WO2013117615A1 - Piperidino-pyrimidine derivatives for the treatment of viral infections - Google Patents

Piperidino-pyrimidine derivatives for the treatment of viral infections Download PDF

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Publication number
WO2013117615A1
WO2013117615A1 PCT/EP2013/052372 EP2013052372W WO2013117615A1 WO 2013117615 A1 WO2013117615 A1 WO 2013117615A1 EP 2013052372 W EP2013052372 W EP 2013052372W WO 2013117615 A1 WO2013117615 A1 WO 2013117615A1
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WIPO (PCT)
Prior art keywords
formula
compound
alky
heterocycle
heteroaryl
Prior art date
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PCT/EP2013/052372
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English (en)
French (fr)
Inventor
David Craig Mc Gowan
Pierre Jean-Marie Bernard Raboisson
Tim Hugo Maria Jonckers
Mourad DAOUBI KHAMLICHI
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Janssen R&D Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Priority to US14/377,064 priority Critical patent/US9133192B2/en
Priority to IN1736MUN2014 priority patent/IN2014MN01736A/en
Priority to SG11201404743TA priority patent/SG11201404743TA/en
Priority to JP2014556041A priority patent/JP6283320B2/ja
Priority to ES13703055T priority patent/ES2716811T3/es
Priority to NZ627036A priority patent/NZ627036A/en
Priority to DK13703055.7T priority patent/DK2812331T3/en
Priority to EP13703055.7A priority patent/EP2812331B1/en
Application filed by Janssen R&D Ireland filed Critical Janssen R&D Ireland
Priority to EA201491486A priority patent/EA033907B1/ru
Priority to CA2862823A priority patent/CA2862823C/en
Priority to CN201380008467.4A priority patent/CN104245695B/zh
Priority to BR112014019699-0A priority patent/BR112014019699B1/pt
Priority to KR1020147022432A priority patent/KR102064807B1/ko
Priority to HK15101591.4A priority patent/HK1201254B/xx
Priority to AU2013218072A priority patent/AU2013218072B2/en
Priority to MX2014009556A priority patent/MX357296B/es
Priority to UAA201407816A priority patent/UA112668C2/uk
Publication of WO2013117615A1 publication Critical patent/WO2013117615A1/en
Priority to IL233499A priority patent/IL233499B/en
Priority to PH12014501738A priority patent/PH12014501738A1/en
Priority to ZA2014/05820A priority patent/ZA201405820B/en
Priority to US14/818,094 priority patent/US9365571B2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Definitions

