WO2017201877A1 - 一种红曲葡萄酒及其制备方法 - Google Patents

一种红曲葡萄酒及其制备方法 Download PDF

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WO2017201877A1
WO2017201877A1 PCT/CN2016/093213 CN2016093213W WO2017201877A1 WO 2017201877 A1 WO2017201877 A1 WO 2017201877A1 CN 2016093213 W CN2016093213 W CN 2016093213W WO 2017201877 A1 WO2017201877 A1 WO 2017201877A1
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red yeast
parts
chinese medicine
medicine extract
traditional chinese
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English (en)
French (fr)
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马艳敏
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牟伟
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
    • C12G1/00—Preparation of wine or sparkling wine
    • C12G1/02—Preparation of must from grapes; Must treatment and fermentation
    • C12G1/0203—Preparation of must from grapes; Must treatment and fermentation by microbiological or enzymatic treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
    • C12G1/00—Preparation of wine or sparkling wine
    • C12G1/02—Preparation of must from grapes; Must treatment and fermentation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
    • C12G3/00—Preparation of other alcoholic beverages
    • C12G3/02—Preparation of other alcoholic beverages by fermentation
    • C12G3/023—Preparation of other alcoholic beverages by fermentation of botanical family Solanaceae, e.g. potato
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/884—Alismataceae (Water-plantain family)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
    • C12G3/00—Preparation of other alcoholic beverages
    • C12G3/02—Preparation of other alcoholic beverages by fermentation
    • C12G3/021—Preparation of other alcoholic beverages by fermentation of botanical family Poaceae, e.g. wheat, millet, sorghum, barley, rye, or corn
    • C12G3/022—Preparation of other alcoholic beverages by fermentation of botanical family Poaceae, e.g. wheat, millet, sorghum, barley, rye, or corn of botanical genus Oryza, e.g. rice
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
    • C12G3/00—Preparation of other alcoholic beverages
    • C12G3/02—Preparation of other alcoholic beverages by fermentation
    • C12G3/024—Preparation of other alcoholic beverages by fermentation of fruits other than botanical genus Vitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
    • C12G3/00—Preparation of other alcoholic beverages
    • C12G3/02—Preparation of other alcoholic beverages by fermentation
    • C12G3/026—Preparation of other alcoholic beverages by fermentation with health-improving ingredients, e.g. flavonoids, flavones, polyphenols or polysaccharides, added before or during the fermentation stage; with flavouring ingredients added before or during the fermentation stage

Definitions

  • the invention relates to the field of food processing and biological fermentation technology, in particular to a red yeast wine.
  • Wine is a high-grade beverage with a variety of nutrients. Moderate drinking wine can directly affect the nervous system of the human body and increase the muscle's tonicity. A variety of amino acids, minerals and vitamins contained in wine can be directly absorbed by the body. Among them, potassium can protect the heart muscle and maintain heart beat; calcium can calm nerves, magnesium is a protective factor for cardiovascular disease, and magnesium deficiency can cause coronary artery hardening. These three elements are important components of the human bones and muscles. Manganese has the function of coagulation and synthesis of cholesterol and insulin. Therefore, wine can regulate the physiological functions of the human body, especially those who are weak, suffer from sleep disorders and the elderly.
  • Red yeast rice also known as “Dan Qu” has always been considered as a product with both medicinal and edible effects.
  • Li Shizhen described the application of red yeast in traditional Chinese medicine in the “Compendium of Materia Medica”: “Hongqu is in charge of digestion and activating blood circulation, spleen and stomach, cure red and white sputum, and get into the water valley. Brewing, breaking blood and taking medicine, treating smashing damage ".
  • Monascus can produce a variety of secondary metabolites, mainly Monascus pigment, lovastatin, and red yeast rice also contains ergosterol, glucosamine, and gamma-aminobutyric acid (GABA).
  • GABA gamma-aminobutyric acid
  • physiologically active substances such as unsaturated fatty acids, red yeast polysaccharides, and flavonoids. It is these physiologically active substances that give red yeast rice multiple functions such as lowering blood fat, lowering blood pressure, resisting oxidation, antibacterial, anti-fatigue, softening blood vessels, preventing senile dementia, and making it highly commercially valuable.
