WO2014038195A1 - 口腔用組成物 - Google Patents
口腔用組成物 Download PDFInfo
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- WO2014038195A1 WO2014038195A1 PCT/JP2013/005231 JP2013005231W WO2014038195A1 WO 2014038195 A1 WO2014038195 A1 WO 2014038195A1 JP 2013005231 W JP2013005231 W JP 2013005231W WO 2014038195 A1 WO2014038195 A1 WO 2014038195A1
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- Prior art keywords
- hydroxyapatite
- comparative example
- monohydrogen phosphate
- calcium monohydrogen
- composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
Definitions
- the present invention relates to a composition for oral cavity that suppresses hypersensitivity by promoting the sealing ability of dental dentin tubules.
- a method for blocking dentinal tubules which is one of the means for suppressing this hypersensitivity to dentin
- an acidic fluorophosphate-tannic acid solution component, a lanthanum chloride aqueous solution component, and a fluoroapatite glass powder are used.
- a method using a dental hypersensitivity therapeutic agent contained (Patent Document 1) and a method using a dentin hypersensitivity therapeutic agent composed of an oxalic acid compound solution and a calcium compound solution (Patent Document 2) have been proposed.
- a method of sealing dentinal tubules using hydroxyapatite a method using a composition for hypersensitivity using hydroxyapatite having a particle size of 1.0 ⁇ m to 5.0 ⁇ m (Patent Document 3), a particle size of A method of using a sealing material for dentinal tubules by using sintered particles of hydroxyapatite of 900 nm or less as a dentinal tubule sealing material (Patent Document 4) has been proposed.
- potassium nitrate is used as an agent for alleviating hypersensitivity and as an inhibitor.
- a hypersensitivity toothpaste containing potassium nitrate and stannous fluoride (Patent Document 5) and potassium nitrate are used as an oral composition using potassium nitrate.
- Oral compositions containing amino acids and salts thereof or nucleic acids and salts thereof (Patent Document 6), or oral compositions containing potassium salts and aluminum salts at specific concentrations (Patent Documents) 7), compositions for oral cavity containing potassium nitrate and reduced palatinose (Patent Document 8) have been proposed.
- calcium monohydrogen phosphate dihydrate (dibasic calcium phosphate) is used as a dentifrice base, a cleaning agent, an abrasive and the like, and an oral cavity using calcium monohydrogen phosphate dihydrate.
- the composition for use include calcium carbonate having a mean particle size of 3.5 to 10 ⁇ m and a disintegration strength of 0.1 to 5 g / piece, for the purpose of removing dental plaque on the tooth surface and making the teeth whiter.
- a dentifrice composition (Patent Document 9) containing agglomerated particles of particles selected from calcium diphosphate, tricalcium phosphate, calcium pyrophosphate and hydroxyapatite, and effectively removes colored teeth without damaging the teeth.
- powders used as abrasives such as apatite, aluminum hydroxide, alumina, calcium carbonate, magnesium carbonate, calcium sulfate, zeolite, composite aluminosilicate, bengara, etc.
- Granules having a strength of 0.1 to 10 g / piece, zeolite having a Mohs hardness of 2 to 6 and an average particle size of 0.5 to 5 ⁇ m, calcium carbonate, anhydrous dibasic calcium phosphate, tribasic calcium phosphate, hydroxyapatite, and A dentifrice composition (Patent Document 10) containing at least one abrasive powder selected from aluminum hydroxide has been proposed.
- An object of the present invention is to provide a composition for oral cavity that has a high ability to seal dentinal tubules and is excellent in the effect of suppressing hypersensitivity.
- the present inventors are known to have the ability to seal dental dentinal tubules together with hydroxyapatite, which has been known to have the ability to seal dental dentinal tubules.
- the ability to seal the dentin tubules was improved by adding potassium nitrate and calcium monohydrogen phosphate at the same time, and the present invention was completed.
- potassium nitrate does not have the ability to seal dentinal dentinal tubules alone, and even when mixed with either hydroxyapatite or calcium monohydrogen phosphate, it does not show any particular effect, but hydroxyapatite and phosphate
- the unexpected effect that the sealing ability of a dental dentin tubule can be remarkably improved by using together with calcium monohydrogen was discovered.
- the present invention includes (1) a composition for oral cavity having the ability to seal dentin tubules characterized by containing hydroxyapatite, potassium nitrate, and calcium monohydrogen phosphate, and (2) calcium monohydrogen phosphate.