  • This invention relates to piperdino-py midine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
  • the present invention relates to the use of piperidino-pyrimidine derivatives in the treatment of viral infections, immune or inflammatory disorders, whereby the modulation, or agonism, of toll -I ike-receptors (TLRs) is involved.
  • TLRs toll -I ike-receptors
  • Toll-Like Receptors are primary transmembrane proteins characterized by an extracellular leucine rich domain and a cytoplasmic extension that contains a conserved region.
  • the innate immune system can recognize pathogen- associated molecular patterns via these TLRs expressed on the cell surface of certain types of immune cells. Recognition of foreign pathogens activates the production of cytokines and upregulation of co-stimulatory molecules on phagocytes. This leads to the modulation of T cell behaviour.
  • TLR1 to TLR13 TLRs
  • TLR1 to TLR13 TLRs
  • equivalent forms of many of these have been found in other mammalian species.
  • equivalents of certain TLR found in humans are not present in all mammals.
  • a gene coding for a protein analogous to TLR10 in humans is present in mice, but appears to have been damaged at some point in the past by a retrovirus.
  • mice express TLRs 1 1 , 12, and 13, none of which are represented in humans.
  • Other mammals may express TLRs which are not found in humans.
  • Other non-mammalian species may have TLRs distinct from mammals, as demonstrated by TLR14, which is found in the Takifugu pufferfish. This may complicate the process of using experimental animals as models of human innate immunity.
  • A is selected from the group consisting of CH 2 , NCOR 2 , CHR 3 and CR 3 R 3 in any stereo chemical configuration
  • B is selected from the group consisting of CH 2 , NCOR 4 , CHR 3 and CR 3 R 3 in any stereo chemical configuration, with the proviso that when A is NCOR 2 then B is not NCOR 4 and with the proviso that A and B are not both selected from CH 2 , CHR 3 or CR 3 R 3 , X is selected from CH 2 or CHR 5 in any stereo chemical configuration,
  • R 1 is selected from Ci-salkyl optionally substituted with one or more of the following: Chalky!, C3 -7 cycloalkyl, hydroxyl, hydroxyalkyl, amino, nitrile, alkoxy, alkoxy(Ci -4 )alkyl, carboxylic acid, carboxylic ester, carbamate or sulfone,
  • R 2 is selected from substituted and unsubstituted Chalky!, C3- 7 cycloalkyl, heterocycle, aryl, heteroaryl, heteroarylalkyi, each of which is optionally substituted by one or more substituents independently selected from halogen, hydroxyl, amino, Chalky!, di-(Ci-6)alkylamino, Ci-6alkylamino, Chalky!, Ci-6alkoxy, C3-6cycloalkyl, carboxylic acid, carboxylic ester, carboxylic amide, heterocycle, aryl, alkenyl, alkynyl, arylalkyi, heteroaryl, heteroarylalkyi or nitrile, R 3 is selected from hydrogen, substituted and unsubstituted Chalky!, alkoxy, alkoxy-(Ci -4 )alkyl, C3- 7 cycloalkyl, C 4-7 heterocycle, aromatic, bicyclic heterocycle, arylalkyi, heteroaryl, heteroaryl
  • R 4 is selected from substituted or unsubstituted Ci -7 alkyl, alkoxy, alkoxy- (Ci -4 )alkyl, aryl or C3 -7 cycloalkyl each of which is optionally substituted by heterocycle, nitrile, heteroarylalkyl or heteroaryl and wherein
  • R 5 is selected from aromatic, bicyclic heterocycle, aryl, heteroaryl, each of which is optionally substituted by one or more substituents independently selected from halogen, hydroxyl, amino, Ci-6alkyl, di-(Ci-6)alkylamino, Ci-6alkylamino, Ci-6alkyl, Ci-6alkoxy, C3-6cycloalkyl, carboxylic acid, carboxylic ester, carboxylic amide, heterocycle, aryl, alkenyl, alkynyl, arylalkyl, heteroaryl, heteroarylalkyl or nitrile.
  • the present invention provides compounds of formula (I) wherein R1 is butyl and wherein A, B, and X are as specified above.
  • the invention concerns compounds of formula (I) wherein R 1 is C 4- salkyl substituted with hydroxyl, and wherein A, B, and X are as specified above.
  • R 1 being C 4- salkyl substituted with hydroxyl
  • the present invention also provides compounds of formula (I) wherein X is CH 2 and wherein A, and B are as specified above.
  • the present invention provides compounds of formula (I) wherein X is CH 2 and wherein A is CH 2 and B are as specified above.
  • the invention relates to compounds of formula (I) wherein R 2 is one of the following examples that can be further substituted with C h alky!, hydroxyl, alkoxy, nitrile, heterocycle, carboxylic ester, or carboxylic amide:
  • Preferred compounds are compound numbers 3 and 1 having the following chemical structures res ectively:
  • the compounds of formula (I) and their pharmaceutically acceptable salt, tautomer(s), solvate or polymorph thereof have activity as pharmaceuticals, in particular as modulators of Toll-Like Receptors (especially TLR7 and/or TLR8) activity.
  • the present invention provides a pharmaceutical composition
  • a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate or polymorph thereof together with one or more pharmaceutically acceptable excipients, diluents or carriers.