  • the present invention provides a red koji wine rich in lovastatin, which is mellow in taste, clear in color, and does not lose the original nutrients of the grapes.
  • the present invention provides the following technical solutions:
  • red yeast wine having the following raw materials, all in parts by weight: red yeast 20-40, grape 40-60, Chinese medicine extract 10-20, rock sugar 5-20;
  • the traditional Chinese medicine extract comprises the following components in parts by weight: grape seed 10-15, guarana 5-10, medlar 10-15, Alisma 10-15, angelica 10-15, hawthorn 10-15 , Bupleurum 5-10, chrysanthemum 5-10, dried tangerine peel 5-10.
  • the traditional Chinese medicine extract is divided into parts by weight, including the following components: grape seed 12, guarana 8, hazelnut 12, diarrhea 12, angelica 12, hawthorn 12, Bupleurum 8, chrysanthemum 5-10, tangerine peel 8 .
  • red yeast rice is water-soluble red yeast rice, and the content of lovastatin in red yeast rice is 100,000 to 200,000 mg/kg.
  • a method for preparing a red yeast wine the steps are as follows:
  • the non-plastic container described in the step (1) is a glass container or a ceramic can.
  • the traditional Chinese medicine extract in the step (2) is not added with any organic solvent.
  • the fermentation temperature is controlled at 25-30 ° C, and the fermentation time is 15-20 days.
  • the dry yeast in the step (3) is 0.01 to 0.1 parts of dry yeast powder.
  • Grape seed is the waste of the winery and is rich in various amino acids, vitamins and minerals. Grape seed extract has the function of scavenging free radicals and anti-liver tumors, and can also resist damage to the nervous system. Grape seed extract has super antioxidant capacity, 50 times that of vitamin E, which can delay aging and prevent arteriosclerosis. .
  • Guarana is an evergreen vine plant whose seeds are brown and slightly bitter after drying. Its main ingredient is Guaranain, which is long-term consumption. It has the functions of refreshing, nourishing yin and yang, restoring vitality, replenishing energy and strengthening the body. In addition, it is rich in amino acids, alkaloids and various minerals. Acid, multivitamins and carbohydrates are very beneficial to the absorption of human tissues. They have the effect of changing the structure of the human body and prolonging life. They can be eaten by men, women and children, especially for people with chronic diseases.
  • Angelica alias Qingui, Yungui, Xi Danggui, Dangdang Angelica, sweet, spicy, bitter, and warm.
  • Scorpion has the effect of lowering blood sugar, lowering blood pressure, resisting fatty liver, and resisting atherosclerosis.
  • Alisma, hawthorn, Bupleurum, chrysanthemum, dried tangerine peel, etc. not only nourish yin and tonify kidney, improve essence and fill the marrow, promote blood circulation, and can restore physical strength, replenish energy, enhance immunity and strengthen the body.
  • the processing method of the invention is simple, cost-saving, no added organic solvent, high alcohol conversion rate and no pollution in environment, and the prepared red yeast wine has anti-neurasthenia and anti-ultra fatigue effect, and has a mellow taste and clear color. Unique flavor.
  • the invention has rich nutritional value and medicine and health care function while satisfying the function of drinking wine, and is combined with water-soluble red yeast to ferment, and lovastatin contained in the wine has the effect of lowering blood fat and lowering blood pressure, red yeast
  • the active ingredients in the Chinese medicine and the active ingredients in the extract of the traditional Chinese medicine are coordinated and synergistic, and the effects are mutually enhanced.
  • Embodiment 1 is a diagrammatic representation of Embodiment 1:
  • a red yeast wine having the following raw materials, all of which are in parts by weight: red yeast 20, grape 40, Chinese herbal extract 10, rock sugar 5-20, the red yeast rice is water-soluble red yeast rice, and the red yeast rice is lovastatin.
  • the content is 100000-200000 mg/kg; the traditional Chinese medicine extract is divided into parts by weight, including the following components: grape seed 10, guarana 5, medlar 10, Alisma 10, angelica 10, hawthorn 10, Bupleurum 5 , chrysanthemum 5, dried tangerine peel 5.
  • the preparation steps of the red yeast wine are as follows:
  • grape juice the grapes are washed, dried, pulverized, filtered, and placed in a sterilized glass container or ceramic jar to obtain grape juice;
  • canning the above sterilized wine is filled, placed in a cool place sealed and preserved, that is, red wine.
