WO2012148786A1 - ELECTROLYTE AND pH MONITORING FOR FLUID REMOVAL PROCESSES - Google Patents

ELECTROLYTE AND pH MONITORING FOR FLUID REMOVAL PROCESSES Download PDF

Info

Publication number
WO2012148786A1
WO2012148786A1 PCT/US2012/034330 US2012034330W WO2012148786A1 WO 2012148786 A1 WO2012148786 A1 WO 2012148786A1 US 2012034330 W US2012034330 W US 2012034330W WO 2012148786 A1 WO2012148786 A1 WO 2012148786A1
Authority
WO
WIPO (PCT)
Prior art keywords
blood
fluid
indicator
dialysate
sensor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/034330
Other languages
English (en)
French (fr)
Inventor
Martin T. Gerber
John E. Burnes
Suping Lyu
Manda R. VENKATESH
Bryant J. Pudil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Inc
Original Assignee
Medtronic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47067087&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2012148786(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Medtronic Inc filed Critical Medtronic Inc
Priority to CN201280020932.1A priority Critical patent/CN103717132B/zh
Priority to EP12722951.6A priority patent/EP2701596B1/en
Priority to EP19167435.7A priority patent/EP3527134A1/en
Priority to JP2014508435A priority patent/JP6153923B2/ja
Publication of WO2012148786A1 publication Critical patent/WO2012148786A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1601—Control or regulation
    • A61M1/1603—Regulation parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0031—Implanted circuitry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A61B5/0295—Measuring blood flow using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A61B5/0537—Measuring body composition by impedance, e.g. tissue hydration or fat content
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14535—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring haematocrit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring pH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6866—Extracorporeal blood circuits, e.g. dialysis circuits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1601—Control or regulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1601—Control or regulation
    • A61M1/1603—Regulation parameters
    • A61M1/1605—Physical characteristics of the dialysate fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1601—Control or regulation
    • A61M1/1603—Regulation parameters
    • A61M1/1605—Physical characteristics of the dialysate fluid
    • A61M1/1607—Physical characteristics of the dialysate fluid before use, i.e. upstream of dialyser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1601—Control or regulation
    • A61M1/1613—Profiling or modelling of patient or predicted treatment evolution or outcome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403—Regulation parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3607—Regulation parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3607—Regulation parameters
    • A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3607—Regulation parameters
    • A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
    • A61M1/361—Physical characteristics of the blood, e.g. haematocrit, urea before treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3607—Regulation parameters
    • A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
    • A61M1/3612—Physical characteristics of the blood, e.g. haematocrit, urea after treatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24—Dialysis ; Membrane extraction
    • B01D61/32—Controlling or regulating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
    • B01D65/02—Membrane cleaning or sterilisation ; Membrane regeneration
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/40—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/63—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/70—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16Z—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS, NOT OTHERWISE PROVIDED FOR
    • G16Z99/00—Subject matter not provided for in other main groups of this subclass
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/04—General characteristics of the apparatus implanted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/18—General characteristics of the apparatus with alarm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3303—Using a biosensor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A61M2205/3313—Optical measuring means used specific wavelengths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A61M2205/3334—Measuring or controlling the flow rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3375—Acoustical, e.g. ultrasonic, measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3507—Communication with implanted devices, e.g. external control
    • A61M2205/3523—Communication with implanted devices, e.g. external control using telemetric means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/70—General characteristics of the apparatus with testing or calibration facilities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/005—Parameter used as control input for the apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/207—Blood composition characteristics hematocrit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/208—Blood composition characteristics pH-value
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/65—Impedance, e.g. conductivity, capacity
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/12—Use of permeate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/40—Automatic control of cleaning processes