  • a compound of formula (I) or a pharmaceutically acceptable salt, solvate or polymorph thereof according to the current invention, or a pharmaceutical composition comprising said compound of formula (I) or a pharmaceutically acceptable salt, solvate or polymorph thereof can be used as a medicament.
  • a compound of formula (I) or a pharmaceutically acceptable salt, solvate or polymorph thereof, or said pharmaceutical composition comprising said compound of formula (I) or a pharmaceutically acceptable salt, solvate or polymorph thereof can be used accordingly in the treatment of a disorder in which the modulation of TLR7 and /or TLR8 is involved.
  • alkyl refers to a straight-chain or branched-chain saturated aliphatic hydrocarbon containing the specified number of carbon atoms.
  • halogen refers to fluorine, chlorine, bromine or iodine.
  • alkenyl refers to an alkyl as defined above consisting of at least two carbon atoms and at least one carbon-carbon double bond.
  • alkynyl refers to an alkyl as defined above consisting of at least two carbon atoms and at least one carbon-carbon triple bond.
  • cycloalkyl refers to a carbocyclic ring containing the specified number of carbon atoms.
  • heteroaryl means an aromatic ring structure as defined for the term “aryl” comprising at least 1 heteroatom selected from N, O and S, in particular from N and O.
  • aryl means an aromatic ring structure optionally comprising one or two heteroatoms selected from N, O and S, in particular from N and O.
  • Said aromatic ring structure may have 4, 5, 6 or 7 ring atoms.
  • said aromatic ring structure may have 5 or 6 ring atoms.
  • bicyclic heterocycle means an aromatic ring structure, as defined for the term “aryl” comprised of two fused aromatic rings. Each ring is optionally comprised of heteroatoms selected from N, O and S, in particular from N and O.
  • arylalkyl means an aromatic ring structure as defined for the term “aryl” optionally substituted with an alkyl group.
  • heteroarylalkyl means an aromatic ring structure as defined for the term “heteroaryl” optionally substituted by an alkyl group.
  • alkoxy refers to an alkyl (carbon and hydrogen chain) group singular bonded to oxygen like for instance a methoxy group or ethoxy group.
  • Heterocycle refers to molecules that are saturated or partially saturated and include ethyloxide, tetrahydrofuran, dioxane or other cyclic ethers.
  • Heterocycles containing nitrogen include, for example azetidine, morpholine, piperidine, piperazine, pyrrolidine, and the like.
  • Other heterocycles include, for example, thiomorpholine, dioxolinyl, and cyclic sulfones.
  • Heteroaryl groups are heterocyclic groups which are aromatic in nature. These are monocyclic, bicyclic, or polycyclic containing one or more heteroatoms selected from N, O or S. Heteroaryl groups can be, for example, imidazolyl, isoxazolyl, furyl, oxazolyl, pyrrolyl, pyridonyl, pyridyl, pyridazinyl, or pyrazinyl.
  • Pharmaceutically acceptable salts of the compounds of formula (I) include the acid addition and base salts thereof. Suitable acid addition salts are formed from acids which form non-toxic salts. Suitable base salts are formed from bases which form non-toxic salts.
  • the compounds of the invention may also exist in unsolvated and solvated forms.
  • solvate is used herein to describe a molecular complex comprising the compound of the invention and one or more pharmaceutically acceptable solvent molecules, for example, ethanol.
  • polymorph refers to the ability of the compound of the invention to exist in more than one form or crystal structure.
  • the compounds of the present invention may be administered as crystalline or amorphous products. They may be obtained for example as solid plugs, powders, or films by methods such as precipitation, crystallization, freeze drying, spray drying, or evaporative drying. They may be administered alone or in combination with one or more other compounds of the invention or in combination with one or more other drugs. Generally, they will be administered as a formulation in association with one or more pharmaceutically acceptable excipients.
  • excipient is used herein to describe any ingredient other than the compound(s) of the invention. The choice of excipient depends largely on factors such as the particular mode of administration, the effect of the excipient on solubility and stability, and the nature of the dosage form.
  • compositions of the present invention may be formulated into various pharmaceutical forms for administration purposes.
  • compositions there may be cited all compositions usually employed for systemically administering drugs.
  • an effective amount of the particular compound, optionally in addition salt form, as the active ingredient is combined in intimate admixture with a pharmaceutically acceptable carrier, which carrier may take a wide variety of forms depending on the form of preparation desired for administration.
