WO2011091390A3 - Traitement de maladies liées à la rnase h1 par l'inhibition du produit de transcription naturel antisens de la rnase h1 - Google Patents
Traitement de maladies liées à la rnase h1 par l'inhibition du produit de transcription naturel antisens de la rnase h1 Download PDFInfo
- Publication number
- WO2011091390A3 WO2011091390A3 PCT/US2011/022304 US2011022304W WO2011091390A3 WO 2011091390 A3 WO2011091390 A3 WO 2011091390A3 US 2011022304 W US2011022304 W US 2011022304W WO 2011091390 A3 WO2011091390 A3 WO 2011091390A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- rnase
- inhibition
- treatment
- related diseases
- natural antisense
- Prior art date
Links
- 108020005544 Antisense RNA Proteins 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 108020000948 Antisense Oligonucleotides Proteins 0.000 abstract 2
- 102100025290 Ribonuclease H1 Human genes 0.000 abstract 2
- 239000000074 antisense oligonucleotide Substances 0.000 abstract 2
- 238000012230 antisense oligonucleotides Methods 0.000 abstract 2
- 108010052833 ribonuclease HI Proteins 0.000 abstract 2
- 230000000692 anti-sense effect Effects 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
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- C—CHEMISTRY; METALLURGY
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020127018234A KR101853510B1 (ko) | 2010-01-25 | 2011-01-25 | Rnase h1에 대한 천연 안티센스 전사체의 억제에 의한 rnase h1과 관련된 질환의 치료 |
JP2012550201A JP5981850B2 (ja) | 2010-01-25 | 2011-01-25 | RNaseH1に対する天然アンチセンス転写物の阻害によるRNaseH1関連疾患の治療 |
EP11735332.6A EP2529015B1 (fr) | 2010-01-25 | 2011-01-25 | Traitement de maladies liées à la rnase h1 par l'inhibition du produit de transcription naturel antisens de la rnase h1 |
NO11735332A NO2529015T3 (fr) | 2010-01-25 | 2011-01-25 | |
ES11735332.6T ES2671877T3 (es) | 2010-01-25 | 2011-01-25 | Tratamiento de enfermedades relacionadas con la RNASA (H1) mediante inhibición del transcrito antisentido natural a RNASA H1 |
US13/575,206 US8946182B2 (en) | 2010-01-25 | 2011-01-25 | Treatment of RNASE H1 related diseases by inhibition of natural antisense transcript to RNASE H1 |
RU2012127702A RU2611192C2 (ru) | 2010-01-25 | 2011-01-25 | ЛЕЧЕНИЕ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С РНКазой Н1, ПУТЕМ ИНГИБИРОВАНИЯ ПРИРОДНОГО АНТИСМЫСЛОВОГО ТРАНСКРИПТА К РНКазе Н1 |
CA2786568A CA2786568A1 (fr) | 2010-01-25 | 2011-01-25 | Traitement de maladies liees a la rnase h1 par l'inhibition du produit de transcription naturel antisens de la rnase h1 |
CN2011800062572A CN102782135A (zh) | 2010-01-25 | 2011-01-25 | 通过抑制rna酶h1的天然反义转录物而治疗rna酶h1相关疾病 |
DK11735332.6T DK2529015T3 (en) | 2010-01-25 | 2011-01-25 | TREATMENT OF RNASE H1-RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO RNASE H1 |
US14/573,326 US9745582B2 (en) | 2010-01-25 | 2014-12-17 | Treatment of RNASE H1 related diseases by inhibition of natural antisense transcript to RNASE H1 |
US15/684,234 US10337013B2 (en) | 2010-01-25 | 2017-08-23 | Treatment of RNASE H1 related diseases by inhibition of natural antisense transcript to RNASE H1 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29787810P | 2010-01-25 | 2010-01-25 | |
US61/297,878 | 2010-01-25 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/575,206 A-371-Of-International US8946182B2 (en) | 2010-01-25 | 2011-01-25 | Treatment of RNASE H1 related diseases by inhibition of natural antisense transcript to RNASE H1 |
US14/573,326 Division US9745582B2 (en) | 2010-01-25 | 2014-12-17 | Treatment of RNASE H1 related diseases by inhibition of natural antisense transcript to RNASE H1 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011091390A2 WO2011091390A2 (fr) | 2011-07-28 |
WO2011091390A3 true WO2011091390A3 (fr) | 2011-12-29 |
Family
ID=44307656
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2011/022304 WO2011091390A2 (fr) | 2010-01-25 | 2011-01-25 | Traitement de maladies liées à la rnase h1 par l'inhibition du produit de transcription naturel antisens de la rnase h1 |
Country Status (11)
Country | Link |
---|---|
US (3) | US8946182B2 (fr) |
EP (1) | EP2529015B1 (fr) |
JP (1) | JP5981850B2 (fr) |