- composition for oral cavity of the present invention is an oral composition comprising three components of hydroxyapatite, potassium nitrate, and calcium monohydrogen phosphate as active ingredients, and has a high ability to seal dentinal tubules, thereby suppressing hypersensitivity. Very good.
- FIG. It is a photograph which shows the untreated dentin surface. It is a photograph which shows the dentin surface after the immersion process of Example 15.
- FIG. It is a photograph which shows the dentin surface after the immersion process of Example 30. It is a photograph which shows the dentin surface after the immersion process of the comparative example 11. It is a photograph which shows the dentin surface after the immersion process of the comparative example 30. It is a photograph which shows the dentin surface after the immersion process of the comparative example 31. It is a photograph which shows the dentin surface after the immersion process of the comparative example 43. It is a figure of the split chamber (divided pore) apparatus used for the fluid penetration test in a dentinal tubule.
- the oral composition having the ability to seal the dentinal tubules of the present invention is not particularly limited as long as it contains hydroxyapatite, potassium nitrate, and calcium monohydrogen phosphate, and the oral composition of the present invention.
- the form of the composition may be any form of solid, solid, liquid, liquid, gel, paste, gum, etc.
- toothpaste, liquid toothpaste, liquid toothpaste, moisture examples thereof include dentifrices such as toothpastes, mouthwashes, ointments and the like.
- composition for oral cavity of the present invention has an unexpected effect of synergistically improving the dentin tubule blockage rate by containing three components of hydroxyapatite, potassium nitrate, and calcium monohydrogen phosphate. That is, even if two of these three components are blended, a synergistic improvement effect of the dentinal tubule blockage rate is not observed, but only by blending these three components is the synergistic effect of the dentin tubule blockage rate. (See the examples for details).
- Hydroxyapatite used in the present invention is a kind of calcium phosphate, and is obtained from fish bones of pork, pork bones, cow bones, etc. of edible fish such as salmon as natural hard tissues in addition to those synthesized by ordinary methods. There may be.
- hydroxyapatite is stoichiometrically represented by a composition composed of Ca 10 (PO 4 ) 6 (OH) 2 , but is non-stoichiometric with a Ca / P molar ratio of not 1.67. Even in this case, it exhibits the properties of hydroxyapatite and can have an apatite structure.
- synthetic hydroxyapatite having a Ca / P molar ratio of about 1.4 to 1.8 is also included in the hydroxyapatite in the present invention.
- the hydroxyapatite used in the present invention may be crystalline, low crystalline, or amorphous, but it is low crystalline or amorphous hydroxyapatite from the viewpoint of caries prevention effect.
- low crystalline hydroxyapatite and amorphous hydroxyapatite are referred to as “amorphous hydroxyapatite”.
- “Low crystallinity” means that the X-ray diffraction peak is broader than that of highly crystalline powder, and “amorphous” means that the X-ray diffraction pattern has a wide halo. The diffraction pattern showing the characteristics of the crystal cannot be obtained.
- Such amorphous hydroxyapatite can be obtained, for example, by freeze-drying apatite synthesized by a wet synthesis method, drying at a temperature of 100 ° C. or lower, or baking at about 300 ° C. or lower.
- the hydroxyapatite of the present invention is usually used in the form of powder or suspended in water, and the maximum particle size measured with a laser diffraction / scattering particle size distribution analyzer (LA-950, Horiba Seisakusho) is 100 ⁇ m or less. It is preferable that the lower limit of the particle size is about 0.001 ⁇ m in production.
- the average particle size is preferably 0.01 to 10 ⁇ m, more preferably 0.05 to 5 ⁇ m.
- the specific surface area of hydroxyapatite according to the BET method is about 100 m 2 / g or less.
- a powder that has been subjected to a drying process, a porous process, an electrostatic process, or the like after powdering can be used.
- the compounding amount of hydroxyapatite in the oral composition of the present invention is preferably as much as possible from the viewpoint of improving the sealing performance of dental dentin tubules. %, More preferably 1 to 10% by weight, still more preferably 5 to 10% by weight.
- the blocking action of hydroxyapatite on dental dentinal tubules is conventionally known, and as described above, the more preferable it is from the viewpoint of improving the sealing performance of dental dentinal tubules.
- potassium nitrate and phosphate By using it together with hydrogen, the effect can be increased synergistically, so that the amount of expensive hydroxyapatite used can be reduced.
- the potassium nitrate used in the present invention is a kind of nitrate represented by the chemical formula KNO 3 , and any food additive, first grade reagent, special grade reagent, etc. can be used.
