2025-05-14 St. Jude Medical, Cardiology Division, Inc. Bowed runners and corresponding valve assemblies for paravalvular leak protection
EP2907479A1 (en) 2014-02-18 2015-08-19 Medtentia International Ltd Oy A system and a method for delivery of an annuloplasty implant
CA2938614C (en) 2014-02-21 2024-01-23 Edwards Lifesciences Cardiaq Llc Delivery device for controlled deployement of a replacement valve
CA3189691A1 (en) 2014-02-21 2015-08-27 Mitral Valve Technologies Sarl Devices, systems and methods for delivering a prosthetic mitral valve and anchoring device
US9889003B2 (en) 2014-03-11 2018-02-13 Highlife Sas Transcatheter valve prosthesis
US9763779B2 (en) 2014-03-11 2017-09-19 Highlife Sas Transcatheter valve prosthesis
US10064719B2 (en) 2014-03-11 2018-09-04 Highlife Sas Transcatheter valve prosthesis
DE102014102650A1 (de) 2014-02-28 2015-09-03 Highlife Sas Transkatheter-Klappenprothese
CA2937566C (en) 2014-03-10 2023-09-05 Tendyne Holdings, Inc. Devices and methods for positioning and monitoring tether load for prosthetic mitral valve
US9687343B2 (en) 2014-03-11 2017-06-27 Highlife Sas Transcatheter valve prosthesis
EP2918248A1 (en) 2014-03-11 2015-09-16 Epygon Sasu An expandable stent-valve and a delivery device
EP3119351B1 (en) 2014-03-18 2021-10-20 St. Jude Medical, Cardiology Division, Inc. Mitral valve replacement toggle cell securement
EP2921140A1 (en) 2014-03-18 2015-09-23 St. Jude Medical, Cardiology Division, Inc. Percutaneous valve anchoring for a prosthetic aortic valve
JP6526043B2 (ja) 2014-03-26 2019-06-05 セント・ジュード・メディカル，カーディオロジー・ディヴィジョン，インコーポレイテッド 経カテーテル僧帽弁ステントフレーム
WO2015153755A2 (en) 2014-04-01 2015-10-08 Medtronic Inc. Anti-paravalvular leakage component for a transcatheter valve prosthesis
US10029037B2 (en) 2014-04-15 2018-07-24 Tc1 Llc Sensors for catheter pumps
EP3131503B1 (en) 2014-04-17 2019-06-12 Medtronic Vascular Galway Hinged transcatheter prosthetic heart valve delivery system
US10154904B2 (en) 2014-04-28 2018-12-18 Edwards Lifesciences Corporation Intravascular introducer devices
US10195025B2 (en) 2014-05-12 2019-02-05 Edwards Lifesciences Corporation Prosthetic heart valve
USRE49792E1 (en) 2014-05-14 2024-01-09 Corcym S.R.L. Implant device and implantation kit
US20150328000A1 (en) 2014-05-19 2015-11-19 Cardiaq Valve Technologies, Inc. Replacement mitral valve with annular flap
US9532870B2 (en) 2014-06-06 2017-01-03 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
US10111749B2 (en) 2014-06-11 2018-10-30 Medtronic Vascular, Inc. Prosthetic valve with flow director
US9974647B2 (en) 2014-06-12 2018-05-22 Caisson Interventional, LLC Two stage anchor and mitral valve assembly
EP3157469B2 (en) 2014-06-18 2024-10-02 Polares Medical Inc. Mitral valve implants for the treatment of valvular regurgitation
GB2527747A (en) 2014-06-19 2016-01-06 Neosurgical Ltd Laparoscopic surgical device
US9700412B2 (en) 2014-06-26 2017-07-11 Mitralix Ltd. Heart valve repair devices for placement in ventricle and delivery systems for implanting heart valve repair devices
CN104055604B (zh) 2014-07-07 2016-06-01 宁波健世生物科技有限公司 一种带锚定装置的心脏瓣膜植入器械
US9180005B1 (en) 2014-07-17 2015-11-10 Millipede, Inc. Adjustable endolumenal mitral valve ring
US10058424B2 (en) 2014-08-21 2018-08-28 Edwards Lifesciences Corporation Dual-flange prosthetic valve frame
WO2016036774A1 (en) 2014-09-01 2016-03-10 Clph, Llc Steerable catheters and methods for making them
JP2017527373A (ja) 2014-09-08 2017-09-21 メドテンティア・インターナショナル・リミテッド・オサケユキチュアＭｅｄｔｅｎｔｉａ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｔｄ Ｏｙ 弁輪形成インプラント
US10016272B2 (en) 2014-09-12 2018-07-10 Mitral Valve Technologies Sarl Mitral repair and replacement devices and methods
US10576249B2 (en) 2014-09-30 2020-03-03 St. Jude Medical Cardiology Division, Inc. Medical device including an actuator restraining assembly
EP3138465A4 (en) 2014-10-01 2018-01-03 Olympus Corporation Endoscope bending tube and endoscope provided with endoscope bending tube
WO2016061139A1 (en) 2014-10-13 2016-04-21 Hlt, Inc. Inversion delivery device and method for a prosthesis
FR3027212A1 (fr) 2014-10-16 2016-04-22 Seguin Jacques Implant intervalvulaire pour valve mitrale
US9750605B2 (en) 2014-10-23 2017-09-05 Caisson Interventional, LLC Systems and methods for heart valve therapy
