WO2005037299A1 - Verfahren zur herstellung eines lagerstabilen extraktes aus efeublättern, sowie ein nach diesem verfahren hergestellter extrakt - Google Patents
Verfahren zur herstellung eines lagerstabilen extraktes aus efeublättern, sowie ein nach diesem verfahren hergestellter extrakt Download PDFInfo
- Publication number
- WO2005037299A1 WO2005037299A1 PCT/EP2004/010093 EP2004010093W WO2005037299A1 WO 2005037299 A1 WO2005037299 A1 WO 2005037299A1 EP 2004010093 W EP2004010093 W EP 2004010093W WO 2005037299 A1 WO2005037299 A1 WO 2005037299A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- extract
- hederacoside
- hederin
- ivy
- ivy leaves
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
- B01J8/08—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with moving particles
- B01J8/085—Feeding reactive fluids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B17/00—Machines or apparatus for drying materials in loose, plastic, or fluidised form, e.g. granules, staple fibres, with progressive movement
- F26B17/10—Machines or apparatus for drying materials in loose, plastic, or fluidised form, e.g. granules, staple fibres, with progressive movement with movement performed by fluid currents, e.g. issuing from a nozzle, e.g. pneumatic, flash, vortex or entrainment dryers
- F26B17/107—Machines or apparatus for drying materials in loose, plastic, or fluidised form, e.g. granules, staple fibres, with progressive movement with movement performed by fluid currents, e.g. issuing from a nozzle, e.g. pneumatic, flash, vortex or entrainment dryers pneumatically inducing within the drying enclosure a curved flow path, e.g. circular, spiral, helical; Cyclone or Vortex dryers
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B3/00—Drying solid materials or objects by processes involving the application of heat
- F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
- F26B3/06—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour flowing through the materials or objects to be dried
- F26B3/08—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour flowing through the materials or objects to be dried so as to loosen them, e.g. to form a fluidised bed
- F26B3/092—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour flowing through the materials or objects to be dried so as to loosen them, e.g. to form a fluidised bed agitating the fluidised bed, e.g. by vibrating or pulsating
- F26B3/0926—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour flowing through the materials or objects to be dried so as to loosen them, e.g. to form a fluidised bed agitating the fluidised bed, e.g. by vibrating or pulsating by pneumatic means, e.g. spouted beds
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B3/00—Drying solid materials or objects by processes involving the application of heat
- F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
- F26B3/10—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it
- F26B3/12—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it in the form of a spray, i.e. sprayed or dispersed emulsions or suspensions
Definitions
- the present invention relates to a process for the preparation of a storage-stable extract of ivy leaves, using an extractant, wherein the extract comprises at least the ingredients hederacoside C and ⁇ -hederin.
- storage-stable in the context of the present invention means that a particular hederacoside C / ⁇ -hederin ratio in the extract, whether by the natural composition of the Extracts, whether adjusted by targeted measures, remain stable for long periods of time.
- Extracts of ivy leaves are successfully used today mainly for the treatment of respiratory diseases, as the extract shows spasmolytic, expectorant and antiobstructive effects. These effects are particularly due to the therapeutically important ingredients of the ivy leaf extracts, which belong to the class of triterpene saponins.
- the main aponin is the bis-desmosidic hederacoside C and the ⁇ -hederin resulting therefrom by ester hydrolysis. As another saponin hederagenin could be detected.
- extracts of ivy leaves can be obtained by various methods, these extracts often have different efficiencies. This is due to the fact that the content of the ingredients depends not only on the natural design of the ivy leaves, but also on the particular method of extract production.
- ⁇ -hederin in particular is responsible for the spasmolytic action of ivy leaf extracts, since this active substance binds to ⁇ -adrenergic receptors, which leads to relaxation in the smooth muscles of the bronchial systems via further cascades leads.
- a process for the preparation of dry extracts from plant materials is known for example from DE 101 12 168 AI.
- the content of lipophilic and hydrophilic substances should be able to be adjusted.
- the plant material is subjected to at least two extractions with solvents of different lipophilicity and the extracts thereof are recovered separately.
- the extracts are dried separately and mixed in the desired ratio. In this way, the content of lipophilic and hydrophilic substances can be adjusted.
- the method should also be suitable for obtaining dry extracts of ivy (Hedera helix).
- DE 30 25 223 A1 discloses a pharmaceutical preparation based on ivy extracts and a process for the production thereof in which, using acetone and methanol, an ivy extract having a hederasaponin C content of 60 or 90% is obtained.