- This potassium nitrate has recently been used as a dentifrice for hypersensitivity because ionized potassium has the effect of suppressing nerve transmission and relieving the pain of hypersensitivity. (See Comparative Examples 8 to 11).
- this potassium nitrate in combination with hydroxyapatite and calcium monohydrogen phosphate, an unexpected effect of remarkably improving the sealing performance of dental dentin tubules is exhibited.
- the compounding amount of potassium nitrate in the oral composition of the present invention is preferably as much as possible from the viewpoint of improving the sealing properties of the dental dentin tubules, but considering the formulation viewpoint such as viscosity, it is 2.5 to 10% by weight. Preferably, it is 5 to 10% by weight.
- the calcium monohydrogen phosphate used in the present invention is one type of calcium phosphate represented by the chemical formula CaHPO 4 , and may be anhydrous or hydrated.
- calcium monohydrogen phosphate calcium monohydrogen phosphate dihydrate (DCPD) represented by the chemical formula CaHPO 4 .2H 2 O is preferable from the viewpoint of hygroscopicity and stability.
- DCPD calcium monohydrogen phosphate dihydrate
- Calcium monohydrogen phosphate dihydrate is widely used as a pharmaceutical excipient, calcium fortifier, dentifrice base, feed additive, synthetic resin modifier, glaze raw material, ceramic raw material.
- the calcium monohydrogen phosphate dihydrate used in the present invention may be any food additive, Japanese pharmacopoeia, quasi-drug raw material standard 2006, and the like.
- anhydrous calcium phosphate is used as the calcium monohydrogen phosphate
- the anhydrous calcium phosphate is hygroscopic, so that it is stable during preparation or use of the oral composition of the present invention.
- -It exists as a dihydrate.
- the blending amount of calcium monohydrogen phosphate in the oral composition of the present invention the larger the amount, the better the sealing performance of the dental dentin tubules, but it is preferable.
- the content is preferably 0.5 to 25% by weight, more preferably 1 to 20% by weight, and still more preferably 5 to 20% by weight.
- calcium monohydrogen phosphate dihydrate alone has the ability to seal dental dentinal tubules and contributes to the sealing of dental dentinal tubules (Comparative Examples 12 to 17). See), when used in combination with hydroxyapatite and potassium nitrate, the blocking ability can be remarkably improved.
- composition for oral cavity of the present invention it is preferable to use a large amount of hydroxyapatite as compared with calcium monohydrogen phosphate when realizing an extremely high blocking ability, and a predetermined high blocking ability is realized at a low cost.
- the oral composition of the present invention contains various components such as an additive, a wetting agent, a foaming agent, a fragrance, a sweetener, and an antiseptic that are usually used in the oral composition in addition to the above-described three essential components. be able to. Specific examples of these components are shown below.
- blended with the composition for oral cavity of this invention is not limited to these components.
- polishing agents calcium phosphate, tricalcium phosphate, calcium carbonate, calcium pyrophosphate, abrasive precipitated silica, abrasive gel silica and other silica, calcium silicate, aluminum silicate, aluminum oxide, aluminum hydroxide, alumina, zeolite, titanium oxide
- examples thereof include zirconium silicate, insoluble sodium metaphosphate, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, magnesium sulfate, polymethyl methacrylate, bentonite, and synthetic resin.
- wetting agent examples include polyhydric alcohols such as glycerin, propylene glycol, polyethylene glycol, sorbitol, xylitol, ethylene glycol, 1,3-butylene glycol, and isopropylene glycol.
- polyhydric alcohols such as glycerin, propylene glycol, polyethylene glycol, sorbitol, xylitol, ethylene glycol, 1,3-butylene glycol, and isopropylene glycol.
- foaming agent examples include sodium lauryl sulfate, sodium N-lauroyl sarcosine, a nonionic surfactant, and the like.
- thickeners examples include hydroxyethylcellulose, sodium carboxymethylcellulose, carrageenan, carboxyvinyl polymer, xanthan gum, gelatin, pullulan, sodium alginate, sodium polyacrylate, polyvinyl alcohol, locust bean gum, guar gum, hydroxypropyl methylcellulose, etc. it can.
- Binders include methylcellulose, propylene glycol alginate, pullulan, tragacanth gum, xanthan gum, pectin, fercelan, chitosan, polyethylene oxide, polyvinylpyrrolidone, polyacrylic acid, polymethacrylic acid, peptone, casein, collagen, albumin, gum arabic, Examples include Karaya gum, Eudragit, ethyl cellulose, cellulose acetate, sodium polyacrylate, polyvinyl alcohol, polyvinyl acetal / dimethylaminoacetate, cellulose acetate / dibutylhydroxypropyl ether, and the like.