Definitions

  • the present disclosure relates generally to devices, systems and uses for monitoring indicators of electrolytes or pH in patients for which blood cleaning or fluid removal is indicated, such as patients suffering from kidney disease or heart failure.
  • the patient undergoes periodic examinations that allow a healthcare provider to set various parameters of the blood fluid removal procedures, such as the profile of fluid removal, the composition of dialysate or replacement fluid employed, and the like. These examinations typically occur once a month in accordance with current standards of care.
  • Hemodialysis or similar procedures may occur three to four times a week.
  • the patient may undergo 10 to 15 or more blood fluid removal sessions before the
  • prescription or parameters are changed. It is possible, for example, that a prescription with regard to a dialysate electrolyte and pH buffer composition will not be appropriate for a patient several days or weeks after the prescription is set. Accordingly, it may be desirable to more frequently determine whether the electrolyte or pH concentration of a fluid used in blood fluid removal sessions is appropriate. In addition, it may be desirable to adjust the concentration or composition of the fluid during a blood fluid removal session in a manner that may improve patient health and reduce morbidity.
  • This disclosure describes devices, systems and uses for monitoring indicators of pH or electrolytes in patients for which blood fluid removal sessions are indicated.
  • the monitoring may occur during a blood fluid removal session, and the concentration or composition of buffer or electrolytes may be adjusted based on monitored data acquired during the blood fluid removal session.
  • the dialysate of replacement fluid may be adjusted during a session to enhance patient safety.
  • a use includes initiating a blood fluid removal procedure for a patient in need thereof.
  • the procedure includes use of a fluid selected from a dialysate fluid or a replacement fluid.
  • the fluid has an initial pH buffer composition or electrolyte composition.
  • the use further includes monitoring an indicator of blood electrolyte concentration or blood pH of the patient during the blood fluid removal session, and adjusting the pH buffer composition or the electrolyte composition of the fluid based on a value of the monitored indicator.
  • the monitoring may be of blood before or after the blood has passed through the blood fluid removal device, or may be of fluid removed from the blood.
  • data acquired from monitoring performed on blood before and after passing through the blood fluid removal device is compared to data acquired from fluid (e.g., dialysate) before and after passing through blood fluid removal media of the device, and based on the comparison, the pH buffer composition or the electrolyte composition of the fluid is adjusted.
  • fluid e.g., dialysate
  • a system includes a blood fluid removal device, which has (i) an inlet for receiving blood from a patient, (ii) an outlet for returning blood from the patient, (iii) a medium for removing fluid and contaminants from the blood, the medium being positioned between the inlet and the first outlet, and (iv) a fluid source for carrying a fluid, where the fluid is selected from dialysate and replacement fluid. If the fluid is dialysate, the fluid source carries the fluid to the medium. If the fluid is replacement fluid, the fluid source carries the fluid to the blood after the blood exits the medium.
  • the system further includes (i) a concentrate source for housing a concentrate solution comprising concentrated electrolyte or pH buffer, (ii) a concentrate flow control element for controlling the rate that the concentrate solution enters the fluid source; (iii) a sensor for monitoring an indicator of blood pH or blood electrolyte concentration; and (iv) control electronics in operable communication with the sensor and the concentrate flow control element.
  • the control electronics are configured, via the concentrate flow control element, to adjust the rate at which the concentrate solution enters the fluid source based on data obtained from the sensor.
  • a system includes (i) a medium housing defining a major chamber; (ii) a blood flow removal membrane disposed in the housing and sealingly dividing the major chamber into first and second minor chambers; (iii) a first inlet and a first outlet in fluid communication with the first minor chamber, wherein the system is configured such that blood enters the first minor chamber through the first inlet and exits the first minor chamber through the first outlet; (iv) a second inlet and a second outlet in fluid communication with the second minor chamber, wherein the system is configured such that dialysate enters the second minor chamber through the second inlet and exits the second minor chamber through the second outlet; (vi) a dialysate regeneration medium in fluid communication with and disposed in a dialysate flow path between the second inlet and the second outlet; (vii) a concentrate source for housing a concentrate solution comprising concentrated electrolyte or pH buffer; (viii) a concentrate flow control element for controlling the rate that the concentrate solution enters the dialy
  • One or more embodiments of the systems, devices and uses described herein may provide one or more advantages over prior systems, devices and uses for blood fluid removal in patients. Such advantages will be apparent to those skilled in the art upon reading the following detailed description. BRIEF DESCRIPTION OF THE DRAWINGS
  • FIGS. 1-3 are schematic block diagrams showing interaction of blood fluid removal devices with a patient showing flow of blood (dashed arrows) and fluid (solid arrows), which blood fluid removal devices may be used in various embodiments described herein.
  • FIG. 4 is a schematic block diagram showing some selected components of an
  • FIGS. 5-6 are schematic block diagrams showing sensors and blood flow between
  • FIGS. 7-8 are schematic block diagrams showing flow paths and some control
  • FIGS. 9-10 are schematic block diagrams of some components of blood fluid removal devices that are configured to adjust pH or electrolyte concentrations of fluids in response to data regarding monitored pH or electrolyte levels in blood.
  • FIGS. 11-13 are flow diagrams illustrating overviews of general uses in accordance with embodiments described herein.
  • the schematic drawings presented herein are not necessarily to scale.
  • Like numbers used in the figures refer to like components, steps and the like. However, it will be understood that the use of a number to refer to a component in a given figure is not intended to limit the component in another figure labeled with the same number. In addition, the use of different numbers to refer to components is not intended to indicate that the different numbered components cannot be the same or similar.
  • a "patient for which a blood fluid removal session is indicated" is a patient for which a blood fluid removal session is indicated.
  • patient that has undergone, is undergoing, or is likely to undergo at least one blood fluid removal session In general, such patients are fluid overloaded patients, such as patients suffering from heart failure, chronic kidney disease, or acute kidney failure. Often such patients are stage 3 to stage 5 chronic kidney disease patients, are unresponsive or under- responsive to diuretics, or the like.
  • a "blood fluid removal process,” or the like refers to a process from
  • blood fluid removal processes include ultrafiltration, hemofiltration, hemodialysis, hemodiafiltration, peritoneal dialysis, and the like. Any patient for which blood fluid removal is indicated may benefit from the devices, systems and uses described herein.
  • the sensors are configured and positioned to monitor pH or electrolytes in one or more of (i) blood of the patient before the blood enters a fluid removal or cleaning medium of the blood fluid removal device; (ii) blood of the patient before after blood exits the medium before being returned to the patient; (iii) fluid removed from the blood of the patient after passing through the medium; (iv) fluid, such as dialysate, before entering the medium; (v) fluid upstream or downstream of the addition of a concentrate for use in altering the composition of the fluid (e.g., dialysate or replacement fluid); (vi) or the like. Additional discussion with regard to sensor placement and use of such sensors will follow. First, however, a brief discussion of blood fluid removal devices or systems that may be used in accordance with the teachings presented herein is presented.
  • Any suitable device or system for removing fluid, or fluid and contaminants, from blood may be used in accordance with the teachings presented herein.
  • the devices, or components thereof, may be traditional large counsel-type, wearable, or implantable.
  • FIGS. 1-3 Block diagrams of some example devices and systems are shown in FIGS. 1-3.
  • blood may be removed from a patient 10 and fluid may be removed via a blood fluid removal device 100 and returned to the patient 10. Removed fluid may be diverted. In some embodiments where the blood fluid removal device 100 or system, or components thereof, are implanted, the removed fluid may be diverted to the patient' s bladder.
  • blood fluid removal devices 100 that may operate as depicted in FIG. 1 are ultrafiltration and hemofiltration devices. Examples of such devices and components thereof that may be employed in accordance with the teachings presented herein are well known in the art. It will be understood that peritoneal dialysis, where dialysate is introduced into the peritoneal cavity, may also be employed.
  • replacement fluid may be introduced into the patient's blood if fluid is removed from the blood by the device 100 at too great of a rate or amount.
  • the replacement fluid may be added to the original blood before fluid removal or may be added to the blood after initial fluid removal and prior to return to the patient' s cardiovascular system.
  • the replacement fluid is added after initial fluid removal.
  • the pH and electrolyte concentration of the replacement fluid may be set or adjusted, e.g. as described in more detail below, based on monitoring of pH or electrolytes of the patient.
  • the blood fluid removal device 100 may employ dialysate to assist in removal of contaminants from the patient's blood and in maintaining proper pH and electrolyte balance.
  • the pH or electrolyte concentration of the dialysate may be set or adjusted, e.g. as described in more detail below, based on monitoring of pH or electrolytes.
  • Used dialysate and fluid removed from the blood may be diverted.
  • the used dialysate and removed fluid, or a portion thereof may be regenerated (indicated by dashed lined regeneration system 150) to produce fresh dialysate for re-use in the blood fluid removal process.
  • REDY regenerative dialysis
  • Nephrology 4:275- 278, 1998 which system may be employed or readily modified for use in embodiments described herein.
  • a concentrate may be added to the regenerated dialysate to adjust the pH and electrolytes of the regenerated dialysate to an amount suitable for re-use as fresh dialysate.
  • dialysate Regardless of whether the dialysate is regenerated, systems and devices that operate in a manner shown in the embodiment of FIG. 2 include hemodialysis and hemodiafiltration systems. Examples of such devices and components thereof that may be employed in accordance with the teachings presented herein are well known in the art. It will be understood that peritoneal dialysis, where the dialysate is introduced into peritoneal cavity may also be employed.
  • replacement fluid may be introduced into the patient's blood, upstream or downstream of fluid removal, e.g. as described above with regard to FIG. 1.
  • one goal of hemodialysis, ultrafiltration, and the like is to ensure that the patient's blood pH and electrolyte concentrations are within acceptable ranges.
  • Typical ranges of pH and blood electrolyte concentration that are desired during or following a blood fluid removal session are provided in Table 1 below. As indicated in Table 1, concentrations of various acids or bases (or salts or hydrates thereof) are often important in determining the pH of blood. Accordingly, some typical target concentrations of such acids, bases are presented in Table 1.
  • buffers are typically employed to maintain proper blood pH.
  • Some suitable buffers that may be used in fluid, such as replacement fluid or dialysate include bicarbonate, acetate, citrate, lactate, amino acid and protein buffers. The concentration and composition of the buffers and components thereof may be adjusted based on monitored pH of the patient's blood. Similarly, the concentration of electrolytes such as sodium, potassium, calcium, and chloride in replacement fluid or dialysate may be set or altered based the monitored levels of electrolytes.
  • any suitable sensor may be employed to monitor pH or electrolytes.
  • FIG. 4 a block diagram showing some components that a sensing device 200 may include is depicted.
  • the sensing device 200 is shown as a stand-alone device in FIG. 4, but is will be understood that the device, one or more components thereof, may be incorporated into other devices, such as a blood fluid cleaning device.
  • the sensor 200 depicted in FIG. 4 has a housing 299 (which can be shared with another device if the sensor, or portion thereof, is incorporated into the other device) for containing various electronic components 296, 297, 289, 295.
  • any suitable transducer may be employed to detect pH or electrolytes.
  • the transducer is an ion selective electrode configured to detect H + ions, K + ions, Na + ions, Ca 2+ ions, CI " ions, phosphate ions, magnesium ions, acetate ions, amino acids ions, or the like.
  • Such electrodes, and components of sensors employing such electrodes are known in the art and may be employed, or modified to be employed, for use in the monitoring described herein.
  • pH sensor is Medtronic, Inc.'s Bravo® pH sensor.
  • potassium selective electrode is the Thermo Scientific Potassium Ionplus®.
  • Other examples of ion-selective electrodes are contained in the CCX Stat Profile® produced by Nova Biomedical.
  • one or more sensors are employed to detect one or more ions to gauge pH or electrolytes in the blood.
  • a sensor may have more than one transducer, even if leadless, that may monitor more than one ionic species. By measuring more than one ionic species, a more detailed understanding of the levels of various electrolytes or blood components may be had. For example, in some patients in some situations, one electrolyte may be at elevated levels while another may be at reduced levels.
  • more than one sensor for the same ion is employed for purposes of result confirmation and redundancy, which can improve reliability and accuracy.
  • sensors for the same ion may be configured to accurately detect different ranges of concentrations of the ion.
  • more than one transducer is present in a single unit. This allows for convenient data collection and circuitry, as all the data may be collected in one place at the same time. Further, the multiple transducers may share the same fluid collection mechanism (e.g., a microdialyzer in the case of an implant), and if needed or desired, may share the same data processing and memory storage components.
  • a fluid collection mechanism e.g., a microdialyzer in the case of an implant
  • a sensor (or transducer) may be placed at any suitable location for purposes of
  • a blood fluid removal system and sensors is depicted.
  • sensors 200A, 200B may be employed.
  • a pH or electrolyte sensor 200A may be located external to the patient 10 and configured to monitor pH or electrolyte levels in the blood before the blood enters the blood fluid removal device 100 (or before entering blood fluid removal medium, as will be discussed below in more detail).
  • sensor 200A may be positioned such that a transducer is placed within a catheter carrying blood from the patient 10 to the blood fluid removal device 100 or blood fluid removal media.
  • Data acquired from a sensor 200A upstream of the fluid delivery device 100 or blood fluid removal media provides an indication of the actual status of the patient 10.
  • data acquired from a sensor 200A upstream of the fluid delivery device 100 or medium can be used to determine whether blood pH and electrolytes are approaching target ranges or to determine the rate at which pH and electrolytes are changing in the patient as a result of the blood fluid removal process. While not intending to be bound by theory, it is possible that too rapid of a change in pH or electrolyte concentrations can lead to patient hypotension or sudden death that is seen in patient populations that undergo blood fluid removal processes. By monitoring and controlling the rate of change of pH or electrolyte changes in the blood of a patient during the blood fluid removal session, perhaps the incidence of crashing or sudden death can be reduced.
  • a sensor 200B is located external to the patient 10 and configured to monitor pH or electrolyte levels in the blood after the blood exits the blood fluid removal device 100 (or after exiting the blood fluid removal medium) and before being returned to the patient 10.
  • sensor 200B may be positioned such that a transducer is placed within a catheter carrying blood from the blood fluid removal device 100 (or medium) to the patient 10.
  • Such a downstream sensor 200B may be used to ensure that pH and electrolyte levels of blood to be returned to the patient are not out of range.
  • the system employs both an upstream sensor 200A and a
  • the pH or electrolyte levels detected upstream and downstream may be compared, and the compared data may be used to adjust the pH or electrolyte concentration or composition of fluid employed during a blood fluid removal session.
  • the compared data may also be used to determine the rate of change of blood electrolyte concentration or pH.
  • the patient prior to a blood fluid removal session or in the early parts of such a session, the patient is typically fluid over-loaded and the concentration of electrolytes may be low (due to the increased fluid volume). It may be appropriate to allow a slightly higher than target concentration electrolyte to be introduced back into the patient when the patient's electrolyte levels are low.
  • the electrolyte levels in the returned blood should within target range. Monitoring both upstream and downstream will allow for adjustments and checks on progress that may not be attainable by monitoring only one or the other.
  • FIG. 6 a system employing sensors 200C, 200D, 200E, 200F in
  • sensors 200C, 200D, 200E, 200F may be employed.
  • the system may also employ one or more downstream sensors as described with regard to FIG. 5, but are not shown in FIG. 6.
  • a brief discussion of some possible configurations and uses of sensors 200C, 200D, 200E, 200F is provided herein. However, it will be understood that meaningful data may be obtained from configurations other than those described below.
  • the system (e.g., the system depicted in FIG. 6) employs two upstream sensors 200C, 200D.
  • the first upstream sensor 200C is positioned to monitor pH or electrolyte levels in the blood after it exits the blood fluid removal device 100 or medium but before replacement fluid is added.
  • the second sensor 200D is positioned to monitor pH or electrolyte levels of the blood after the replacement fluid is added and before the blood is returned to the patient 10.
  • the first sensor 200C may be used to determine what adjustments may be needed to pH and electrolyte levels, and the second sensor 200D may be used to verify that the appropriate adjustments were made to achieve the desired pH and electrolyte concentrations prior to returning the blood to the patient.
  • the system employs a sensor 200E to monitor pH or electrolytes
  • the blood fluid removal device 100 or medium may include a sensor 200D configured and positioned to monitor pH or electrolytes of fluid (in the depicted case, dialysate) prior to entering the blood fluid device 100 or medium.
  • a sensor 200D configured and positioned to monitor pH or electrolytes of fluid (in the depicted case, dialysate) prior to entering the blood fluid device 100 or medium.
  • pH or electrolytes of fluid in the depicted case, dialysate
  • the pH or levels of electrolytes (or change in pH or electrolytes) exiting the device 100 or medium may be used to predict the blood pH and electrolyte levels without having to measure the levels in the blood directly.
  • data acquired from the sensors may be used to adjust the pH or electrolyte concentrations of fluid (e.g.
  • dialysate or replacement fluid used during the dialysis session.
  • concentrations of dialysate or replacement fluid are varied and the patient's response to the varying concentrations, as measured by one or more of sensors, is used to determine how best to proceed with further adjustments.
  • the system may be configured to learn what works best for the particular patient 10. For example, dialysate or replacement fluid having different buffer concentrations or compositions or different electrolyte concentrations may be used during an initial blood fluid session or early in a blood fluid session. The patient's response to these different fluids can be monitored via sensors, and the system can learn what works best for the patient.
  • the system can determine whether the use of the different fluids resulted in the patient's blood levels approaching target levels or deviating from target levels, as well as the rate at which the levels approach or deviate from target ranges. Based on the initial sessions or stages, the system may begin to predict how to react to a particular monitored pH or electrolyte level for the patient and adjust the fluid pH and electrolyte concentrations accordingly.
  • the pH and electrolyte concentration of the fluid may be adjusted in any suitable manner.
  • FIGS. 7-8 some representative components of an example of a closed-loop system (FIG.7) and an open- loop system (FIG. 8) for adjusting pH and electrolyte concentrations of fluid are shown.
  • FIG. 7 data from one or more sensor 200 is presented to control electronics 495, which are configured to control flow control elements 415, 425, 435, such as valves.
  • the electronically controllable flow control elements 415, 425, 435 are in fluid communication with supplies of concentrated electrolyte or buffer solutions 410, 420, 430 and with fluid line 440, which may be a catheter for carrying fresh dialysate or a catheter for carrying replacement fluid.
  • the concentrates 410, 420, 430 are added to bulk fluid 400 to adjust the concentration of electrolytes or the pH of the bulk fluid (and thus the blood).
  • data from one or more sensor 200 may be processed and
  • a display 600 which may be a part of the blood fluid removal device, a separate computer, or the like.
  • a healthcare provider may use the information presented on the display 600 to adjust the concentration of electrolytes or pH. This can be done, for example, by transmitting appropriate instructions to the control electronics via an input device 500.
  • Any suitable input device 500 may be used.
  • input device 500 may be a keyboard, a computer, a tablet, a personal data assistant, a physician programmer, or the like.
  • the input device 500 is the display 600; e.g., where the display 600 is a touch screen device.
  • the control electronics 495 can control flow control elements 415, 425, 435 to control the amount of concentrate 410, 420, 430 introduced to bulk fluid 400, which may be dialysate or replacement fluid.
  • any number of suitable concentrates may be used.
  • one concentrate may be sufficient with higher amounts being added when the electrolytes are determined to be low in the patient' s blood, and smaller amounts being added when the electrolytes are determined to be high in the patient's blood.
  • More than one concentrate may be used when it is desired to, for example, control pH and electrolyte concentration independently or to control concentration of different electrolytes independently.
  • the number of concentrates is the same as the number of ion species (pH and electrolytes) monitored.
  • Control elements 415, 425, 435 may be any suitable control element, such as electronically controllable valves, electronically controllable pump mechanisms, or the like.
  • Any suitable system may be configured as depicted in FIGS. 7-8 to provide control of adjustment of pH or electrolytes based on data acquired from one or more sensors.
  • FIGS. 9- 10 selected components of two example systems are illustrated in FIGS. 9- 10.
  • the system in FIG. 9 illustrates control of flow of a concentrate into replacement fluid
  • the system in FIG. 10 illustrates control of flow of a concentrate into dialysate.
  • the depicted device 100 includes a fluid pathway for adding replacement fluid to blood before it is returned to the patient.
  • the device 100 includes an inlet 110 for receiving blood from the patient and an outlet 140 for returning blood to the patient.
  • a blood flow control element 120 In the flow path between the inlet 110 and outlet 140 are a blood flow control element 120 and a medium for removing fluid and contaminants from the blood.
  • the blood flow control element 120 is operably coupled to control electronics 150 which provide instructions to control the rate at which blood is passed through medium 130. Fluids and contaminants removed from the blood by the medium 130 may exit via outlet 180.
  • the device 100 depicted in FIG. 9 also includes an inlet 197 for receiving bulk
  • the device 100 also includes (i) an inlet 401 for receiving a concentrate for adjusting the pH or electrolyte concentration of the bulk replacement fluid, and (ii) a concentrate flow control element 415 in
  • the concentrate is added to the replacement fluid prior to the replacement fluid being added to the blood (as depicted) so that the concentrate may be mixed or diluted prior to being added to the blood.
  • the device may include a mixer (not shown) to mix the concentrate and bulk replacement fluid prior to adding to the blood.
  • control electronics 150 are operably coupled to the concentrate flow control element 415 and are configured to control the rate at which the concentrate flow control element 415 adds fluid to the replacement fluid or blood based on data received from one or more sensors 200 that monitor pH or electrolytes levels (e.g., as described above). By controlling the rate at which the concentrate is introduced into replacement fluid or blood, the concentration or pH (or buffering capacity) of the returned blood can be controlled.
  • FIG. 10 in which components that are numbered the same as in FIG.
  • the device has an inlet 110 for receiving blood from a patient, a blood flow control element 120 in communication with the inlet 110 and configured to control the rate at which blood flows through medium 130 for removing fluid and contaminates from the blood.
  • the device also includes an outlet 140 in communication with the medium 130 for returning blood to the patient.
  • the medium 130 component has a housing 139 defining a major chamber 131.
  • dialysate is regenerated by passing through dialysate regeneration medium 402 or components, such REDY regeneration medium and components, or the like, to regenerate bulk dialysate.
  • the device also has an outlet 180 in communication with the medium 130 for diverting fluid removed from the blood out of the device.
  • a flow regulator element 700 such as a valve, is operably coupled to control electronics 150 and is disposed in the flow path between the medium 130 and the outlet 180 to control the amount of fluid that exits the device (as a portion of the fluid is regenerated).
  • the regeneration media or components (402) remove much of the pH buffer or electrolytes from the dialysate.
  • a concentrate containing concentrated electrolytes and pH buffers is added to the regenerated dialysate before the dialysate re-enters the medium 130.
  • a sensor 299 is positioned downstream of the regeneration medium 402 to monitor a level of a component of the regenerated dialysate.
  • the sensor 299 may be a pH or electrolyte sensor and data acquired from sensor 299 may be used in determining how much concentrate to add to the regenerated fluid (which data may be provided to control electronics 150).
  • the sensor 299 may be a sensor that monitors a blood waste product, such as urea, to determine whether the regeneration media 402 is properly functioning.
  • the concentrate 410 is stored in a reservoir 410, having an inlet 401 that allows the concentrate supply in the reservoir 410 to be replenished from time to time.
  • the rate at which the concentrate is added to the regenerated dialysate is controlled by concentrate flow control element 415, which is operably coupled to control electronics 150, and is based on data received from sensor 200 that monitors pH or electrolyte concentrations (e.g., as described above).
  • the device 100 in FIG. 10 also has a dialysis flow control element 170 for controlling the rate at which dialysis is introduced into the dialysis flow compartment of the medium 130.
  • the device 100 also includes a negative pressure control element 190 in communication with the dialysate compartment of the medium
  • the negative pressure control element 190 which may include a pump or the like, may be used to generate or change a pressure differential across the membrane to control the rate at which fluid is removed from blood that passes though the medium component 130.
  • the control electronics 150 which may include a processor, memory, etc., are operably coupled to, and configured to control, the blood flow control element 120, the dialysis flow control element 170, and the negative pressure control element 190. By controlling these elements in a coordinated manner, the rate at which fluid is removed from blood may be controlled. It will be understood that a device 100 need not have all of the controllable elements (120, 170, 190) depicted in FIG. 10 to effectively control rate of fluid removal from blood.
  • control element Any suitable control element may be used for the various control elements (120, 150,
  • FIGS. 9-10 show devices that can adjust blood electrolyte or pH by adjusting the pH or electrolyte concentration of replacement fluid or dialysate, it will be understood that pH and concentration can also be adjusted by, for example, adjusting the rate at which dialysate or blood is passed over a dialysis membrane. The rate of transfer between blood and dialysate of electrolytes, etc. across the membrane will be dependent on the flow rate of the blood and the dialysate. Accordingly, in systems where dialysate electrolyte concentration or pH cannot be readily adjusted, the rate of flow of blood or dialysate flow may be altered to achieve similar effects to adjusting the concentration of electrolytes in dialysate.
  • FIGS. 9-10 depict components as being within a single unit, it will be understood that one or more of the components may be housed in separate units.
  • the control electronics, or a portion thereof may be housed in a separate device, such as a computer, tablet, physician programmer, or the like.
  • the computer, tablet, etc. may receive input from sensors, determine appropriate action to take, and instruct appropriate components of a blood fluid removal device to take the appropriate action.
  • blood fluid removal devices and systems, and components thereof, described herein are presented for purposes of illustration and not limitation. Components, devices and systems other than those described herein, or derivations of the components, devices and systems described herein, may be employed. Further, components of the devices depicted and discussed above may be interchanged, substituted or added to components of alternative embodiments, as appropriate. Further, it will be understood that, while many of the blood fluid removal devices depicted in a variety of the figures, such as FIGS. 1-3 and 5-6, are shown as external to the patient, the teachings presented herein apply if the device, or components thereof, were implanted in the patient.
  • FIGS. 11-13 The devices and systems described above, or components thereof, may be used to carry out the uses depicted in FIGS. 11-13 and described below, or portions thereof. Of course, any suitable device or system may be employed to carry out the uses, or portions thereof, described below. It will be understood that various steps of the uses presented with regard to any one of FIGS. 11-13 below may be interchanged, substituted, or added to steps presented with regard to any other of FIGS. 11-13.
  • the depicted use includes initiating a blood fluid removal session (801) and monitoring an indicator pH or electrolyte concentration of blood (810); e.g. detecting pH or electrolytes in blood or in fluid from which pH or electrolyte levels in blood can be derived.
  • an indicator pH or electrolyte concentration of blood e.g. detecting pH or electrolytes in blood or in fluid from which pH or electrolyte levels in blood can be derived.
  • the pH or electrolyte composition or concentration of fluid e.g., dialysate or replacement fluid
  • the fluid composition may be adjusted, e.g. as discussed above.
  • continuous, periodic or intermittent determinations may be made as to whether the pH or electrolyte concentration is out of range (830) based on data acquired during the monitoring (810). For example, a determination (830) may be made as to whether pH or electrolyte levels crossed a threshold (e.g., a ceiling or floor). If the pH or electrolytes are determined to be within range, monitoring (810) may continue. If the pH or electrolytes are determined to be out of range (e.g., cross a threshold), an alert (840) may be issued to notify the patient or a healthcare provider of the situation.
  • a threshold e.g., a ceiling or floor
  • the situation may warrant stopping (890) of the blood fluid removal session; e.g., if the detected pH or electrolytes are too far out of range or cross a heightened threshold. In other cases, it may be suitable to continue with the blood fluid removal session with heightened awareness of a situation for which increased attention may be warranted.
  • the depicted use includes initiating a blood fluid removal session (801) and monitoring an indicator pH or electrolyte concentration upstream (815) and downstream (813) of blood fluid removal. Data acquired from upstream and downstream sensors may be compared to determine how to adjust (860) the fluid composition, e.g. as described above.
  • FIG. 13 the depicted use show a use where blood electrolyte
  • concentration or pH is adjusted by altering the flow rate of dialysate or blood.
  • the use includes initiating a blood fluid removal session (900), such as a hemodialysis session, and monitoring an indicator of pH or electrolyte (910), which can be in the patient, upstream of the device, downstream of the device, within the device, or the like. Based on the monitored data (910), adjustments to the flow of dialysate or blood may be made (920) to adjust the electrolyte concentration or pH in the blood that gets returned to the patient.
  • the uses described herein may be carried out by sensor devices, blood fluid removal devices, or other devices in communication with sensor devices or blood fluid removal devices. These uses may be algorithms or instructions programmed into memory of such devices, which may be carried out by processors or other control electronics of the devices. Preferably, the processor is in communication with appropriate control elements of the devices and is configured to control such elements in a manner such that the programmed instructions are carried out by the appropriate device. It will be understood that a computer readable medium programmed with instructions that cause a sensor device, blood fluid removal device, or other suitable device to carry out a use, or a portion thereof, as described herein are contemplated.
  • the computer readable medium may be non-transitory, i.e. lasting for more than a fleeting instant or seconds.
  • the medium may be memory, such as RAM or ROM, a cd or dvd, flash memory, or the like.
  • a system comprises: (a) a blood fluid removal device comprising (i) an inlet for receiving blood from a patient, (ii) an outlet for returning blood from the patient, (iii) a medium for removing fluid and contaminants from the blood, the medium being positioned between the inlet and the first outlet, and (iv) a fluid source for carrying a fluid, the fluid selected from dialysate and replacement fluid, wherein if the fluid is dialysate the fluid source carries the fluid to the medium, and wherein if the fluid is replacement fluid the fluid source carries the fluid to the blood after the blood exits the medium; (b) a concentrate source for housing a concentrate solution comprising concentrated electrolyte or pH buffer; (c) a concentrate flow control element for controlling the rate that the concentrate solution enters the fluid source; (d) a first sensor configured to monitor an indicator of blood electrolyte concentration or blood pH; and (e) control electronics in operable communication with the sensor and the concentrate flow control element, wherein the
  • a second aspect is a system of the first aspect, wherein the first sensor is configured to monitor blood before the blood enters the medium.
  • a third aspect is a system of the second aspect, further comprising a second sensor
  • the second sensor being configured to monitor blood after the blood exits the medium.
  • a fourth aspect is a system of the third aspect, wherein the control electronics are in
  • control electronics are configured to adjust the rate at which the concentrate solution enters the fluid source based on the comparison of the data acquired from the first sensor and the second sensor.
  • a fifth aspect is a system of aspect 1, wherein the first sensor is configured to monitor the indicator in fluid removed from the blood after the fluid removed from the blood exits the medium
  • a sixth aspect is a system of aspect 5, wherein the control electronics are configured to derive the blood pH or blood electrolyte concentration based on data acquired from the first sensor.
  • a seventh aspect is a system of aspect 5, further comprising a second sensor configured to monitor the indicator in dialysate in the fluid source before the dialysate enters the medium, wherein the control electronics are control electronics are in operable communication with the second sensor and are configured to compare data acquired from the first sensor to data acquired from the second sensor, and wherein the control electronics are configured to adjust the rate at which the concentrate solution enters the fluid source based on the comparison of the data acquired from the first sensor and the second sensor.
  • An eighth aspect is a system of the first aspect, wherein the first sensor is configured to monitor the indicator in the blood after the blood exits the medium and before
  • a ninth aspect is a system of aspect 8, further comprising a second sensor configured to monitor the indicator in the blood after the replacement fluid has been added to the blood.
  • a tenth aspect is a system of any of aspects 1-9, wherein the control electronics, or
  • An eleventh aspect is a system of any of aspects 1-10, further comprising a computer readable medium, wherein the computer readable medium comprises instructions that cause the control electronics to control the concentrate flow control element to adjust the rate at which the concentrate solution enters the fluid source based on data obtained from the sensor.
  • a twelfth aspect is a use carried out by a blood fluid removal device or system
  • a thirteenth aspect is use of aspect 12, wherein monitoring the indicator comprises
  • a fourteenth aspect is a use of aspect 13, further comprising comparing a value of the indicator monitored before the blood is passed through the medium to a value of the indicator monitored after passing the blood through the medium, wherein adjusting the pH buffer composition or the electrolyte composition comprises adjusting the
  • composition based on the comparison.
  • a fifteenth aspect is a use of any of aspects 12-14, wherein adjusting the composition comprises adding a concentrated electrolyte solution or buffer solution to the fluid.
  • a sixteenth aspect is a use of any of aspects 12-15, further comprising (i) determining whether a value of the monitored indicator crosses a threshold; and (ii) providing an alert if the value of the monitored indicator is determined to cross the threshold.
  • a seventeenth aspect is a use of aspect 12, wherein monitoring the indicator comprises monitoring the indicator in fluid removed from the blood.
  • An eighteenth aspect is a use of aspect 17, further comprising determining a blood
  • electrolyte concentration or pH from a value of the monitored indicator of the fluid removed from the blood.
  • a nineteenth aspect is a use of aspect 17 or aspect 18, wherein the fluid for use in the blood fluid removal procedure is dialysate, and wherein monitoring the indicator further comprises monitoring the indicator in the dialysate prior to the dialysate entering a blood fluid removal medium, and wherein the use further comprises comparing a value of the monitored indicator in fluid removed from the blood to a value of the monitored indicator in the dialysate prior to entering the blood fluid removal medium.
  • a twentieth aspect is a use of aspect 12, wherein the fluid for use in the blood fluid
  • monitoring the indicator comprises monitoring the indicator in blood downstream of a blood fluid removal medium and upstream of addition of the replacement fluid to the blood.
  • a twenty-first aspect is a use of aspect 20, wherein monitoring the indicator further
  • the use further comprises comparing a value of the monitored indicator obtained upstream of the addition of replacement fluid to a value of the monitored indicator obtained downstream of the addition of replacement fluid.
  • a twenty-second aspect is a system comprising: (i) a medium housing defining a major chamber; (ii) a blood flow removal membrane disposed in the housing and sealingly dividing the major chamber into first and second minor chambers; (iii) a first inlet and a first outlet in fluid communication with the first minor chamber, wherein the system is configured such that blood enters the first minor chamber through the first inlet and exits the first minor chamber through the first outlet; (iv) a second inlet and a second outlet in fluid communication with the second minor chamber, wherein the system is configured such that dialysate enters the second minor chamber through the second inlet and exits the second minor chamber through the second outlet; (v) a dialysate regeneration medium in fluid communication with and disposed in a dialysate flow path between the second inlet and the second outlet; (vi) a concentrate source for housing a concentrate solution comprising concentrated electrolyte or pH buffer; (vii) a concentrate flow control element for controlling the rate that the concentrate solution enters
  • a twenty-third aspect is a use carried out by a blood fluid removal device or system, comprising: (i) initiating blood fluid removal procedure for a patient in need thereof, wherein the procedure comprises use of a dialysate fluid and a dialysate membrane, as at least a part of a blood fluid removal medium, across which electrolytes may be exchanged between blood and the dialysate fluid; (ii) monitoring an indicator of blood electrolyte concentration or blood pH during the blood fluid removal session; and (iii) adjusting the flow rate of the dialysate fluid or blood based on a value of the monitored indicator.
  • a twenty-fourth aspect is a use of aspect 23, wherein monitoring the indicator comprises monitoring the indicator in blood before passing the blood through the blood fluid removal medium and after passing the blood through the blood fluid removal medium.
  • a twenty-fifth aspect is a use of aspect 23, further comprising comparing a value of the indicator monitored before the blood is passed through the medium to a value of the indicator monitored after passing the blood through the medium, wherein adjusting the flow rate of the dialysate fluid or the blood comprises adjusting the composition based on the comparison.
  • a twenty-sixth aspect is a use of any of aspects 23-25, wherein monitoring the indicator comprises monitoring the indicator in fluid removed from the blood.
  • a twenty- seventh aspect is a use of aspect 23, further comprising determining a blood electrolyte concentration or pH from a value of the monitored indicator of the fluid removed from the blood.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physiology (AREA)
  • Water Supply & Treatment (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • General Business, Economics & Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Business, Economics & Management (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • External Artificial Organs (AREA)
  • Artificial Intelligence (AREA)
  • Signal Processing (AREA)
PCT/US2012/034330 2011-04-29 2012-04-19 ELECTROLYTE AND pH MONITORING FOR FLUID REMOVAL PROCESSES Ceased WO2012148786A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201280020932.1A CN103717132B (zh) 2011-04-29 2012-04-19 液体清除治疗的电解质和pH值的监测
EP12722951.6A EP2701596B1 (en) 2011-04-29 2012-04-19 Electrolyte and ph monitoring for fluid removal processes
EP19167435.7A EP3527134A1 (en) 2011-04-29 2012-04-19 Electrolyte and ph monitoring for fluid removal processes
JP2014508435A JP6153923B2 (ja) 2011-04-29 2012-04-19 流体除去プロセスのための電解質およびｐＨの監視

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US201161480541P 2011-04-29 2011-04-29
US201161480530P 2011-04-29 2011-04-29
US201161480539P 2011-04-29 2011-04-29
US201161480532P 2011-04-29 2011-04-29
US201161480528P 2011-04-29 2011-04-29
US201161480535P 2011-04-29 2011-04-29
US201161480544P 2011-04-29 2011-04-29
US61/480,544 2011-04-29
US61/480,541 2011-04-29
US61/480,528 2011-04-29
US61/480,530 2011-04-29
US61/480,532 2011-04-29
US61/480,539 2011-04-29
US61/480,535 2011-04-29
US13/424,479 US9192707B2 (en) 2011-04-29 2012-03-20 Electrolyte and pH monitoring for fluid removal processes
US13/424,479 2012-03-20

Publications (1)

Publication Number Publication Date
WO2012148786A1 true WO2012148786A1 (en) 2012-11-01

Family

ID=47067087

Family Applications (8)