  • a pharmaceutically acceptable carrier which carrier may take a wide variety of forms depending on the form of preparation desired for administration.
  • These pharmaceutical compositions are desirably in unitary dosage form suitable, for example, for oral, rectal, or percutaneous administration.
  • any of the usual pharmaceutical media may be employed such as, for example, water, glycols, oils, alcohols and the like in the case of oral liquid preparations such as suspensions, syrups, elixirs, emulsions, and solutions; or solid carriers such as starches, sugars, kaolin, diluents, lubricants, binders, disintegrating agents and the like in the case of powders, pills, capsules, and tablets. Because of their ease in administration, tablets and capsules represent the most advantageous oral dosage unit forms, in which case solid pharmaceutical carriers are obviously employed. Also included are solid form preparations that can be converted, shortly before use, to liquid forms.
  • the carrier optionally comprises a penetration enhancing agent and/or a suitable wetting agent, optionally combined with suitable additives of any nature in minor proportions, which additives do not introduce a significant deleterious effect on the skin. Said additives may facilitate the administration to the skin and/or may be helpful for preparing the desired compositions.
  • These compositions may be administered in various ways, e.g., as a transdermal patch, as a spot-on, as an ointment.
  • the compounds of the present invention may also be administered via inhalation or insufflation by means of methods and formulations employed in the art for administration via this way.
  • the compounds of the present invention may be administered to the lungs in the form of a solution, a suspension or a dry powder.
  • Unit dosage form refers to physically discrete units suitable as unitary dosages, each unit containing a predetermined quantity of active ingredient calculated to produce the desired therapeutic effect in association with the required pharmaceutical carrier.
  • unit dosage forms are tablets (including scored or coated tablets), capsules, pills, powder packets, wafers, suppositories, injectable solutions or suspensions and the like, and segregated multiples thereof.
  • an effective daily amount would be from 0.01 mg/kg to 50 mg/kg body weight, more preferably from 0.1 mg/kg to 10 mg/kg body weight. It may be appropriate to administer the required dose as two, three, four or more sub-doses at appropriate intervals throughout the day. Said sub-doses may be formulated as unit dosage forms, for example, containing 1 to 1000 mg, and in particular 5 to 200 mg of active ingredient per unit dosage form.
  • the exact dosage and frequency of administration depends on the particular compound of formula (I) used, the particular condition being treated, the severity of the condition being treated, the age, weight and general physical condition of the particular patient as well as other medication the individual may be taking, as is well known to those skilled in the art. Furthermore, it is evident that the effective amount may be lowered or increased depending on the response of the treated subject and/or depending on the evaluation of the physician prescribing the compounds of the instant invention. The effective amount ranges mentioned above are therefore only guidelines and are not intended to limit the scope or use of the invention to any extent.
  • amide products of formula I can be made by reacting VII with either: an acid chloride in combination with excess base (e.g. triethylamine); a carboxylic acid in combination with a coupling agent (e.g. HBTU) and a base (e.g. triethylamine). Examples.
  • the mixture was extracted with ethyl acetate (3 x 10 ml_) and the combined organic layers were dried over MgSO 4 , the solids were removed via filtration and the solvents of the filtrate were removed under reduced pressure.
  • the crude was purified via silica column chromatography using a heptane to ethyl acetate gradient. The best fractions were pooled, and the solvents were removed under reduced pressure to afford compound 1.
  • the crude was purified via silica column chromatography using a using a dichloromethane to 3% methanol in dichloromethane gradient.
  • the purified boc-protected product was deprotected by addition of HCI in isopropanol.
  • TLR7 and/or TLR8 The ability of compounds to activate human TLR7 and/or TLR8 was assessed in a cellular reporter assay using HEK293 cells transiently transfected with a TLR7 or TLR8 expression vector and NFKB-IUC reporter construct.
  • the TLR expression construct expresses the respective wild type sequence or a mutant sequence comprising a deletion in the second leucine- rich repeat of the TLR.
  • Such mutant TLR proteins have previously been shown to be more susceptible to agonist activation (US 7498409).
  • HEK293 cells were grown in culture medium (DMEM supplemented with 10% FCS and 2 mM Glutamine).
