WO2009017226A1 - 細胞のスクリーニング方法 - Google Patents
細胞のスクリーニング方法 Download PDFInfo
- Publication number
- WO2009017226A1 WO2009017226A1 PCT/JP2008/063874 JP2008063874W WO2009017226A1 WO 2009017226 A1 WO2009017226 A1 WO 2009017226A1 JP 2008063874 W JP2008063874 W JP 2008063874W WO 2009017226 A1 WO2009017226 A1 WO 2009017226A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cells
- wells
- coating layer
- substance
- target cells
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000012216 screening Methods 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 11
- 239000011247 coating layer Substances 0.000 abstract 5
- 239000000126 substance Substances 0.000 abstract 5
- 239000001963 growth medium Substances 0.000 abstract 3
- 238000009630 liquid culture Methods 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 238000002372 labelling Methods 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 238000007598 dipping method Methods 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/34—Measuring or testing with condition measuring or sensing means, e.g. colony counters
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Sustainable Development (AREA)
- Biophysics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200880101692.1A CN101861383B (zh) | 2007-08-02 | 2008-08-01 | 细胞筛选方法 |
EA201070220A EA025219B1 (ru) | 2007-08-02 | 2008-08-01 | Микролуночный чип для скрининга целевых клеток и его применение |
ES08792087T ES2570633T3 (es) | 2007-08-02 | 2008-08-01 | Método para detectar células |
US12/671,690 US9494575B2 (en) | 2007-08-02 | 2008-08-01 | Cells screening method |
AU2008283301A AU2008283301B2 (en) | 2007-08-02 | 2008-08-01 | Cells screening method |
KR1020107004417A KR101371840B1 (ko) | 2007-08-02 | 2008-08-01 | 세포 스크리닝 방법 |
EP08792087.2A EP2184345B1 (en) | 2007-08-02 | 2008-08-01 | Cell screening method |
HK10107253.5A HK1140789A1 (zh) | 2007-08-02 | 2010-07-28 | 細胞篩選方法 |
US15/285,200 US9977017B2 (en) | 2007-08-02 | 2016-10-04 | Apparatus for screening cells |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007201493A JP4148367B1 (ja) | 2007-08-02 | 2007-08-02 | 細胞のスクリーニング方法 |
JP2007-201493 | 2007-08-02 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/671,690 A-371-Of-International US9494575B2 (en) | 2007-08-02 | 2008-08-01 | Cells screening method |
US15/285,200 Division US9977017B2 (en) | 2007-08-02 | 2016-10-04 | Apparatus for screening cells |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009017226A1 true WO2009017226A1 (ja) | 2009-02-05 |
Family
ID=39787854
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/063874 WO2009017226A1 (ja) | 2007-08-02 | 2008-08-01 | 細胞のスクリーニング方法 |
Country Status (10)
Country | Link |
---|---|
US (2) | US9494575B2 (ja) |
EP (1) | EP2184345B1 (ja) |
JP (1) | JP4148367B1 (ja) |
KR (1) | KR101371840B1 (ja) |
CN (1) | CN101861383B (ja) |
AU (1) | AU2008283301B2 (ja) |
EA (2) | EA201691174A1 (ja) |
ES (1) | ES2570633T3 (ja) |
HK (1) | HK1140789A1 (ja) |
WO (1) | WO2009017226A1 (ja) |
Cited By (7)
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JP2010213649A (ja) * | 2009-03-18 | 2010-09-30 | Seiko Epson Corp | 生体試料反応容器及び生体試料反応方法 |