- polyoxyethylene hydrogenated castor oil sorbitan monostearate, glycerin fatty acid ester, propylene glycol fatty acid ester, alkyl glyceryl ether, polyoxyethylene sorbitol fatty acid ester, polysorbate, polyoxyethylene, lauromacrogol, sodium alkyl sulfate
- examples include alkyl phosphate esters, sodium alkylbenzene sulfonates, sodium N-acyl sarcosine, N-acyl glutamates, sucrose fatty acid esters, alkyl glycosides, alkyl dimethyl amine oxides, alkyl betaines and the like.
- Oils and fats include liquid paraffin, paraffin, cetyl alcohol, higher alcohols such as stearyl alcohol, fatty acid esters such as isopropyl myristate, lanolin, whale wax, carnauba wax, fatty acids, octyldodecyl myristate, diisopropyl adipate, hexadecyl isostearate And ester compounds such as decyl oleate, squalane, squalene, medium chain fatty acid triglycerides, silicon and the like.
- alcohols such as stearyl alcohol, fatty acid esters such as isopropyl myristate, lanolin, whale wax, carnauba wax, fatty acids, octyldodecyl myristate, diisopropyl adipate, hexadecyl isostearate
- ester compounds such as decyl oleate, squalane,
- Alcohols include lower alcohols such as ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol, ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, 1,5-pentadiol, sorbit Examples thereof include polyhydric alcohols such as polyethylene glycol.
- Surfactants include nonionic surfactants such as sorbitan fatty acid ester, glycerin fatty acid ester, decaglycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol / pentaerythritol fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene.
- nonionic surfactants such as sorbitan fatty acid ester, glycerin fatty acid ester, decaglycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol / pentaerythritol fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene.
- pH adjusters examples include citric acid and its salts, phosphoric acid and its salts, malic acid and its salts, gluconic acid and its salts, maleic acid and its salts, aspartic acid and its salts, gluconic acid and its salts, succinic acid And salts thereof, glucuronic acid and salts thereof, fumaric acid and salts thereof, glutamic acid and salts thereof, adipic acid and salts thereof, inorganic acids such as hydrochloric acid, hydrofluoric acid, sodium hydroxide, potassium hydroxide, etc. Examples include alkali metals, amines such as triethanolamine, diethanolamine, and diisopropanolamine.
- preservative examples include paraoxybenzoic acid ester, alkyldiaminoethylglycine hydrochloride, methylparaben, ethylparaben, sodium benzoate and the like.
- the stabilizer examples include sodium sulfite, sodium hydrogen sulfite, dibutylhydroxytoluene, butylhydroxyanisole, edetic acid or salts thereof.
- Perfumes include essential oils such as menthol, peppermint, spearmint, eucalyptus oil, orange oil, lemon oil, winder green oil, clove oil, peppermint oil, thyme oil, carvone, linalool, eugenol, anethole, herb mint, etc. Can be illustrated.
- stabilizers include vitamin C, vitamin E and derivatives thereof, sodium sulfite, sodium pyrosulfite, sodium hydrogen sulfite, butylhydroxytoluene, butylhydroxyanisole and the like.
- sweetening agents include saccharin sodium, aspartame, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, asparatylphenylalanine methyl ester, acesulfame potassium, perilartine, p-methoxycinnamic aldehyde, xylitol and the like.
- Other medicinal ingredients include allantoin, tocopherol acetate, isopropylphenol, triclosan, chlorhexidine, chlorophyll, flavonoids, tranexamic acid, hinokitiol, cetylpyridinium chloride, sodium fluoride, stannous fluoride, sodium monofluorophosphate, dextran
- Illustrative examples include nuclease, mutanase, protease, aminocaproic acid, glycyrrhizic acid, glycyrrhetinic acid, azulene, allantoin, lysozyme chloride, oat extract, polyphosphoric acid, sodium chloride and the like.
- the compounding quantity of these arbitrary components is used suitably in the range accept
- hydroxyapatite, potassium nitrate, calcium monohydrogen phosphate, and other optional components may be added at any stage of the production process.
- hydroxyapatite A 30% by mass phosphoric acid aqueous solution was dropped into the calcium hydroxide suspension under stirring until pH 10 was reached, and the resulting gel-like substance was aged at room temperature for 1 day. Thereafter, the gel-like substance was filtered with a glass filter, and the remaining substance was dried in air at 100 ° C. to obtain a hydroxyapatite powder.