  • cells were detached with Trypsin-EDTA, transfected with a mix of CMV-TLR7 or TLR8 plasmid (750 ng), NFKB-IUC plasmid (375 ng) and a transfection reagent and incubated overnight at 37°C in a humidified 5% CO2 atmosphere.
  • Transfected cells were then detached with Trypsin-EDTA, washed in PBS and resuspended in medium to a density of 1 .67 x 10 5 cells/mL. Thirty microliters of cells were then dispensed into each well in 384-well plates, where 10 ⁇ of compound in 4% DMSO was already present.
  • the luciferase activity was determined by adding 15 ⁇ of Steady Lite Plus substrate (Perkin Elmer) to each well and readout performed on a ViewLux ultraHTS microplate imager (Perkin Elmer). Dose response curves were generated from measurements performed in quadruplicates. Lowest effective concentrations (LEC) values, defined as the concentration that induces an effect which is at least two fold above the standard deviation of the assay, were determined for each compound. Compound toxicity was determined in parallel using a similar dilution series of compound with 30 ⁇ _ per well of cells transfected with the CMV-TLR7 construct alone (1 .67 x 10 5 cells/mL), in 384-well plates.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Communicable Diseases (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PCT/EP2013/052372 2012-02-08 2013-02-07 Piperidino-pyrimidine derivatives for the treatment of viral infections WO2013117615A1 (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
MX2014009556A MX357296B (es) 2012-02-08 2013-02-07 Derivados piperidinopirimidinicos para el tratamiento de infecciones viricas.
CA2862823A CA2862823C (en) 2012-02-08 2013-02-07 Piperidino-pyrimidine derivatives for the treatment of viral infections.
SG11201404743TA SG11201404743TA (en) 2012-02-08 2013-02-07 Piperidino-pyrimidine derivatives for the treatment of viral infections
JP2014556041A JP6283320B2 (ja) 2012-02-08 2013-02-07 ウイルス感染の治療のためのピペリジノ−ピリミジン誘導体
ES13703055T ES2716811T3 (es) 2012-02-08 2013-02-07 Derivados piperidinopirimidínicos para el tratamiento de infecciones víricas
NZ627036A NZ627036A (en) 2012-02-08 2013-02-07 Piperidino-pyrimidine derivatives for the treatment of viral infections
DK13703055.7T DK2812331T3 (en) 2012-02-08 2013-02-07 PIPERIDINOPYRIMIDINE DERIVATIVES FOR TREATING VIRUS INFECTIONS
BR112014019699-0A BR112014019699B1 (pt) 2012-02-08 2013-02-07 Derivados de piperidino-pirimidina, seu uso no tratamento de infecções virais e composição farmacêutica que os compreende
IN1736MUN2014 IN2014MN01736A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2012-02-08 2013-02-07
EA201491486A EA033907B1 (ru) 2012-02-08 2013-02-07 Производные пиперидино-пиримидина, фармацевтическая композиция и их применение
CN201380008467.4A CN104245695B (zh) 2012-02-08 2013-02-07 用于治疗病毒性感染的哌啶基‑嘧啶衍生物
US14/377,064 US9133192B2 (en) 2012-02-08 2013-02-07 Piperidino-pyrimidine derivatives for the treatment of viral infections
EP13703055.7A EP2812331B1 (en) 2012-02-08 2013-02-07 Piperidino-pyrimidine derivatives for the treatment of viral infections
KR1020147022432A KR102064807B1 (ko) 2012-02-08 2013-02-07 바이러스 감염을 치료하기 위한 피페리디노-피리미딘 유도체
HK15101591.4A HK1201254B (en) 2012-02-08 2013-02-07 Piperidino-pyrimidine derivatives for the treatment of viral infections
AU2013218072A AU2013218072B2 (en) 2012-02-08 2013-02-07 Piperidino-pyrimidine derivatives for the treatment of viral infections
UAA201407816A UA112668C2 (uk) 2012-02-08 2013-07-02 Похідні піперидинопіримідину для лікування вірусних інфекцій
IL233499A IL233499B (en) 2012-02-08 2014-07-03 History of piperidino-pyrimidine for the treatment of viral infections
PH12014501738A PH12014501738A1 (en) 2012-02-08 2014-08-01 Piperidino-pyrimidine derivatives for the treatment of viral infections
ZA2014/05820A ZA201405820B (en) 2012-02-08 2014-08-07 Piperidino-pyrimidine derivatives for the treatment of viral infections
US14/818,094 US9365571B2 (en) 2012-02-08 2015-08-04 Piperidino-pyrimidine derivatives for the treatment of viral infections

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12154474.6 2012-02-08
EP12154474 2012-02-08

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US14/377,064 A-371-Of-International US9133192B2 (en) 2012-02-08 2013-02-07 Piperidino-pyrimidine derivatives for the treatment of viral infections
US14/818,094 Continuation US9365571B2 (en) 2012-02-08 2015-08-04 Piperidino-pyrimidine derivatives for the treatment of viral infections
US14377064 A-371-Of-International 2023-02-07

Publications (1)

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WO2013117615A1 true WO2013117615A1 (en) 2013-08-15

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PCT/EP2013/052372 WO2013117615A1 (en) 2012-02-08 2013-02-07 Piperidino-pyrimidine derivatives for the treatment of viral infections

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EP (1) EP2812331B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP6283320B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR102064807B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN104245695B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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