WO2012133572A1 (ja) | 2011-03-30 | 2012-10-04 | 国立大学法人富山大学 | 形質細胞または形質芽細胞の選択方法、目的抗原特異的な抗体の製造方法、新規モノクローナル抗体 |
JP2016536587A (ja) * | 2013-10-31 | 2016-11-24 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 中和抗体を検出するための競合リガンド結合アッセイ |
WO2019030377A1 (en) | 2017-08-11 | 2019-02-14 | Blink Biomedical Sas | CD96 BINDING AGENTS AS IMMUNOMODULATORS |
US10488321B2 (en) | 2015-03-19 | 2019-11-26 | The Board Of Trustees Of The Leland Stanford Junior University | Devices and methods for high-throughput single cell and biomolecule analysis and retrieval in a microfluidic chip |
EP3747906A1 (en) | 2016-01-11 | 2020-12-09 | Forty Seven, Inc. | Humanized, mouse or chimeric anti-cd47 monoclonal antibodies |
US11513076B2 (en) | 2016-06-15 | 2022-11-29 | Ludwig-Maximilians-Universität München | Single molecule detection or quantification using DNA nanotechnology |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0923933A (ja) * | 1995-07-13 | 1997-01-28 | Roasu Kk | パソコン用ラック等における補助テーブル |
US7776553B2 (en) | 2005-09-16 | 2010-08-17 | Presidents And Fellows Of Harvard College | Screening assays and methods |
US20130115606A1 (en) | 2010-07-07 | 2013-05-09 | The University Of British Columbia | System and method for microfluidic cell culture |
US10087408B2 (en) | 2010-07-07 | 2018-10-02 | The University Of British Columbia | System and method for microfluidic cell culture |
US9188593B2 (en) | 2010-07-16 | 2015-11-17 | The University Of British Columbia | Methods for assaying cellular binding interactions |
EP2724157B1 (en) * | 2011-06-27 | 2017-03-08 | Valneva | Method for screening cells |
JP6327734B2 (ja) * | 2012-03-07 | 2018-05-23 | 国立大学法人富山大学 | T細胞の刺激方法およびその利用 |
US20150191772A1 (en) | 2012-06-29 | 2015-07-09 | Danmarks Tekniske Universitet | Method of charging a test carrier and a test carrier |
EP2708890B1 (en) * | 2012-09-14 | 2015-11-18 | Molecular Devices (New Milton) Ltd | Method of selecting a monoclonal cell colony |
JP6293409B2 (ja) * | 2012-10-04 | 2018-03-14 | 国立大学法人富山大学 | 抗原特異的ウサギ抗体産生細胞の迅速な特定方法およびその利用 |
JP2014110785A (ja) * | 2012-11-12 | 2014-06-19 | Nagoya Univ | 生理活性物質を分泌及び/又は表面提示する細胞の1細胞スクリーニング方法及びそれに用いられるイムノチャンバー |
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PL413909A1 (pl) * | 2015-09-15 | 2017-03-27 | Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością | Sposób detekcji i selekcji komórek hybrydomalnych produkujących pożądane przeciwciała |
EP3357998A4 (en) * | 2015-09-29 | 2019-06-12 | Tokyo Ohka Kogyo Co., Ltd. | SUBSTRATE, STRUCTURE, STRUCTURE MANUFACTURING METHOD, CELL SORTING METHOD, CELL MANUFACTURING METHOD AND SECRETION MANUFACTURING METHOD |
EP3378488A4 (en) | 2015-11-18 | 2019-10-30 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR ENHANCING THE HUMORAL IMMUNE RESPONSE |
CN108885211A (zh) * | 2016-03-31 | 2018-11-23 | 古河电气工业株式会社 | 细胞收纳芯片和使用该细胞收纳芯片的筛选方法 |
US11384331B2 (en) | 2016-12-07 | 2022-07-12 | Tokyo Ohka Kogyo Co., Ltd. | Particle capture device |
CN110799654A (zh) | 2017-03-21 | 2020-02-14 | 穆韦尔斯有限公司 | 密封微孔测定法 |
JP7045924B2 (ja) | 2018-05-11 | 2022-04-01 | 東京応化工業株式会社 | 細胞捕捉用フィルター膜及びその使用 |