- the obtained hydroxyapatite powder had a maximum particle size of about 40 ⁇ m, a minimum particle size of about 0.05 ⁇ m, and an average particle size of about 5 ⁇ m.
- potassium nitrate a reagent special grade manufactured by Wako Pure Chemical Industries, Ltd. was used.
- compositions for oral cavity of Examples and Comparative Examples A toothpaste, a mouthwash, and a dentinal tubule sealant having the following composition were produced according to a conventional method, and a dentinal tubule sealability test was performed.
- test Using healthy human extracted teeth, sections were cut out so that the dentin and dentinal tubules were exposed, polished to a thickness of about 500 ⁇ m, and ultrasonically cleaned. A test solution was prepared by adjusting 25 g each of the dentifrice, mouthwash, and dentinal tubule sealant of Examples and Comparative Examples to 40 mL with distilled water. Sections masked except for the test surface were infiltrated into the test solution at 37 ° C. for 9 minutes a day, and immersed for 5 days.
- FIGS. 1 to 7 show electron micrographs of the surface of the untreated and treated surface of the dentin after the completion of the immersion test. As is apparent from FIGS. 1 to 7, the treatment with the oral composition of the present invention confirmed the sealing ability of the dental dentin tubules.
- a liquid passing test inside the dentinal tubule was performed.
- the fluid flow test inside the ivory tubule was performed according to the method of Pashley et al. Shown in “OW Reeder et al, J.Dent.Res., 57, (2); 187-193,1978”.
- a (divided pore) device was produced and carried out.
- a dentin section was sandwiched between the inlet chamber and the outlet chamber of the apparatus, and the test solution was placed in the inlet chamber to treat the dentin surface.
- Ringer's solution was introduced into the inlet chamber by pressure, and the dentinal tubule permeability was confirmed by the amount of passage into the outlet chamber.
- Dentin tubule permeation suppression effect of each test solution was calculated by the following formula using the difference between the passage amount of Ringer's solution before treatment and the passage amount after treatment, and the permeation inhibition rate of dentinal tubules as a percentage. .
- Blocking rate (%) (passage before treatment ⁇ passage after treatment) / (passage before treatment) ⁇ 100
- hydroxyapatite and calcium monohydrogen phosphate dihydrate have a single tooth dentinal tubule sealing ability, The blockage rate increases as the number increases.
- potassium nitrate alone has no ability to seal dental dentinal tubules.
- Example 1 blocking rate: 29.6%
- Example 5 blocking rate: 34.5%)
- Comparative Example 18 blocking rate: 9.3%
- Example 2 blocking rate: 49.0%
- Example 6 blocking rate: 53.7%)
- Comparative Example 21 blocking rate: 28.7%
- Example 9 blocking rate: 51.3%
- Comparative Example 24 blocking rate: 23.9%
- Example 8 blocking rate: 59.9%
- Example 12 blocking rate: 65.1%) compared with Comparative Example 27 (blocking rate: 34.6%), Example 13 (blocking rate: 51.9%) or Example 17 (blocking rate: 56.3%)
- Example 33 blocking rate: 21.9%
- Example 21 blocking rate: 70.6%
- Comparative Example 39 blocking rate: 21.9%
- the oral composition of the present invention is very excellent in suppressing hypersensitivity and has high industrial utility.
