BR9911596A - Nucleosìdeos tendo porção açúcar bicìclico - Google Patents

Nucleosìdeos tendo porção açúcar bicìclico

Info

Publication number
BR9911596A
BR9911596A BR9911596-4A BR9911596A BR9911596A BR 9911596 A BR9911596 A BR 9911596A BR 9911596 A BR9911596 A BR 9911596A BR 9911596 A BR9911596 A BR 9911596A
Authority
BR
Brazil
Prior art keywords
nucleosides
bicyclic sugar
sugar portion
compounds
linker
Prior art date
Application number
BR9911596-4A
Other languages
English (en)
Inventor
Guangyi Wang
Original Assignee
Icn Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icn Pharmaceuticals filed Critical Icn Pharmaceuticals
Publication of BR9911596A publication Critical patent/BR9911596A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Patente de Invenção: <B>"NUCLEOSìDEOS TENDO PORçãO AçúCAR BICìCLICO"<D>. Análogos nucleosídeos de ponte 2',4' conformacionalmente restritos são aqui descritos. Os compostos podem ser preparados por ciclização em C2' e C4' de nucleosídeos através de um ligador ou molécula ligante. Estes novos nucleosídeos têm um desejado franzido de açúcar fechado e são potencialmente úteis como ingredientes farmacêuticos. Oligonucleotídios compostos por estes novos nucleosídeos são úteis para compostos oligonucleotídios terapêuticos e diagnósticos.
BR9911596-4A 1998-05-26 1999-05-24 Nucleosìdeos tendo porção açúcar bicìclico BR9911596A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8671998P 1998-05-26 1998-05-26
PCT/US1999/011442 WO1999060855A1 (en) 1998-05-26 1999-05-24 Novel nucleosides having bicyclic sugar moiety

Publications (1)

Publication Number Publication Date
BR9911596A true BR9911596A (pt) 2001-10-02

Family

ID=22200439

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9911596-4A BR9911596A (pt) 1998-05-26 1999-05-24 Nucleosìdeos tendo porção açúcar bicìclico

Country Status (21)

Country Link
US (1) US6403566B1 (pt)
EP (1) EP1082012A4 (pt)
JP (1) JP2002516256A (pt)
CN (1) CN1311630A (pt)
AU (1) AU757724B2 (pt)
BR (1) BR9911596A (pt)
CA (1) CA2333380A1 (pt)
HR (1) HRP20000751A2 (pt)
HU (1) HUP0102152A3 (pt)
IL (1) IL139420A0 (pt)
MX (1) MXPA00011473A (pt)
NO (1) NO20005938L (pt)
NZ (1) NZ507913A (pt)
PL (1) PL344303A1 (pt)
RU (1) RU2211223C2 (pt)
SI (1) SI20474A (pt)
SK (1) SK17432000A3 (pt)
UA (1) UA61997C2 (pt)
WO (1) WO1999060855A1 (pt)
YU (1) YU73600A (pt)
ZA (1) ZA200006315B (pt)

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CA2333380A1 (en) 1999-12-02
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AU757724B2 (en) 2003-03-06
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HUP0102152A3 (en) 2002-04-29
NO20005938D0 (no) 2000-11-24
NO20005938L (no) 2001-01-16
SK17432000A3 (sk) 2001-07-10
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HRP20000751A2 (en) 2001-12-31
ZA200006315B (en) 2002-02-04
EP1082012A1 (en) 2001-03-14
US6403566B1 (en) 2002-06-11
MXPA00011473A (es) 2002-04-24
AU4010099A (en) 1999-12-13
JP2002516256A (ja) 2002-06-04
HUP0102152A2 (hu) 2001-12-28
WO1999060855A1 (en) 1999-12-02
CN1311630A (zh) 2001-09-05
EP1082012A4 (en) 2002-01-16

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