DE102018214872A1 (de) * | 2018-08-31 | 2020-03-05 | Genome Identification Diagnostics Gmbh | Verfahren zur in vitro Diagnose und/oder in vitro Therapieverfolgung einer Infektion und/oder Krankheit, insbesondere Infektionskrankheit, und/oder Tumorerkrankung und/oder Autoimmunerkrankung und/oder Allergie und/oder zur Impfkontrolle und/oder zum Nachweis einer Kreuzprotektivität sowie Verwendung eines Kits in einem solchen Verfahren |
CN113454457A (zh) * | 2019-02-18 | 2021-09-28 | 株式会社Nb健康研究所 | 细胞的筛选方法、核酸的制造方法、重组细胞的制造方法、目标物质的制造方法、药物组合物的制造方法及试剂 |
US11866685B2 (en) | 2019-09-27 | 2024-01-09 | University Of South Carolina | Temperature responsive device for mechanobiological manipulation |
WO2021065766A1 (ja) * | 2019-09-30 | 2021-04-08 | 東京応化工業株式会社 | 分泌物産生細胞のスクリーニング方法、及び分泌物産生細胞のスクリーニングキット |
JP2021073888A (ja) * | 2019-11-07 | 2021-05-20 | 国立大学法人富山大学 | Tcr様抗体の製造方法およびその利用 |
CN112626063B (zh) * | 2020-12-18 | 2023-07-14 | 上海药明生物技术有限公司 | 一种利用cd138+生物标志物富集小鼠浆细胞制备杂交瘤的方法及应用 |
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WO2024071374A1 (ja) * | 2022-09-30 | 2024-04-04 | 富士フイルム株式会社 | 目的物質を産生する細胞のスクリーニング方法、核酸の製造方法、及び、目的物質の製造方法 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0621509A (ja) | 1992-07-06 | 1994-01-28 | Fujitsu Ltd | ポーラスシリコンの製造方法 |
WO2003035824A1 (en) * | 2001-10-25 | 2003-05-01 | Bar-Ilan University | Interactive transparent individual cells biochip processor |
WO2004041061A2 (en) * | 2002-05-22 | 2004-05-21 | Platypus Technologies, Llc | Substrates, devices, and methods for cellular assays |
JP2004173681A (ja) | 2002-11-14 | 2004-06-24 | Atsushi Muraguchi | 抗原特異的リンパ球検出用マイクロウェルアレイチップ、抗原特異的リンパ球の検出法及び製造方法 |
JP2004187676A (ja) | 2002-11-29 | 2004-07-08 | Atsushi Muraguchi | 抗原特異的リンパ球抗原受容体遺伝子のクローニング方法 |
WO2004087911A1 (ja) | 2003-03-28 | 2004-10-14 | Toyama New Industry Organization | 1個の抗原特異的bリンパ球を用いた抗原特異的抗体産生ハイブリドーマの作製方法及びモノクローナル抗体の製造方法 |
WO2005031349A2 (en) * | 2003-09-22 | 2005-04-07 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4529712A (en) * | 1981-09-18 | 1985-07-16 | Research Corporation | Coated cells and their use |
US5272081A (en) | 1982-05-10 | 1993-12-21 | Bar-Ilan University | System and methods for cell selection |
US5310674A (en) | 1982-05-10 | 1994-05-10 | Bar-Ilan University | Apertured cell carrier |
IL68507A (en) | 1982-05-10 | 1986-01-31 | Univ Bar Ilan | System and methods for cell selection |
EP0258565A3 (en) | 1986-07-02 | 1989-05-24 | E.I. Du Pont De Nemours And Company | Location identifying means |
JPH05240869A (ja) | 1992-02-28 | 1993-09-21 | Suzuki Motor Corp | 血液等の凝集パターン出力装置 |
US6410252B1 (en) | 1995-12-22 | 2002-06-25 | Case Western Reserve University | Methods for measuring T cell cytokines |
PT937251E (pt) | 1996-09-06 | 2007-01-31 | Ortho Mcneil Pharm Inc | Purificação de células específicas de antigénio |
US6156389A (en) | 1997-02-03 | 2000-12-05 | Cytonix Corporation | Hydrophobic coating compositions, articles coated with said compositions, and processes for manufacturing same |
US6548263B1 (en) | 1997-05-29 | 2003-04-15 | Cellomics, Inc. | Miniaturized cell array methods and apparatus for cell-based screening |
