WO1998022115A1 - Agent therapeutique contre les infections a escherichia coli enterohemorragique - Google Patents
Agent therapeutique contre les infections a escherichia coli enterohemorragique Download PDFInfo
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- WO1998022115A1 WO1998022115A1 PCT/JP1997/004254 JP9704254W WO9822115A1 WO 1998022115 A1 WO1998022115 A1 WO 1998022115A1 JP 9704254 W JP9704254 W JP 9704254W WO 9822115 A1 WO9822115 A1 WO 9822115A1
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- Prior art keywords
- therapeutic agent
- acid
- escherichia coli
- formula
- cam
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- 229960002518 gentamicin Drugs 0.000 description 1
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- 239000001087 glyceryl triacetate Substances 0.000 description 1
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- 229960005404 sulfamethoxazole Drugs 0.000 description 1
- JLKIGFTWXXRPMT-UHFFFAOYSA-N sulphamethoxazole Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 JLKIGFTWXXRPMT-UHFFFAOYSA-N 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
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- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 125000005591 trimellitate group Chemical group 0.000 description 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
- 229960001082 trimethoprim Drugs 0.000 description 1
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- 229920002554 vinyl polymer Polymers 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Definitions
- the biggest problem in treating diarrhea with verotoxin-producing pathogenic Escherichia coli is the treatment of haemolytic uremics based on beta toxins.
- haemolytic uremics based on beta toxins when considering the treatment of food poisoning caused by pathogenic Escherichia coli, it is more important to suppress the production of toxins by bacteria than to control diarrhea itself.
- the present inventors have conducted intensive studies to search for a compound that suppresses the growth of bacteria and suppresses the production of toxin toxin.As a result, certain macrolide antibiotics were found to be present at low concentrations in such concentrations. The present invention has been found to have an excellent action, and the present invention has been completed based on the findings.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Agent thérapeutique contre les infections à Escherichia coli entérohémorragique, contenant comme principe actif un composé représenté par la formule générale (I), (dans laquelle X représente un atome d'hydrogène ou un groupe hydroxyle), ou sel pharmaceutiquement acceptable dudit composé, qui peut prévenir ou traiter sans danger les maladies infectieuses dues à une Escherichia coli capable de produire une vérotoxine et un syndrome hémolytique et urémique (SHU).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU50664/98A AU5066498A (en) | 1996-11-22 | 1997-11-21 | Therapeutic agent for enterohemorrhagic escharichia coli infections |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP31166896 | 1996-11-22 | ||
JP8/311668 | 1996-11-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998022115A1 true WO1998022115A1 (fr) | 1998-05-28 |
Family
ID=18020051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1997/004254 WO1998022115A1 (fr) | 1996-11-22 | 1997-11-21 | Agent therapeutique contre les infections a escherichia coli enterohemorragique |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU5066498A (fr) |
WO (1) | WO1998022115A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003105870A1 (fr) * | 2002-06-13 | 2003-12-24 | 天藤製薬株式会社 | Inhibiteur de production de verotoxine |
-
1997
- 1997-11-21 AU AU50664/98A patent/AU5066498A/en not_active Abandoned
- 1997-11-21 WO PCT/JP1997/004254 patent/WO1998022115A1/fr active Application Filing
Non-Patent Citations (1)
Title |
---|
CHEMICAL ABSTRACTS, 124:140746, PRADO J., "In Vitro Susceptibility of Enterohemorrhagic E. Coli to Antimicrobials. Relation Between Susceptibility and Toxigenic Genotypes"; & REV. MED. CHILE, (1995), 123(9), p. 1085-1090. * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003105870A1 (fr) * | 2002-06-13 | 2003-12-24 | 天藤製薬株式会社 | Inhibiteur de production de verotoxine |
Also Published As
Publication number | Publication date |
---|---|
AU5066498A (en) | 1998-06-10 |
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