Application Number Title Priority Date Filing Date
PCT/US2012/034332 Ceased WO2012148788A1 (en) 2011-04-29 2012-04-19 Cardiovascular monitoring for fluid removal processes
PCT/US2012/034327 Ceased WO2013101292A2 (en) 2011-04-29 2012-04-19 Fluid volume monitoring for patients with renal disease
PCT/US2012/034334 Ceased WO2012148790A1 (en) 2011-04-29 2012-04-19 Adaptive system for blood fluid removal
PCT/US2012/034335 Ceased WO2012148791A1 (en) 2011-04-29 2012-04-19 Intersession monitoring for blood fluid removal therapy
PCT/US2012/034333 Ceased WO2012148789A1 (en) 2011-04-29 2012-04-19 Chronic ph or electrolyte monitoring
PCT/US2012/034329 Ceased WO2012148785A2 (en) 2011-04-29 2012-04-19 Monitoring fluid volume for patients with renal disease
PCT/US2012/034330 Ceased WO2012148786A1 (en) 2011-04-29 2012-04-19 ELECTROLYTE AND pH MONITORING FOR FLUID REMOVAL PROCESSES
PCT/US2012/034331 Ceased WO2012148787A1 (en) 2011-04-29 2012-04-19 Blood fluid removal system performance monitoring

Family Applications Before (6)

Application Number Title Priority Date Filing Date
PCT/US2012/034332 Ceased WO2012148788A1 (en) 2011-04-29 2012-04-19 Cardiovascular monitoring for fluid removal processes
PCT/US2012/034327 Ceased WO2013101292A2 (en) 2011-04-29 2012-04-19 Fluid volume monitoring for patients with renal disease
PCT/US2012/034334 Ceased WO2012148790A1 (en) 2011-04-29 2012-04-19 Adaptive system for blood fluid removal
PCT/US2012/034335 Ceased WO2012148791A1 (en) 2011-04-29 2012-04-19 Intersession monitoring for blood fluid removal therapy
PCT/US2012/034333 Ceased WO2012148789A1 (en) 2011-04-29 2012-04-19 Chronic ph or electrolyte monitoring
PCT/US2012/034329 Ceased WO2012148785A2 (en) 2011-04-29 2012-04-19 Monitoring fluid volume for patients with renal disease

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2012/034331 Ceased WO2012148787A1 (en) 2011-04-29 2012-04-19 Blood fluid removal system performance monitoring

Country Status (6)

Country Link
US (17) US9561316B2 (enExample)
EP (10) EP3527134A1 (enExample)
JP (11) JP5705373B2 (enExample)
CN (10) CN103747817B (enExample)
ES (1) ES2785107T3 (enExample)
WO (8) WO2012148788A1 (enExample)

Cited By (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8951219B2 (en) 2011-04-29 2015-02-10 Medtronic, Inc. Fluid volume monitoring for patients with renal disease
US9289165B2 (en) 2005-02-07 2016-03-22 Medtronic, Inc. Ion imbalance detector
US9456755B2 (en) 2011-04-29 2016-10-04 Medtronic, Inc. Method and device to monitor patients with kidney disease
US9526822B2 (en) 2013-02-01 2016-12-27 Medtronic, Inc. Sodium and buffer source cartridges for use in a modular controlled compliant flow path
JP2017516572A (ja) * 2014-05-29 2017-06-22 フレセニウス メディカル ケア ホールディングス インコーポレーテッド 透析液を処理する方法、透析システム及び透析システムを用いて治療するための透析患者を事前評価する方法
US9707328B2 (en) 2013-01-09 2017-07-18 Medtronic, Inc. Sorbent cartridge to measure solute concentrations
US9713665B2 (en) 2014-12-10 2017-07-25 Medtronic, Inc. Degassing system for dialysis
US9713668B2 (en) 2012-01-04 2017-07-25 Medtronic, Inc. Multi-staged filtration system for blood fluid removal
US9827361B2 (en) 2013-02-02 2017-11-28 Medtronic, Inc. pH buffer measurement system for hemodialysis systems
US9848778B2 (en) 2011-04-29 2017-12-26 Medtronic, Inc. Method and device to monitor patients with kidney disease
US9855379B2 (en) 2013-02-02 2018-01-02 Medtronic, Inc. Sorbent cartridge configurations for improved dialysate regeneration
US9872949B2 (en) 2013-02-01 2018-01-23 Medtronic, Inc. Systems and methods for multifunctional volumetric fluid control
US9895479B2 (en) 2014-12-10 2018-02-20 Medtronic, Inc. Water management system for use in dialysis
US9943633B2 (en) 2009-09-30 2018-04-17 Medtronic Inc. System and method to regulate ultrafiltration
US10010663B2 (en) 2013-02-01 2018-07-03 Medtronic, Inc. Fluid circuit for delivery of renal replacement therapies
US10076283B2 (en) 2013-11-04 2018-09-18 Medtronic, Inc. Method and device to manage fluid volumes in the body
US10098993B2 (en) 2014-12-10 2018-10-16 Medtronic, Inc. Sensing and storage system for fluid balance
US10478545B2 (en) 2013-11-26 2019-11-19 Medtronic, Inc. Parallel modules for in-line recharging of sorbents using alternate duty cycles
US10543052B2 (en) 2013-02-01 2020-01-28 Medtronic, Inc. Portable dialysis cabinet
US10595775B2 (en) 2013-11-27 2020-03-24 Medtronic, Inc. Precision dialysis monitoring and synchronization system
US10695481B2 (en) 2011-08-02 2020-06-30 Medtronic, Inc. Hemodialysis system having a flow path with a controlled compliant volume
US10850016B2 (en) 2013-02-01 2020-12-01 Medtronic, Inc. Modular fluid therapy system having jumpered flow paths and systems and methods for cleaning and disinfection
US10857277B2 (en) 2011-08-16 2020-12-08 Medtronic, Inc. Modular hemodialysis system
US10874787B2 (en) 2014-12-10 2020-12-29 Medtronic, Inc. Degassing system for dialysis
US10881777B2 (en) 2013-01-09 2021-01-05 Medtronic, Inc. Recirculating dialysate fluid circuit for blood measurement
US10905816B2 (en) 2012-12-10 2021-02-02 Medtronic, Inc. Sodium management system for hemodialysis
US10926017B2 (en) 2014-06-24 2021-02-23 Medtronic, Inc. Modular dialysate regeneration assembly
US10981148B2 (en) 2016-11-29 2021-04-20 Medtronic, Inc. Zirconium oxide module conditioning
US10994064B2 (en) 2016-08-10 2021-05-04 Medtronic, Inc. Peritoneal dialysate flow path sensing
US11013843B2 (en) 2016-09-09 2021-05-25 Medtronic, Inc. Peritoneal dialysis fluid testing system
US11033667B2 (en) 2018-02-02 2021-06-15 Medtronic, Inc. Sorbent manifold for a dialysis system
US11045790B2 (en) 2014-06-24 2021-06-29 Medtronic, Inc. Stacked sorbent assembly
US11110215B2 (en) 2018-02-23 2021-09-07 Medtronic, Inc. Degasser and vent manifolds for dialysis
US11154648B2 (en) 2013-01-09 2021-10-26 Medtronic, Inc. Fluid circuits for sorbent cartridge with sensors
US11213616B2 (en) 2018-08-24 2022-01-04 Medtronic, Inc. Recharge solution for zirconium phosphate
US11219880B2 (en) 2013-11-26 2022-01-11 Medtronic, Inc System for precision recharging of sorbent materials using patient and session data
US11278654B2 (en) 2017-12-07 2022-03-22 Medtronic, Inc. Pneumatic manifold for a dialysis system
US11395868B2 (en) 2015-11-06 2022-07-26 Medtronic, Inc. Dialysis prescription optimization for decreased arrhythmias
US11565029B2 (en) 2013-01-09 2023-01-31 Medtronic, Inc. Sorbent cartridge with electrodes
US11806457B2 (en) 2018-11-16 2023-11-07 Mozarc Medical Us Llc Peritoneal dialysis adequacy meaurements
US11806456B2 (en) 2018-12-10 2023-11-07 Mozarc Medical Us Llc Precision peritoneal dialysis therapy based on dialysis adequacy measurements
US11850344B2 (en) 2021-08-11 2023-12-26 Mozarc Medical Us Llc Gas bubble sensor
US11883576B2 (en) 2016-08-10 2024-01-30 Mozarc Medical Us Llc Peritoneal dialysis intracycle osmotic agent adjustment
US11883794B2 (en) 2017-06-15 2024-01-30 Mozarc Medical Us Llc Zirconium phosphate disinfection recharging and conditioning
US11944733B2 (en) 2021-11-18 2024-04-02 Mozarc Medical Us Llc Sodium and bicarbonate control
US11965763B2 (en) 2021-11-12 2024-04-23 Mozarc Medical Us Llc Determining fluid flow across rotary pump
US12128165B2 (en) 2020-04-27 2024-10-29 Mozarc Medical Us Llc Dual stage degasser
US12154673B2 (en) 2021-08-02 2024-11-26 Mozarc Medical Us Llc Artificial intelligence assisted home therapy settings for dialysis
US12285552B2 (en) 2018-08-14 2025-04-29 Mozarc Medical Us Llc Precision dialysis therapy based on sorbent effluent analysis
US12329892B2 (en) 2016-04-04 2025-06-17 Mozarc Medical Us Llc Dextrose concentration sensor for a peritoneal dialysis system
US12397093B2 (en) 2021-05-18 2025-08-26 Mozarc Medical Us Llc Sorbent cartridge designs
US12433976B2 (en) 2019-01-08 2025-10-07 Mozarc Medical Us Llc Bicarbonate sensor for dialysis