US6232066B1 (en) | 1997-12-19 | 2001-05-15 | Neogen, Inc. | High throughput assay system |
US6565813B1 (en) | 1998-02-04 | 2003-05-20 | Merck & Co., Inc. | Virtual wells for use in high throughput screening assays |
US6210910B1 (en) | 1998-03-02 | 2001-04-03 | Trustees Of Tufts College | Optical fiber biosensor array comprising cell populations confined to microcavities |
US6087103A (en) | 1998-03-04 | 2000-07-11 | Lifespan Biosciences, Inc. | Tagged ligand arrays for identifying target-ligand interactions |
US6197575B1 (en) | 1998-03-18 | 2001-03-06 | Massachusetts Institute Of Technology | Vascularized perfused microtissue/micro-organ arrays |
US20030027214A1 (en) | 1999-02-17 | 2003-02-06 | Kamb Carl Alexander | Methods for substrate-ligand interaction screening |
US7148058B2 (en) * | 2000-06-05 | 2006-12-12 | Chiron Corporation | Protein microarrays on mirrored surfaces for performing proteomic analyses |
DE10042947A1 (de) | 2000-08-31 | 2002-03-21 | Osram Opto Semiconductors Gmbh | Strahlungsemittierendes Halbleiterbauelement auf GaN-Basis |
US6734000B2 (en) | 2000-10-12 | 2004-05-11 | Regents Of The University Of California | Nanoporous silicon support containing macropores for use as a bioreactor |
US7211209B2 (en) | 2000-11-08 | 2007-05-01 | Surface Logix, Inc. | Method of making device for arraying biomolecules and for monitoring cell motility in real-time |
KR20020086625A (ko) | 2001-01-09 | 2002-11-18 | 마쯔시다덴기산교 가부시키가이샤 | 세포외 전위 측정용 디바이스, 그것을 사용한 세포외 전위측정 방법 및 그것을 구비한 고속 약품 스크리닝 장치 |
CN2478109Y (zh) * | 2001-03-09 | 2002-02-20 | 赵翀 | 免疫检测板 |
US20020141906A1 (en) | 2001-03-30 | 2002-10-03 | American Type Culture Collection | Microtiter plate sealing cover with well identifiers |
JP4755368B2 (ja) | 2001-07-24 | 2011-08-24 | 株式会社セルシード | 高密度細胞アレイ用基板、製造法、及びその利用方法 |
US7169577B2 (en) | 2001-07-27 | 2007-01-30 | Surface Logix, Inc. | Cell isolation and screening device and method of using same |
JP4754746B2 (ja) | 2001-09-28 | 2011-08-24 | オリンパス株式会社 | 棒状担体およびこれを具備するシリンダー反応容器 |
AU2003250303A1 (en) | 2002-07-10 | 2004-02-02 | Siemens Aktiengesellschaft | Transmission of an emergency call message to an emergency call recipient |
DK1566635T3 (da) | 2002-11-14 | 2012-03-19 | Vivalis | Chip med array af mikrobrønde til påvisning af antigenspecifik lymfocyt, fremgangsmåde til påvisning af antigenspecifik lymfocyt og fremgangsmåde til kloning af antigenspecifik lymfocyt-antigenreceptorgen |
WO2005025749A1 (en) | 2003-09-08 | 2005-03-24 | Irm, Llc | Multi-well containers, systems, and methods of using the same |
US20050220675A1 (en) | 2003-09-19 | 2005-10-06 | Reed Mark T | High density plate filler |
JP4069171B2 (ja) * | 2003-09-25 | 2008-04-02 | 富山県 | マイクロウェルアレイチップ及びその製造方法 |
JP2005253412A (ja) * | 2004-03-15 | 2005-09-22 | Masayasu Suzuki | マイクロウェルアレイチップ、その製造方法及び被検体の活性検定方法 |
PT2360479E (pt) * | 2005-12-22 | 2014-07-10 | Baxter Healthcare Sa | Teste de activação de monócitos melhorado mais capaz de detectar contaminantes pirogénicos sem serem endotoxinas em produtos médicos |
-