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Abstract
Description
攪拌下の水酸化カルシウム懸濁液中に、30質量%濃度のリン酸水溶液を、pH10になるまで滴下し、生成したゲル状物質を室温で1日間放置して熟成した。その後、ゲル状物質をガラスフィルターで濾過し、残った物質を100℃の空気中で乾燥を行うことにより、ハイドロキシアパタイト粉末を得た。得られたハイドロキシアパタイト粉末は、最大粒径が約40μm、最小粒径が約0.05μm、平均粒径が約5μmであった。
硝酸カリウムは、和光純薬工業株式会社製、試薬特級を使用した。
リン酸一水素カルシウム・2水和物は、太平化学産業株式会社製、医薬部外品原料規格2006を使用した。
下記組成の練歯磨剤、洗口剤、及び象牙細管封鎖剤を常法に従って製造し、象牙細管封鎖性試験を行なった。
健全なヒト抜去歯を用いて、象牙質と象牙細管が露出されるように切片を切り出し、厚さ約500μmに研磨し、超音波洗浄した。実施例及び比較例の歯磨剤、洗口剤、象牙細管封鎖剤それぞれ25gを蒸留水で40mLに調整したものをテスト溶液とした。試験面以外をマスキングした切片をテスト溶液に37℃で1日9分間浸透させ、5日間の浸漬処理を行なった。
具体的に、例えば、実施例1(封鎖率:29.6%)又は実施例5(封鎖率:34.5%)と比較例18(封鎖率:9.3%),実施例2(封鎖率:49.0%)又は実施例6(封鎖率:53.7%)と比較例21(封鎖率:28.7%),実施例9(封鎖率:51.3%)と比較例24(封鎖率:23.9%),実施例8(封鎖率:59.9%)又は実施例12(封鎖率:65.1%)と比較例27(封鎖率:34.6%),実施例13(封鎖率:51.9%)又は実施例17(封鎖率:56.3%)と比較例33(封鎖率:21.9%),実施例21(封鎖率:70.6%)と比較例39(封鎖率:32.4%),実施例22(封鎖率:85.7%)と比較例36(封鎖率:45.7%),実施例28(封鎖率:100%)と比較例44(封鎖率:53.4%),実施例26(封鎖率:100%)又は実施例30(封鎖率:100%)と比較例42(封鎖率:64.6%)等から、3成分併用の相乗効果は明らかである。
Claims (5)
- ハイドロキシアパタイト、硝酸カリウム、及びリン酸一水素カルシウムを含有することを特徴とする歯牙象牙質細管封鎖能を有する口腔用組成物。
- リン酸一水素カルシウムがリン酸一水素カルシウム・2水和物であることを特徴とする請求項1記載の口腔用組成物。
- ハイドロキシアパタイトの配合量が0.5~20重量%であることを特徴とする請求項1又は2記載の口腔用組成物。
- 硝酸カリウムの配合量が2.5~10重量%であることを特徴とする請求項1~3のいずれか記載の口腔用組成物。
- リン酸一水素カルシウムの配合量が、リン酸一水素カルシウム・2水和物換算で、0.5~25重量%であることを特徴とする請求項1~4のいずれか記載の口腔用組成物。
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
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RU2015109262/15A RU2587054C1 (ru) | 2012-09-05 | 2013-09-04 | Композиция для ухода за полостью рта |
CA2881621A CA2881621C (en) | 2012-09-05 | 2013-09-04 | Oral composition |
EP13835202.6A EP2893918B1 (en) | 2012-09-05 | 2013-09-04 | Oral composition |
CN201380054503.0A CN104736127B (zh) | 2012-09-05 | 2013-09-04 | 口腔用组合物 |
JP2014534195A JP6199871B2 (ja) | 2012-09-05 | 2013-09-04 | 口腔用組成物 |
KR1020157004119A KR101703800B1 (ko) | 2012-09-05 | 2013-09-04 | 구강용 조성물 |
US14/425,537 US9468593B2 (en) | 2012-09-05 | 2013-09-04 | Oral composition |
HK15108307.4A HK1207819A1 (en) | 2012-09-05 | 2015-08-26 | Oral composition |
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JP2012-195044 | 2012-09-05 | ||
JP2012195044 | 2012-09-05 |
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WO2014038195A1 true WO2014038195A1 (ja) | 2014-03-13 |
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US (1) | US9468593B2 (ja) |
EP (1) | EP2893918B1 (ja) |
JP (1) | JP6199871B2 (ja) |
KR (1) | KR101703800B1 (ja) |
CN (1) | CN104736127B (ja) |
CA (1) | CA2881621C (ja) |
HK (1) | HK1207819A1 (ja) |
RU (1) | RU2587054C1 (ja) |
WO (1) | WO2014038195A1 (ja) |
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US9927422B2 (en) * | 2014-05-13 | 2018-03-27 | The Procter & Gamble Company | Method and device for measuring dentin permeability |
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WO2017081725A1 (ja) * | 2015-11-09 | 2017-05-18 | 花王株式会社 | 口腔用組成物 |
KR102136730B1 (ko) * | 2020-02-13 | 2020-07-22 | 대구보건대학교산학협력단 | 충치의 자가 진단 기능을 갖는 구강 청결제 |
Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08175943A (ja) | 1994-12-22 | 1996-07-09 | Lion Corp | 口腔用組成物 |