Families Citing this family (280)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9867530B2 (en) 2006-08-14 2018-01-16 Volcano Corporation Telescopic side port catheter device with imaging system and method for accessing side branch occlusions
US10219780B2 (en) 2007-07-12 2019-03-05 Volcano Corporation OCT-IVUS catheter for concurrent luminal imaging
EP2178442B1 (en) 2007-07-12 2017-09-06 Volcano Corporation Catheter for in vivo imaging
US9596993B2 (en) 2007-07-12 2017-03-21 Volcano Corporation Automatic calibration systems and methods of use
US8514491B2 (en) 2009-11-20 2013-08-20 Pelican Imaging Corporation Capturing and processing of images using monolithic camera array with heterogeneous imagers
US11141063B2 (en) 2010-12-23 2021-10-12 Philips Image Guided Therapy Corporation Integrated system architectures and methods of use
US11040140B2 (en) 2010-12-31 2021-06-22 Philips Image Guided Therapy Corporation Deep vein thrombosis therapeutic methods
US9132217B2 (en) 2011-04-29 2015-09-15 Medtronic, Inc. Multimodal dialysis system
WO2013033592A1 (en) 2011-08-31 2013-03-07 Volcano Corporation Optical-electrical rotary joint and methods of use
WO2013043751A1 (en) 2011-09-19 2013-03-28 Pelican Imaging Corporation Systems and methods for controlling aliasing in images captured by an array camera for use in super resolution processing using pixel apertures
CN104081414B (zh) 2011-09-28 2017-08-01 Fotonation开曼有限公司 用于编码和解码光场图像文件的系统及方法
WO2013126578A1 (en) 2012-02-21 2013-08-29 Pelican Imaging Corporation Systems and methods for the manipulation of captured light field image data
EP2653178A1 (de) * 2012-04-16 2013-10-23 Zentrum für biomedizinische Technologie der Donau- Universität Krems Sicherheitseinrichtung für eine extrakorporale Blutbehandlung
US11871901B2 (en) 2012-05-20 2024-01-16 Cilag Gmbh International Method for situational awareness for surgical network or surgical network connected device capable of adjusting function based on a sensed situation or usage
US9100635B2 (en) 2012-06-28 2015-08-04 Pelican Imaging Corporation Systems and methods for detecting defective camera arrays and optic arrays
EP2888698A4 (en) 2012-08-23 2016-06-29 Pelican Imaging Corp PROPERTY-BASED HIGH-RESOLUTION MOTION ESTIMATION FROM LOW-RESOLUTION IMAGES RECORDED WITH AN ARRAY SOURCE
US9968306B2 (en) * 2012-09-17 2018-05-15 Abbott Diabetes Care Inc. Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems
US9478940B2 (en) 2012-10-05 2016-10-25 Volcano Corporation Systems and methods for amplifying light
US20140100454A1 (en) 2012-10-05 2014-04-10 Volcano Corporation Methods and systems for establishing parameters for three-dimensional imaging
US10568586B2 (en) 2012-10-05 2020-02-25 Volcano Corporation Systems for indicating parameters in an imaging data set and methods of use
US9286673B2 (en) 2012-10-05 2016-03-15 Volcano Corporation Systems for correcting distortions in a medical image and methods of use thereof
US9324141B2 (en) 2012-10-05 2016-04-26 Volcano Corporation Removal of A-scan streaking artifact
US9367965B2 (en) 2012-10-05 2016-06-14 Volcano Corporation Systems and methods for generating images of tissue
US9292918B2 (en) 2012-10-05 2016-03-22 Volcano Corporation Methods and systems for transforming luminal images
US10070827B2 (en) 2012-10-05 2018-09-11 Volcano Corporation Automatic image playback
US11272845B2 (en) 2012-10-05 2022-03-15 Philips Image Guided Therapy Corporation System and method for instant and automatic border detection
US9858668B2 (en) 2012-10-05 2018-01-02 Volcano Corporation Guidewire artifact removal in images
US9307926B2 (en) 2012-10-05 2016-04-12 Volcano Corporation Automatic stent detection
US9840734B2 (en) 2012-10-22 2017-12-12 Raindance Technologies, Inc. Methods for analyzing DNA
US9143711B2 (en) 2012-11-13 2015-09-22 Pelican Imaging Corporation Systems and methods for array camera focal plane control
EP2931132B1 (en) 2012-12-13 2023-07-05 Philips Image Guided Therapy Corporation System for targeted cannulation
DE102012025052A1 (de) * 2012-12-20 2014-06-26 Fresenius Medical Care Deutschland Gmbh Hämodiafiltrationsverfahren
US10942022B2 (en) 2012-12-20 2021-03-09 Philips Image Guided Therapy Corporation Manual calibration of imaging system
US10939826B2 (en) 2012-12-20 2021-03-09 Philips Image Guided Therapy Corporation Aspirating and removing biological material
CA2895502A1 (en) 2012-12-20 2014-06-26 Jeremy Stigall Smooth transition catheters
US11406498B2 (en) 2012-12-20 2022-08-09 Philips Image Guided Therapy Corporation Implant delivery system and implants
WO2014113188A2 (en) 2012-12-20 2014-07-24 Jeremy Stigall Locating intravascular images
CA2895989A1 (en) 2012-12-20 2014-07-10 Nathaniel J. Kemp Optical coherence tomography system that is reconfigurable between different imaging modes
CA2895993A1 (en) 2012-12-21 2014-06-26 Jason Spencer System and method for graphical processing of medical data
CA2896004A1 (en) 2012-12-21 2014-06-26 Nathaniel J. Kemp Power-efficient optical buffering using optical switch
US10058284B2 (en) 2012-12-21 2018-08-28 Volcano Corporation Simultaneous imaging, monitoring, and therapy
JP2016507272A (ja) * 2012-12-21 2016-03-10 ヴォルカノ コーポレイションＶｏｌｃａｎｏ Ｃｏｒｐｏｒａｔｉｏｎ 機能的利得の測定技術及び表示
WO2014100606A1 (en) 2012-12-21 2014-06-26 Meyer, Douglas Rotational ultrasound imaging catheter with extended catheter body telescope
JP2016501625A (ja) 2012-12-21 2016-01-21 ジェローム マイ， 可変線密度での超音波撮像
CA2896006A1 (en) 2012-12-21 2014-06-26 David Welford Systems and methods for narrowing a wavelength emission of light
US9612105B2 (en) 2012-12-21 2017-04-04 Volcano Corporation Polarization sensitive optical coherence tomography system
US10413317B2 (en) 2012-12-21 2019-09-17 Volcano Corporation System and method for catheter steering and operation
US9486143B2 (en) 2012-12-21 2016-11-08 Volcano Corporation Intravascular forward imaging device
JP2016501623A (ja) 2012-12-21 2016-01-21 アンドリュー ハンコック， 画像信号のマルチ経路処理のためのシステムおよび方法
WO2014121162A1 (en) * 2013-02-01 2014-08-07 Medtronic, Inc. Sorbent cartridge to measure solute concentrations
WO2014133974A1 (en) 2013-02-24 2014-09-04 Pelican Imaging Corporation Thin form computational and modular array cameras
US10226597B2 (en) 2013-03-07 2019-03-12 Volcano Corporation Guidewire with centering mechanism
WO2014138555A1 (en) 2013-03-07 2014-09-12 Bernhard Sturm Multimodal segmentation in intravascular images
US20140276923A1 (en) 2013-03-12 2014-09-18 Volcano Corporation Vibrating catheter and methods of use
US10638939B2 (en) 2013-03-12 2020-05-05 Philips Image Guided Therapy Corporation Systems and methods for diagnosing coronary microvascular disease
US9301687B2 (en) 2013-03-13 2016-04-05 Volcano Corporation System and method for OCT depth calibration
US11026591B2 (en) 2013-03-13 2021-06-08 Philips Image Guided Therapy Corporation Intravascular pressure sensor calibration
EP2967488B1 (en) 2013-03-13 2021-06-16 Jinhyoung Park System for producing an image from a rotational intravascular ultrasound device
US12343198B2 (en) 2013-03-14 2025-07-01 Philips Image Guided Therapy Corporation Delivery catheter having imaging capabilities
US10426590B2 (en) 2013-03-14 2019-10-01 Volcano Corporation Filters with echogenic characteristics
US10292677B2 (en) 2013-03-14 2019-05-21 Volcano Corporation Endoluminal filter having enhanced echogenic properties
US10219887B2 (en) 2013-03-14 2019-03-05 Volcano Corporation Filters with echogenic characteristics
GB201305755D0 (en) 2013-03-28 2013-05-15 Quanta Fluid Solutions Ltd Re-Use of a Hemodialysis Cartridge
WO2014162330A1 (ja) 2013-04-01 2014-10-09 テルモ株式会社 循環装置及びその制御方法
EP2799009A1 (en) * 2013-04-29 2014-11-05 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Non-invasive method for prediction of opioid-analgesia and opioid-blood-concentrations
US20150025449A1 (en) * 2013-07-22 2015-01-22 Fresenius Medical Care Holdings, Inc. Activating Peripheral Devices in a Dialysis System
DE102013108543A1 (de) * 2013-08-07 2015-02-26 B. Braun Avitum Ag Vorrichtung und ein Verfahren zur Vorhersage intradialytischer Parameter
GB201314512D0 (en) 2013-08-14 2013-09-25 Quanta Fluid Solutions Ltd Dual Haemodialysis and Haemodiafiltration blood treatment device
WO2015048694A2 (en) 2013-09-27 2015-04-02 Pelican Imaging Corporation Systems and methods for depth-assisted perspective distortion correction
EP2856941B1 (en) * 2013-10-01 2020-11-25 Fresenius Medical Care Deutschland GmbH Method and apparatuses for determining a patient's daily loss of iron
DE102013018284B4 (de) * 2013-10-31 2015-08-27 Fresenius Medical Care Deutschland Gmbh Verfahren und Vorrichtung zur Erfassung der Hämolyse oder zur Bestimmung eines den Einfluss der Hämolyse auf eine Messung des Hämatokrits korrigierenden Korrekturfaktors
US10119808B2 (en) 2013-11-18 2018-11-06 Fotonation Limited Systems and methods for estimating depth from projected texture using camera arrays
EP2918297B1 (de) * 2014-03-13 2016-11-16 Oertli-Instrumente AG Kassettenmodul
GB201409796D0 (en) 2014-06-02 2014-07-16 Quanta Fluid Solutions Ltd Method of heat sanitization of a haemodialysis water circuit using a calculated dose
DE102014012024B3 (de) * 2014-08-13 2016-02-04 Fresenius Medical Care Deutschland Gmbh Vorrichtung zur Bestimmung des peritonealen Druckes
JP5839212B1 (ja) 2014-08-20 2016-01-06 泉工医科工業株式会社 血液循環システム
US11992594B2 (en) 2014-08-20 2024-05-28 Senko Medical Instrument Mfg. Co., Ltd. Blood circulation system
CN104174080B (zh) * 2014-09-16 2016-02-03 王卫国 一种可独立调整透析液浓度的血液透析机
KR101517072B1 (ko) * 2014-10-08 2015-05-04 이의호 신장의 사구체 여과율 측정 방법 및 장치
US11504192B2 (en) 2014-10-30 2022-11-22 Cilag Gmbh International Method of hub communication with surgical instrument systems
CN104437099B (zh) * 2014-12-19 2016-09-07 山东中保康医疗器具有限公司 一次性使用去白细胞滤器膜材清洗用水的检测方法
US10842926B2 (en) * 2015-01-14 2020-11-24 Fresenius Medical Care Deutschland Gmbh Medical fluid treatment machines and related systems and methods
US12465324B2 (en) 2015-02-12 2025-11-11 Foundry Innovation & Research 1, Ltd. Patient fluid management systems and methods employing integrated fluid status sensing
KR102358589B1 (ko) 2015-02-12 2022-02-03 파운드리 이노베이션 앤드 리서치 1 리미티드 심부전 모니터링을 위한 이식가능 장치 및 관련 방법
CN112370593B (zh) * 2015-02-27 2024-07-30 迈奎特心肺有限公司 流体流量测量和气泡检测装置
WO2017024051A1 (en) 2015-08-03 2017-02-09 Foundry Innovation & Research 1, Ltd. Devices and methods for measurement of vena cava dimensions, pressure, and oxygen saturation
GB2544509B (en) 2015-11-19 2020-12-09 Spectrum Medical Ltd Blood flow rate control apparatus for an extracorporeal perfusion system
US10617809B2 (en) 2015-12-29 2020-04-14 Fresenius Medical Care Holdings, Inc. Electrical sensor for fluids
US10406269B2 (en) 2015-12-29 2019-09-10 Fresenius Medical Care Holdings, Inc. Electrical sensor for fluids
GB201523104D0 (en) * 2015-12-30 2016-02-10 Quanta Fluid Solutions Ltd Dialysis machine
GB2547214A (en) 2016-02-10 2017-08-16 Quanta Fluid Solutions Ltd Membrane pump usage condition detection
US12491301B2 (en) 2016-04-04 2025-12-09 Mozarc Medical Us Llc Peritoneal dialysate preparation and sensor system
CN105999451A (zh) * 2016-06-17 2016-10-12 中国人民武装警察部队后勤学院附属医院 野战便携式血液净化机
US10537673B2 (en) 2016-08-10 2020-01-21 Medtronic, Inc. Intersession adaptive peritoneal dialysis fluid removal for multiple session optimization
US10744253B2 (en) 2016-08-10 2020-08-18 Medtronic, Inc. Adaptive peritoneal dialysis intra-session adjustments for overall session optimization
US10758659B2 (en) 2016-08-10 2020-09-01 Medtronic, Inc. Peritoneal dialysis filtrate sampling and adaptive prescription
US11206992B2 (en) 2016-08-11 2021-12-28 Foundry Innovation & Research 1, Ltd. Wireless resonant circuit and variable inductance vascular monitoring implants and anchoring structures therefore
EP3496606A1 (en) 2016-08-11 2019-06-19 Foundry Innovation & Research 1, Ltd. Systems and methods for patient fluid management
US11701018B2 (en) 2016-08-11 2023-07-18 Foundry Innovation & Research 1, Ltd. Wireless resonant circuit and variable inductance vascular monitoring implants and anchoring structures therefore
EP3506962B1 (en) 2016-08-30 2023-11-22 NxStage Medical, Inc. Parameter monitoring in medical treatment systems
EP3511033A4 (en) * 2016-09-08 2020-04-22 Kabushiki Kaisya Advance System for managing information relating to differences between individuals in dialysis treatment
JP6716428B2 (ja) * 2016-11-11 2020-07-01 日機装株式会社 血液浄化治療支援システム
CN110300546B (zh) 2016-11-29 2023-03-31 铸造创新&研究第一有限责任公司 用于监测患者脉管系统和流体状态的系统和方法
GB201622119D0 (en) 2016-12-23 2017-02-08 Quanta Dialysis Tech Ltd Improved valve leak detection system
US11439310B2 (en) * 2017-01-11 2022-09-13 Cypher Medical, Llc Method of estimating blood volume
GB201701740D0 (en) 2017-02-02 2017-03-22 Quanta Dialysis Tech Ltd Phased convective operation
GB201705273D0 (en) 2017-03-31 2017-05-17 Quanta Dialysis Tech Ltd Data storage amd exchange by medical device components
US11779238B2 (en) 2017-05-31 2023-10-10 Foundry Innovation & Research 1, Ltd. Implantable sensors for vascular monitoring
US11944495B2 (en) 2017-05-31 2024-04-02 Foundry Innovation & Research 1, Ltd. Implantable ultrasonic vascular sensor
WO2019002065A1 (en) * 2017-06-28 2019-01-03 Gambro Lundia Ab SYSTEM AND METHOD FOR RENAL REPLACEMENT THERAPY
WO2019002067A1 (en) * 2017-06-28 2019-01-03 Gambro Lundia Ab SYSTEM AND METHOD FOR TREATMENT OF RENAL SUBSTITUTION
US10842924B2 (en) 2017-06-29 2020-11-24 Fresenius Medical Care Deutschland Gmbh Therapy control by comprehensive feedback
GB201710546D0 (en) 2017-06-30 2017-08-16 Quanta Dialysis Tech Ltd Dialysis systems, devices and methods
CN107273705A (zh) * 2017-07-25 2017-10-20 北京品驰医疗设备有限公司 人体植入式医疗装置参数确定、设置方法及设备
USD907211S1 (en) 2017-09-28 2021-01-05 Quanta Dialysis Technologies Ltd. Dialysis machine
US11911045B2 (en) 2017-10-30 2024-02-27 Cllag GmbH International Method for operating a powered articulating multi-clip applier
US11311342B2 (en) 2017-10-30 2022-04-26 Cilag Gmbh International Method for communicating with surgical instrument systems
US11291510B2 (en) 2017-10-30 2022-04-05 Cilag Gmbh International Method of hub communication with surgical instrument systems
US11759224B2 (en) 2017-10-30 2023-09-19 Cilag Gmbh International Surgical instrument systems comprising handle arrangements
US11317919B2 (en) 2017-10-30 2022-05-03 Cilag Gmbh International Clip applier comprising a clip crimping system
US11229436B2 (en) 2017-10-30 2022-01-25 Cilag Gmbh International Surgical system comprising a surgical tool and a surgical hub
US11801098B2 (en) 2017-10-30 2023-10-31 Cilag Gmbh International Method of hub communication with surgical instrument systems
US11564756B2 (en) 2017-10-30 2023-01-31 Cilag Gmbh International Method of hub communication with surgical instrument systems
US11510741B2 (en) 2017-10-30 2022-11-29 Cilag Gmbh International Method for producing a surgical instrument comprising a smart electrical system
US11413042B2 (en) 2017-10-30 2022-08-16 Cilag Gmbh International Clip applier comprising a reciprocating clip advancing member
CN107982621B (zh) * 2017-12-21 2023-04-18 中国人民解放军总医院 吸痰管
US11666331B2 (en) 2017-12-28 2023-06-06 Cilag Gmbh International Systems for detecting proximity of surgical end effector to cancerous tissue
US11304699B2 (en) 2017-12-28 2022-04-19 Cilag Gmbh International Method for adaptive control schemes for surgical network control and interaction
US12458351B2 (en) 2017-12-28 2025-11-04 Cilag Gmbh International Variable output cartridge sensor assembly
US11304745B2 (en) * 2017-12-28 2022-04-19 Cilag Gmbh International Surgical evacuation sensing and display
US11056244B2 (en) 2017-12-28 2021-07-06 Cilag Gmbh International Automated data scaling, alignment, and organizing based on predefined parameters within surgical networks
US11659023B2 (en) 2017-12-28 2023-05-23 Cilag Gmbh International Method of hub communication
US11571234B2 (en) 2017-12-28 2023-02-07 Cilag Gmbh International Temperature control of ultrasonic end effector and control system therefor
US12127729B2 (en) 2017-12-28 2024-10-29 Cilag Gmbh International Method for smoke evacuation for surgical hub
US11969216B2 (en) 2017-12-28 2024-04-30 Cilag Gmbh International Surgical network recommendations from real time analysis of procedure variables against a baseline highlighting differences from the optimal solution
US11253315B2 (en) 2017-12-28 2022-02-22 Cilag Gmbh International Increasing radio frequency to create pad-less monopolar loop
US11273001B2 (en) 2017-12-28 2022-03-15 Cilag Gmbh International Surgical hub and modular device response adjustment based on situational awareness
US11857152B2 (en) 2017-12-28 2024-01-02 Cilag Gmbh International Surgical hub spatial awareness to determine devices in operating theater
US10918310B2 (en) 2018-01-03 2021-02-16 Biosense Webster (Israel) Ltd. Fast anatomical mapping (FAM) using volume filling
US11304720B2 (en) 2017-12-28 2022-04-19 Cilag Gmbh International Activation of energy devices
US11257589B2 (en) 2017-12-28 2022-02-22 Cilag Gmbh International Real-time analysis of comprehensive cost of all instrumentation used in surgery utilizing data fluidity to track instruments through stocking and in-house processes
US11410259B2 (en) 2017-12-28 2022-08-09 Cilag Gmbh International Adaptive control program updates for surgical devices
US11234756B2 (en) 2017-12-28 2022-02-01 Cilag Gmbh International Powered surgical tool with predefined adjustable control algorithm for controlling end effector parameter
US11423007B2 (en) 2017-12-28 2022-08-23 Cilag Gmbh International Adjustment of device control programs based on stratified contextual data in addition to the data
US11166772B2 (en) 2017-12-28 2021-11-09 Cilag Gmbh International Surgical hub coordination of control and communication of operating room devices
US10966791B2 (en) 2017-12-28 2021-04-06 Ethicon Llc Cloud-based medical analytics for medical facility segmented individualization of instrument function
US10943454B2 (en) 2017-12-28 2021-03-09 Ethicon Llc Detection and escalation of security responses of surgical instruments to increasing severity threats
US11903601B2 (en) 2017-12-28 2024-02-20 Cilag Gmbh International Surgical instrument comprising a plurality of drive systems
US11100631B2 (en) 2017-12-28 2021-08-24 Cilag Gmbh International Use of laser light and red-green-blue coloration to determine properties of back scattered light