CN104298404B (zh) 2014-10-28 2017-05-31 上海天马微电子有限公司 阵列基板及其制作方法、显示装置及其驱动方法
US10213307B2 (en) 2014-11-05 2019-02-26 Medtronic Vascular, Inc. Transcatheter valve prosthesis having an external skirt for sealing and preventing paravalvular leakage
US9788893B2 (en) 2014-11-20 2017-10-17 Biosense Webster (Israel) Ltd. Catheter with soft distal tip for mapping and ablating tubular region
US9901445B2 (en) 2014-11-21 2018-02-27 Boston Scientific Scimed, Inc. Valve locking mechanism
US9693860B2 (en) 2014-12-01 2017-07-04 Medtronic, Inc. Segmented transcatheter valve prosthesis having an unsupported valve segment
CN106999178B (zh) 2014-12-02 2019-12-24 4科技有限公司 偏心组织锚定器
WO2016093877A1 (en) 2014-12-09 2016-06-16 Cephea Valve Technologies, Inc. Replacement cardiac valves and methods of use and manufacture
CN107427364B (zh) 2014-12-19 2019-12-10 杭州启明医疗器械股份有限公司 具有边沿的微创二尖瓣瓣膜置换
EP3244809B1 (en) 2014-12-19 2020-02-05 Paradox Medical Implantable intracardiac device
EP3037064B1 (en) 2014-12-23 2018-03-14 Venus MedTech (HangZhou), Inc. Minimally invasive mitral valve replacement with brim
EP3141179A4 (en) 2015-01-21 2018-01-10 Olympus Corporation Endoscope insertion part and endoscope
US10188833B2 (en) 2015-01-21 2019-01-29 Medtronic Vascular, Inc. Guide catheter with steering mechanisms
US10039637B2 (en) 2015-02-11 2018-08-07 Edwards Lifesciences Corporation Heart valve docking devices and implanting methods
JP6735294B2 (ja) 2015-02-13 2020-08-05 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． インプラント可能な心臓弁装置
EP4706567A2 (en) 2015-03-05 2026-03-11 Ancora Heart, Inc. Devices of visualizing and determining depth of penetration in cardiac tissue
CA2979817C (en) 2015-03-18 2023-03-28 Mitralign, Inc. Tissue anchors and percutaneous tricuspid valve repair using a tissue anchor
EP3273910B1 (en) 2015-03-24 2024-12-18 St. Jude Medical, Cardiology Division, Inc. Mitral heart valve replacement
CN107949351A (zh) 2015-03-30 2018-04-20 伊诺佩斯生物医药有限公司 用于血管内装置的天线
EP3078350B1 (en) 2015-04-09 2018-01-31 Frid Mind Technologies 3d filter for prevention of stroke
US10368986B2 (en) 2015-04-15 2019-08-06 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system and method
US10064718B2 (en) * 2015-04-16 2018-09-04 Edwards Lifesciences Corporation Low-profile prosthetic heart valve for replacing a mitral valve
US10441416B2 (en) 2015-04-21 2019-10-15 Edwards Lifesciences Corporation Percutaneous mitral valve replacement device
EP3087952A1 (en) 2015-04-29 2016-11-02 Kephalios S.A.S. An annuloplasty system and a method for monitoring the effectiveness of an annuloplasty treatment
US10376363B2 (en) 2015-04-30 2019-08-13 Edwards Lifesciences Cardiaq Llc Replacement mitral valve, delivery system for replacement mitral valve and methods of use
EP3288496B1 (en) 2015-04-30 2024-05-29 Edwards Lifesciences Innovation (Israel) Ltd. Annuloplasty technologies
US9629720B2 (en) 2015-05-04 2017-04-25 Jacques Seguin Apparatus and methods for treating cardiac valve regurgitation
WO2016183526A1 (en) 2015-05-14 2016-11-17 Cephea Valve Technologies, Inc. Replacement mitral valves
WO2016183523A1 (en) 2015-05-14 2016-11-17 Cephea Valve Technologies, Inc. Cardiac valve delivery devices and systems
ES3001450T3 (en) 2015-05-14 2025-03-05 Edwards Lifesciences Corp Heart valve sealing devices and delivery devices therefor
US10028733B2 (en) 2015-05-28 2018-07-24 National University Of Ireland, Galway Fistula treatment device
EP3307207A1 (en) 2015-06-12 2018-04-18 St. Jude Medical, Cardiology Division, Inc. Heart valve repair and replacement
US10092400B2 (en) 2015-06-23 2018-10-09 Edwards Lifesciences Cardiaq Llc Systems and methods for anchoring and sealing a prosthetic heart valve
US10335277B2 (en) 2015-07-02 2019-07-02 Boston Scientific Scimed Inc. Adjustable nosecone
US9974650B2 (en) 2015-07-14 2018-05-22 Edwards Lifesciences Corporation Prosthetic heart valve
US9895222B2 (en) 2015-08-17 2018-02-20 Venus Medtech (Hangzhou) Inc. Aortic replacement valve
US10631977B2 (en) 2015-08-24 2020-04-28 Edwards Lifesciences Corporation Covering and assembly method for transcatheter valve
US10575951B2 (en) 2015-08-26 2020-03-03 Edwards Lifesciences Cardiaq Llc Delivery device and methods of use for transapical delivery of replacement mitral valve
US10117744B2 (en) 2015-08-26 2018-11-06 Edwards Lifesciences Cardiaq Llc Replacement heart valves and methods of delivery