JPH08319224A (ja) * | 1995-03-22 | 1996-12-03 | Asahi Optical Co Ltd | 口腔用組成物 |
JPH09249515A (ja) | 1996-03-15 | 1997-09-22 | Taihei Kagaku Sangyo Kk | 歯科用知覚過敏治療剤 |
JPH1017449A (ja) | 1996-07-05 | 1998-01-20 | Sangi Co Ltd | 知覚過敏症用組成物 |
JPH10265355A (ja) * | 1997-03-26 | 1998-10-06 | Hideki Aoki | 複合歯磨きペースト製品 |
JPH10316547A (ja) | 1997-05-20 | 1998-12-02 | Kao Corp | 歯磨剤組成物 |
JP2000053547A (ja) * | 1998-08-07 | 2000-02-22 | Sunstar Inc | 口腔用組成物 |
JP2000154126A (ja) | 1998-11-18 | 2000-06-06 | Kao Corp | 歯磨剤組成物 |
JP2001172146A (ja) | 1999-12-21 | 2001-06-26 | Kobayashi Pharmaceut Co Ltd | 口腔用組成物 |
JP2001247456A (ja) | 2000-03-08 | 2001-09-11 | Kunio Ishikawa | シュウ酸系象牙質知覚過敏症治療剤 |
JP2002512177A (ja) | 1998-04-23 | 2002-04-23 | コルゲート・パーモリブ・カンパニー | カリウム塩とスズ塩とを含む知覚過敏抑制歯磨き剤 |
JP2003073246A (ja) | 2001-08-31 | 2003-03-12 | Sunstar Inc | 口腔用組成物 |
JP2005325102A (ja) | 2004-04-13 | 2005-11-24 | Japan Science & Technology Agency | 象牙細管封鎖材 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5257339A (en) * | 1975-11-07 | 1977-05-11 | Kao Corp | Tooth paste composition |
GB8811830D0 (en) * | 1988-05-19 | 1988-06-22 | Unilever Plc | Oral compositions |
PL214004B1 (pl) * | 2002-08-05 | 2013-06-28 | Colgate Palmolive Co | Dwuskladnikowa kompozycja dentystyczna |
US20090186090A1 (en) * | 2007-04-30 | 2009-07-23 | Colgate-Palmolive | Oral Care Composition to Reduce or Eliminate Dental Sensitivity |
US20080268001A1 (en) * | 2007-04-30 | 2008-10-30 | Lynette Zaidel | Oral care composition to reduce or eliminate dental sensitivity |
WO2010113800A1 (ja) * | 2009-03-30 | 2010-10-07 | クラレメディカル株式会社 | 象牙質石灰化剤及びその製造方法 |
US20120067748A1 (en) | 2010-09-17 | 2012-03-22 | Peter Jung | Prophylaxis Paste Holder Dispenser with Multiple Prophylaxis Pastes |
CN103228245A (zh) * | 2010-10-06 | 2013-07-31 | 可乐丽则武齿科株式会社 | 牙本质小管封闭剂及其制造方法 |
KR101262293B1 (ko) * | 2011-01-18 | 2013-05-08 | 주식회사 바이오알파 | 중성에서 안정한 고농도 인산칼슘 수용액의 제조방법 |
CN103120623B (zh) | 2012-12-01 | 2014-10-01 | 云南白药集团股份有限公司 | 抗牙本质敏感口腔清洁护理制剂 |
-
2013
- 2013-09-04 CA CA2881621A patent/CA2881621C/en active Active
- 2013-09-04 US US14/425,537 patent/US9468593B2/en active Active
- 2013-09-04 WO PCT/JP2013/005231 patent/WO2014038195A1/ja active Application Filing
- 2013-09-04 JP JP2014534195A patent/JP6199871B2/ja active Active
- 2013-09-04 EP EP13835202.6A patent/EP2893918B1/en active Active
- 2013-09-04 RU RU2015109262/15A patent/RU2587054C1/ru active
- 2013-09-04 KR KR1020157004119A patent/KR101703800B1/ko active IP Right Grant
- 2013-09-04 CN CN201380054503.0A patent/CN104736127B/zh active Active
-
2015
- 2015-08-26 HK HK15108307.4A patent/HK1207819A1/xx unknown
Patent Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08175943A (ja) | 1994-12-22 | 1996-07-09 | Lion Corp | 口腔用組成物 |
JPH08319224A (ja) * | 1995-03-22 | 1996-12-03 | Asahi Optical Co Ltd | 口腔用組成物 |
JPH09249515A (ja) | 1996-03-15 | 1997-09-22 | Taihei Kagaku Sangyo Kk | 歯科用知覚過敏治療剤 |
JPH1017449A (ja) | 1996-07-05 | 1998-01-20 | Sangi Co Ltd | 知覚過敏症用組成物 |
JPH10265355A (ja) * | 1997-03-26 | 1998-10-06 | Hideki Aoki | 複合歯磨きペースト製品 |
JPH10316547A (ja) | 1997-05-20 | 1998-12-02 | Kao Corp | 歯磨剤組成物 |
