WO2006025767A2 - Composition antimicrobienne destinee a une administration perorale - Google Patents
Composition antimicrobienne destinee a une administration perorale Download PDFInfo
- Publication number
- WO2006025767A2 WO2006025767A2 PCT/RU2005/000434 RU2005000434W WO2006025767A2 WO 2006025767 A2 WO2006025767 A2 WO 2006025767A2 RU 2005000434 W RU2005000434 W RU 2005000434W WO 2006025767 A2 WO2006025767 A2 WO 2006025767A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- lactulose
- antimicrobial composition
- composition
- composition according
- antibiotic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Definitions
- Antimicrobial composition for oral administration is provided.
- the invention relates to the field of medicine and the pharmaceutical industry and relates to antibiotic formulations.
- C. difficile is considered as one of the most important etiological factors in the development of diarrhea and colitis, but they can also be caused by other microbes, such as Salmopella spr., ⁇ lostridium refrippy type A, Starhulosossus aureus and, possibly, fungi of the genus ⁇ réelle ⁇ Playassiiller.
- C. difficile does not guarantee intestinal sanitation from spores of clostridia, in connection with which, as a rule, relapses appear.
- antibiotics are used in the form of various dosage forms: tablets, capsules, parenteral solutions, suppositories, syrups, etc.
- lactose and other sugars are used, as well as sugar alcohols, cellulose derivatives, starch, organic food acids or their salts, which improve the organoleptic properties of the drug (RF patent 2202340 Cl, experimental 20.04.2003, patent RF 2085190 Cl, typical .27.07.1997, RF patent 1805953 AZ, publ. 30.03.1993).
- Oral forms of antibiotics are known in the form of gel-forming compositions comprising polyethylene oxide and a hydrophilic base (RF patent 2220715 C2, publ. 04/10/2004, A61K 9/22). The creation of this composition is aimed at stabilizing the drugs during storage, but does not solve the problems of side effects of antibiotics.
- Known antimicrobial combination drug "Tetracycline with nystatin" containing tetracycline is a broad-spectrum bacteriostatic antibiotic and nystatin is an antifungal drug (Mashkovsky MD, Medicines, M., Medicine, 2001, v. 2, p. 255).
- Adding nystatin to antibiotic dosage forms prevents the development of candidiasis, but does not prevent the development of other side effects of antibiotics.
- the objective of the invention is to obtain an antibiotic preparation in the form suitable for oral administration, having high activity and storage stability and preventing the development of side effects.
- a new antimicrobial composition containing an antibiotic selected from the group: lincosamides (e.g. clindamycin), broad-spectrum penicillins (e.g. ampicillin, amoxicillin), cephalosporins (e.g. cephalexin, cefexime), tetracyclines, e.g. doxycycline, tetra macrolides (for example, erythromycin), and lactulose with a ratio of l: (1-100), and the average particle size of lactulose is 100 nm-200 microns.
- antibiotic selected from the group: lincosamides (e.g. clindamycin), broad-spectrum penicillins (e.g. ampicillin, amoxicillin), cephalosporins (e.g. cephalexin, cefexime), tetracyclines, e.g. doxycycline, tetra macrolides (for example, erythromycin), and lactulose with
- the oral form may be a syrup, suspension, powder, tablet, capsule, granules.
- Lactulose is a synthetic non-adsorbable disaccharide (4-0-bD-galactopyranosyl-D-fructose), which is an optical isomer of lactose. In nature, lactulose is found in small amounts only in breast milk.
- the lactulose molecule consists of easily digestible residues of galactose and fructose
- a person does not receive these carbohydrates, but instead receives products of their microbial fermentation, consisting mainly of lactic, acetic, propionic and butyric acids.
- the products of metabolism of putrefactive microflora mainly ammonia, dissociate into ions that are not absorbed by the colon mucosa, thereby preventing intoxication of the body.
- a decrease in pH in the colon helps to stop the decay of proteins.