US11633237B2 (en) 2017-12-28 2023-04-25 Cilag Gmbh International Usage and technique analysis of surgeon / staff performance against a baseline to optimize device utilization and performance for both current and future procedures
US11678881B2 (en) 2017-12-28 2023-06-20 Cilag Gmbh International Spatial awareness of surgical hubs in operating rooms
US11179208B2 (en) 2017-12-28 2021-11-23 Cilag Gmbh International Cloud-based medical analytics for security and authentication trends and reactive measures
US11896443B2 (en) 2017-12-28 2024-02-13 Cilag Gmbh International Control of a surgical system through a surgical barrier
US10595887B2 (en) 2017-12-28 2020-03-24 Ethicon Llc Systems for adjusting end effector parameters based on perioperative information
US11559308B2 (en) 2017-12-28 2023-01-24 Cilag Gmbh International Method for smart energy device infrastructure
US10758310B2 (en) 2017-12-28 2020-09-01 Ethicon Llc Wireless pairing of a surgical device with another device within a sterile surgical field based on the usage and situational awareness of devices
US10944728B2 (en) 2017-12-28 2021-03-09 Ethicon Llc Interactive surgical systems with encrypted communication capabilities
US11998193B2 (en) 2017-12-28 2024-06-04 Cilag Gmbh International Method for usage of the shroud as an aspect of sensing or controlling a powered surgical device, and a control algorithm to adjust its default operation
US11213359B2 (en) 2017-12-28 2022-01-04 Cilag Gmbh International Controllers for robot-assisted surgical platforms
US11051876B2 (en) 2017-12-28 2021-07-06 Cilag Gmbh International Surgical evacuation flow paths
US11832840B2 (en) 2017-12-28 2023-12-05 Cilag Gmbh International Surgical instrument having a flexible circuit
US12096916B2 (en) 2017-12-28 2024-09-24 Cilag Gmbh International Method of sensing particulate from smoke evacuated from a patient, adjusting the pump speed based on the sensed information, and communicating the functional parameters of the system to the hub
US11529187B2 (en) 2017-12-28 2022-12-20 Cilag Gmbh International Surgical evacuation sensor arrangements
US10695081B2 (en) 2017-12-28 2020-06-30 Ethicon Llc Controlling a surgical instrument according to sensed closure parameters
US11832899B2 (en) 2017-12-28 2023-12-05 Cilag Gmbh International Surgical systems with autonomously adjustable control programs
US11602393B2 (en) 2017-12-28 2023-03-14 Cilag Gmbh International Surgical evacuation sensing and generator control
US11324557B2 (en) 2017-12-28 2022-05-10 Cilag Gmbh International Surgical instrument with a sensing array
US11419667B2 (en) 2017-12-28 2022-08-23 Cilag Gmbh International Ultrasonic energy device which varies pressure applied by clamp arm to provide threshold control pressure at a cut progression location
US11132462B2 (en) 2017-12-28 2021-09-28 Cilag Gmbh International Data stripping method to interrogate patient records and create anonymized record
US11045591B2 (en) 2017-12-28 2021-06-29 Cilag Gmbh International Dual in-series large and small droplet filters
US20190201113A1 (en) 2017-12-28 2019-07-04 Ethicon Llc Controls for robot-assisted surgical platforms
US11464535B2 (en) 2017-12-28 2022-10-11 Cilag Gmbh International Detection of end effector emersion in liquid
US11424027B2 (en) 2017-12-28 2022-08-23 Cilag Gmbh International Method for operating surgical instrument systems
US10849697B2 (en) 2017-12-28 2020-12-01 Ethicon Llc Cloud interface for coupled surgical devices
US10892899B2 (en) 2017-12-28 2021-01-12 Ethicon Llc Self describing data packets generated at an issuing instrument
US11969142B2 (en) 2017-12-28 2024-04-30 Cilag Gmbh International Method of compressing tissue within a stapling device and simultaneously displaying the location of the tissue within the jaws
US20190201112A1 (en) 2017-12-28 2019-07-04 Ethicon Llc Computer implemented interactive surgical systems
US11937769B2 (en) 2017-12-28 2024-03-26 Cilag Gmbh International Method of hub communication, processing, storage and display
US11160605B2 (en) 2017-12-28 2021-11-02 Cilag Gmbh International Surgical evacuation sensing and motor control
US10932872B2 (en) 2017-12-28 2021-03-02 Ethicon Llc Cloud-based medical analytics for linking of local usage trends with the resource acquisition behaviors of larger data set
US11864728B2 (en) 2017-12-28 2024-01-09 Cilag Gmbh International Characterization of tissue irregularities through the use of mono-chromatic light refractivity
US10892995B2 (en) 2017-12-28 2021-01-12 Ethicon Llc Surgical network determination of prioritization of communication, interaction, or processing based on system or device needs
US11076921B2 (en) 2017-12-28 2021-08-03 Cilag Gmbh International Adaptive control program updates for surgical hubs
US12376855B2 (en) 2017-12-28 2025-08-05 Cilag Gmbh International Safety systems for smart powered surgical stapling
US11464559B2 (en) 2017-12-28 2022-10-11 Cilag Gmbh International Estimating state of ultrasonic end effector and control system therefor
US20190201039A1 (en) 2017-12-28 2019-07-04 Ethicon Llc Situational awareness of electrosurgical systems
US11069012B2 (en) 2017-12-28 2021-07-20 Cilag Gmbh International Interactive surgical systems with condition handling of devices and data capabilities
US11266468B2 (en) 2017-12-28 2022-03-08 Cilag Gmbh International Cooperative utilization of data derived from secondary sources by intelligent surgical hubs
US11576677B2 (en) 2017-12-28 2023-02-14 Cilag Gmbh International Method of hub communication, processing, display, and cloud analytics
US11432885B2 (en) 2017-12-28 2022-09-06 Cilag Gmbh International Sensing arrangements for robot-assisted surgical platforms
US11291495B2 (en) 2017-12-28 2022-04-05 Cilag Gmbh International Interruption of energy due to inadvertent capacitive coupling
US12396806B2 (en) 2017-12-28 2025-08-26 Cilag Gmbh International Adjustment of a surgical device function based on situational awareness
US11278281B2 (en) 2017-12-28 2022-03-22 Cilag Gmbh International Interactive surgical system
US11672605B2 (en) 2017-12-28 2023-06-13 Cilag Gmbh International Sterile field interactive control displays
US11896322B2 (en) 2017-12-28 2024-02-13 Cilag Gmbh International Sensing the patient position and contact utilizing the mono-polar return pad electrode to provide situational awareness to the hub
US11364075B2 (en) 2017-12-28 2022-06-21 Cilag Gmbh International Radio frequency energy device for delivering combined electrical signals
US11540855B2 (en) 2017-12-28 2023-01-03 Cilag Gmbh International Controlling activation of an ultrasonic surgical instrument according to the presence of tissue
US20190201087A1 (en) 2017-12-28 2019-07-04 Ethicon Llc Smoke evacuation system including a segmented control circuit for interactive surgical platform
US11147607B2 (en) 2017-12-28 2021-10-19 Cilag Gmbh International Bipolar combination device that automatically adjusts pressure based on energy modality
US10987178B2 (en) 2017-12-28 2021-04-27 Ethicon Llc Surgical hub control arrangements
US20190206569A1 (en) 2017-12-28 2019-07-04 Ethicon Llc Method of cloud based data analytics for use with the hub
US11786251B2 (en) 2017-12-28 2023-10-17 Cilag Gmbh International Method for adaptive control schemes for surgical network control and interaction
US11304763B2 (en) 2017-12-28 2022-04-19 Cilag Gmbh International Image capturing of the areas outside the abdomen to improve placement and control of a surgical device in use
US11096693B2 (en) 2017-12-28 2021-08-24 Cilag Gmbh International Adjustment of staple height of at least one row of staples based on the sensed tissue thickness or force in closing
US11446052B2 (en) 2017-12-28 2022-09-20 Cilag Gmbh International Variation of radio frequency and ultrasonic power level in cooperation with varying clamp arm pressure to achieve predefined heat flux or power applied to tissue
US11818052B2 (en) 2017-12-28 2023-11-14 Cilag Gmbh International Surgical network determination of prioritization of communication, interaction, or processing based on system or device needs
US11308075B2 (en) 2017-12-28 2022-04-19 Cilag Gmbh International Surgical network, instrument, and cloud responses based on validation of received dataset and authentication of its source and integrity
US11589888B2 (en) 2017-12-28 2023-02-28 Cilag Gmbh International Method for controlling smart energy devices
US11311306B2 (en) 2017-12-28 2022-04-26 Cilag Gmbh International Surgical systems for detecting end effector tissue distribution irregularities
US11389164B2 (en) 2017-12-28 2022-07-19 Cilag Gmbh International Method of using reinforced flexible circuits with multiple sensors to optimize performance of radio frequency devices
US20190201090A1 (en) 2017-12-28 2019-07-04 Ethicon Llc Capacitive coupled return path pad with separable array elements
US11559307B2 (en) 2017-12-28 2023-01-24 Cilag Gmbh International Method of robotic hub communication, detection, and control
US11786245B2 (en) 2017-12-28 2023-10-17 Cilag Gmbh International Surgical systems with prioritized data transmission capabilities
US11317937B2 (en) 2018-03-08 2022-05-03 Cilag Gmbh International Determining the state of an ultrasonic end effector
US11612444B2 (en) 2017-12-28 2023-03-28 Cilag Gmbh International Adjustment of a surgical device function based on situational awareness
US11376002B2 (en) 2017-12-28 2022-07-05 Cilag Gmbh International Surgical instrument cartridge sensor assemblies
US11419630B2 (en) 2017-12-28 2022-08-23 Cilag Gmbh International Surgical system distributed processing
US12062442B2 (en) 2017-12-28 2024-08-13 Cilag Gmbh International Method for operating surgical instrument systems
US11202570B2 (en) 2017-12-28 2021-12-21 Cilag Gmbh International Communication hub and storage device for storing parameters and status of a surgical device to be shared with cloud based analytics systems
US11744604B2 (en) 2017-12-28 2023-09-05 Cilag Gmbh International Surgical instrument with a hardware-only control circuit
US11284936B2 (en) 2017-12-28 2022-03-29 Cilag Gmbh International Surgical instrument having a flexible electrode
US11109866B2 (en) 2017-12-28 2021-09-07 Cilag Gmbh International Method for circular stapler control algorithm adjustment based on situational awareness
US20190201042A1 (en) 2017-12-28 2019-07-04 Ethicon Llc Determining the state of an ultrasonic electromechanical system according to frequency shift
WO2019133143A1 (en) 2017-12-28 2019-07-04 Ethicon Llc Surgical hub and modular device response adjustment based on situational awareness
US10881347B2 (en) 2017-12-29 2021-01-05 Fresenius Medical Care Holdings, Inc. Closed loop dialysis treatment using adaptive ultrafiltration rates
JP7276155B2 (ja) * 2018-01-10 2023-05-18 ニプロ株式会社 細胞外液量算出装置及び細胞外液量算出方法
US11259830B2 (en) 2018-03-08 2022-03-01 Cilag Gmbh International Methods for controlling temperature in ultrasonic device
US12303159B2 (en) 2018-03-08 2025-05-20 Cilag Gmbh International Methods for estimating and controlling state of ultrasonic end effector
US11589915B2 (en) 2018-03-08 2023-02-28 Cilag Gmbh International In-the-jaw classifier based on a model
US11839396B2 (en) 2018-03-08 2023-12-12 Cilag Gmbh International Fine dissection mode for tissue classification
US11406382B2 (en) 2018-03-28 2022-08-09 Cilag Gmbh International Staple cartridge comprising a lockout key configured to lift a firing member
US11207067B2 (en) 2018-03-28 2021-12-28 Cilag Gmbh International Surgical stapling device with separate rotary driven closure and firing systems and firing member that engages both jaws while firing
US11219453B2 (en) 2018-03-28 2022-01-11 Cilag Gmbh International Surgical stapling devices with cartridge compatible closure and firing lockout arrangements
US11471156B2 (en) 2018-03-28 2022-10-18 Cilag Gmbh International Surgical stapling devices with improved rotary driven closure systems
US10973520B2 (en) 2018-03-28 2021-04-13 Ethicon Llc Surgical staple cartridge with firing member driven camming assembly that has an onboard tissue cutting feature
US11259806B2 (en) 2018-03-28 2022-03-01 Cilag Gmbh International Surgical stapling devices with features for blocking advancement of a camming assembly of an incompatible cartridge installed therein
US11096688B2 (en) 2018-03-28 2021-08-24 Cilag Gmbh International Rotary driven firing members with different anvil and channel engagement features
US11278280B2 (en) 2018-03-28 2022-03-22 Cilag Gmbh International Surgical instrument comprising a jaw closure lockout
US11090047B2 (en) 2018-03-28 2021-08-17 Cilag Gmbh International Surgical instrument comprising an adaptive control system
CN112638442B (zh) 2018-06-29 2024-10-29 爱德芳世株式会社 经皮端子
CA3107075A1 (en) 2018-07-26 2020-01-30 Baxter International Inc. Dialysis system and methods including sensor feedback to improve patient experience
US11491267B2 (en) 2018-07-27 2022-11-08 Fresenius Medical Care Holdings, Inc. Method for tailoring dialysis treatment based on sensed potassium concentration in blood serum or dialysate
CA3114930A1 (en) * 2018-10-05 2020-04-09 Pharmacophotonics, Inc., D/B/A Fast Biomedical Method and apparatus for determining interstitial volume
JP7183006B2 (ja) * 2018-11-22 2022-12-05 旭化成メディカル株式会社 体液分離システム及び体液分離システムの作動方法
CN109394200B (zh) * 2018-12-16 2021-10-19 冯兴怀 用于液体治疗、容量管理的微循环脉冲血流监测系统和方法
US11369377B2 (en) 2019-02-19 2022-06-28 Cilag Gmbh International Surgical stapling assembly with cartridge based retainer configured to unlock a firing lockout
US11317915B2 (en) 2019-02-19 2022-05-03 Cilag Gmbh International Universal cartridge based key feature that unlocks multiple lockout arrangements in different surgical staplers
US11517309B2 (en) 2019-02-19 2022-12-06 Cilag Gmbh International Staple cartridge retainer with retractable authentication key
US11464511B2 (en) 2019-02-19 2022-10-11 Cilag Gmbh International Surgical staple cartridges with movable authentication key arrangements
US11357503B2 (en) 2019-02-19 2022-06-14 Cilag Gmbh International Staple cartridge retainers with frangible retention features and methods of using same
CN110152087A (zh) * 2019-04-19 2019-08-23 暨南大学 一种血液透析过程的监测方法
CN110124138B (zh) * 2019-04-19 2022-05-10 暨南大学 一种血液透析过程中干体重控制系统
US11160503B2 (en) * 2019-04-23 2021-11-02 Fresenius Medical Care Holdings, Inc. Wearable continuous vascular access monitor
US11684503B2 (en) * 2019-05-15 2023-06-27 Syn LLC Gastric reduction apparatus and related methods
GB2584335A (en) 2019-05-31 2020-12-02 Quanta Dialysis Technologies Ltd Source container connector
US10926019B2 (en) 2019-06-05 2021-02-23 Choon Kee Lee Gradient dialysate hemodiafiltration
USD952144S1 (en) 2019-06-25 2022-05-17 Cilag Gmbh International Surgical staple cartridge retainer with firing system authentication key
USD950728S1 (en) 2019-06-25 2022-05-03 Cilag Gmbh International Surgical staple cartridge
USD964564S1 (en) 2019-06-25 2022-09-20 Cilag Gmbh International Surgical staple cartridge retainer with a closure system authentication key
CN114555142B (zh) * 2019-10-10 2025-09-26 弗雷塞尼斯医疗保健控股公司 用于在腹膜透析期间监视液体容量的系统和方法
US11510614B1 (en) 2019-12-02 2022-11-29 Express Scripts Strategic Development, Inc. Wearable devices and systems for prescription adherence
EP3834860B1 (fr) * 2019-12-11 2024-08-14 Infomed SA Dispositif de circulation extracorporelle du sang
EP4129356A4 (en) * 2020-03-31 2023-08-23 Asahi Kasei Medical Co., Ltd. BLOOD PURIFICATION SYSTEM, CONTROL METHOD, CONTROL PROGRAM, LEARNING DEVICE AND LEARNING METHOD
JP7679358B2 (ja) * 2020-03-31 2025-05-19 旭化成メディカル株式会社 血液浄化システム、制御方法、制御プログラム、学習装置及び学習方法
US20220047793A1 (en) * 2020-08-12 2022-02-17 Medtronic, Inc. Dialysis catheter including pressure and impedance sensors
DE102020122936A1 (de) 2020-09-02 2022-03-03 B.Braun Avitum Ag Automatische Reinfusion von Blut nach einer Blutbehandlungstherapie
DE102020128298A1 (de) 2020-10-28 2022-04-28 Fresenius Medical Care Deutschland Gmbh Patientenmonitorsystem zum Erfassen von Daten eines Patienten, Anzeigevorrichtung, medizinische Behandlungsvorrichtung und Verfahren
EP4085940A1 (en) * 2021-05-07 2022-11-09 Imec VZW A method and a maintenance device for automatic maintenance of an autonomous dialysis system
JP2024517095A (ja) * 2021-05-14 2024-04-19 フレセニウス メディカル ケア ホールディングス インコーポレーテッド 二次膜を除去するための体外デバイスおよび方法
US20220392621A1 (en) * 2021-06-08 2022-12-08 Medtronic, Inc. Artificially intelligent smart home assistant for home-based medical therapy
JP2023049991A (ja) * 2021-09-29 2023-04-10 旭化成メディカル株式会社 血液浄化システム、制御方法、制御プログラム、学習装置及び学習方法
JP2023049969A (ja) * 2021-09-29 2023-04-10 旭化成メディカル株式会社 血液浄化システム、制御方法、制御プログラム、学習装置及び学習方法
DE102021129072A1 (de) * 2021-11-09 2023-05-11 Fresenius Medical Care Deutschland Gmbh Steuervorrichtung für eine Blutbehandlungsvorrichtung, Blutbehandlungsvorrichtung, System und Verfahren
EP4444382A1 (en) * 2021-12-08 2024-10-16 Orrum Clinical Analytics, Inc. Blood volume sensor system
JP7775757B2 (ja) * 2022-03-22 2025-11-26 ニプロ株式会社 医療装置
EP4561673A1 (en) 2022-07-29 2025-06-04 Foundry Innovation & Research 1, Ltd. Multistranded conductors adapted to dynamic in vivo environments
US12004874B2 (en) 2022-10-24 2024-06-11 Applied Cognition, Inc. Wearable device and method for non-invasive assessment of glymphatic flow
CN115998253B (zh) * 2022-12-22 2023-08-04 北大荒集团总医院 一种腹腔积液变化情况监测方法及监测装置
US20250325734A1 (en) * 2024-04-12 2025-10-23 Unit Medical Devices LTD Medical fluid delivery devices and methods
TWI887078B (zh) * 2024-08-12 2025-06-11 臺北醫學大學 用於血液透析患者的生理監控系統與身體阻抗監測方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040019312A1 (en) * 2002-07-19 2004-01-29 Childers Robert W. Systems and methods for performing peritoneal dialysis
US20050236330A1 (en) * 2000-12-22 2005-10-27 Fresenius Medical Care Deutschland Gmbh. Method for determining concentration; a dialyser
US7077819B1 (en) * 1998-12-24 2006-07-18 Fresenius Medical Care Deutschland Gmbh Method for determining the distribution volume of a blood component during an extracorporeal blood treatment and device for carrying out the method
US20070066928A1 (en) * 2005-09-22 2007-03-22 Jean-Michel Lannoy Automation and optimization of CRRT treatment using regional citrate anticoagulation
WO2009026603A1 (de) * 2007-08-31 2009-03-05 Zentrum Für Biomedizinische Technologie Der Donau-Universität Krems Verfahren zum erfassen der ionenkonzentration bei citrat-antikoagulierter extrakorporaler blutreinigung