US10034747B2 (en) 2015-08-27 2018-07-31 Medtronic Vascular, Inc. Prosthetic valve system having a docking component and a prosthetic valve component
US10350066B2 (en) 2015-08-28 2019-07-16 Edwards Lifesciences Cardiaq Llc Steerable delivery system for replacement mitral valve and methods of use
CA2995855C (en) 2015-09-02 2024-01-30 Edwards Lifesciences Corporation Spacer for securing a transcatheter valve to a bioprosthetic cardiac structure
US10080653B2 (en) 2015-09-10 2018-09-25 Edwards Lifesciences Corporation Limited expansion heart valve
US10327894B2 (en) 2015-09-18 2019-06-25 Tendyne Holdings, Inc. Methods for delivery of prosthetic mitral valves
US10350067B2 (en) 2015-10-26 2019-07-16 Edwards Lifesciences Corporation Implant delivery capsule
WO2017087424A1 (en) 2015-11-17 2017-05-26 Millipede, Inc. Implantable device and delivery system for reshaping a heart valve annulus
US11033387B2 (en) 2015-11-23 2021-06-15 Edwards Lifesciences Corporation Methods for controlled heart valve delivery
FR3043907A1 (fr) 2015-11-23 2017-05-26 Alain Dibie Assemblage pour le remplacement de la valve atrio-ventriculaire tricuspide
US10265169B2 (en) 2015-11-23 2019-04-23 Edwards Lifesciences Corporation Apparatus for controlled heart valve delivery
US10357351B2 (en) 2015-12-04 2019-07-23 Edwards Lifesciences Corporation Storage assembly for prosthetic valve
CN105581858B (zh) 2015-12-15 2018-04-10 先健科技(深圳)有限公司 人工心脏瓣膜支架及人工心脏瓣膜
US10905555B2 (en) 2015-12-22 2021-02-02 Medtentia International Ltd Oy Medical securing device for securing a cardiac implant device with a securing member
EP3818963B1 (en) 2015-12-30 2025-08-27 Caisson Interventional, LLC Systems for heart valve therapy
CN105496606A (zh) 2016-01-11 2016-04-20 北京迈迪顶峰医疗科技有限公司 一种经导管输送主动脉瓣瓣膜装置
US11833034B2 (en) 2016-01-13 2023-12-05 Shifamed Holdings, Llc Prosthetic cardiac valve devices, systems, and methods
CN108882978B (zh) 2016-01-22 2020-11-06 梅德坦提亚国际有限公司 瓣膜成形术植入物
EP3410984B1 (en) 2016-02-04 2023-03-29 Boston Scientific Scimed, Inc. Mitral valve inversion prostheses
US10363130B2 (en) 2016-02-05 2019-07-30 Edwards Lifesciences Corporation Devices and systems for docking a heart valve
CN114392007A (zh) 2016-03-01 2022-04-26 米特拉尔爱有限责任公司 用于锚固和/或密封心脏瓣膜假体的系统、装置和方法
US10667904B2 (en) 2016-03-08 2020-06-02 Edwards Lifesciences Corporation Valve implant with integrated sensor and transmitter
WO2019241777A1 (en) 2018-06-15 2019-12-19 Dura Llc Heart valve leaflet replacement device and multi-stage, multi-lumen heart valve delivery system and method for the same
EP3426195A4 (en) 2016-03-08 2019-11-20 Dura LLC VALVE BLADE REPLACEMENT SYSTEM AND ASSOCIATED METHOD
WO2017160823A1 (en) 2016-03-14 2017-09-21 Medtronic Vascular Inc. Stented prosthetic heart valve having a wrap and delivery devices
EP3434312B1 (en) 2016-03-22 2020-09-09 Terumo Kabushiki Kaisha Long body for medical use
USD815744S1 (en) 2016-04-28 2018-04-17 Edwards Lifesciences Cardiaq Llc Valve frame for a delivery system
WO2017196909A1 (en) 2016-05-12 2017-11-16 St. Jude Medical, Cardiology Division, Inc. Mitral heart valve replacement
US10201416B2 (en) 2016-05-16 2019-02-12 Boston Scientific Scimed, Inc. Replacement heart valve implant with invertible leaflets
US10456245B2 (en) 2016-05-16 2019-10-29 Edwards Lifesciences Corporation System and method for applying material to a stent
WO2017214098A1 (en) 2016-06-06 2017-12-14 Medtronic Vascular Inc. Transcatheter prosthetic heart valve delivery system with lateral offset control
US10828150B2 (en) 2016-07-08 2020-11-10 Edwards Lifesciences Corporation Docking station for heart valve prosthesis
WO2018013725A1 (en) 2016-07-12 2018-01-18 Graftworx, Inc. System and method for measuring blood flow parameters in a blood vessel having an endovascular prosthesis
US11185413B2 (en) 2016-07-13 2021-11-30 Medfree, Inc. Tissue grasping devices and related methods
US10716916B2 (en) 2016-07-21 2020-07-21 Creganna Unlimited Company High load steerable shaft and method for cardiac catheter
US10350062B2 (en) 2016-07-21 2019-07-16 Edwards Lifesciences Corporation Replacement heart valve prosthesis
US11304698B2 (en) 2016-07-25 2022-04-19 Virender K. Sharma Cardiac shunt device and delivery system
US20180028784A1 (en) 2016-07-28 2018-02-01 Cook Medical Technolgoies Llc Control wire distal securement in steerable catheter