- F. Retuelu discovered the bifidogenic activity of the drug and designated lactulose as a “bifidogenic agent”.
- Lactulose which is an ideal nutrient medium for bifidobacteria and lactate-producing microorganisms, modifies the composition of microflora, increasing the number of bifidobacteria and lactobacilli. In addition, there was a significant decrease in fucobacteria, clostridia, and bacteroids, which are a measure of potentially pathogenic microorganisms. Lactulose decontaminates chronic carriers of salmonella.
- Antibiotics like most medicinal substances, do not have the ability to direct tabletting, and require the introduction of excipients. Moreover, the use of wet granulation technology often leads to decomposition of drugs and a decrease in activity. Lactulose avoids the need for this stage of the tabletting process. In addition, the introduction of large quantities of excipients is not required. Lactulose itself is an excellent excipient. Another problem associated with the production of preparative forms of antibiotics is their poor organoleptic characteristics. The introduction of lactulose can improve the taste of the compositions. Antibiotics are included in the composition in conventional, therapeutically effective doses for them.
- auxiliary substances can be introduced, for example, flavors, flavors, colorants, acceptable organic acids, starch, its derivatives, PVP, microcrystalline cellulose or cellulose derivatives, mannitol, stearates, talc, and the like.
- Citric acid 1 g Strawberry flavor 1 g
- the shell includes hydroxypropyl methylcellulose, PEG 6000, titanium dioxide, taken at a ratio of 6.5: 1: 1
- Ampicillin at a dose of 350 mg / kg after 10-day oral administration caused a slight decrease in the content of bifidobacteria in the digestive tract of mice.
- Ampicillin also caused a significant (100-fold) inhibition of the growth of lactobacilli.
- the use of the composition according to example 2 prevented a decrease in the level of lactobatter. Their content by 3 Ig exceeded that in mice treated with a single antibiotic, and was even slightly higher than in the control.
- Tetracycline at a dose of 750 mg / kg after 10-day oral administration caused a decrease in the content of bifidobacteria in the large intestine.
- Example 3 The administration of an antibacterial composition containing tetracycline and lactulose in Example 3 prevented the inhibition of bifidoflora, the content of bifidobacteria and was even slightly higher than the initial level (by 2 Ig).
- the study of antimicrobial activity was carried out by the method of serial dilutions in a daily agar test culture of Starhulosossus aureus.
- 10 sterile tubes 1 ml broth was poured, 1 ml of the suspension according to Example No. 5 was added, mixed, 1 ml was transferred to a second tube, etc.
- dilutions were prepared using industrial suspension.
- Suspension of the microbial mixture was introduced into all tubes with antibiotic and control tubes, kept in an thermostat at 37 ° C for 24 hours, and tubes with a visible growth retardation were taken.
- the study showed that in the inventive mixture and in the known, similar results were obtained: the activity of 0.1-0.2 ⁇ g / ml
- the administration of lactulose does not reduce the activity of the antibiotic.
- the therapeutic effect of the drugs was also studied in a group of patients with acute intestinal infection. Ampicillin and nystatin were administered orally to patients according to the generally accepted schedule. Improvement and normalization of stool was noted on the 9-10th day of treatment. Another group of patients was prescribed the drug according to example 2. Improving the condition on day 3, improving stool on 4-5 days. A microbiological study of the composition of the intestinal microflora in the first group on the 10th day showed the presence of Escherichia (lac ⁇ ), in the patients of the second group on the 5th day the study showed negative results on the conditionally pathogenic floridid nutrient medium, meat and peptone broth. For the experiments used.
- the stability of the drugs was studied on accelerated aging models at a temperature of 37 ° C. Samples were taken every 10 days.
- control 1 an example was used without grinding lactulose.
- control 2 a drug without lactulose was used. Stability was assessed by the change in the minimum inhibitory activity against the standard Starchulosos- sauce aureus.
- the proposed oral antibacterial composition can prevent the side effects of antibiotics.