  • Embodiment 2 is a diagrammatic representation of Embodiment 1:
  • a red yeast wine having the following raw materials, all of which are in parts by weight: red yeast 30, grape 50, Chinese herbal extract 15, and rock sugar 5-20, the red yeast rice is water-soluble red yeast rice, and the red yeast rice is lovastatin.
  • the content is 100000-200000 mg/kg; the traditional Chinese medicine extract is divided into parts by weight, including the following components: grape seed 12, guarana 8, scorpion 12, diarrhea 12, angelica 12, hawthorn 12, Bupleurum 8 , chrysanthemum 5-10, dried tangerine peel 8.
  • the preparation steps of the red yeast wine are as follows:
  • grape juice the grapes are washed, dried, pulverized, filtered, and placed in a sterilized glass container or ceramic jar to obtain grape juice;
  • canning the above sterilized wine is filled, placed in a cool place sealed and preserved, that is, red wine.
  • Embodiment 3 is a diagrammatic representation of Embodiment 3
  • a red yeast wine having the following raw materials, all in parts by weight: red yeast 40, grape 60, Chinese herbal extract 20, rock sugar 5-20, the red yeast rice is water-soluble red yeast rice, and the red yeast rice is lovastatin.
  • the content of the traditional Chinese medicine extract is in parts by weight, including the following components: grape seed 15, guarana 10, wolfberry 15, diarrhea 15, angelica 15, hawthorn 15, bupleurum 10 , chrysanthemum 10, dried tangerine peel 10.
  • the preparation steps of the red yeast wine are as follows:
  • grape juice the grapes are washed, dried, crushed, filtered, and placed in a sterilized glass container or ceramic In the tank, get the grape juice;
  • canning the above sterilized wine is filled, placed in a cool place sealed and preserved, that is, red wine.
  • 180 red blood wines of the present invention are used as a treatment method, and 180 people aged 40-80 years old with hypertension and hyperlipidemia (including 40-50-50 middle-aged people, 50 - 60 middle-aged and elderly people, 60-year-old 60-80-year-olds) were divided into two groups for human trials, which were experimental group and control group, twice per person, twice a cup, 100 ml, and experimental group.
  • the red yeast wine of the third embodiment was taken, and the control group took the same amount of wine, and the therapeutic effect was statistically obtained for 90 days.
  • the test results are shown in Table 1.
  • test standard for blood pressure reduction is that the range of systolic blood pressure reduction is 10-30 mmHg, which is markedly effective; the range of systolic blood pressure reduction is 5-10 mmHg, which is effective; there is no improvement in systolic blood pressure, which is ineffective.
  • the test standard for blood lipid lowering is that the diagnostic criteria for hyperlipidemia are judged according to the level of cholesterol in the human body, so the total cholesterol lowering range is 0.5-1mmol/L, which is markedly effective; the total cholesterol lowering range is 0.1-0.5mmol/ L, is effective; no improvement in total cholesterol, is invalid.
  • Example 3 The experimental group taking the red wine of Example 3 and the control group taking ordinary wine went to the hospital for a medical examination. It can be seen from Table 1 that the symptoms of middle-aged, middle-aged and elderly people are greatly improved, blood pressure and blood lipids are reduced, and the effect is remarkable.
  • red yeast rice is rich in Active ingredient, which complements various amino acids, alkaloids, vitamins and other substances in traditional Chinese medicine extracts, synergistically acts together to regulate the body, has anti-fatigue, supplements energy, promotes blood circulation, prevents arteriosclerosis, enhances immunity, strengthens health
  • Active ingredient which complements various amino acids, alkaloids, vitamins and other substances in traditional Chinese medicine extracts, synergistically acts together to regulate the body, has anti-fatigue, supplements energy, promotes blood circulation, prevents arteriosclerosis, enhances immunity, strengthens health
  • the red yeast wine of the present invention has rich nutritional value and medical and health care effects while satisfying the function of drinking wine, and is suitable for different groups.