WO2018025260A1 (en) 2016-07-31 2018-02-08 Mvalve Technologies Ltd. Intracardiac devices comprising wire-supported valve leaflets
WO2018026904A1 (en) 2016-08-03 2018-02-08 Spence Paul A Devices, systems and methods to improve placement and prevent heart block with percutaneous aortic valve replacement
EP3284413B1 (en) 2016-08-16 2019-12-18 Medtentia International Ltd Oy Medical securing device for securing a cardiac implant device with a securing member
US10646340B2 (en) 2016-08-19 2020-05-12 Edwards Lifesciences Corporation Steerable delivery system for replacement mitral valve
US10722359B2 (en) 2016-08-26 2020-07-28 Edwards Lifesciences Corporation Heart valve docking devices and systems
CR20190069A (es) * 2016-08-26 2019-05-14 Edwards Lifesciences Corp Valvulas y sistemas de acoplamiento de valvulas corazon
CN114569289A (zh) 2016-08-26 2022-06-03 爱德华兹生命科学公司 多部分置换心脏瓣膜假体
CN109890326B (zh) 2016-10-26 2026-04-03 美敦力瓦斯科尔勒公司 具有瓣周密封包裹部的带支架的假体心脏瓣膜
US10758348B2 (en) 2016-11-02 2020-09-01 Edwards Lifesciences Corporation Supra and sub-annular mitral valve delivery system
US11376121B2 (en) 2016-11-04 2022-07-05 Highlife Sas Transcatheter valve prosthesis
US10188514B2 (en) 2016-11-04 2019-01-29 Highlife Sas Transcatheter valve prosthesis
US10195027B2 (en) 2016-11-04 2019-02-05 Highlife Sas Transcatheter valve prosthesis
US10456247B2 (en) 2016-11-04 2019-10-29 Highlife Sas Transcatheter valve prosthesis
US9999502B2 (en) 2016-11-04 2018-06-19 Highlife Sas Transcather valve prosthesis
US10463484B2 (en) 2016-11-17 2019-11-05 Edwards Lifesciences Corporation Prosthetic heart valve having leaflet inflow below frame
US10973631B2 (en) 2016-11-17 2021-04-13 Edwards Lifesciences Corporation Crimping accessory device for a prosthetic valve
AU2017363069B2 (en) 2016-11-18 2020-08-20 Cephea Valve Technologies, Inc. Cardiac valve delivery devices and systems
US10603165B2 (en) 2016-12-06 2020-03-31 Edwards Lifesciences Corporation Mechanically expanding heart valve and delivery apparatus therefor
FR3060292B1 (fr) 2016-12-15 2019-01-25 Cmi'nov Dispositif pour realiser ou preparer une annuloplastie mitrale par voie transfemorale
JP7440263B2 (ja) 2016-12-16 2024-02-28 エドワーズ ライフサイエンシーズ コーポレイション 人工弁用のアンカリングデバイスを送達するための展開システム、ツール、および方法
SG10202109534TA (en) 2016-12-20 2021-10-28 Edwards Lifesciences Corp Systems and mechanisms for deploying a docking device for a replacement heart valve
US10813749B2 (en) 2016-12-20 2020-10-27 Edwards Lifesciences Corporation Docking device made with 3D woven fabric
JP2020501842A (ja) 2016-12-22 2020-01-23 ハート・リペアー・テクノロジーズ・インコーポレーテッド インプラントを心臓弁輪に固定する経皮的送達システム
EP3342355B1 (en) 2016-12-29 2020-04-22 Medtentia International Ltd Oy Medical securing device for securing an object with a securing member
US11696828B2 (en) 2016-12-30 2023-07-11 Pipeline Medical Technologies, Inc. Method and apparatus for mitral valve chord repair
US9877833B1 (en) 2016-12-30 2018-01-30 Pipeline Medical Technologies, Inc. Method and apparatus for transvascular implantation of neo chordae tendinae
US11083580B2 (en) 2016-12-30 2021-08-10 Pipeline Medical Technologies, Inc. Method of securing a leaflet anchor to a mitral valve leaflet
AU2018203053B2 (en) 2017-01-23 2020-03-05 Cephea Valve Technologies, Inc. Replacement mitral valves
CA3051272C (en) 2017-01-23 2023-08-22 Cephea Valve Technologies, Inc. Replacement mitral valves
US11013600B2 (en) 2017-01-23 2021-05-25 Edwards Lifesciences Corporation Covered prosthetic heart valve
US10912919B2 (en) 2017-01-23 2021-02-09 Edwards Lifesciences Corporation Expandable sheath
US11654023B2 (en) 2017-01-23 2023-05-23 Edwards Lifesciences Corporation Covered prosthetic heart valve
US10743991B2 (en) 2017-01-23 2020-08-18 Edwards Lifesciences Corporation Chordae tendineae adjustment
US11185406B2 (en) 2017-01-23 2021-11-30 Edwards Lifesciences Corporation Covered prosthetic heart valve
US10905550B2 (en) 2017-02-01 2021-02-02 Medtronic Vascular, Inc. Heart valve prostheses including torque anchoring mechanisms and delivery devices for the heart valve prostheses
US10675017B2 (en) 2017-02-07 2020-06-09 Edwards Lifesciences Corporation Transcatheter heart valve leaflet plication
US12201517B2 (en) 2017-02-17 2025-01-21 Cardiovascular Diagnostics Inc. Transcatheter heart valve apparatus for calcific mitral stenosis