KR (1) | KR101853510B1 (fr) |
CN (1) | CN102782135A (fr) |
CA (1) | CA2786568A1 (fr) |
DK (1) | DK2529015T3 (fr) |
ES (1) | ES2671877T3 (fr) |
NO (1) | NO2529015T3 (fr) |
RU (1) | RU2611192C2 (fr) |
WO (1) | WO2011091390A2 (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5982288B2 (ja) * | 2009-12-29 | 2016-08-31 | カッパーアールエヌエー,インコーポレイテッド | 腫瘍タンパク質63(p63)に対する天然アンチセンス転写物の阻害による腫瘍タンパク質63関連疾患の治療 |
KR101838308B1 (ko) * | 2010-02-22 | 2018-03-13 | 큐알엔에이, 인크. | 피롤린-5-카르복실레이트 환원효소 1(pycr1)에 대한 천연 안티센스 전사체의 억제에 의한 pycr1과 관련된 질환의 치료 |
US9920317B2 (en) | 2010-11-12 | 2018-03-20 | The General Hospital Corporation | Polycomb-associated non-coding RNAs |
EP3260540A1 (fr) | 2010-11-12 | 2017-12-27 | The General Hospital Corporation | Arn non codants associés à polycomb |
EA201492121A1 (ru) | 2012-05-16 | 2015-10-30 | Рана Терапьютикс, Инк. | Композиции и способы для модулирования экспрессии семейства генов гемоглобина |
SG11201407483YA (en) | 2012-05-16 | 2014-12-30 | Rana Therapeutics Inc | Compositions and methods for modulating smn gene family expression |
WO2013173645A1 (fr) | 2012-05-16 | 2013-11-21 | Rana Therapeutics, Inc. | Compositions et méthodes pour moduler l'expression de utrn |
EA201492116A1 (ru) | 2012-05-16 | 2015-05-29 | Рана Терапьютикс, Инк. | Композиции и способы для модулирования экспрессии mecp2 |
US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
CA2873766A1 (fr) | 2012-05-16 | 2013-11-21 | Rana Therapeutics Inc. | Compositions et methodes pour moduler l'expression de atp2a2 |
DK2850189T3 (en) | 2012-05-16 | 2019-02-25 | Translate Bio Ma Inc | COMPOSITIONS AND PROCEDURES FOR MODULATING GENEPRESSION |
US10174328B2 (en) | 2013-10-04 | 2019-01-08 | Translate Bio Ma, Inc. | Compositions and methods for treating amyotrophic lateral sclerosis |
CA2966044A1 (fr) | 2014-10-30 | 2016-05-06 | The General Hospital Corporation | Procedes de modulation de la repression genique dependant d'atrx |
US10900036B2 (en) | 2015-03-17 | 2021-01-26 | The General Hospital Corporation | RNA interactome of polycomb repressive complex 1 (PRC1) |
JP7130639B2 (ja) | 2016-11-01 | 2022-09-05 | ザ・リサーチ・ファウンデーション・フォー・ザ・ステイト・ユニヴァーシティ・オブ・ニューヨーク | 5-ハロウラシル修飾マイクロrna及びがんの処置におけるその使用 |
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WO2008095192A2 (fr) * | 2007-02-01 | 2008-08-07 | Genesegues, Inc. | Blocage de gène par poly(nucléotides) monobrins |
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- 2011-01-25 DK DK11735332.6T patent/DK2529015T3/en active
- 2011-01-25 ES ES11735332.6T patent/ES2671877T3/es active Active
- 2011-01-25 RU RU2012127702A patent/RU2611192C2/ru not_active IP Right Cessation
- 2011-01-25 CA CA2786568A patent/CA2786568A1/fr not_active Abandoned
- 2011-01-25 EP EP11735332.6A patent/EP2529015B1/fr not_active Not-in-force
- 2011-01-25 NO NO11735332A patent/NO2529015T3/no unknown
- 2011-01-25 WO PCT/US2011/022304 patent/WO2011091390A2/fr active Application Filing
- 2011-01-25 KR KR1020127018234A patent/KR101853510B1/ko active IP Right Grant
- 2011-01-25 US US13/575,206 patent/US8946182B2/en not_active Expired - Fee Related
- 2011-01-25 JP JP2012550201A patent/JP5981850B2/ja not_active Expired - Fee Related
-
2014
- 2014-12-17 US US14/573,326 patent/US9745582B2/en not_active Expired - Fee Related
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Also Published As
Publication number | Publication date |
---|---|
ES2671877T3 (es) | 2018-06-11 |
WO2011091390A2 (fr) | 2011-07-28 |
JP5981850B2 (ja) | 2016-08-31 |
US20120295959A1 (en) | 2012-11-22 |
JP2013517778A (ja) | 2013-05-20 |
US10337013B2 (en) | 2019-07-02 |
US9745582B2 (en) | 2017-08-29 |
CA2786568A1 (fr) | 2011-07-28 |
NO2529015T3 (fr) | 2018-04-14 |
US20150133525A1 (en) | 2015-05-14 |
RU2012127702A (ru) | 2014-03-10 |
DK2529015T3 (en) | 2018-02-26 |
US8946182B2 (en) | 2015-02-03 |
RU2611192C2 (ru) | 2017-02-21 |
KR20120113755A (ko) | 2012-10-15 |
EP2529015B1 (fr) | 2017-11-15 |
US20170355996A1 (en) | 2017-12-14 |
EP2529015A4 (fr) | 2014-10-01 |
EP2529015A2 (fr) | 2012-12-05 |
KR101853510B1 (ko) | 2018-06-20 |
CN102782135A (zh) | 2012-11-14 |
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