Abstract

一种红曲葡萄酒，由下列原料按重量份计组成：红曲20-40，葡萄40-60，中药提取液10-20，冰糖5-20；所述中药提取液按重量份计，包括以下组分：葡萄籽10-15，瓜拉纳5-10，枸杞子10-15，泽泻10-15，当归10-15，山楂10-15，柴胡5-10，菊花5-10，陈皮5-10。

Description

一种红曲葡萄酒及其制备方法 技术领域
本发明涉及食品加工和生物发酵技术领域，具体涉及一种红曲葡萄酒。
背景技术
葡萄酒是具有多种营养成分的高级饮料，适度饮用葡萄酒能直接对人体的神经系统产生作用，提高肌肉的张度。葡萄酒中含有的多种氨基酸、矿物质和维生素等能直接被人体吸收，其中，钾能保护心肌，维持心脏跳动；钙能镇定神经，镁是心血管病的保护因子，缺镁易引起冠状动脉硬化。这三种元素是构成人体骨骼、肌肉的重要组成部分，锰有凝血和合成胆固醇、胰岛素的作用。因此葡萄酒能调节人体的生理机能，尤其身体虚弱、患有睡眠障碍者及老年人的效果更好。
红曲也称“丹曲”，一直被认为是具有药用和食用双重功效的产品。明代李时珍在《本草纲目》中记述了红曲在中医学中的应用：“红曲主治消食活血，健脾燥胃，治赤白痢，下水谷。酿酒，破血行药势，治打扑伤损”。现代科学研究报告表明，红曲菌能产生多种次级代谢产物，主要是红曲色素，洛伐他汀，此外红曲米中还含有麦角固醇、葡萄糖胺、γ～氨基丁酸(GABA)，不饱和脂肪酸、红曲多糖、黄酮等多种生理活性物质。正是这些生理活性物质赋予了红曲具有降血脂、降血压、抗氧化、抗菌、抗疲劳、软化血管、预防老年痴呆等多重功效，并且使其具有很高的商业价值。
发明内容
针对上述现有技术中存在的问题，本发明提供一种口感醇厚、色泽澄清、葡萄的原有营养元素不会流失，并且富含高洛伐他汀的红曲葡萄酒。
为实现上述目的，本发明提供如下技术方案：
一种红曲葡萄酒，有下列原料组成，均为重量份：红曲20-40，葡萄40-60，中药提取液10-20，冰糖5-20；
所述中药提取液按重量份数计，包括以下组分：葡萄籽10-15，瓜拉纳5-10，枸杞子10-15，泽泻10-15，当归10-15，山楂10-15，柴胡5-10，菊花5-10，陈皮5-10。
进一步，有下列原料组成，均为重量份：红曲30，葡萄50，中药提取液15，冰糖5-20；
所述中药提取液按重量份数计，包括以下组分：葡萄籽12，瓜拉纳8，枸杞子12，泽泻12，当归12，山楂12，柴胡8，菊花5-10，陈皮8。
进一步，所述红曲为水溶性红曲，红曲中洛伐他汀的含量为100000-200000mg/kg。
进一步，一种红曲葡萄酒的制备方法，步骤如下：
(1)制葡萄汁：将葡萄清洗、晾干、粉碎、过滤后，放入经过消毒的非塑料容器内，得葡萄汁；
(2)制中药提取液：将葡萄籽、瓜拉纳、枸杞子、泽泻、当归、山楂、柴胡、菊花、陈皮烘干粉碎成粗粉，按照所述重量份装入通透袋中，将装有中药的通透袋放入锅中，加入中药质量10-15倍的水，大火加热至沸腾后，小火熬煮20-30分钟，取出通透袋，倒出药液，再次将通透袋放入锅中，加水熬煮，重复操作一次，合并两次所得药液，减压浓缩成中药提取液，离心除杂，灭菌；
(3)发酵：将红曲、葡萄汁以及步骤(2)中的所述中药提取液置于发酵罐中，调整各成分的含量，然后加入干酵母和冰糖混合均匀，进行发酵；
(4)过滤灭菌：将发酵后的酒液过滤，去除沉淀物，并对酒液灭菌；
(5)装罐：将上述灭菌后的酒液进行灌装，放置阴凉处密封保存，即得红曲葡萄酒。
进一步，步骤(1)中所述非塑料容器为玻璃容器或陶瓷罐。