EP3585312A4 (en) 2017-02-27 2020-12-02 Dura LLC NEW TRANSCATHETER VALVE REPLACEMENT DEVICE
WO2018165064A1 (en) 2017-03-06 2018-09-13 Boston Scientific Scimed, Inc. Replacement heart valve system having docking station with sacrificial valve
CN114587711A (zh) 2017-03-13 2022-06-07 宝来瑞斯医疗有限公司 用于经导管治疗瓣膜返流的装置、系统和方法
US10653524B2 (en) 2017-03-13 2020-05-19 Polares Medical Inc. Device, system, and method for transcatheter treatment of valvular regurgitation
US10478303B2 (en) 2017-03-13 2019-11-19 Polares Medical Inc. Device, system, and method for transcatheter treatment of valvular regurgitation
CN113081391A (zh) 2017-03-22 2021-07-09 爱德华兹生命科学公司 用于将生物假体装置植入和固定到湿组织的系统和方法
WO2018178966A1 (en) 2017-03-27 2018-10-04 Truleaf Medical Ltd. Docking elements
US20210113332A1 (en) 2017-03-27 2021-04-22 Truleaf Medical Ltd. Invertible valve support frame for use with prosthetic heart valve apparatus
CN110520079B (zh) 2017-03-28 2022-09-27 美敦力公司 实现经导管的带支架的假体的压缩的张力构件引导设计
US11318018B2 (en) 2017-03-28 2022-05-03 Cardiac Success Ltd. Method of improving cardiac function
CA3058150A1 (en) 2017-03-28 2018-10-04 Cardiac Success Ltd. Devices for delivering a band to encircle a plurality of papillary muscles in the heart
US12252712B2 (en) 2017-04-03 2025-03-18 Organovo, Inc. Use of engineered liver tissue constructs for modeling liver disorders
US11123187B2 (en) 2017-04-05 2021-09-21 Opus Medical Therapies, LLC Transcatheter atrial anchors and methods of implantation
US10820992B2 (en) 2017-04-05 2020-11-03 Opus Medical Therapies, LLC Transcatheter atrial sealing skirt, anchor, and tether and methods of implantation
US10716668B2 (en) 2017-04-05 2020-07-21 Medtronic, Inc. Delivery system with anchoring nosecone and method of delivery
US11337685B2 (en) 2017-04-05 2022-05-24 Opus Medical Therapies, LLC Transcatheter anchoring assembly for a mitral valve, a mitral valve, and related methods
CA3178029A1 (en) 2017-04-05 2018-10-11 Opus Medical Therapies, LLC Transcatheter atrial sealing skirt, anchor, and tether and methods of implantation
US11103351B2 (en) 2017-04-05 2021-08-31 Opus Medical Therapies, LLC Transcatheter atrial sealing skirt and related method
US10765515B2 (en) 2017-04-06 2020-09-08 University Of Maryland, Baltimore Distal anchor apparatus and methods for mitral valve repair
CN106890035A (zh) 2017-04-17 2017-06-27 乐普（北京）医疗器械股份有限公司 一种经导管植入式主动脉瓣膜装置
US10702378B2 (en) 2017-04-18 2020-07-07 Twelve, Inc. Prosthetic heart valve device and associated systems and methods
US10433961B2 (en) 2017-04-18 2019-10-08 Twelve, Inc. Delivery systems with tethers for prosthetic heart valve devices and associated methods
EP3395296B1 (en) 2017-04-28 2019-12-18 Medtentia International Ltd Oy Annuloplasty implant
US11135056B2 (en) 2017-05-15 2021-10-05 Edwards Lifesciences Corporation Devices and methods of commissure formation for prosthetic heart valve
EP3406225B1 (en) 2017-05-23 2023-04-26 HVR Cardio Oy Annuloplasty implant
US12064341B2 (en) 2017-05-31 2024-08-20 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
IL309520B2 (en) 2017-05-31 2026-02-01 Edwards Lifesciences Corp Sealing component for heart valve bushing
US10646338B2 (en) 2017-06-02 2020-05-12 Twelve, Inc. Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods
US10952842B2 (en) 2017-06-07 2021-03-23 W. L. Gore & Associates, Inc. Prosthetic valve with improved washout
EP3417831B2 (en) 2017-06-19 2023-05-24 HVR Cardio Oy Delivery device for an annuloplasty implant
EP3417832A1 (en) 2017-06-22 2018-12-26 Medtentia International Ltd Oy Medical securing device for securing an object with a securing member
US11202643B2 (en) 2017-06-22 2021-12-21 Smith & Nephew, Inc. Anchor delivery system
AU2018294423B2 (en) 2017-06-30 2023-11-09 Lakshmi Prasad Dasi Prosthetic heart valve with tri-leaflet design for use in percutaneous valve replacement procedures
SG11201912180QA (en) 2017-06-30 2020-01-30 Edwards Lifesciences Corp Docking stations transcatheter valves
US10729541B2 (en) 2017-07-06 2020-08-04 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
JP7134229B2 (ja) 2017-07-06 2022-09-09 ラグビア バスデ， 組織把持デバイスおよび関連方法
EP3648708A4 (en) 2017-07-06 2021-03-31 Edwards Lifesciences Corporation CONTROLLED DISPENSING SYSTEM AND COMPONENTS