- the proposed oral compositions according to the present invention are stable, effective forms that practically do not cause side effects. Tablets, powders and capsules, as well as syrup containing the proposed pharmaceutical composition, can be widely recommended for implementation in clinical practice.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
Claims
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/661,472 US8231871B2 (en) | 2004-08-30 | 2005-08-25 | Perorally administrable antimicrobial composition |
DK05782960T DK1790357T3 (da) | 2004-08-30 | 2005-08-25 | Peroralt indgivelig antimikrobiel sammensætning |
PL05782960T PL1790357T3 (pl) | 2004-08-30 | 2005-08-25 | Kompozycja antybakteryjna do podawania doustnego |
EA200700357A EA200700357A1 (ru) | 2004-08-30 | 2005-08-25 | Антимикробная композиция для перорального введения |
EP05782960A EP1790357B1 (en) | 2004-08-30 | 2005-08-25 | Perorally administrable antimicrobial composition |
CN2005800291966A CN101031321B (zh) | 2004-08-30 | 2005-08-25 | 口服抗菌组合物 |
DE602005010280T DE602005010280D1 (de) | 2004-08-30 | 2005-08-25 | Oral verabreichbare antimikrobielle zusammensetzung |
AU2005280704A AU2005280704B2 (en) | 2004-08-30 | 2005-08-25 | Perorally administrable antimicrobial composition |
BRPI0514708-5A BRPI0514708A (pt) | 2004-08-30 | 2005-08-25 | composição antimicrobiana para administração peroral |
JP2007529762A JP5062480B2 (ja) | 2004-08-30 | 2005-08-25 | 経口投与可能な抗菌性組成物 |
CA2620919A CA2620919C (en) | 2004-08-30 | 2005-08-25 | Perorally administrable antimicrobial composition |
NZ554212A NZ554212A (en) | 2004-08-30 | 2005-08-25 | Perorally administrable antimicrobial composition comprising an antibiotic drug and lactulose particles |
MX2007002291A MX2007002291A (es) | 2004-08-30 | 2005-08-25 | Composicion antimicrobiana administrable oralmente. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2004126203 | 2004-08-30 | ||
RU2004126203/15A RU2284832C2 (ru) | 2004-08-30 | 2004-08-30 | Антимикробная композиция для перорального введения |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2006025767A2 true WO2006025767A2 (fr) | 2006-03-09 |
WO2006025767A3 WO2006025767A3 (fr) | 2006-08-17 |
WO2006025767A8 WO2006025767A8 (fr) | 2007-04-05 |
Family
ID=36000449
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/RU2005/000434 WO2006025767A2 (fr) | 2004-08-30 | 2005-08-25 | Composition antimicrobienne destinee a une administration perorale |
Country Status (21)
Country | Link |
---|---|
US (1) | US8231871B2 (ru) |
EP (1) | EP1790357B1 (ru) |
JP (1) | JP5062480B2 (ru) |
CN (1) | CN101031321B (ru) |
AT (1) | ATE410185T1 (ru) |
AU (1) | AU2005280704B2 (ru) |
BR (1) | BRPI0514708A (ru) |
CA (1) | CA2620919C (ru) |
DE (1) | DE602005010280D1 (ru) |
DK (1) | DK1790357T3 (ru) |
EA (1) | EA200700357A1 (ru) |
ES (1) | ES2314708T3 (ru) |
MX (1) | MX2007002291A (ru) |
NZ (1) | NZ554212A (ru) |
PL (1) | PL1790357T3 (ru) |
PT (1) | PT1790357E (ru) |
RU (1) | RU2284832C2 (ru) |