进一步，步骤(2)中所述中药提取液不添加任何有机溶剂。
进一步，所述步骤(3)中，发酵温度控制在25-30℃，发酵时间为15-20天。
进一步，所述步骤(3)中的干酵母为0.01-0.1份的干酵母粉。
葡萄籽是葡萄酒厂的下脚料，含有丰富各种氨基酸、维生素及矿物质。葡萄籽提取物，具有清除自由基、抗肝脏肿瘤的作用，还可以对抗神经系统的损伤，同时葡萄籽提取物具有超强抗氧化能力，是维他命E的50倍，能延缓老化，预防动脉硬化。
瓜拉纳是一种常绿蔓生植物，其种子烘干后，呈棕褐色，略带苦味。其主要成份是瓜拉纳因，长期食用，有提神醒脑、滋阴壮阳、恢复体力、补充能量、强身健体之功效，此外，还含有丰富的氨基酸、生物碱、多种矿物质丹宁酸，多种维生素和碳水化合物，非常利于人体的组织吸收，有改变人体组织结构而延年益寿的功效，不论男女老幼都可食用，尤其适用于机能衰退有慢性疾病的人。
当归别名秦归、云归、西当归、岷当归，味甘、辛、苦、性温。补血活血、润燥滑肠、免疫之功效。
枸杞子具有降低血糖、降血压、抗脂肪肝作用，并能抗动脉粥样硬化。泽泻、山楂、柴胡、菊花、陈皮等不仅滋阴补肾、益精填髓、活血化瘀，并且能恢复体力、补充能量、增强免疫力及强身健体之功效。
相对于现有技术，本发明的有益效果在于：
(1)本发明的加工方法简单、节约成本、无添加有机溶剂、酒精转化率高，环境无污染，制备的红曲葡萄酒具有抗神经衰弱、抗过度疲劳的功效，其口感醇厚，色泽澄清、风味独特。
(2)本发明在满足饮用酒功能的同时，具有丰富的营养价值和医药保健作用，其与水溶性红曲结合发酵，酒中含有的洛伐他汀具有降血脂，降血压的功效，红曲中的有效成分与中药提取液中的有效成分相互协调，协同作用，功效相互增进。
具体实施方式
为了使本领域的人员更好地理解本发明的技术方案，下面结合本发明的附图，对本发明的技术方案进行清楚、完整的描述，基于本申请中的实施例，本领域普通技术人员在没有做出创造性劳动的前提下所获得的其它类同实施例，都应当属于本申请保护的范围。
实施例一：
一种红曲葡萄酒，有下列原料组成，均为重量份：红曲20，葡萄40，中药提取液10，冰糖5-20，所述红曲为水溶性红曲，红曲中洛伐他汀的含量为100000-200000mg/kg；所述中药提取液按重量份数计，包括以下组分：葡萄籽10，瓜拉纳5，枸杞子10，泽泻10，当归10，山楂10，柴胡5，菊花5，陈皮5。
所述红曲葡萄酒的制备步骤如下：
(1)、制葡萄汁：将葡萄清洗、晾干、粉碎、过滤后，放入经过消毒的玻璃容器或陶瓷罐内，得葡萄汁；
(2)、制中药提取液：将葡萄籽、枸杞子、泽泻、当归、山楂、柴胡、菊花、陈皮烘干粉碎成粗粉，按照所述重量份装入通透袋中，将装有中药的通透袋放入锅中，加入中药质量10-15倍的水，大火加热至沸腾后，小火熬煮20-30分钟，取出通透袋，倒出药液，再次将通透袋放入锅中，加水熬煮，重复操作一次，合并两次所得药液，减压浓缩成中药提取液，离心除杂，灭菌，在此提取过程中不添加任何有机溶剂；
(3)、发酵：将红曲、葡萄汁以及步骤(2)中的所述中药提取液置于发酵罐中，调整各成分的含量，然后加入干酵母和冰糖混合均匀，进行发酵，并把发酵温度控制在25-30℃，发酵时间为15-20天，所述干酵母为0.01-0.1份的干酵母粉；
(4)、过滤灭菌：将发酵后的酒液过滤，去除沉淀物，并对酒液灭菌；
(5)、装罐：将上述灭菌后的酒液进行灌装，放置阴凉处密封保存，即得红曲葡萄酒。
实施例二：