US10888421B2 (en) 2017-09-19 2021-01-12 Cardiovalve Ltd. Prosthetic heart valve with pouch
US11083575B2 (en) 2017-08-14 2021-08-10 Edwards Lifesciences Corporation Heart valve frame design with non-uniform struts
US10932903B2 (en) 2017-08-15 2021-03-02 Edwards Lifesciences Corporation Skirt assembly for implantable prosthetic valve
WO2019036548A2 (en) 2017-08-17 2019-02-21 Boston Scientific Scimed, Inc. Anchor delivery system and methods for valve repair
US10898319B2 (en) 2017-08-17 2021-01-26 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
US10973628B2 (en) 2017-08-18 2021-04-13 Edwards Lifesciences Corporation Pericardial sealing member for prosthetic heart valve
US10856971B2 (en) 2017-08-18 2020-12-08 Edwards Lifesciences Corporation Sealing members for prosthetic heart valve
US10722353B2 (en) 2017-08-21 2020-07-28 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
EP3672525A1 (en) 2017-08-24 2020-07-01 Medtronic Vascular Inc. Transseptal delivery systems having a deflecting segment and methods of use
US10722351B2 (en) 2017-08-24 2020-07-28 Medtronic Vascular, Inc. Transcatheter prosthesis with sealing component, and systems and methods for delivering and deployment thereof
CN111263622A (zh) 2017-08-25 2020-06-09 内奥瓦斯克迪亚拉公司 顺序展开的经导管二尖瓣假体
US11051939B2 (en) 2017-08-31 2021-07-06 Edwards Lifesciences Corporation Active introducer sheath system
US11083572B2 (en) 2017-08-31 2021-08-10 Half Moon Medical, Inc. Prosthetic leaflet device
US10973629B2 (en) 2017-09-06 2021-04-13 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
US11147667B2 (en) 2017-09-08 2021-10-19 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
EP3456377B1 (en) 2017-09-14 2023-04-26 Sorin CRM SAS Attachment means for implantable cardiac device
CN109498213A (zh) 2017-09-14 2019-03-22 上海微创心通医疗科技有限公司 一种瓣膜支架和瓣膜假体
CN111132636B (zh) 2017-09-27 2022-04-08 W.L.戈尔及同仁股份有限公司 带有可扩张框架的假体瓣膜以及相关系统和方法
CN109567985A (zh) 2017-09-29 2019-04-05 上海微创心通医疗科技有限公司 心脏瓣膜假体
WO2019081777A1 (en) 2017-10-27 2019-05-02 Medtentia International Ltd Oy IMPLANT OF ANNULOPLASTY
EP3476366B1 (en) 2017-10-27 2020-12-16 Medtentia International Ltd Oy Annuloplasty implant
CN120770981A (zh) 2017-10-30 2025-10-14 安多拉米诺科学公司 用于防渗漏血管内假体的可扩张密封裙部技术
US10835221B2 (en) 2017-11-02 2020-11-17 Valtech Cardio, Ltd. Implant-cinching devices and systems
US10806574B2 (en) 2017-11-20 2020-10-20 Medtronic Vascular, Inc. Delivery systems having a temporary valve and methods of use
US20200383679A1 (en) 2017-11-27 2020-12-10 T.A.G. Medical Devices - Agriculture Cooperative Ltd. Multiple anchor delivery system and method
WO2019108765A1 (en) 2017-11-29 2019-06-06 Medtronic, Inc. Tissue conduction communication using ramped drive signal
CN111479531B (zh) 2017-11-30 2022-11-04 波士顿科学国际有限公司 用于瓣膜修复的连接的锚固件输送系统和方法
JP7480944B2 (ja) 2017-12-11 2024-05-10 カリフォルニア インスティテュート オブ テクノロジー 血管内埋込可能補綴弁の製造に関するシステム、デバイス、および方法
GB201720803D0 (en) 2017-12-13 2018-01-24 Mitraltech Ltd Prosthetic Valve and delivery tool therefor
WO2019126794A1 (en) 2017-12-22 2019-06-27 Poly-Med, Inc. Tubular implants with controlled biodegradation
WO2019134000A2 (en) 2017-12-29 2019-07-04 Harris Cooper Method and apparatus for digital commerce
US20210052384A1 (en) 2018-01-05 2021-02-25 Medtentia International Ltd Oy A medical fastening device
CN110013359A (zh) 2018-01-07 2019-07-16 苏州杰成医疗科技有限公司 心脏瓣膜假体和制造膜的方法
CN110013353B (zh) 2018-01-07 2023-06-23 苏州杰成医疗科技有限公司 假体心脏瓣膜输送系统
US10980635B2 (en) 2018-01-07 2021-04-20 William Joseph Drasler Annuloplasty device and methods
US11547563B2 (en) 2018-01-08 2023-01-10 Medtentia International Ltd. Oy Annuloplasty device
IL276116B2 (en) 2018-01-19 2025-03-01 Edwards Lifesciences Corp Wrapped artificial heart valve
EP3720390B1 (en) 2018-01-25 2024-05-01 Edwards Lifesciences Corporation Delivery system for aided replacement valve recapture and repositioning post- deployment
WO2019147504A1 (en) 2018-01-25 2019-08-01 Cephea Valve Technologies, Inc. Cardiac valve delivery devices and systems
CN108125732A (zh) 2018-02-06 2018-06-08 北京迈迪顶峰医疗科技有限公司 人工瓣膜及人工瓣膜装置
EP3749253B1 (en) 2018-02-09 2023-07-05 The Provost, Fellows, Foundation Scholars, and the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin A heart valve therapeutic device
CN111787885B (zh) 2018-02-22 2024-08-02 美敦力瓦斯科尔勒公司 假体心脏瓣膜递送系统和方法
US11051934B2 (en) 2018-02-28 2021-07-06 Edwards Lifesciences Corporation Prosthetic mitral valve with improved anchors and seal