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Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0621509A (ja) | 1992-07-06 | 1994-01-28 | Fujitsu Ltd | ポーラスシリコンの製造方法 |
WO2003035824A1 (en) * | 2001-10-25 | 2003-05-01 | Bar-Ilan University | Interactive transparent individual cells biochip processor |
WO2004041061A2 (en) * | 2002-05-22 | 2004-05-21 | Platypus Technologies, Llc | Substrates, devices, and methods for cellular assays |
JP2004173681A (ja) | 2002-11-14 | 2004-06-24 | Atsushi Muraguchi | 抗原特異的リンパ球検出用マイクロウェルアレイチップ、抗原特異的リンパ球の検出法及び製造方法 |
JP2004187676A (ja) | 2002-11-29 | 2004-07-08 | Atsushi Muraguchi | 抗原特異的リンパ球抗原受容体遺伝子のクローニング方法 |
WO2004087911A1 (ja) | 2003-03-28 | 2004-10-14 | Toyama New Industry Organization | 1個の抗原特異的bリンパ球を用いた抗原特異的抗体産生ハイブリドーマの作製方法及びモノクローナル抗体の製造方法 |
WO2005031349A2 (en) * | 2003-09-22 | 2005-04-07 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor |
Non-Patent Citations (9)
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010213649A (ja) * | 2009-03-18 | 2010-09-30 | Seiko Epson Corp | 生体試料反応容器及び生体試料反応方法 |
WO2012133572A1 (ja) | 2011-03-30 | 2012-10-04 | 国立大学法人富山大学 | 形質細胞または形質芽細胞の選択方法、目的抗原特異的な抗体の製造方法、新規モノクローナル抗体 |
US9487583B2 (en) | 2011-03-30 | 2016-11-08 | National University Corporation University Of Toyama | Method for selecting plasma cells or plasmablasts, method for producing target antigen specific antibodies, and novel monoclonal antibodies |
JP2016536587A (ja) * | 2013-10-31 | 2016-11-24 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 中和抗体を検出するための競合リガンド結合アッセイ |
US10261094B2 (en) | 2013-10-31 | 2019-04-16 | Regeneron Pharmaceuticals, Inc. | Competitive ligand binding assay for detecting neutralizing antibodies |
US10488321B2 (en) | 2015-03-19 | 2019-11-26 | The Board Of Trustees Of The Leland Stanford Junior University | Devices and methods for high-throughput single cell and biomolecule analysis and retrieval in a microfluidic chip |
EP3747906A1 (en) | 2016-01-11 | 2020-12-09 | Forty Seven, Inc. | Humanized, mouse or chimeric anti-cd47 monoclonal antibodies |
US11513076B2 (en) | 2016-06-15 | 2022-11-29 | Ludwig-Maximilians-Universität München | Single molecule detection or quantification using DNA nanotechnology |
WO2019030377A1 (en) | 2017-08-11 | 2019-02-14 | Blink Biomedical Sas | CD96 BINDING AGENTS AS IMMUNOMODULATORS |
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Publication number | Publication date |
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US20170023562A1 (en) | 2017-01-26 |
EA201070220A1 (ru) | 2010-12-30 |
KR20100106294A (ko) | 2010-10-01 |
EP2184345A4 (en) | 2010-10-27 |
EA201691174A1 (ru) | 2016-10-31 |
US9977017B2 (en) | 2018-05-22 |
AU2008283301B2 (en) | 2013-11-07 |
KR101371840B1 (ko) | 2014-03-07 |
HK1140789A1 (zh) | 2010-10-22 |
US9494575B2 (en) | 2016-11-15 |
US20110294678A1 (en) | 2011-12-01 |
EP2184345A1 (en) | 2010-05-12 |
JP2009034047A (ja) | 2009-02-19 |
CN101861383B (zh) | 2015-11-25 |
EA025219B1 (ru) | 2016-12-30 |
CN101861383A (zh) | 2010-10-13 |
JP4148367B1 (ja) | 2008-09-10 |
AU2008283301A1 (en) | 2009-02-05 |
ES2570633T3 (es) | 2016-05-19 |
EP2184345B1 (en) | 2016-03-23 |
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