一种红曲葡萄酒，有下列原料组成，均为重量份：红曲30，葡萄50，中药提取液15，冰糖5-20，所述红曲为水溶性红曲，红曲中洛伐他汀的含量为100000-200000mg/kg；所述中药提取液按重量份数计，包括以下组分：葡萄籽12，瓜拉纳8，枸杞子12，泽泻12，当归12，山楂12，柴胡8，菊花5-10，陈皮8。
所述红曲葡萄酒的制备步骤如下：
(1)、制葡萄汁：将葡萄清洗、晾干、粉碎、过滤后，放入经过消毒的玻璃容器或陶瓷罐内，得葡萄汁；
(2)、制中药提取液：将葡萄籽、枸杞子、泽泻、当归、山楂、柴胡、菊花、陈皮烘干粉碎成粗粉，按照所述重量份装入通透袋中，将装有中药的通透袋放入锅中，加入中药质量10-15倍的水，大火加热至沸腾后，小火熬煮20-30分钟，取出通透袋，倒出药液，再次将通透袋放入锅中，加水熬煮，重复操作一次，合并两次所得药液，减压浓缩成中药提取液，离心除杂，灭菌，在此提取过程中不添加任何有机溶剂；
(3)、发酵：将红曲、葡萄汁以及步骤(2)中的所述中药提取液置于发酵罐中，调整各成分的含量，然后加入干酵母和冰糖混合均匀，进行发酵，并把发酵温度控制在25-30℃，发酵时间为15-20天，所述干酵母为0.01-0.1份的干酵母粉；
(4)、过滤灭菌：将发酵后的酒液过滤，去除沉淀物，并对酒液灭菌；
(5)、装罐：将上述灭菌后的酒液进行灌装，放置阴凉处密封保存，即得红曲葡萄酒。
实施例三：
一种红曲葡萄酒，有下列原料组成，均为重量份：红曲40，葡萄60，中药提取液20，冰糖5-20，所述红曲为水溶性红曲，红曲中洛伐他汀的含量为100000-200000mg/kg；所述中药提取液按重量份数计，包括以下组分：葡萄籽15，瓜拉纳10，枸杞子15，泽泻15，当归15，山楂15，柴胡10，菊花10，陈皮10。
所述红曲葡萄酒的制备步骤如下：
(1)、制葡萄汁：将葡萄清洗、晾干、粉碎、过滤后，放入经过消毒的玻璃容器或陶瓷 罐内，得葡萄汁；
(2)、制中药提取液：将葡萄籽、枸杞子、泽泻、当归、山楂、柴胡、菊花、陈皮烘干粉碎成粗粉，按照所述重量份装入通透袋中，将装有中药的通透袋放入锅中，加入中药质量10-15倍的水，大火加热至沸腾后，小火熬煮20-30分钟，取出通透袋，倒出药液，再次将通透袋放入锅中，加水熬煮，重复操作一次，合并两次所得药液，减压浓缩成中药提取液，离心除杂，灭菌，在此提取过程中不添加任何有机溶剂；
(3)、发酵：将红曲、葡萄汁以及步骤(2)中的所述中药提取液置于发酵罐中，调整各成分的含量，然后加入干酵母和冰糖混合均匀，进行发酵，并把发酵温度控制在25-30℃，发酵时间为15-20天，所述干酵母为0.01-0.1份的干酵母粉；
(4)、过滤灭菌：将发酵后的酒液过滤，去除沉淀物，并对酒液灭菌；
(5)、装罐：将上述灭菌后的酒液进行灌装，放置阴凉处密封保存，即得红曲葡萄酒。
为验证本发明红曲葡萄酒的效果，以本发明红曲葡萄酒为治疗手段，将180位患有高血压、高血脂的40-80岁人群(其中，40-50岁中年人50名，50-60岁中老年人64名，60-80岁老年人66名)平均分成两组进行人体试验，分别为实验组和对照组，每人每天两次，每次两杯，一杯100ml，实验组服用本实施例三的红曲葡萄酒，对照组则服用等量的葡萄酒，90天统计疗效，测试结果见表1。
其中血压降低的测试标准为：收缩压降低的范围在10-30mmHg，为显效；收缩压降低的范围在5-10mmHg，为有效；收缩压无任何改善，为无效。
血脂降低的测试标准为：高血脂的诊断标准是按照人体内部胆固醇的高低来判断的，所以总胆固醇降低的范围在0.5-1mmol/L，为显效；总胆固醇降低的范围在0.1-0.5mmol/L，为有效；总胆固醇无任何改善，为无效。