WO2019195860A2 (en) 2018-04-04 2019-10-10 Vdyne, Llc Devices and methods for anchoring transcatheter heart valve
EP3784174B8 (en) 2018-04-24 2024-12-11 Caisson Interventional, LLC Systems for heart valve therapy
US11318011B2 (en) 2018-04-27 2022-05-03 Edwards Lifesciences Corporation Mechanically expandable heart valve with leaflet clamps
CN112423709A (zh) 2018-05-18 2021-02-26 万能医药公司 心脏瓣膜修复的方法和装置
US11234818B2 (en) 2018-05-21 2022-02-01 Medtentia International Ltd Oy Annuloplasty device
US11083571B2 (en) 2018-06-27 2021-08-10 Edwards Lifesciences Corporation Frame for prosthetic heart valve
WO2020018630A1 (en) 2018-07-18 2020-01-23 Millipede, Inc. Deployment restraint and delivery system for implantable cardiac device
US12290456B2 (en) 2018-08-21 2025-05-06 Shifamed Holdings, Llc Prosthetic cardiac valve devices, systems, and methods
US12161551B2 (en) 2018-08-30 2024-12-10 Edwards Lifesciences Corporation Systems and methods for sizing and implanting prosthetic heart valves
CA3109649A1 (en) 2018-09-06 2020-03-12 Edwards Lifesciences Corporation Pre-shaped tissue anchors and needles for tissue anchor deployment
WO2020051591A1 (en) 2018-09-07 2020-03-12 Icahn School Of Medicine At Mount Sinai Heart valve delivery system and method with rotational alignment
US20200060820A1 (en) 2018-09-20 2020-02-27 Mitralix Ltd. Systems and methods for positioning medical devices relative to heart valve anatomy
US11413147B2 (en) 2018-10-03 2022-08-16 Edwards Lifesciences Corporation Ventricular remodeling using coil devices
US11413146B2 (en) 2018-10-03 2022-08-16 Edwards Lifesciences Corporation Spring and coil devices for papillary muscle approximation and ventricle remodeling
EP3860519A4 (en) 2018-10-05 2022-07-06 Shifamed Holdings, LLC HEART VALVE PROSTHESIS, SYSTEMS AND PROCEDURES
US12232955B2 (en) 2018-10-06 2025-02-25 The Foundry Modular valve replacement systems and associated devices and methods of use
CN113056302B (zh) 2018-10-19 2023-03-28 施菲姆德控股有限责任公司 可调节医疗装置
US11686043B2 (en) 2018-11-05 2023-06-27 Acclarent, Inc. Pull wire with coated fibers
US11583401B2 (en) 2018-12-13 2023-02-21 Medtronic Vascular, Inc. Heart valve repair
WO2020157018A1 (en) 2019-01-28 2020-08-06 Tricares SAS Three part stent second generation
JP7480161B2 (ja) 2019-02-08 2024-05-09 エドワーズ ライフサイエンシーズ コーポレイション 直接的心臓圧力監視
EP3923869A4 (en) 2019-02-11 2022-11-09 Heart Repair Technologies, Inc. PERCUTANEOUS DELIVERY SYSTEMS FOR ANCHORING AN IMPLANT IN A HEART VALVE RING
JP7541023B2 (ja) 2019-03-04 2024-08-27 エドワーズ ライフサイエンシーズ コーポレイション 人工弁のための交連部取付
WO2020191216A1 (en) 2019-03-19 2020-09-24 Shifamed Holdings, Llc Prosthetic cardiac valve devices, systems, and methods
US11602429B2 (en) 2019-04-01 2023-03-14 Neovasc Tiara Inc. Controllably deployable prosthetic valve
WO2020210652A1 (en) 2019-04-10 2020-10-15 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
US20220054261A1 (en) 2019-04-12 2022-02-24 Shifamed Holdings, Llc Minimal frame prosthetic cardiac valve delivery devices, systems, and methods
WO2020236830A1 (en) 2019-05-20 2020-11-26 Caisson Interventional, LLC Systems and methods for heart valve therapy
CA3140397A1 (en) 2019-06-07 2020-12-10 Edwards Lifesciences Corporation Systems, devices, and methods for treating heart valves
CA3146170A1 (en) 2019-07-09 2021-01-14 Amx Clip Management, Llc Method and device for removing heart valve therapy
EP4480454A3 (en) 2019-07-31 2025-07-09 St. Jude Medical, Cardiology Division, Inc. Alternate stent caf design for tavr
CN114502103B (zh) 2019-08-14 2025-12-12 因诺韦尔弗生物医疗有限公司 房室瓣置换
EP4013353B1 (en) 2019-08-16 2023-09-27 Medtronic Vascular, Inc. Heart valve repair
US20220273430A1 (en) 2019-09-18 2022-09-01 Cardiac Success Ltd. Transcatheter papillary muscle band
US20220401214A1 (en) 2019-10-30 2022-12-22 Shifamed Holdings, Llc Prosthetic cardiac valve delivery devices, systems, and methods
EP4114313B1 (en) 2020-03-03 2025-10-01 Shifamed Holdings, LLC Prosthetic cardiac valve devices, systems
US20230118748A1 (en) 2020-03-13 2023-04-20 Shifamed Holdings, Llc Prosthetic cardiac valve devices, systems, and methods
EP4132428A4 (en) 2020-04-08 2024-05-01 Shifamed Holdings, LLC VALVE DISPENSING SYSTEM
WO2021257722A1 (en) 2020-06-16 2021-12-23 Shifamed Holdings, Llc Minimal frame prosthetic cardiac valve delivery devices, systems, and methods