TR (1) | TR200703565T1 (ru) |
UA (1) | UA85608C2 (ru) |
WO (1) | WO2006025767A2 (ru) |
ZA (1) | ZA200704449B (ru) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10190153B2 (en) | 2013-05-07 | 2019-01-29 | Micronics, Inc. | Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103040773A (zh) | 2003-07-25 | 2013-04-17 | 沃纳奇尔科特有限责任公司 | 多西环素金属络合物固体剂型 |
ES2588584T3 (es) * | 2005-01-21 | 2016-11-03 | Warner Chilcott Company, Llc | Un complejo metálico de tetraciclina en una forma de dosificación sólida |
BRPI0822485A2 (pt) * | 2008-03-18 | 2015-06-16 | Aleksander Vladimirovich Dikovskiy | Composição farmacêutica para prevenção de disbiose associada com administração enteral de antibióticos. |
CN101998858A (zh) | 2008-03-18 | 2011-03-30 | 亚历山大·弗拉基米罗维奇·季科夫斯基 | 抗生素和益生元的药物组合物用于预防和治疗抗生素治疗中的微生态失调 |
CN113476472A (zh) * | 2021-07-22 | 2021-10-08 | 中国科学院烟台海岸带研究所 | 一种用于缓解肠道紊乱的益生元组合物 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1582068A (en) * | 1977-12-09 | 1980-12-31 | Morinaga Milk Industry Co Ltd | Powder composition comprising viable bifidobacteria cells containing powder and lactulose containing powder |
EP0169700B1 (en) * | 1984-07-23 | 1990-05-16 | Eli Lilly And Company | Improved pharmaceutical formulations for ceftazidime |
US4963141A (en) * | 1985-08-16 | 1990-10-16 | Alza Corporation | Dispensing system for administering beneficial agent formulation to ruminants |
JPH0614862B2 (ja) * | 1987-05-22 | 1994-03-02 | 東京田辺製薬株式会社 | ビフィドバクテリウム菌の増殖促進剤 |
JPS6483025A (en) * | 1987-09-24 | 1989-03-28 | Fujio Hayashi | Blended preparation of drug-resistant live bacterium agent for controlling intestinal function and antibacterial agent |
CA1329805C (en) * | 1988-03-18 | 1994-05-24 | Hendrikus W. Weterings | Method of preparing solid lactulose |
FI87880C (fi) * | 1990-06-27 | 1993-03-10 | Valio Meijerien | Foder som befraemjar tillvaexten och tarmfunktionen hos djur |
ATE226090T1 (de) * | 1994-04-22 | 2002-11-15 | Yamanouchi Pharma Co Ltd | Kolon-spezifisches arzneistofffreisetzungssystem |
ATE197900T1 (de) * | 1996-08-15 | 2000-12-15 | Losan Pharma Gmbh | Gut schluckbare orale arzneiform |
JPH10194975A (ja) * | 1997-01-10 | 1998-07-28 | Morinaga Milk Ind Co Ltd | 肝疾患治療剤 |
IT1297538B1 (it) * | 1997-08-01 | 1999-12-17 | Francesco Vicidomini | Enteroclisma di lattulosio/lattitolo con o senza aggiunta di neomicina per la cura della encefalopatia portosistemica acuta |
FR2769839B1 (fr) * | 1997-10-21 | 1999-12-17 | Odette Mercedes Salsarulo | Composition anhydre a base de lactulose |
US6368591B2 (en) * | 1998-05-15 | 2002-04-09 | Shanghai Sine Pharmaceutical Corporation Ltd. | Beneficial microbe composition, new protective materials for the microbes, method to prepare the same and uses thereof |
RU2131260C1 (ru) * | 1998-10-14 | 1999-06-10 | Плисов Николай Валерьевич | Препарат для лечения желудочно-кишечных заболеваний |
CN1345333A (zh) * | 1999-03-03 | 2002-04-17 | 伊莱利利公司 | 棘白菌素/糖类复合物 |