Family Cites Families (401)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2002A (en) 1841-03-12 Tor and planter for plowing
US1383728A (en) 1921-07-05 new yobk
GB1189458A (en) 1967-09-27 1970-04-29 Nat Res Dev Improvements in or relating to dialysers
US3602222A (en) 1968-09-16 1971-08-31 Honeywell Inc Rate meter, particularly a beat-by-beat cardiotachometer
US3669878A (en) 1968-12-02 1972-06-13 Health Education And Welfare U Treatment of dialysate solution for removal of urea
GB1280521A (en) 1969-06-28 1972-07-05 Whitely Lang And Neill Ltd Peritoneal dialysis apparatus
US3669880A (en) 1969-06-30 1972-06-13 Cci Aerospace Corp Recirculation dialysate system for use with an artificial kidney machine
US3754867A (en) 1970-12-11 1973-08-28 Bjorksten Res Lab Inc Carbon dioxide sensing system
DE2239254C2 (de) 1970-12-30 1983-08-04 Organon Teknika Corp., Oklahoma City, Okla. "Säule zur Regenerierung einer zirkulierenden Dialysatlösung und Verwendung dieser Säule".
US3850835A (en) 1971-11-08 1974-11-26 Cci Life Systems Inc Method of making granular zirconium hydrous oxide ion exchangers, such as zirconium phosphate and hydrous zirconium oxide, particularly for column use
US3884808A (en) 1973-06-20 1975-05-20 Res Dev Systems Inc Wearable, self-regenerating dialysis appliance
US3930181A (en) 1973-12-28 1975-12-30 Ibm Lens and deflection unit arrangement for electron beam columns
US3990973A (en) 1974-11-04 1976-11-09 Cobe Laboratories, Inc. Apparatus for measuring ultrafiltration rate
US3989625A (en) 1975-02-25 1976-11-02 Ma-De Inc. Detector for air in blood dialysis systems
US4060485A (en) 1975-06-09 1977-11-29 I T L Technology, Inc. Dialysis apparatus
US4581141A (en) 1978-02-27 1986-04-08 Purdue Research Foundation Dialysis material and method for removing uremic substances
JPS55138462A (en) * 1979-04-18 1980-10-29 Mediks Kk Living body installing type hydrogen ion concentration asjusting device
US4556063A (en) 1980-10-07 1985-12-03 Medtronic, Inc. Telemetry system for a medical device
US4374382A (en) 1981-01-16 1983-02-15 Medtronic, Inc. Marker channel telemetry system for a medical device
US4371385A (en) 1981-04-28 1983-02-01 Cobe Laboratories, Inc. Deaerating liquid
US4381999A (en) 1981-04-28 1983-05-03 Cobe Laboratories, Inc. Automatic ultrafiltration control system
US4750494A (en) 1981-05-12 1988-06-14 Medtronic, Inc. Automatic implantable fibrillation preventer
JPS58155864A (ja) * 1982-03-10 1983-09-16 株式会社豊田中央研究所 血液浄化装置
EP0097366B1 (de) 1982-06-21 1988-09-07 Fresenius AG Dialysevorrichtung mit geregelter Zusammensetzung der Dialysierlösung
DE3224823A1 (de) 1982-07-02 1984-01-05 Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München Verfahren zur herstellung einer fuer den entsprechenden krankheitsfall optimierten elektrolytloesung zur anwendung in der haemodialyse
US4650587A (en) 1982-09-09 1987-03-17 Akzona Incorporated Ammonia scavenger
US4460555A (en) 1983-08-25 1984-07-17 Organon Teknika Corporation Ammonia scavenger
US4678408A (en) 1984-01-06 1987-07-07 Pacesetter Infusion, Ltd. Solenoid drive apparatus for an external infusion pump
US4562751A (en) 1984-01-06 1986-01-07 Nason Clyde K Solenoid drive apparatus for an external infusion pump
US4685903A (en) 1984-01-06 1987-08-11 Pacesetter Infusion, Ltd. External infusion pump apparatus
US4718891A (en) * 1984-05-03 1988-01-12 Henry Ford Hospital Automated hemodialysis control based upon patient blood pressure and heart rate
US4747822A (en) 1984-07-09 1988-05-31 Peabody Alan M Continuous flow peritoneal dialysis system and method
US5643201A (en) 1984-07-09 1997-07-01 Peabody; Alan M. Continuous peritoneal dialysis apparatus
US4661246A (en) 1984-10-01 1987-04-28 Ash Medical Systems, Inc. Dialysis instrument with dialysate side pump for moving body fluids
JPS61119276A (ja) 1984-11-14 1986-06-06 株式会社　ニツシヨ− 限外濾過量制御装置
IT1191613B (it) 1985-05-15 1988-03-23 Eniricerche Spa Fosfato di zirconio e suo metodo di preparazione
US5091094A (en) * 1985-06-24 1992-02-25 Veech Richard L Hemodialysis processes & hemodialysis solutions
US4772560A (en) 1985-11-18 1988-09-20 Attar Amir J Laminated wafer for sensing and monitoring exposure to gases
US4976683A (en) 1986-06-20 1990-12-11 Abbott Laboratories Peritoneal dialysis method
DE3785147T2 (de) 1986-11-07 1996-09-19 Asahi Chemical Ind Membran aus regenerierter Zellulose und Verfahren zu ihrer Herstellung.
DE3640089A1 (de) * 1986-11-24 1988-06-01 Fresenius Ag Verfahren und vorrichtung zur bestimmung des intravasalen blutvolumens waehrend der haemodialyse
US4799493A (en) 1987-03-13 1989-01-24 Cardiac Pacemakers, Inc. Dual channel coherent fibrillation detection system
US4828693A (en) 1987-09-22 1989-05-09 Baxter Travenol Laboratories, Inc. Water pressure regulator for hemodialysis apparatus
GB8722854D0 (en) * 1987-09-29 1987-11-04 Hardy S M Implantable artificial kidney
SE465404B (sv) * 1988-03-03 1991-09-09 Gambro Ab Dialyssystem
CA1327838C (fr) 1988-06-13 1994-03-15 Fred Zacouto Dispositif implantable de protection contre les affections liees a la coagulation sanguine
US5092838A (en) 1989-11-30 1992-03-03 Baxter International Inc. Histidine buffered peritoneal dialysis solution
DE68911517T2 (de) 1989-06-15 1994-05-26 Alan M Peabody System zur kontinuierlichen zyklischen Peritonealdialyse.
US5127404A (en) 1990-01-22 1992-07-07 Medtronic, Inc. Telemetry format for implanted medical device
US5141493A (en) 1990-01-26 1992-08-25 Sarcos Group Peritoneal dialysis system
FR2660866B1 (fr) * 1990-04-13 1992-06-12 Hogamed Procede et dispositif de preparation d'un liquide de substitution.
US5080653A (en) 1990-04-16 1992-01-14 Pacesetter Infusion, Ltd. Infusion pump with dual position syringe locator
US5097122A (en) 1990-04-16 1992-03-17 Pacesetter Infusion, Ltd. Medication infusion system having optical motion sensor to detect drive mechanism malfunction
US5091642A (en) 1990-05-11 1992-02-25 Mda Scientific, Inc. Colorimetric detection apparatus
US5032265A (en) 1990-06-20 1991-07-16 Millipore Corporation Method and system for producing sterile aqueous solutions
FR2680975B1 (fr) * 1991-09-10 1998-12-31 Hospal Ind Rein artificiel muni de moyens pour doser une substance dans le sang.
FR2680976B1 (fr) 1991-09-10 1998-12-31 Hospal Ind Rein artificiel muni de moyens de determination caracteristiques du sang et procede de determination correspondant.
JPH0599464A (ja) 1991-10-08 1993-04-20 Nec Corp エアシヤワー装置
FR2687307B1 (fr) 1992-02-14 1999-06-04 Lascombes Jean Jacques Dispositif pour la preparation d'une solution a usage medical.
US5284470A (en) 1992-11-02 1994-02-08 Beltz Alex D Wearable, portable, light-weight artificial kidney
DE4303860C2 (de) 1993-02-10 1995-11-09 Draegerwerk Ag Träger für den kolorimetrischen Gasnachweis in Folienverbundbauweise
US5302288A (en) 1993-03-19 1994-04-12 Zimpro Environmental, Inc. Treatment of highly colored wastewaters
JPH06327767A (ja) * 1993-05-10 1994-11-29 Shinton Chem Ind Corp Ltd 即時適切に透析を行う装置及び方法
DE4321927C2 (de) 1993-07-01 1998-07-09 Sartorius Gmbh Filtereinheit mit Entgasungsvorrichtung
US5364593A (en) 1993-07-26 1994-11-15 Mihaylov Gueorgui M Direct-read colorimetric exposimeter
US5308315A (en) 1993-07-27 1994-05-03 Raja N. Khuri Method for determining the adequacy of dialysis
US5507723A (en) * 1994-05-24 1996-04-16 Baxter International, Inc. Method and system for optimizing dialysis clearance
FR2723002B1 (fr) * 1994-07-26 1996-09-06 Hospal Ind Dispositif et procede pour preparer un liquide de traitement par filtration
US5591344A (en) 1995-02-13 1997-01-07 Aksys, Ltd. Hot water disinfection of dialysis machines, including the extracorporeal circuit thereof
US5944684A (en) 1995-08-31 1999-08-31 The Regents Of The University Of California Wearable peritoneum-based system for continuous renal function replacement and other biomedical applications
US6363279B1 (en) 1996-01-08 2002-03-26 Impulse Dynamics N.V. Electrical muscle controller
US5683432A (en) 1996-01-11 1997-11-04 Medtronic, Inc. Adaptive, performance-optimizing communication system for communicating with an implanted medical device
US5819007A (en) 1996-03-15 1998-10-06 Siemens Medical Systems, Inc. Feature-based expert system classifier
JPH09327511A (ja) * 1996-06-12 1997-12-22 A S A Sangyo Kk 腹膜透析液の回収・再生方法並びにそのための処理装置及び付属器具
WO1998002209A2 (en) 1996-07-11 1998-01-22 Medtronic, Inc. Minimally invasive implantable device for monitoring physiologic events
US5902336A (en) 1996-10-15 1999-05-11 Mirimedical, Inc. Implantable device and method for removing fluids from the blood of a patient method for implanting such a device and method for treating a patient experiencing renal failure
US6048732A (en) 1996-10-16 2000-04-11 Board Of Regents, The University Of Texas System Receptor and method for citrate determination
WO1998054563A1 (en) 1997-05-29 1998-12-03 Angelo Joseph P D Estimation of active infection by helicobacter pylori
US6042721A (en) 1997-07-23 2000-03-28 Fabco Industries, Inc. Effluent treatment apparatus
CA2211848C (en) 1997-07-28 2002-06-11 Joseph E. Dadson Peritoneal dialysis apparatus
SE9703600D0 (sv) 1997-10-02 1997-10-02 Pacesetter Ab Heart stimulator
US6088608A (en) 1997-10-20 2000-07-11 Alfred E. Mann Foundation Electrochemical sensor and integrity tests therefor
DE19747360B8 (de) 1997-10-27 2007-05-16 Fresenius Medical Care De Gmbh Verfahren zur Messung von Leistungsparametern von Stoff- und Energieaustausch Modulen
SE9703958D0 (sv) 1997-10-29 1997-10-29 Pacesetter Ab Method and device for determination of concentration
US6648845B1 (en) 1998-01-07 2003-11-18 Fresenius Medical Care North America Method and apparatus for determining hemodialysis parameters
SE520638C2 (sv) 1998-01-21 2003-08-05 Gambro Lundia Ab Säkerhetsanordning vid dialysmaskin
SE9800407D0 (sv) 1998-02-12 1998-02-12 Pacesetter Ab Heart stimulator
US6074315A (en) 1998-02-19 2000-06-13 Linda C. Yimoyines Racquet with visually differentiated grommets and method of stringing thereof
US6197197B1 (en) 1998-04-23 2001-03-06 Dialysis Systems, Inc. Method for fluid delivery in a dialysis clinic
US6058331A (en) 1998-04-27 2000-05-02 Medtronic, Inc. Apparatus and method for treating peripheral vascular disease and organ ischemia by electrical stimulation with closed loop feedback control
US6561996B1 (en) * 1998-05-19 2003-05-13 Transvivo, Inc. Apparatus and method for in vivo hemodialysis
DE19823570A1 (de) 1998-05-27 1999-12-02 Kfh Kuratorium Fuer Dialyse Un Verfahren und Vorrichtung zum Austausch von Flüssigkeiten und/oder gelöster Substanzen insbesondere bei einer Dialysebehandlung
US6554798B1 (en) 1998-08-18 2003-04-29 Medtronic Minimed, Inc. External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities
US7670491B2 (en) 1998-10-20 2010-03-02 Advanced Renal Technologies Buffered compositions for dialysis
US6726647B1 (en) 1998-10-23 2004-04-27 Gambro Ab Method and device for measuring access flow
EP1124599B1 (en) 1998-10-23 2013-07-24 Gambro Lundia AB Device for measuring access flow by dialysis
US6248093B1 (en) 1998-10-29 2001-06-19 Minimed Inc. Compact pump drive system
DK1716884T3 (en) 1998-10-29 2014-03-10 Medtronic Minimed Inc reservoir Connection
US6254567B1 (en) 1999-02-26 2001-07-03 Nxstage Medical, Inc. Flow-through peritoneal dialysis systems and methods with on-line dialysis solution regeneration
US6274103B1 (en) 1999-03-26 2001-08-14 Prismedical Corporation Apparatus and method for preparation of a peritoneal dialysis solution
US6230059B1 (en) 1999-03-17 2001-05-08 Medtronic, Inc. Implantable monitor
SE9901165D0 (sv) 1999-03-30 1999-03-30 Gambro Lundia Ab Method, apparatus and components of dialysis systems
US6669663B1 (en) * 1999-04-30 2003-12-30 Medtronic, Inc. Closed loop medicament pump
DE60025716T2 (de) 1999-04-30 2006-10-19 Children's Hospital Medical Center, Cincinnati Hämofiltrationssystem
US6505075B1 (en) 1999-05-29 2003-01-07 Richard L. Weiner Peripheral nerve stimulation method
IT1310659B1 (it) * 1999-07-30 2002-02-19 Hospal Dasco Spa Metodo di controllo di una macchina per dialisi avente un filtrosemipermeabile.
DE19938691A1 (de) 1999-08-14 2001-02-15 Volkswagen Ag Verfahren zur verkehrsgeführten Beeinflussung und/oder Unterstützung von Kraftfahrzeugen
US6272377B1 (en) 1999-10-01 2001-08-07 Cardiac Pacemakers, Inc. Cardiac rhythm management system with arrhythmia prediction and prevention
FR2799727B1 (fr) 1999-10-19 2001-11-23 Entpr De Mecanique Et D Outil Dispositif de repartition des comprimes ou equivalents pour installation de conditionnement dans des feuilles alveolees en deplacement
IT1308861B1 (it) 1999-11-02 2002-01-11 Gambro Dasco Spa Metodo di controllo di una apparecchiatura di dialisi dedicataall'implementazione della tecnica dialitica afbk e relativa
DE19955578C1 (de) 1999-11-18 2001-09-06 Fresenius Medical Care De Gmbh Mehrkammerbehälter, mit Glucosekonzentratkompartiment und Salzsäurekonzentratkompartiment
FR2804265B1 (fr) 2000-01-25 2003-06-27 Centre Nat Rech Scient Systeme pour le suivi a distance de patients
US6602399B1 (en) 2000-03-22 2003-08-05 Max-Planck-Gesellschaft Zur Forderung Der Wissenchaften E.V. Signal recording of a receptor-effector-system by an extracellular planar potential-sensitive electrode
US20010041869A1 (en) 2000-03-23 2001-11-15 Causey James D. Control tabs for infusion devices and methods of using the same
IL136079A0 (en) 2000-04-19 2001-05-20 Cheetah Medical Inc C O Pepper Method and apparatus for monitoring the cardiovascular condition, particularly the degree of arteriosclerosis in individuals
AU2001259469A1 (en) 2000-05-05 2001-11-20 Hemocleanse, Inc. Use of magnetic particles or other particles having relatively high density in afluid for mixing and/or leak detection
US6887214B1 (en) 2000-09-12 2005-05-03 Chf Solutions, Inc. Blood pump having a disposable blood passage cartridge with integrated pressure sensors
US6890315B1 (en) 2000-05-23 2005-05-10 Chf Solutions, Inc. Method and apparatus for vein fluid removal in heart failure
US20010048637A1 (en) 2000-05-24 2001-12-06 Weigl Bernhard H. Microfluidic system and method
KR100713606B1 (ko) * 2000-06-15 2007-05-02 가부시끼가이샤 제이엠에스 자동 혈액투석장치
US6589229B1 (en) 2000-07-31 2003-07-08 Becton, Dickinson And Company Wearable, self-contained drug infusion device
US6615077B1 (en) 2000-08-14 2003-09-02 Renal Research Institute, Llc Device and method for monitoring and controlling physiologic parameters of a dialysis patient using segmental bioimpedence
US6689083B1 (en) 2000-11-27 2004-02-10 Chf Solutions, Inc. Controller for ultrafiltration blood circuit which prevents hypotension by monitoring osmotic pressure in blood
US7033498B2 (en) 2000-11-28 2006-04-25 Renal Solutions, Inc. Cartridges useful in cleaning dialysis solutions
US6627164B1 (en) 2000-11-28 2003-09-30 Renal Solutions, Inc. Sodium zirconium carbonate and zirconium basic carbonate and methods of making the same
JP4230223B2 (ja) 2000-12-12 2009-02-25 ユラク セパレーション アクティーゼルスカブ イオン種を液体から単離するための方法及び装置
ES2432351T3 (es) 2000-12-20 2013-12-02 Nephros, Inc. Aparato de hemodiafiltración/hemofiltración de varias etapas
EP1364666A1 (en) 2000-12-27 2003-11-26 Philips Japan, Ltd Biological information and blood treating device information control system, biological information and blood treating device information control device, and biological information and blood treating device information control method
US6706007B2 (en) 2000-12-29 2004-03-16 Chf Solutions, Inc. Feedback control of ultrafiltration to prevent hypotension
SE523860C2 (sv) 2001-01-08 2004-05-25 Gambro Lundia Ab Kopplingsanordning och medicinsk ledningsuppsättning med sådan kopplingsanordning
JP2003010319A (ja) * 2001-07-03 2003-01-14 Nippon Colin Co Ltd 透析装置
US6544212B2 (en) 2001-07-31 2003-04-08 Roche Diagnostics Corporation Diabetes management system
US6960179B2 (en) 2001-11-16 2005-11-01 National Quality Care, Inc Wearable continuous renal replacement therapy device
SE525132C2 (sv) 2001-11-23 2004-12-07 Gambro Lundia Ab Metod vid manövrering av dialysanordning
US6878283B2 (en) 2001-11-28 2005-04-12 Renal Solutions, Inc. Filter cartridge assemblies and methods for filtering fluids
US20030114787A1 (en) 2001-12-13 2003-06-19 Victor Gura Wearable peritoneal dialysis system
US20030113931A1 (en) 2001-12-14 2003-06-19 Li Pan Ammonia and ammonium sensors
DE10204963A1 (de) 2002-02-06 2003-08-14 Isco Inc Fotometrische Sonde für Untersuchungen an Flüssigkeiten sowie Verfahren hierfür
US6711439B1 (en) 2002-02-14 2004-03-23 Pacesetter, Inc. Evoked response variability as an indicator of autonomic tone and surrogate for patient condition
US7076299B2 (en) 2002-03-28 2006-07-11 Tran Thong Method and apparatus for preventing heart tachyarrhythmia
US20030199951A1 (en) 2002-04-22 2003-10-23 Pardo Xavier E. Implantable lead with improved conductor lumens
US7207946B2 (en) 2002-05-09 2007-04-24 Spiration, Inc. Automated provision of information related to air evacuation from a chest cavity
US20030216677A1 (en) * 2002-05-15 2003-11-20 Li Pan Biosensor for dialysis therapy
US7153286B2 (en) 2002-05-24 2006-12-26 Baxter International Inc. Automated dialysis system
US20040001931A1 (en) * 2002-06-25 2004-01-01 3M Innovative Properties Company Linerless printable adhesive tape
JP2004049492A (ja) * 2002-07-18 2004-02-19 Jms Co Ltd 基準体重算出方法および血液透析装置
JP4129866B2 (ja) * 2002-07-18 2008-08-06 日機装株式会社 血液処理装置
ES2427174T3 (es) 2002-07-19 2013-10-29 Baxter International Inc. Sistemas para desarrollar una diálisis peritoneal
DK1523351T3 (da) 2002-07-19 2010-04-26 Baxter Int System til peritonealdialyse
US7238164B2 (en) 2002-07-19 2007-07-03 Baxter International Inc. Systems, methods and apparatuses for pumping cassette-based therapies
US6609023B1 (en) 2002-09-20 2003-08-19 Angel Medical Systems, Inc. System for the detection of cardiac events
US7144384B2 (en) 2002-09-30 2006-12-05 Insulet Corporation Dispenser components and methods for patient infusion device
US7128727B2 (en) 2002-09-30 2006-10-31 Flaherty J Christopher Components and methods for patient infusion device
US20040099593A1 (en) 2002-11-25 2004-05-27 Potito De Paolis Concurrent dialysate purification cartridge
US9700663B2 (en) 2005-01-07 2017-07-11 Nxstage Medical, Inc. Filtration system for preparation of fluids for medical applications
DE602004021672D1 (de) 2003-01-07 2009-08-06 Nxstage Medical Inc Chargenfiltriersystem zur herstellung einer sterilen ersatzflüssigkeit für nierenbehandlungen
US7276042B2 (en) 2003-01-23 2007-10-02 National Quality Care, Inc. Low hydraulic resistance cartridge
US20060228256A1 (en) 2003-02-07 2006-10-12 Board Of Regents, The University Of Texas System Multi-shell microspheres with integrated chomatographic and detection layers for use in array sensors
AU2003900572A0 (en) 2003-02-10 2003-02-20 Metal Storm Limited Electronically selectable kinetic energy projectile
US7330750B2 (en) 2003-04-25 2008-02-12 Instrumentarium Corp. Estimation of cardiac death risk
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
DE10339342B3 (de) 2003-08-25 2005-01-20 Fresenius Medical Care Deutschland Gmbh Blutbehandlungsvorrichtung
US8026729B2 (en) 2003-09-16 2011-09-27 Cardiomems, Inc. System and apparatus for in-vivo assessment of relative position of an implant
US8086323B2 (en) * 2003-09-23 2011-12-27 Medtronic Minimed, Inc. Implantable multi-parameter sensing system and method
US20050065760A1 (en) 2003-09-23 2005-03-24 Robert Murtfeldt Method for advising patients concerning doses of insulin
EP1691863B1 (en) 2003-10-13 2008-02-20 Gambro Lundia AB A device for carrying out a peritoneal dialysis treatment
SE0302698L (sv) 2003-10-13 2005-04-14 Gambro Lundia Ab Anordning för genomförande av en peritonealdialys -behandling
US7575564B2 (en) 2003-10-28 2009-08-18 Baxter International Inc. Priming, integrity and head height methods and apparatuses for medical fluid systems
US8029454B2 (en) 2003-11-05 2011-10-04 Baxter International Inc. High convection home hemodialysis/hemofiltration and sorbent system
CA2549190A1 (en) 2003-12-11 2005-06-30 Board Of Regents, The University Of Texas System Method and system for the analysis of saliva using a sensor array
US7744553B2 (en) 2003-12-16 2010-06-29 Baxter International Inc. Medical fluid therapy flow control systems and methods
JP4903583B2 (ja) 2003-12-24 2012-03-28 ケミカ テクノロジーズ， インコーポレイテッド 携帯式個人透析用透析液再生システム
WO2005077260A1 (en) * 2004-02-12 2005-08-25 Biopeak Corporation Non-invasive method and apparatus for determining a physiological parameter
DE102004013814A1 (de) 2004-03-20 2005-10-13 B. Braun Medizintechnologie Gmbh Verfahren zur Gestattung von Bedienereingaben an einem medizinischen Gerät
US20050234354A1 (en) 2004-04-15 2005-10-20 Rowlandson G I System and method for assessing a patient's risk of sudden cardiac death
US7509159B2 (en) 2004-04-15 2009-03-24 Ge Medical Systems Information Technologies, Inc. Method and apparatus for detecting cardiac repolarization abnormality
US7247493B2 (en) 2004-05-18 2007-07-24 Virbac Corporation Reusable pH sensor device and related methods
US7776210B2 (en) 2004-06-09 2010-08-17 Renal Solutions, Inc. Dialysis system
ITMO20040191A1 (it) * 2004-07-23 2004-10-23 Gambro Lundia Ab Macchina e metodo per il trattamento extracorporeo di sangue.
US7373195B2 (en) * 2004-07-30 2008-05-13 Medtronic, Inc. Ion sensor for long term use in complex medium
US7356366B2 (en) 2004-08-02 2008-04-08 Cardiac Pacemakers, Inc. Device for monitoring fluid status
US8202248B2 (en) 2004-08-18 2012-06-19 Sequana Medical Ag Dialysis implant and methods of use
JP4094600B2 (ja) * 2004-10-06 2008-06-04 日機装株式会社 血液浄化装置
JP5328152B2 (ja) 2004-12-28 2013-10-30 レナル ソリューションズ，インク． リン酸ジルコニウム粒子の合成法
US7756572B1 (en) 2005-01-25 2010-07-13 Pacesetter, Inc. System and method for efficiently distinguishing among cardiac ischemia, hypoglycemia and hyperglycemia using an implantable medical device and an external system
EP1850910A1 (en) 2005-02-07 2007-11-07 Medtronic, Inc. Ion imbalance detector
US20060195064A1 (en) 2005-02-28 2006-08-31 Fresenius Medical Care Holdings, Inc. Portable apparatus for peritoneal dialysis therapy
US7404799B1 (en) 2005-04-05 2008-07-29 Pacesetter, Inc. System and method for detection of respiration patterns via integration of intracardiac electrogram signals
JP4726045B2 (ja) * 2005-04-08 2011-07-20 日機装株式会社 血液透析装置
US7537569B2 (en) 2005-04-29 2009-05-26 Medtronic, Inc. Method and apparatus for detection of tachyarrhythmia using cycle lengths
US20060257500A1 (en) * 2005-05-05 2006-11-16 Duke University TRPC6 involved in glomerulonephritis
US7641649B2 (en) 2005-05-06 2010-01-05 Medtronic Minimed, Inc. Reservoir support and method for infusion device
JP5214438B2 (ja) 2005-05-06 2013-06-19 クアンタ フルーイド ソリューションズ リミテッド 流体処理装置
US20070007184A1 (en) 2005-07-07 2007-01-11 Delphi Technologies, Inc. Specialized sensor-assisted dialysis
US20070031972A1 (en) 2005-08-05 2007-02-08 Attar Amir J Detection of poisons in materials such as food using colorimetric detection
US7529580B2 (en) 2005-08-11 2009-05-05 Pacesetter, Inc. Detection of renal failure by cardiac implantable medical device
US7674231B2 (en) 2005-08-22 2010-03-09 Massachusetts Institute Of Technology Wearable pulse wave velocity blood pressure sensor and methods of calibration thereof
US7775983B2 (en) 2005-09-16 2010-08-17 Cardiac Pacemakers, Inc. Rapid shallow breathing detection for use in congestive heart failure status determination
US7658884B2 (en) 2005-10-05 2010-02-09 Swan Analytische Instrumente Ag Photometric method and apparatus for measuring a liquid's turbidity, fluorescence, phosphorescence and/or absorption coefficient
US20100137693A1 (en) 2005-11-01 2010-06-03 Fresenius Medical Care Holdings, Inc. Methods and systems for patient care
JP4822258B2 (ja) * 2005-11-11 2011-11-24 日機装株式会社 血液透析装置