AU2021306283A1 (en) 2020-07-07 2023-02-09 Shifamed Holdings, Llc Valve delivery system
WO2022047274A1 (en) 2020-08-31 2022-03-03 Shifamed Holdings, Llc Prosthetic cardiac valve delivery systems and methods
EP4203860A4 (en) 2020-08-31 2024-10-09 Shifamed Holdings, LLC PROSTHETIC IMPLANT DELIVERY SYSTEM
US20230320850A1 (en) 2020-08-31 2023-10-12 Shifamed Holdings, Llc Access sheath for prosthetic cardiac valve delivery systems
WO2022047095A1 (en) 2020-08-31 2022-03-03 Shifamed Holdings, Llc Anchor for prosthetic cardiac valve devices
US20230320845A1 (en) 2020-08-31 2023-10-12 Shifamed Holdings, Llc Flared prosthetic cardiac valve delivery devices and systems
EP4203857A4 (en) 2020-08-31 2024-10-09 Shifamed Holdings, LLC INTERFACE FOR HEART VALVE PROSTHESIS AND RELEASE SYSTEMS
WO2022066720A1 (en) 2020-09-22 2022-03-31 Shifamed Holdings, Llc Prosthetic cardiac valve sensor devices, systems, and methods with imaging
US20230355380A1 (en) 2020-09-22 2023-11-09 Shifamed Holdings, Llc Systems, methods, and devices for expandable sensors
US20240016609A1 (en) 2020-12-03 2024-01-18 Shifamed Holdings, Llc Mitral valve implants
US12329635B2 (en) 2020-12-04 2025-06-17 Shifamed Holdings, Llc Flared prosthetic cardiac valve delivery devices and systems
WO2022174160A1 (en) 2021-02-12 2022-08-18 Shifamed Holdings, Llc Anchor for prosthetic cardiac valve delivery devices and systems
US12201521B2 (en) 2021-03-22 2025-01-21 Shifamed Holdings, Llc Anchor position verification for prosthetic cardiac valve devices
US20220387755A1 (en) 2021-06-03 2022-12-08 Cardiovascular Systems, Inc. Echolucent Intravascular Cannula and Echolucent Locating of Portions of Intravascular Medical Devices
WO2023091254A1 (en) 2021-11-19 2023-05-25 Edwards Lifesciences Corporation Prosthetic valve docking device

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8449599B2 (en) * 2009-12-04 2013-05-28 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
WO2015023579A1 (en) 2013-08-12 2015-02-19 Mitral Valve Technologies Sa Apparatus and methods for implanting a replacement heart valve
US10052198B2 (en) * 2013-08-14 2018-08-21 Mitral Valve Technologies Sarl Coiled anchor for supporting prosthetic heart valve, prosthetic heart valve, and deployment device
WO2015127264A1 (en) * 2014-02-20 2015-08-27 Mitral Valve Technologies Sarl Coiled anchor for supporting prosthetic heart valve, prosthetic heart valve, and deployment device
US20170128203A1 (en) * 2015-11-06 2017-05-11 Micor Limited Mitral valve prosthesis
US20180228610A1 (en) * 2017-02-10 2018-08-16 Millipede, Inc. Implantable device and delivery system for reshaping a heart valve annulus

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP3860519A4

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11833034B2 (en) 2016-01-13 2023-12-05 Shifamed Holdings, Llc Prosthetic cardiac valve devices, systems, and methods
US12290456B2 (en) 2018-08-21 2025-05-06 Shifamed Holdings, Llc Prosthetic cardiac valve devices, systems, and methods
US11986389B2 (en) 2018-10-05 2024-05-21 Shifamed Holdings, Llc Prosthetic cardiac valve devices, systems, and methods
US11672657B2 (en) 2018-10-05 2023-06-13 Shifamed Holdings, Llc Prosthetic cardiac valve devices, systems, and methods
US12419743B2 (en) 2018-10-05 2025-09-23 Shifamed Holdings, Llc Prosthetic cardiac valve devices, systems, and methods
US12403008B2 (en) 2018-10-19 2025-09-02 Shifamed Holdings, Llc Adjustable medical device
US11471282B2 (en) 2019-03-19 2022-10-18 Shifamed Holdings, Llc Prosthetic cardiac valve devices, systems, and methods
WO2021183610A1 (en) 2020-03-13 2021-09-16 Shifamed Holdings, Llc Prosthetic cardiac valve devices, systems, and methods
WO2021207545A1 (en) 2020-04-08 2021-10-14 Shifamed Holdings, Llc Valve delivery system
US12053371B2 (en) 2020-08-31 2024-08-06 Shifamed Holdings, Llc Prosthetic valve delivery system
US12329635B2 (en) 2020-12-04 2025-06-17 Shifamed Holdings, Llc Flared prosthetic cardiac valve delivery devices and systems
US12201521B2 (en) 2021-03-22 2025-01-21 Shifamed Holdings, Llc Anchor position verification for prosthetic cardiac valve devices
WO2022262117A1 (zh) * 2021-06-17 2022-12-22 上海臻亿医疗科技有限公司 一种心脏瓣膜的锚固装置

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