表1 测试结果
Figure PCTCN2016093213-appb-000001
服用实施例三红曲葡萄酒的实验人群和服用普通葡萄酒的对照人群，去医院进行体检， 从表1可以看出，中年、中老年以及老年人的症状都有较大改善，血压、血脂降低，效果显著，这与红曲中的洛伐他汀密切相关，此外红曲中富含多种活性成分，其与中药提取液的多种氨基酸、生物碱，维生素等物质相辅相成，协同作用，共同调节机体，具有抗疲劳、补充能量、活血化瘀、防止动脉硬化、增强免疫力、强身健体之功效，因此本发明红曲葡萄酒在满足饮用酒功能的同时，还具有丰富的营养价值和医药保健作用，适用于不同群体。
此外，应当理解，虽然本说明书按照实施方式加以描述，但并非每个实施方式仅包含一个独立的技术方案，说明书的这种叙述方式仅仅是为清楚起见，本领域技术人员应当将说明书作为一个整体，各实施例中的技术方案也可以经适当组合，形成本领域技术人员可以理解的其他实施方式。

Claims (8)

  1. 一种红曲葡萄酒，其特征在于，有下列原料组成，均为重量份：红曲20-40，葡萄40-60，中药提取液10-20，冰糖5-20；
    所述中药提取液按重量份数计，包括以下组分：葡萄籽10-15，瓜拉纳5-10，枸杞子10-15，泽泻10-15，当归10-15，山楂10-15，柴胡5-10，菊花5-10，陈皮5-10。
  2. 如权利要求1所述的一种红曲葡萄酒，其特征在于，有下列原料组成，均为重量份：红曲30，葡萄50，中药提取液15，冰糖5-20；
    所述中药提取液按重量份数计，包括以下组分：葡萄籽12，瓜拉纳8，枸杞子12，泽泻12，当归12，山楂12，柴胡8，菊花5-10，陈皮8。
  3. 如权利要求2所述的一种红曲葡萄酒，其特征在于，所述红曲为水溶性红曲，红曲中洛伐他汀的含量为100000-200000mg/kg。
  4. 如权利要求3所述的一种红曲葡萄酒的制备方法，其特征在于，步骤如下：
    (1)制葡萄汁：将葡萄清洗、晾干、粉碎、过滤后，放入经过消毒的非塑料容器内，得葡萄汁；
    (2)制中药提取液：将葡萄籽、瓜拉纳、枸杞子、泽泻、当归、山楂、柴胡、菊花、陈皮烘干粉碎成粗粉，按照所述重量份装入通透袋中，将装有中药的通透袋放入锅中，加入中药质量10-15倍的水，大火加热至沸腾后，小火熬煮20-30分钟，取出通透袋，倒出药液，再次将通透袋放入锅中，加水熬煮，重复操作一次，合并两次所得药液，减压浓缩成中药提取液，离心除杂，灭菌；
    (3)发酵：将红曲、葡萄汁以及步骤(2)中的所述中药提取液置于发酵罐中，调整各成分的含量，然后加入干酵母和冰糖混合均匀，进行发酵；
    (4)过滤灭菌：将发酵后的酒液过滤，去除沉淀物，并对酒液灭菌；
    (5)装罐：将上述灭菌后的酒液进行灌装，放置阴凉处密封保存，即得红曲葡萄酒。
  5. 如权力要求4所述的一种红曲葡萄酒的制备方法，其特征在于，步骤(1)中所述非塑料容器为玻璃容器或陶瓷罐。
  6. 如权力要求4所述的一种红曲葡萄酒的制备方法，其特征在于，步骤(2)中所述中药提取液不添加任何有机溶剂。
  7. 如权力要求4所述的一种红曲葡萄酒的制备方法，其特征在于，所述步骤(3)中，发酵温度控制在25-30℃，发酵时间为15-20天。
  8. 如权力要求4所述的一种红曲葡萄酒的制备方法，其特征在于，所述步骤(3)中的干酵母为0.01-0.1份的干酵母粉。
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