DE102005060866B4 (de) 2005-12-20 2009-01-15 Bruker Biospin Gmbh Kombinierte Titrations- und pH-Elektrode für die Präparation von flüssigen Messproben insbesondere für die NMR-Spektroskopie
EP1971380B1 (en) 2005-12-29 2015-12-23 Cuva ApS Method and apparatus for home dialysis
US8409864B2 (en) 2006-01-06 2013-04-02 Renal Solutions, Inc. Ammonia sensor and system for use
JP4548349B2 (ja) * 2006-01-20 2010-09-22 株式会社ジェイ・エム・エス 血液透析装置
EP1979020A4 (en) 2006-01-30 2011-03-30 Univ California PERITONEAL DIALYSIS PROCESS AND DEVICE
US8246563B2 (en) 2006-02-02 2012-08-21 Cardiac Pacemakers, Inc. Cardiac rhythm management device and sensor-suite for the optimal control of ultrafiltration and renal replacement therapies
US7842243B2 (en) 2006-02-21 2010-11-30 Sergey Sergeyevich Sarkisov Chemical sensor with an indicator dye
US8012118B2 (en) * 2006-03-08 2011-09-06 Fresenius Medical Care Holdings, Inc. Artificial kidney dialysis system
US7785463B2 (en) 2006-03-17 2010-08-31 Children's Hospital Medical Center Extracorporeal renal replacement modeling system
JP2007255995A (ja) 2006-03-22 2007-10-04 Nec Corp 色識別装置およびガス特定装置
US7610086B1 (en) 2006-03-31 2009-10-27 Pacesetter, Inc. System and method for detecting cardiac ischemia in real-time using a pattern classifier implemented within an implanted medical device
US7790113B2 (en) 2006-04-04 2010-09-07 Photonic Biosystems, Inc. Visual, continuous and simultaneous measurement of solution ammonia and hydrogen ion concentration
CA2648803C (en) 2006-04-14 2017-06-20 Deka Products Limited Partnership Systems, devices and methods for fluid pumping, heat exchange, thermal sensing, and conductivity sensing
US8366316B2 (en) 2006-04-14 2013-02-05 Deka Products Limited Partnership Sensor apparatus systems, devices and methods
US7942844B2 (en) 2006-04-28 2011-05-17 Medtronic Minimed, Inc. Remote monitoring for networked fluid infusion systems
US7558622B2 (en) 2006-05-24 2009-07-07 Bao Tran Mesh network stroke monitoring appliance
US8496809B2 (en) 2006-06-05 2013-07-30 Baxter International Inc. Dynamic weight balancing of flow in kidney failure treatment systems
CN101460092B (zh) * 2006-06-07 2011-06-01 甘布罗伦迪亚股份公司 快速症状性血压降低的预测
DE102006028172A1 (de) 2006-06-16 2007-12-20 Universität Hannover Verfahren und Vorrichtung zur Elimination von Arsen aus Wasser
US7572232B2 (en) 2006-07-24 2009-08-11 Cardiac Pacemakers, Inc. Cardiac signal display and event detection using multiresolution Z-score transform
CA2659116A1 (en) 2006-07-26 2008-08-14 Detectachem, Llc. Apparatus and method for detection of trace chemicals
SE532971C2 (sv) 2006-08-16 2010-05-25 Triomed Ab System för regenerering av en vätska
US7887502B2 (en) 2006-09-15 2011-02-15 University Of Florida Research Foundation, Inc. Method for using photoplethysmography to optimize fluid removal during renal replacement therapy by hemodialysis or hemofiltration
CA2663897C (en) 2006-09-19 2015-01-06 Gambro Lundia Ab Estimation of propensity to symptomatic hypotension
DE102006045437A1 (de) 2006-09-26 2008-04-03 Fresenius Medical Care Deutschland Gmbh Vorrichtung und Verfahren zur Vorgabe einer Dialysierflüssigkeitsrate oder Blutflussrate für eine extrakorporale Blutbehandlung
EP2086632B1 (en) 2006-10-19 2017-05-03 Second Sight Medical Products, Inc. Visual prosthesis
DE102006050272B4 (de) 2006-10-23 2008-07-24 Fresenius Medical Care Deutschland Gmbh Hämodialysegerät, Hämodiafiltrationsgerät, Verfahren zur Probennahme bei solchen Geräten und Probenentnahmeset zur Anwendung bei solchen Geräten und Verfahren
WO2008052358A1 (en) 2006-11-03 2008-05-08 The Governors Of The University Of Alberta Microfluidic device having an array of spots
US9968266B2 (en) 2006-12-27 2018-05-15 Cardiac Pacemakers, Inc. Risk stratification based heart failure detection algorithm
US8183046B2 (en) 2007-01-11 2012-05-22 The Board Of Trustees Of The University Of Illinois Temperature resistant pH buffers for use at low temperatures
CA2678394C (en) 2007-02-15 2012-08-07 Atsushi Karakama Blood purification system
US7731689B2 (en) 2007-02-15 2010-06-08 Baxter International Inc. Dialysis system having inductive heating
US8042563B2 (en) 2007-02-27 2011-10-25 Deka Products Limited Partnership Cassette system integrated apparatus
KR102029220B1 (ko) 2007-02-27 2019-10-07 데카 프로덕츠 리미티드 파트너쉽 혈액투석 시스템
US20080253911A1 (en) 2007-02-27 2008-10-16 Deka Products Limited Partnership Pumping Cassette
US8491184B2 (en) 2007-02-27 2013-07-23 Deka Products Limited Partnership Sensor apparatus systems, devices and methods
US8409441B2 (en) 2007-02-27 2013-04-02 Deka Products Limited Partnership Blood treatment systems and methods
JP2010523230A (ja) 2007-04-05 2010-07-15 ベロメディックス，インク 自動治療システム及び方法
US7775986B2 (en) 2007-04-10 2010-08-17 B. Braun Medizintechnologie Gmbh Therapy device with a time-variable blood regulation
JP2010528715A (ja) 2007-05-29 2010-08-26 フレゼニウス メディカル ケア ホールディングス インコーポレーテッド 溶液、透析液、及び関連する方法
PT2765139T (pt) 2007-07-20 2017-07-14 Mayo Foundation Polipéptidos natriuréticos
US7981082B2 (en) 2007-08-21 2011-07-19 Hospira, Inc. System and method for reducing air bubbles in a fluid delivery line
DE102007039939B4 (de) 2007-08-23 2013-03-14 Albutec Gmbh Vorrichtung zur Einsparung von Diafiltrat
US20090101577A1 (en) 2007-09-28 2009-04-23 Fulkerson Barry N Methods and Systems for Controlling Ultrafiltration Using Central Venous Pressure Measurements
DE102007052571A1 (de) * 2007-11-03 2009-05-07 Fresenius Medical Care Deutschland Gmbh Verfahren und Vorrichtung zur Überwachung der Zufuhr von Substitutionsflüssigkeit während einer extrakorporalen Blutbehandlung
TWI400062B (zh) 2007-11-08 2013-07-01 私立中原大學 Medical devices that record physiological signals
US9415150B2 (en) 2007-11-09 2016-08-16 Baxter Healthcare S.A. Balanced flow dialysis machine
CA2704011C (en) 2007-11-16 2016-07-05 Fresenius Medical Care Holdings, Inc. Dialysis systems and methods
US8889004B2 (en) 2007-11-16 2014-11-18 Fresenius Medical Care Holdings, Inc. Dialysis systems and methods
WO2009073567A1 (en) 2007-11-29 2009-06-11 Xcorporeal. Inc. System and method for conducting hemodialysis and hemofiltration
US20090149776A1 (en) 2007-12-05 2009-06-11 Adams Scott C Optical sensor for detecting infection and other anomalous conditions associated with catheter systems
CN101482572B (zh) 2008-01-11 2012-07-04 株式会社东芝 自动分析装置以及自动分析方法
NZ586924A (en) 2008-01-18 2012-08-31 Fresenius Med Care Hldg Inc Carbon dioxide gas removal from a fluid circuit of a dialysis device with device having annular concentric housings
EP3594959A1 (en) 2008-01-23 2020-01-15 DEKA Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
AU2008286252B9 (en) 2008-01-25 2014-05-29 Fresenius Medical Care Holdings, Inc. Apparatus and methods for early stage peritonitis detection and for in vivo testing of bodily fluids
CA2712107A1 (en) * 2008-01-31 2009-08-06 Applied Physiology Pty. Ltd. Systems, methods and devices for maintenance, guidance and/or control
US8019406B2 (en) 2008-03-10 2011-09-13 Biotronik Crm Patent Ag Apparatus and method to assess the risk of R-on-T event
JP2009247724A (ja) * 2008-04-09 2009-10-29 Jms Co Ltd 血液透析装置
US20090264776A1 (en) 2008-04-17 2009-10-22 Terence Vardy Measurement of physiological characteristics
AU2009242369A1 (en) 2008-04-30 2009-11-05 Gambro Lundia Ab Hydrophobic deaeration membrane
US8233973B2 (en) 2008-05-02 2012-07-31 Spacelabs Healthcare, Llc Methods for detection of cardiac arrhythmias
US8882700B2 (en) 2008-05-02 2014-11-11 Baxter International Inc. Smart patient transfer set for peritoneal dialysis
US8449495B2 (en) 2008-05-28 2013-05-28 Baxter Healthcare Inc. Dialysis system having automated effluent sampling and peritoneal equilibration test
US8220643B2 (en) 2008-06-06 2012-07-17 Fresenius Medical Care Holdings, Inc. Urea sorbent
ES2821448T3 (es) 2008-06-23 2021-04-26 Temasek Polytechnic Sorbente para un dispositivo de diálisis
US9821105B2 (en) 2008-07-01 2017-11-21 Baxter International Inc. Nanoclay sorbents for dialysis
US8057679B2 (en) * 2008-07-09 2011-11-15 Baxter International Inc. Dialysis system having trending and alert generation
US9147045B2 (en) 2008-07-09 2015-09-29 Baxter International Inc. Peritoneal equilibration test and dialysis system using same
US8696626B2 (en) 2008-07-30 2014-04-15 Claudia F. E. Kirsch Debubbler
CN101644667A (zh) 2008-08-05 2010-02-10 长春吉大·小天鹅仪器有限公司 茶叶质量安全快速检测仪
US20100051552A1 (en) 2008-08-28 2010-03-04 Baxter International Inc. In-line sensors for dialysis applications
EP2163272B1 (en) * 2008-09-15 2014-06-25 B. Braun Avitum AG Device to early predict the Kt/V parameter in kidney substitution treatments
US8613705B2 (en) * 2008-09-19 2013-12-24 Cardiac Pacemakers, Inc. Central venous pressure sensor and method to control a fluid or volume overload therapy
EP2361035B1 (en) * 2008-09-19 2014-12-31 Cardiac Pacemakers, Inc. System for determining a heart failure status
US8409444B2 (en) 2008-09-30 2013-04-02 Fresenius Medical Care Holdings, Inc. Acid zirconium phosphate and alkaline hydrous zirconium oxide materials for sorbent dialysis
WO2010039384A2 (en) 2008-09-30 2010-04-08 Fresenius Medical Care Holdings, Inc. Covalently immobilized enzyme and method to make the same
CN102239113B (zh) 2008-10-03 2013-11-06 弗雷塞尼斯医疗保健控股公司 具有改进的吸附容量的磷酸锆颗粒及其合成方法
US9883799B2 (en) 2008-10-16 2018-02-06 Fresenius Medical Care Holdings, Inc. Method of identifying when a patient undergoing hemodialysis is at increased risk of death
US8777892B2 (en) 2008-11-03 2014-07-15 Fresenius Medical Care Holdings, Inc. Portable peritoneal dialysis system
US9370324B2 (en) 2008-11-05 2016-06-21 Fresenius Medical Care Holdings, Inc. Hemodialysis patient data acquisition, management and analysis system
DE102008061122A1 (de) 2008-12-09 2010-06-17 Fresenius Medical Care Deutschland Gmbh Verfahren und Vorrichtung zum Ermitteln und/oder Überwachen eines körperlichen Zustandes, insbesondere einer kardiovaskulären Größe, eines Patienten basierend auf einer Amplitude eines Drucksignals
US8823490B2 (en) 2008-12-15 2014-09-02 Corventis, Inc. Patient monitoring systems and methods
CN201342127Y (zh) 2008-12-25 2009-11-11 贺心雅 在线式腹膜透析装置
CA2749298C (en) 2009-01-23 2018-02-13 Pioneer Hi-Bred International, Inc. Novel bacillus thuringiensis gene with lepidopteran activity
US8521482B2 (en) 2009-02-20 2013-08-27 Baxter International Inc. Simulation of patient drain phase in peritoneal dialysis
US9005440B2 (en) 2009-03-06 2015-04-14 Baxter International Inc. Hemodialysis and peritoneal dialysis systems having electrodialysis and electrodeionization capabilities
US8858792B2 (en) 2009-03-06 2014-10-14 Baxter International Inc. Hemodialysis and peritoneal dialysis systems having electrodeionization capabilities
US20120029937A1 (en) 2009-03-24 2012-02-02 Debiotech S.A. Dialysis device
US8480581B2 (en) * 2009-03-24 2013-07-09 Cardiac Pacemakers, Inc. Systems and methods for anemia detection, monitoring, and treatment
DE102009018806A1 (de) 2009-04-24 2010-11-25 Fresenius Medical Care Deutschland Gmbh Rechnersystem und Verfahren zum Erzeugen wenigstens einer maschinenlesbaren Datei für eine medizinische Behandlungsvorrichtung
US20100298670A1 (en) * 2009-05-20 2010-11-25 Pacesetter, Inc. Electrolyte monitoring using implanted cardiac rhythm management device
US20100312174A1 (en) 2009-06-06 2010-12-09 Hoffman Josef C A Peritoneal Dialysis System
US20100312172A1 (en) 2009-06-06 2010-12-09 Hoffman Josef C A Method of Peritoneal Dialysis
ES2620580T3 (es) 2009-06-26 2017-06-29 Gambro Lundia Ab Dispositivo y método para la extracción de datos
WO2011002850A1 (en) 2009-07-01 2011-01-06 Board Or Regents, The University Of Texas System Methods of determining the presence and/or concentration of an analyte in a sample
US8404091B2 (en) 2009-08-27 2013-03-26 Baxter International Inc. Dialysis treatment devices for removing urea
EP2292283A1 (en) 2009-09-04 2011-03-09 B. Braun Avitum AG Method and device to obtain physiological parameters and detect clinical or subclinical abnormalities during a kidney substitution treatment
EP2295097A1 (en) 2009-09-09 2011-03-16 Fresenius Medical Care Deutschland GmbH Method and apparatus for evaluating values representing a mass or a concentration of a substance present within the body of a patient
US8239010B2 (en) 2009-09-14 2012-08-07 Sotera Wireless, Inc. System for measuring vital signs during hemodialysis
US20110066043A1 (en) 2009-09-14 2011-03-17 Matt Banet System for measuring vital signs during hemodialysis
US9943236B2 (en) * 2009-09-30 2018-04-17 Medtronic, Inc. Methods for guiding heart failure decompensation therapy
US9399091B2 (en) 2009-09-30 2016-07-26 Medtronic, Inc. System and method to regulate ultrafiltration
US8518260B2 (en) 2009-10-01 2013-08-27 Fresenius Medical Care Holdings, Inc. Method of controlling diffusive sodium transport in dialysis
EP2316334A1 (en) 2009-10-22 2011-05-04 Fresenius Medical Care Deutschland GmbH A method for assessing a patient's fluid status and /or sensitivity to fluid removal, controller, and devices
US20110130666A1 (en) 2009-11-30 2011-06-02 Yanting Dong Enhanced reporting of pathological episodes
US20110141116A1 (en) 2009-12-16 2011-06-16 Baxter International Inc. Methods and apparatus for displaying flow rate graphs and alarms on a dialysis system
CN101726465B (zh) 2009-12-25 2011-07-06 重庆大学 微型阵列式有毒气体检测仪
US8845570B2 (en) * 2010-04-16 2014-09-30 Baxter International Inc. Therapy prediction and optimization for renal failure blood therapy, especially home hemodialysis
US9132219B2 (en) 2010-04-16 2015-09-15 Baxter International Inc. Therapy prediction and optimization of serum potassium for renal failure blood therapy, especially home hemodialysis
EP2377563B1 (en) 2010-04-19 2012-05-30 Gambro Lundia AB Dialysis apparatus
US20110272337A1 (en) 2010-05-04 2011-11-10 C-Tech Biomedical, Inc. Dual mode hemodialysis machine
CN101958264B (zh) 2010-05-06 2012-06-20 东莞宏威数码机械有限公司 无尘式真空动力传送装置
EP2388030B2 (en) 2010-05-20 2022-03-16 B. Braun Avitum AG Kidney substitution device to automate blood sampling procedure in a kidney substitution treatment machine
DE102010022201A1 (de) 2010-05-20 2011-11-24 Fresenius Medical Care Deutschland Gmbh Medizinische Behandlungsanordnung
WO2011149730A2 (en) 2010-05-24 2011-12-01 Baxter International Inc. Systems and methods for removing hydrogen peroxide from water purification systems
US20110301447A1 (en) 2010-06-07 2011-12-08 Sti Medical Systems, Llc Versatile video interpretation, visualization, and management system
WO2011161056A2 (en) 2010-06-23 2011-12-29 Gambro Lundia Ab Dialysis precursor composition
US8395213B2 (en) 2010-08-27 2013-03-12 Acorn Technologies, Inc. Strained semiconductor using elastic edge relaxation of a stressor combined with buried insulating layer
CA3221831A1 (en) 2010-09-07 2012-03-15 Nextteq Llc System for visual and electronic reading of colorimetric tubes
WO2012038384A1 (en) * 2010-09-20 2012-03-29 Gambro Lundia Ab Obtaining control settings for a dialysis machine
EP2433662B1 (en) 2010-09-27 2014-06-04 Gambro Lundia AB Apparatus for extracorporeal treatment of blood
US8784668B2 (en) 2010-10-12 2014-07-22 Fresenius Medical Care Holdings, Inc. Systems and methods for compensation of compliant behavior in regenerative dialysis systems
DE102010048771A1 (de) 2010-10-14 2012-05-16 B. Braun Avitum Ag Verfahren und Vorrichtung zur Messung und Behebung von Systemänderungen in einer Vorrichtung zur Behandlung von Blut
JP4803318B1 (ja) 2010-12-02 2011-10-26 横浜ゴム株式会社 空気入りタイヤ
US9694125B2 (en) 2010-12-20 2017-07-04 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
DE102011008185A1 (de) 2011-01-10 2012-07-12 Fresenius Medical Care Deutschland Gmbh Herstellung von Individualkonzentrat
DE102011003720A1 (de) 2011-02-07 2012-08-09 Robert Bosch Gmbh Anordnung und Verfahren zum Detektieren von Wasserstoffperoxid
US20120220528A1 (en) 2011-02-25 2012-08-30 Medtronic, Inc. Systems and methods for therapy of kidney disease and/or heart failure using chimeric natriuretic peptides
CN202048893U (zh) 2011-03-21 2011-11-23 东华大学 一种纺丝溶液气泡实时检测系统
ITMI20110441A1 (it) 2011-03-21 2012-09-22 Gambro Lundia Ab Apparecchiatura per il trattamento extracorporeo di sangue.
CA2830085A1 (en) 2011-03-23 2012-09-27 Nxstage Medical, Inc. Peritoneal dialysis systems, devices, and methods
US8945936B2 (en) 2011-04-06 2015-02-03 Fresenius Medical Care Holdings, Inc. Measuring chemical properties of a sample fluid in dialysis systems
US20120258546A1 (en) 2011-04-08 2012-10-11 Life Technologies Corporation Automated On-Instrument pH Adjustment
EP2701580B1 (en) 2011-04-29 2020-12-30 Medtronic, Inc. Device to monitor patients with kidney disease
US9320842B2 (en) 2011-04-29 2016-04-26 Medtronic, Inc. Multimodal dialysis system
US9848778B2 (en) 2011-04-29 2017-12-26 Medtronic, Inc. Method and device to monitor patients with kidney disease
US9456755B2 (en) 2011-04-29 2016-10-04 Medtronic, Inc. Method and device to monitor patients with kidney disease
WO2012148781A1 (en) 2011-04-29 2012-11-01 Medtronic, Inc. Multimodal dialysis system
US9132217B2 (en) 2011-04-29 2015-09-15 Medtronic, Inc. Multimodal dialysis system
US9561316B2 (en) 2011-04-29 2017-02-07 Medtronic, Inc. Intersession monitoring for blood fluid removal therapy
US20120303079A1 (en) 2011-05-23 2012-11-29 Deepa Mahajan Apparatus and method for combined cardiac function management and renal therapies
WO2012162515A2 (en) 2011-05-24 2012-11-29 Deka Products Limited Partnership Hemodial ysis system
BR112014001614A2 (pt) 2011-07-29 2017-02-21 Baxter Healthcare Sa aparelho para o tratamento de dialisado gasto, aparelho para a execução de uma terapia de diálise e cartucho de regeneração de dialisado
US10695481B2 (en) 2011-08-02 2020-06-30 Medtronic, Inc. Hemodialysis system having a flow path with a controlled compliant volume
CN103748465B (zh) 2011-08-05 2015-12-09 美艾利尔圣地亚哥公司 监测心衰的方法和试剂
US10857277B2 (en) 2011-08-16 2020-12-08 Medtronic, Inc. Modular hemodialysis system
WO2013028809A2 (en) 2011-08-22 2013-02-28 Medtronic, Inc. Dual flow sorbent cartridge
US8811290B2 (en) 2011-09-29 2014-08-19 Lg Electronics Inc. Method and apparatus for transmitting paging message in wireless communication system
AU2012336423B2 (en) 2011-11-08 2017-08-03 Temasek Polytechnic Sensing system for detecting a substance in a dialysate
JP5099464B1 (ja) 2011-12-29 2012-12-19 富田製薬株式会社 重炭酸イオン濃度可変型の透析液の調製装置及び調製方法、重炭酸イオン濃度可変型の透析剤、並びに重炭酸イオン濃度可変型の透析システム
US9616163B2 (en) 2012-01-04 2017-04-11 Fresenius Medical Care Holdings, Inc. Method and system of enhancing removal of toxic anions and organic solutes in sorbent dialysis
EP2800592B1 (en) 2012-01-04 2019-03-06 Medtronic Inc. Multi-staged filtration system for blood fluid removal
GB201201330D0 (en) 2012-01-26 2012-03-14 Quanta Fluid Solutions Ltd Dialysis machine
US20140276100A1 (en) 2012-02-01 2014-09-18 Invoy Technologies System for measuring breath analytes
WO2013114063A1 (en) 2012-02-02 2013-08-08 Quanta Fluid Solutions Ltd. Dialysis machine
US9682183B2 (en) 2012-02-14 2017-06-20 Quanta Fluid Solutions Ltd. Dialysis machine
EP2641624B1 (en) 2012-03-21 2016-03-02 Gambro Lundia AB Treatment solution delivery in an extracorporeal blood treatment apparatus
DE112012006079T5 (de) 2012-03-23 2014-12-04 Nxstage Medical, Inc. Peritonealdialyse-Systeme, -Vorrichtungen und -Verfahren
US9610392B2 (en) 2012-06-08 2017-04-04 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
US9500188B2 (en) 2012-06-11 2016-11-22 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
DE102012014504A1 (de) 2012-07-20 2014-01-23 Dräger Safety AG & Co. KGaA Gasmesssystem
US9231692B2 (en) 2012-09-04 2016-01-05 Viasat Inc. Paired-beam transponder satellite communication
US9162021B2 (en) 2012-10-22 2015-10-20 Baxter International Inc. Integrated water testing system and method for ultra-low total chlorine detection
US9138520B2 (en) 2012-10-22 2015-09-22 Baxter International Inc. Total chlorine water detection system and method for medical fluid treatments
US9523642B2 (en) 2012-11-09 2016-12-20 Taiwan Semiconductor Manufacturing Company, Ltd. Integrated electro-microfluidic probe card, system and method for using the same
JP2014097224A (ja) 2012-11-15 2014-05-29 Tatsunori Kato 透析ユニットおよびアクセス再循環率の測定方法
US10905816B2 (en) 2012-12-10 2021-02-02 Medtronic, Inc. Sodium management system for hemodialysis
US9399090B2 (en) 2012-12-10 2016-07-26 Medtronic, Inc. Potassium loaded ion-exchange material for use in a dialysate regeneration system
US20140158588A1 (en) 2012-12-10 2014-06-12 Medtronic, Inc. pH AND BUFFER MANAGEMENT SYSTEM FOR HEMODIALYSIS SYSTEMS
CN103901025A (zh) 2012-12-27 2014-07-02 中国科学院烟台海岸带研究所 一种便携式纸基微流控芯片色彩检测装置和方法
US9707328B2 (en) 2013-01-09 2017-07-18 Medtronic, Inc. Sorbent cartridge to measure solute concentrations
US9526822B2 (en) 2013-02-01 2016-12-27 Medtronic, Inc. Sodium and buffer source cartridges for use in a modular controlled compliant flow path
US9173987B2 (en) 2013-02-01 2015-11-03 Medtronic, Inc. Degassing module for a controlled compliant flow path
US10010663B2 (en) 2013-02-01 2018-07-03 Medtronic, Inc. Fluid circuit for delivery of renal replacement therapies
EP2950835B1 (en) 2013-02-01 2019-04-24 Medtronic, Inc. Recirculating dialysate fluid circuit for blood measurement
WO2014121162A1 (en) 2013-02-01 2014-08-07 Medtronic, Inc. Sorbent cartridge to measure solute concentrations
US9144640B2 (en) 2013-02-02 2015-09-29 Medtronic, Inc. Sorbent cartridge configurations for improved dialysate regeneration
US9827361B2 (en) 2013-02-02 2017-11-28 Medtronic, Inc. pH buffer measurement system for hemodialysis systems
US11170883B2 (en) 2013-03-14 2021-11-09 Baxter International Inc. System and method for peritoneal dialysis exchanges having reusable energizing unit
CN103439230B (zh) 2013-09-13 2015-07-01 山东省科学院海洋仪器仪表研究所 一种气泡参数测量方法及测量装置
CN105848581B (zh) 2013-11-04 2019-01-01 美敦力公司 用于管理身体中的体液体积的方法和装置
US9884145B2 (en) 2013-11-26 2018-02-06 Medtronic, Inc. Parallel modules for in-line recharging of sorbents using alternate duty cycles
WO2015081221A1 (en) 2013-11-27 2015-06-04 Medtronic, Inc. Precision dialysis monitoring and synchonization system
SE538124C2 (sv) 2014-02-28 2016-03-08 Triomed Ab Apparat för peritoneal ultrafiltration innefattande kontrollav glukoskoncentrationen i peritonealhålan
US20170027482A1 (en) 2014-04-13 2017-02-02 Spectrophon Ltd Wireless colorimetric sensor
CA2950864C (en) 2014-05-29 2020-03-24 Fresenius Medical Care Holdings, Inc. Method for treating dialysate, dialysis system, and method for pre-evaluating dialysis patients for treatment with same
US9278536B2 (en) 2014-07-22 2016-03-08 Xyzprinting, Inc. Printing head module
EP3220975B1 (en) 2014-11-21 2024-01-24 Triomed AB Apparatus for performing peritoneal ultrafiltration
US9895479B2 (en) 2014-12-10 2018-02-20 Medtronic, Inc. Water management system for use in dialysis
ES2869892T3 (es) 2014-12-17 2021-10-26 Newsol Tech Inc Sistema y método para diálisis peritoneal
CN104833635B (zh) 2015-04-23 2018-03-16 东北大学 一种检测葡萄糖浓度的微型石英空心管复合光纤结构
SE539744C2 (en) 2015-08-27 2017-11-14 Triomed Ab PERFORMING PERITONEAL ULTRAFILTRATION APPLIANCE
CN105115921B (zh) 2015-09-09 2017-10-20 浙江大学 一种用于检测水中气体浓度的检测装置
CN105692957B (zh) 2016-02-26 2018-11-13 宁波惠士康健康科技有限公司 具有杀菌功能的净水器
EP3439712B1 (en) 2016-04-04 2025-10-01 Mozarc Medical US LLC Peritoneal dialysate fluid generation system with integrated cycler
WO2017176687A1 (en) 2016-04-04 2017-10-12 Medtronic, Inc. Regenerative peritoneal dialysis system
CN205672288U (zh) 2016-04-08 2016-11-09 福州东泽医疗器械有限公司 一种自动腹膜透析机加热及温控系统
EP4609891A3 (en) 2016-05-06 2025-11-19 Gambro Lundia AB Systems for peritoneal dialysis having point of use dialysis fluid preparation using water accumulator and disposable set
CN106124491A (zh) 2016-06-15 2016-11-16 安徽有果信息技术服务有限公司 一种甲醛生产在线浓度检测技术
WO2018031711A2 (en) 2016-08-10 2018-02-15 Medtronic, Inc. Catheter and peritoneum health monitoring