- the extract obtained from this process is not stable in its hederacoside C content, since, according to experience, hederacoside C in the extract is hydrolyzed to ⁇ -hederin.
- the object of the present invention is therefore to provide a method with which an ivy extract, in particular a dry extract, can be obtained in a few steps and without much effort, in which the content of the ingredients hederacoside C and ⁇ -hederin is storage-stable.
- the object underlying the invention is achieved in that the method comprises the following steps:
- this process can be used to produce an extract which has at most the amount of ⁇ -hederin already present in the starting drug.
- an extract is obtained which has a high hederacoside C content, which does not change over longer periods of time.
- Such extracts are, for example, then of great interest if these extracts are to serve as a starting material for mixed extracts which have a specific determinable and accurately determined content of the active ingredients hederacoside C and ⁇ -hederin.
- extracts with high hederacoside C content and low ⁇ -hederin content can accordingly be obtained by the process according to the invention.
- the percentage of ⁇ -hederin in the extract obtained by the process according to the invention does not exceed the percentage within the leaves used. Accordingly, for example, a preserved extract, for its recovery leaf batches with a Content of less than 0.5% ⁇ -hederin, a maximum level of 0.5% ⁇ -hederin.
- Such an extract can then advantageously be used, for example, for the specific preparation of mixtures of extracts which each have precisely determinable amounts of the respective active substances - hederacoside C and ⁇ -hederin - so that final extracts are obtained which have a specific specified content contain both active ingredients.
- This vaporization step also opens up the possibility of first permitting some conversion of hederacoside C into ⁇ -hederin, but then breaking it off.
- Dried drugs have the advantage in the manufacture of drugs that they u.Uu. better to handle than fresh drugs. Nevertheless, the use of fresh ivy leaves in the inventive method is not excluded.
- Dried medicinal plants and medicinal plant parts are designated by definition as "drugs" in the field of pharmaceutical technology, and medicinal plants in the form of “drugs” are used either in unmodified or in comminuted form.
- the ivy leaves are comminuted to ⁇ 5 ⁇ 5 mm. Furthermore, it is preferred if the vapor deposition is carried out over a period of 1 to 30 seconds, in particular of 1 to 10 seconds, and preferably of 5 seconds.
- the vapor deposition with steam at a temperature of about 90 ° C (optionally at reduced pressure) to 140 ° C, in particular at a temperature of about 100 to 120 ° C, and preferably at 110 ° C.
- the extractant is a mixture of alcohol and water.
- Ethanol is a proven pharmaceutical solvent and is widely used in the field of pharmaceutical technology as an extractant. Of course, however, it is also possible to use other alcohols, for example propanol, isopropanol, etc., ie all alcohols which can be used as water / alcohol mixtures in the extraction in the sense of the pharmaceutical preparation.
- step c) is carried out by pre-swelling and percolation, and in particular special, if for the Voránn a period of about 1 hour to about 30 hours, preferably a period of 6 hours, is provided.
- Precipitation and percolation are common methods in the art and especially in the field of pharmaceutical preparations of plants. With the pre-swelling and percolation steps, exhaustive extraction of the ivy leaves can be achieved.
- step d) is carried out by thin-film vaporization and subsequent spray-drying.
- Both methods are conventional drying methods, wherein the Dünnfilmvaporisation has proven in the preparation of medicaments as a gentle evaporation method, as well as the spray drying, which can be dried according to experience, liquid preparations into powdery end products, which are characterized in particular by, for example, with water easy to stir ready-to-use preparations again.
- the thin film vaporization is carried out, for example, at about 50 to 60 ° C and at 130 to 180 mbar, and the spray drying at 45 to 60 ° C.
- the process according to the invention is used for producing an extract of ivy leaves with an increased hederacoside C content.
- the method according to the invention it is possible, as shown above, to increase the proportion of hederacoside C in a targeted manner, wherein at the same time the content of ⁇ -hederin in the extract corresponds at most to the content of ⁇ -hederin in the starting drug.
- the invention further relates to a storage-stable extract of ivy leaves, which is produced by the process according to the invention.
- Extracts with a high content of hederacoside are, for example, advantageous if mixtures of extracts are to be produced which have a determinable content of hederacoside.
- ⁇ -hederin is the active constituent of the ivy leaves in the sense of bronchospas
- extracts with a high content of hedera are also coside C advantageous, since these - as mentioned above - can be used for targeted mixtures.