AU5108200A (en) * | 1999-06-09 | 2000-12-28 | Mochida Pharmaceutical Co., Ltd. | System for release in lower digestive tract |
-
2004
- 2004-08-30 RU RU2004126203/15A patent/RU2284832C2/ru not_active IP Right Cessation
-
2005
- 2005-08-25 CA CA2620919A patent/CA2620919C/en not_active Expired - Fee Related
- 2005-08-25 UA UAA200702431A patent/UA85608C2/ru unknown
- 2005-08-25 US US11/661,472 patent/US8231871B2/en not_active Expired - Fee Related
- 2005-08-25 WO PCT/RU2005/000434 patent/WO2006025767A2/ru active Application Filing
- 2005-08-25 BR BRPI0514708-5A patent/BRPI0514708A/pt active Search and Examination
- 2005-08-25 TR TR2007/03565T patent/TR200703565T1/xx unknown
- 2005-08-25 MX MX2007002291A patent/MX2007002291A/es active IP Right Grant
- 2005-08-25 EA EA200700357A patent/EA200700357A1/ru not_active IP Right Cessation
- 2005-08-25 AT AT05782960T patent/ATE410185T1/de active
- 2005-08-25 PL PL05782960T patent/PL1790357T3/pl unknown
- 2005-08-25 EP EP05782960A patent/EP1790357B1/en active Active
- 2005-08-25 PT PT05782960T patent/PT1790357E/pt unknown
- 2005-08-25 ES ES05782960T patent/ES2314708T3/es active Active
- 2005-08-25 NZ NZ554212A patent/NZ554212A/en not_active IP Right Cessation
- 2005-08-25 DE DE602005010280T patent/DE602005010280D1/de active Active
- 2005-08-25 JP JP2007529762A patent/JP5062480B2/ja not_active Expired - Fee Related
- 2005-08-25 CN CN2005800291966A patent/CN101031321B/zh not_active Expired - Fee Related
- 2005-08-25 DK DK05782960T patent/DK1790357T3/da active
- 2005-08-25 AU AU2005280704A patent/AU2005280704B2/en not_active Ceased
-
2007
- 2007-05-30 ZA ZA200704449A patent/ZA200704449B/xx unknown
Non-Patent Citations (1)
Title |
---|
See references of EP1790357A4 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10190153B2 (en) | 2013-05-07 | 2019-01-29 | Micronics, Inc. | Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions |
Also Published As
Publication number | Publication date |
---|---|
RU2284832C2 (ru) | 2006-10-10 |
US20070254023A1 (en) | 2007-11-01 |
EA010199B1 (ru) | 2008-06-30 |
CN101031321B (zh) | 2010-12-15 |
CN101031321A (zh) | 2007-09-05 |
WO2006025767A8 (fr) | 2007-04-05 |
BRPI0514708A (pt) | 2008-06-24 |
MX2007002291A (es) | 2008-02-12 |
TR200703565T1 (tr) | 2007-08-21 |
EP1790357A2 (en) | 2007-05-30 |
DE602005010280D1 (de) | 2008-11-20 |
RU2004126203A (ru) | 2006-02-10 |
NZ554212A (en) | 2009-08-28 |
ES2314708T3 (es) | 2009-03-16 |
EA200700357A1 (ru) | 2008-06-30 |
EP1790357B1 (en) | 2008-10-08 |
US8231871B2 (en) | 2012-07-31 |
CA2620919A1 (en) | 2006-03-09 |
DK1790357T3 (da) | 2009-02-02 |
JP5062480B2 (ja) | 2012-10-31 |
ZA200704449B (en) | 2008-08-27 |
AU2005280704A1 (en) | 2006-03-09 |
ATE410185T1 (de) | 2008-10-15 |
PT1790357E (pt) | 2008-12-31 |
AU2005280704B2 (en) | 2010-10-07 |
CA2620919C (en) | 2014-10-14 |
WO2006025767A3 (fr) | 2006-08-17 |
EP1790357A4 (en) | 2007-11-07 |
PL1790357T3 (pl) | 2009-03-31 |
JP2008511622A (ja) | 2008-04-17 |
UA85608C2 (ru) | 2009-02-10 |
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