JP2002512177A (ja) | 1998-04-23 | 2002-04-23 | コルゲート・パーモリブ・カンパニー | カリウム塩とスズ塩とを含む知覚過敏抑制歯磨き剤 |
JP2000053547A (ja) * | 1998-08-07 | 2000-02-22 | Sunstar Inc | 口腔用組成物 |
JP2000154126A (ja) | 1998-11-18 | 2000-06-06 | Kao Corp | 歯磨剤組成物 |
JP2001172146A (ja) | 1999-12-21 | 2001-06-26 | Kobayashi Pharmaceut Co Ltd | 口腔用組成物 |
JP2001247456A (ja) | 2000-03-08 | 2001-09-11 | Kunio Ishikawa | シュウ酸系象牙質知覚過敏症治療剤 |
JP2003073246A (ja) | 2001-08-31 | 2003-03-12 | Sunstar Inc | 口腔用組成物 |
JP2005325102A (ja) | 2004-04-13 | 2005-11-24 | Japan Science & Technology Agency | 象牙細管封鎖材 |
Non-Patent Citations (6)
Title |
---|
KAWAMATA, H. ET AL.: "Investigation of Dentinal Surface Coating by Nano-hydroxyapatite", 88TH GENERAL SESSION & EXHIBITION OF THE IADR, July 2010 (2010-07-01), XP055192466, Retrieved from the Internet <URL:http://www.sangi-co.com/vcms_1f/paper_o_201002.pdf> [retrieved on 20131118] * |
KAWAMATA, H. ET AL.: "Potassium Nitrate Enhances Occlusion of Dentinal Tubules by Nano-Hydroxyapatite", JOURNAL OF DENTAL RESEARCH, vol. 87, 2008, pages 2265, XP055192581, Retrieved from the Internet <URL:http://www.sangi-co.com/vcms_1f/paper_o_200801.pdf> [retrieved on 20131118] * |
O.W. REEDER ET AL., J. DENT. RES., vol. 57, no. 2, 1978, pages 187 - 193 |
SANGI CO., LTD.: "Chikaku Kabin Yokusei ni Kansuru Atarashii Kenkyu Seika Happyo", July 2008 (2008-07-01), pages 1 - 5, XP055192608, Retrieved from the Internet <URL:http://www.sangi-co.com/vcms_1f/sangi20080704-.pdf> [retrieved on 20131118] * |
SANGI CO., LTD.: "Shikayo Seibun Nano Ryushi Hydoroxyapatite no Atarashii Kenkyu Seika", July 2010 (2010-07-01), pages 1 - 7, XP055192603, Retrieved from the Internet <URL:http://www.sangi-co.com/vcms 1f/release20100715.pdf> [retrieved on 20131118] * |
See also references of EP2893918A4 * |
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JP2016044131A (ja) * | 2014-08-20 | 2016-04-04 | 学校法人近畿大学 | 歯科治療用シート |
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WO2020138500A1 (ja) * | 2018-12-27 | 2020-07-02 | サンスター スイス エスエー | 口腔用組成物 |
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JP7401916B2 (ja) | 2018-12-27 | 2023-12-20 | 白石工業株式会社 | ヒドロキシアパタイト微粒子 |
US11759405B2 (en) | 2018-12-27 | 2023-09-19 | Sunstar Suisse Sa | Composition for oral cavity |
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JP7346104B2 (ja) | 2019-06-28 | 2023-09-19 | サンスター株式会社 | 口腔用組成物 |
JP2021008428A (ja) * | 2019-06-28 | 2021-01-28 | サンスター株式会社 | 口腔用組成物 |
Also Published As
Publication number | Publication date |
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CN104736127B (zh) | 2017-06-13 |
KR20150034270A (ko) | 2015-04-02 |
US20150202128A1 (en) | 2015-07-23 |
CN104736127A (zh) | 2015-06-24 |
JPWO2014038195A1 (ja) | 2016-08-08 |
US9468593B2 (en) | 2016-10-18 |
CA2881621C (en) | 2016-10-11 |
EP2893918B1 (en) | 2017-03-01 |
EP2893918A1 (en) | 2015-07-15 |
HK1207819A1 (en) | 2016-02-12 |
EP2893918A4 (en) | 2016-06-15 |
KR101703800B1 (ko) | 2017-02-07 |
RU2587054C1 (ru) | 2016-06-10 |
JP6199871B2 (ja) | 2017-09-20 |
CA2881621A1 (en) | 2014-03-13 |
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