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7077819B1 (en) * 1998-12-24 2006-07-18 Fresenius Medical Care Deutschland Gmbh Method for determining the distribution volume of a blood component during an extracorporeal blood treatment and device for carrying out the method
US20050236330A1 (en) * 2000-12-22 2005-10-27 Fresenius Medical Care Deutschland Gmbh. Method for determining concentration; a dialyser
US20040019312A1 (en) * 2002-07-19 2004-01-29 Childers Robert W. Systems and methods for performing peritoneal dialysis
US20070066928A1 (en) * 2005-09-22 2007-03-22 Jean-Michel Lannoy Automation and optimization of CRRT treatment using regional citrate anticoagulation
WO2009026603A1 (de) * 2007-08-31 2009-03-05 Zentrum Für Biomedizinische Technologie Der Donau-Universität Krems Verfahren zum erfassen der ionenkonzentration bei citrat-antikoagulierter extrakorporaler blutreinigung

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BLEYER ET AL.: "Sudden and cardiac death rated in hemodialysis patients", KIDNEY INTERNATIONAL, vol. 55, 1999, pages 1552 - 1559
ROBERTS, M: "The regenerative dialysis (REDY) sorbent system", NEPHROLOGY, vol. 4, 1998, pages 275 - 278

Cited By (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9289165B2 (en) 2005-02-07 2016-03-22 Medtronic, Inc. Ion imbalance detector
US9943633B2 (en) 2009-09-30 2018-04-17 Medtronic Inc. System and method to regulate ultrafiltration
US9968721B2 (en) 2011-04-29 2018-05-15 Medtronic, Inc. Monitoring fluid volume for patients with renal disease
US10179198B2 (en) 2011-04-29 2019-01-15 Medtronic, Inc. Electrolyte and pH monitoring for fluid removal processes
US9456755B2 (en) 2011-04-29 2016-10-04 Medtronic, Inc. Method and device to monitor patients with kidney disease
US10506933B2 (en) 2011-04-29 2019-12-17 Medtronic, Inc. Method and device to monitor patients with kidney disease
US9597440B2 (en) 2011-04-29 2017-03-21 Medtronic, Inc. Fluid volume monitoring for patients with renal disease
US9642960B2 (en) 2011-04-29 2017-05-09 Medtronic, Inc. Monitoring fluid volume for patients with renal disease
US10064985B2 (en) 2011-04-29 2018-09-04 Medtronic, Inc. Precision blood fluid removal therapy based on patient monitoring
US9700661B2 (en) 2011-04-29 2017-07-11 Medtronic, Inc. Chronic pH or electrolyte monitoring
US10293092B2 (en) 2011-04-29 2019-05-21 Medtronic, Inc. Electrolyte and pH monitoring for fluid removal processes
US10835656B2 (en) 2011-04-29 2020-11-17 Medtronic, Inc. Method and device to monitor patients with kidney disease
US9302036B2 (en) 2011-04-29 2016-04-05 Medtronic, Inc. Blood fluid removal system performance monitoring
US11759557B2 (en) 2011-04-29 2023-09-19 Mozarc Medical Us Llc Adaptive system for blood fluid removal
US8951219B2 (en) 2011-04-29 2015-02-10 Medtronic, Inc. Fluid volume monitoring for patients with renal disease
US9848778B2 (en) 2011-04-29 2017-12-26 Medtronic, Inc. Method and device to monitor patients with kidney disease
US10406268B2 (en) 2011-04-29 2019-09-10 Medtronic, Inc. Blood fluid removal system performance monitoring
US10967112B2 (en) 2011-04-29 2021-04-06 Medtronic, Inc. Adaptive system for blood fluid removal
US9750862B2 (en) 2011-04-29 2017-09-05 Medtronic, Inc. Adaptive system for blood fluid removal
US9192707B2 (en) 2011-04-29 2015-11-24 Medtronic, Inc. Electrolyte and pH monitoring for fluid removal processes
US10207041B2 (en) 2011-04-29 2019-02-19 Medtronic, Inc. Method and device to monitor patients with kidney disease
US10722636B2 (en) 2011-08-02 2020-07-28 Medtronic, Inc. Hemodialysis system having a flow path with a controlled compliant volume
US10695481B2 (en) 2011-08-02 2020-06-30 Medtronic, Inc. Hemodialysis system having a flow path with a controlled compliant volume
US10857277B2 (en) 2011-08-16 2020-12-08 Medtronic, Inc. Modular hemodialysis system
US9713668B2 (en) 2012-01-04 2017-07-25 Medtronic, Inc. Multi-staged filtration system for blood fluid removal
US10905816B2 (en) 2012-12-10 2021-02-02 Medtronic, Inc. Sodium management system for hemodialysis
US11857712B2 (en) 2013-01-09 2024-01-02 Mozarc Medical Us Llc Recirculating dialysate fluid circuit for measurement of blood solute species
US10881777B2 (en) 2013-01-09 2021-01-05 Medtronic, Inc. Recirculating dialysate fluid circuit for blood measurement
US11154648B2 (en) 2013-01-09 2021-10-26 Medtronic, Inc. Fluid circuits for sorbent cartridge with sensors
US11565029B2 (en) 2013-01-09 2023-01-31 Medtronic, Inc. Sorbent cartridge with electrodes
US9707328B2 (en) 2013-01-09 2017-07-18 Medtronic, Inc. Sorbent cartridge to measure solute concentrations
US12161788B2 (en) 2013-01-09 2024-12-10 Mozarc Medical Us Llc Fluid circuits for sorbent cartridges with sensors
US10532142B2 (en) 2013-01-09 2020-01-14 Medtronic, Inc. Sorbent cartridge to measure solute concentrations
US10850016B2 (en) 2013-02-01 2020-12-01 Medtronic, Inc. Modular fluid therapy system having jumpered flow paths and systems and methods for cleaning and disinfection
US10010663B2 (en) 2013-02-01 2018-07-03 Medtronic, Inc. Fluid circuit for delivery of renal replacement therapies
US10561776B2 (en) 2013-02-01 2020-02-18 Medtronic, Inc. Fluid circuit for delivery of renal replacement therapies
US11786645B2 (en) 2013-02-01 2023-10-17 Mozarc Medical Us Llc Fluid circuit for delivery of renal replacement therapies
US9526822B2 (en) 2013-02-01 2016-12-27 Medtronic, Inc. Sodium and buffer source cartridges for use in a modular controlled compliant flow path
US10532141B2 (en) 2013-02-01 2020-01-14 Medtronic, Inc. Systems and methods for multifunctional volumetric fluid control
US9872949B2 (en) 2013-02-01 2018-01-23 Medtronic, Inc. Systems and methods for multifunctional volumetric fluid control
US10543052B2 (en) 2013-02-01 2020-01-28 Medtronic, Inc. Portable dialysis cabinet
US9855379B2 (en) 2013-02-02 2018-01-02 Medtronic, Inc. Sorbent cartridge configurations for improved dialysate regeneration
US9827361B2 (en) 2013-02-02 2017-11-28 Medtronic, Inc. pH buffer measurement system for hemodialysis systems
US10076283B2 (en) 2013-11-04 2018-09-18 Medtronic, Inc. Method and device to manage fluid volumes in the body
US11064894B2 (en) 2013-11-04 2021-07-20 Medtronic, Inc. Method and device to manage fluid volumes in the body
US11219880B2 (en) 2013-11-26 2022-01-11 Medtronic, Inc System for precision recharging of sorbent materials using patient and session data
US10478545B2 (en) 2013-11-26 2019-11-19 Medtronic, Inc. Parallel modules for in-line recharging of sorbents using alternate duty cycles
US11471100B2 (en) 2013-11-27 2022-10-18 Medtronic, Inc. Precision dialysis monitoring and synchonization system
US11471099B2 (en) 2013-11-27 2022-10-18 Medtronic, Inc. Precision dialysis monitoring and synchronization system
US10617349B2 (en) 2013-11-27 2020-04-14 Medtronic, Inc. Precision dialysis monitoring and synchronization system
US10595775B2 (en) 2013-11-27 2020-03-24 Medtronic, Inc. Precision dialysis monitoring and synchronization system
JP2017516572A (ja) * 2014-05-29 2017-06-22 フレセニウス メディカル ケア ホールディングス インコーポレーテッド 透析液を処理する方法、透析システム及び透析システムを用いて治療するための透析患者を事前評価する方法
US11045790B2 (en) 2014-06-24 2021-06-29 Medtronic, Inc. Stacked sorbent assembly
US11673118B2 (en) 2014-06-24 2023-06-13 Mozarc Medical Us Llc Stacked sorbent assembly
US10926017B2 (en) 2014-06-24 2021-02-23 Medtronic, Inc. Modular dialysate regeneration assembly
US9713665B2 (en) 2014-12-10 2017-07-25 Medtronic, Inc. Degassing system for dialysis
US9895479B2 (en) 2014-12-10 2018-02-20 Medtronic, Inc. Water management system for use in dialysis
US10874787B2 (en) 2014-12-10 2020-12-29 Medtronic, Inc. Degassing system for dialysis
US10098993B2 (en) 2014-12-10 2018-10-16 Medtronic, Inc. Sensing and storage system for fluid balance
US10420872B2 (en) 2014-12-10 2019-09-24 Medtronic, Inc. Degassing system for dialysis
US11395868B2 (en) 2015-11-06 2022-07-26 Medtronic, Inc. Dialysis prescription optimization for decreased arrhythmias
US12329892B2 (en) 2016-04-04 2025-06-17 Mozarc Medical Us Llc Dextrose concentration sensor for a peritoneal dialysis system
US10994064B2 (en) 2016-08-10 2021-05-04 Medtronic, Inc. Peritoneal dialysate flow path sensing
US12194214B2 (en) 2016-08-10 2025-01-14 Mozarc Medical Us Llc Peritoneal dialysate flow path sensing
US11883576B2 (en) 2016-08-10 2024-01-30 Mozarc Medical Us Llc Peritoneal dialysis intracycle osmotic agent adjustment
US11013843B2 (en) 2016-09-09 2021-05-25 Medtronic, Inc. Peritoneal dialysis fluid testing system
US11679186B2 (en) 2016-09-09 2023-06-20 Mozarc Medical Us Llc Peritoneal dialysis fluid testing system
US11642654B2 (en) 2016-11-29 2023-05-09 Medtronic, Inc Zirconium oxide module conditioning
US10981148B2 (en) 2016-11-29 2021-04-20 Medtronic, Inc. Zirconium oxide module conditioning
US11883794B2 (en) 2017-06-15 2024-01-30 Mozarc Medical Us Llc Zirconium phosphate disinfection recharging and conditioning
US11278654B2 (en) 2017-12-07 2022-03-22 Medtronic, Inc. Pneumatic manifold for a dialysis system
US11033667B2 (en) 2018-02-02 2021-06-15 Medtronic, Inc. Sorbent manifold for a dialysis system
US12472292B2 (en) 2018-02-02 2025-11-18 Mozarc Medical Us Llc Sorbent manifold for a dialysis system
US11110215B2 (en) 2018-02-23 2021-09-07 Medtronic, Inc. Degasser and vent manifolds for dialysis
US12285552B2 (en) 2018-08-14 2025-04-29 Mozarc Medical Us Llc Precision dialysis therapy based on sorbent effluent analysis
US11213616B2 (en) 2018-08-24 2022-01-04 Medtronic, Inc. Recharge solution for zirconium phosphate
US11806457B2 (en) 2018-11-16 2023-11-07 Mozarc Medical Us Llc Peritoneal dialysis adequacy meaurements
US11806456B2 (en) 2018-12-10 2023-11-07 Mozarc Medical Us Llc Precision peritoneal dialysis therapy based on dialysis adequacy measurements
US12433976B2 (en) 2019-01-08 2025-10-07 Mozarc Medical Us Llc Bicarbonate sensor for dialysis
US12128165B2 (en) 2020-04-27 2024-10-29 Mozarc Medical Us Llc Dual stage degasser
US12397093B2 (en) 2021-05-18 2025-08-26 Mozarc Medical Us Llc Sorbent cartridge designs
US12154673B2 (en) 2021-08-02 2024-11-26 Mozarc Medical Us Llc Artificial intelligence assisted home therapy settings for dialysis
US11850344B2 (en) 2021-08-11 2023-12-26 Mozarc Medical Us Llc Gas bubble sensor
US11965763B2 (en) 2021-11-12 2024-04-23 Mozarc Medical Us Llc Determining fluid flow across rotary pump
US11944733B2 (en) 2021-11-18 2024-04-02 Mozarc Medical Us Llc Sodium and bicarbonate control

Also Published As

Publication number Publication date
US20150352269A1 (en) 2015-12-10
CN103717243A (zh) 2014-04-09
WO2012148787A1 (en) 2012-11-01
CN103747819B (zh) 2016-06-01
WO2012148785A2 (en) 2012-11-01
JP2014518692A (ja) 2014-08-07
EP2701765A2 (en) 2014-03-05
US20120277604A1 (en) 2012-11-01
WO2012148791A1 (en) 2012-11-01
WO2013101292A2 (en) 2013-07-04
CN105286787B (zh) 2017-10-31
EP2701595A1 (en) 2014-03-05
CN105169509A (zh) 2015-12-23
US11759557B2 (en) 2023-09-19
US8926542B2 (en) 2015-01-06
JP2014518688A (ja) 2014-08-07
JP2017164547A (ja) 2017-09-21
US10293092B2 (en) 2019-05-21
CN103717132B (zh) 2015-08-12
CN103747731B (zh) 2016-08-17
EP3527134A1 (en) 2019-08-21
US9192707B2 (en) 2015-11-24
US9561316B2 (en) 2017-02-07
US20210008265A1 (en) 2021-01-14
CN106063701A (zh) 2016-11-02
CN103747731A (zh) 2014-04-23
US9750862B2 (en) 2017-09-05
CN105286787A (zh) 2016-02-03
US20160206801A1 (en) 2016-07-21
US20120277722A1 (en) 2012-11-01
CN103747817A (zh) 2014-04-23
CN103717244A (zh) 2014-04-09
JP5841238B2 (ja) 2016-01-13
EP2701596A1 (en) 2014-03-05
EP2701761A1 (en) 2014-03-05
JP2018008091A (ja) 2018-01-18
US20120273420A1 (en) 2012-11-01
CN103747817B (zh) 2016-10-12
US20120277552A1 (en) 2012-11-01
CN103747819A (zh) 2014-04-23
JP6138762B2 (ja) 2017-05-31
EP2701764A1 (en) 2014-03-05
CN103717132A (zh) 2014-04-09
ES2785107T3 (es) 2020-10-05
EP2701759A2 (en) 2014-03-05
EP2701764B1 (en) 2021-08-11
WO2012148788A1 (en) 2012-11-01
US10064985B2 (en) 2018-09-04
EP2701595B1 (en) 2016-06-01
US9700661B2 (en) 2017-07-11
CN103717243B (zh) 2015-06-17
EP2701760B1 (en) 2020-02-26
JP2014518691A (ja) 2014-08-07
US9642960B2 (en) 2017-05-09
US20120273415A1 (en) 2012-11-01
EP3932444A1 (en) 2022-01-05
WO2012148785A3 (en) 2013-01-31
JP2017176847A (ja) 2017-10-05
JP2014518689A (ja) 2014-08-07
EP2701596B1 (en) 2019-09-25
CN103717244B (zh) 2016-06-08
US20170100529A1 (en) 2017-04-13
US10179198B2 (en) 2019-01-15
JP5837679B2 (ja) 2015-12-24
US20150080682A1 (en) 2015-03-19
CN103747816A (zh) 2014-04-23
US10967112B2 (en) 2021-04-06
US8951219B2 (en) 2015-02-10
JP6153923B2 (ja) 2017-06-28
JP2015134176A (ja) 2015-07-27
EP2701765B1 (en) 2018-09-05
JP2014518687A (ja) 2014-08-07
CN103747816B (zh) 2017-01-18
US9968721B2 (en) 2018-05-15
US10406268B2 (en) 2019-09-10
US20170361006A1 (en) 2017-12-21
US20120277551A1 (en) 2012-11-01
CN105169509B (zh) 2018-05-29
US20120277650A1 (en) 2012-11-01
WO2012148790A1 (en) 2012-11-01
US9061099B2 (en) 2015-06-23
US9302036B2 (en) 2016-04-05
JP5705373B2 (ja) 2015-04-22
EP2701766A1 (en) 2014-03-05
US9597440B2 (en) 2017-03-21
JP2019150651A (ja) 2019-09-12
US20150088047A1 (en) 2015-03-26
EP2701760A1 (en) 2014-03-05
US20150367054A1 (en) 2015-12-24
US20120277655A1 (en) 2012-11-01
WO2013101292A3 (en) 2013-10-03
EP2701761B1 (en) 2019-03-06
WO2012148789A1 (en) 2012-11-01
US20150151033A1 (en) 2015-06-04
JP2014518690A (ja) 2014-08-07

Similar Documents

Publication Publication Date Title
US10293092B2 (en) Electrolyte and pH monitoring for fluid removal processes
EP3302606B1 (en) Apparatus for extracorporeal blood treatment ii
EP3302605B1 (en) Apparatus for extracorporeal blood treatment i
US12128164B2 (en) Apparatus for performing an extracorporeal blood treatment
EP2377563A1 (en) Dialysis apparatus and method for controlling a dialysis apparatus
WO2012148781A1 (en) Multimodal dialysis system
US20170304516A1 (en) Dialysate potassium control during a dialysis session
EP3544651B1 (en) Apparatus for extracorporeal blood treatment
CA2574529C (en) Dialysis machine with arterial pressure monitoring by measuring oxygen saturation
EP3427773A1 (en) Dialysate potassium control during a dialysis session

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12722951

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2014508435

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2012722951

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: DE