- the invention further relates to the use of the extract according to the invention, in particular of the dry extract, for the production of a medicament, and in particular for the production of a medicament for the treatment of respiratory diseases.
- the medicament according to the invention can then be used for the treatment of respiratory diseases such as, for example, infectious-inflammatory respiratory diseases, such as, for example, pneumonia, tracheitis, bronchitis, etc. , but also in obstructive and restrictive lung diseases such as chronic bronchitis, bronchial asthma, bronchiectasis, etc., so respiratory diseases in which a relaxation of the weak muscles is desired.
- respiratory diseases such as, for example, infectious-inflammatory respiratory diseases, such as, for example, pneumonia, tracheitis, bronchitis, etc.
- obstructive and restrictive lung diseases such as chronic bronchitis, bronchial asthma, bronchiectasis, etc.
- the invention relates to a medicament which comprises an extract which is prepared by the process according to the invention.
- the drug may be in the form of capsules, tablets, dragees, suppositories, granules, powders, solutions, creams, emulsions, aerosols, ointments and oils. Oral administration forms are particularly preferred.
- the drug may include adjuvants conventionally used in drug manufacture. A number of suitable substances are found, for example, in A. Kibbe, Handbook of Pharmaceutical Excipients, 3rd Ed., 2000, American Pharmaceutical Association and Pharmaceutical Press. Further advantages will become apparent from the example and the accompanying figures. Show it
- Fig. La the influence of the drug vaporization on the ingredient spectrum of the extract in a graphical representation
- FIG. 1b shows graphically the influence of drug vapor deposition on the extraction yield of hederasaponins.
- the basis for the control of the ratio of hederacoside C to ⁇ -hederin is to deliberately prevent the elimination of the C28 -containing sugar of hederacoside C during the extraction process.
- a specification to below 0.5% ⁇ -hederin with respect to the dried drug is recommended.
- a homogeneous sample of ivy leaves was analyzed for the content of the two saponins as follows:
- Hederacoside C 6.37% ⁇ -hederin: 0.85%
- the extraction temperature is preferably between about 20 and about 40 ° C, in particular at about 30 ° C.
- the ratio of drug to extractant is, for example, at 1:12.
- the drying can be carried out, for example, by thin film vaporization at, for example, 55 ° C. and 150 mbar and subsequent spray drying at 45 ° -60 ° C.
- Extraction rule 2 The extraction specification corresponds to Extraction Specification 1 with the exception of the process step of the vapor deposition.
- FIGS. 1a and 1b the results are illustrated by the two graphs.
- the figures clearly show that in accordance with Extraction Regulation 1 (with vaporization step) extract has a higher hederacoside C content and a lower ⁇ -hederin content than the extract prepared by a conventional process (without sputtering step) (see FIG. 1a).
- the dried leaf extract prepared according to this specification accordingly had the maximum amount of ⁇ -hederin contained in the leaves used. Overall, extracts with high hederacoside C content and very low ⁇ -hederin content were thus obtained. When using leaf batches containing less than 0.5% ⁇ -hederin, a maximum level of 0.5% ⁇ -hederin may also be assumed for the extract obtained.
- an extract By selective mixing of various enriched with hederacoside extracts thus an extract can be obtained, which is characterized by a specified content of hederacoside C us a maximum content of 0.5% ⁇ -hederin.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Detergent Compositions (AREA)
- Glanulating (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Abstract
Description
Claims
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006526564A JP4773963B2 (ja) | 2003-09-19 | 2004-09-10 | 貯蔵安定性を有するツタの葉抽出物の製造方法および該方法に基いて製造される抽出物 |
SI200430632T SI1663269T1 (sl) | 2003-09-19 | 2004-09-10 | Postopek za pripravo skladiščno stabilnega ekstrakta iz listov bršljana kot tudi ekstrakt, pripravljen po tem postopku |
DK04765026T DK1663269T3 (da) | 2003-09-19 | 2004-09-10 | Fremgangsmåde til fremstilling af en lagerstabil ekstrakt af efeublade, samt en ifölge denne fremgangsmåde fremstillet ekstrakt |
BRPI0414535A BRPI0414535B8 (pt) | 2003-09-19 | 2004-09-10 | método para preparação de um extrato de folhas de hedera helix, e produto farmacêutico |
PL04765026T PL1663269T3 (pl) | 2003-09-19 | 2004-09-10 | Sposób wytwarzania stabilnego w przechowywaniu ekstraktu z liści bluszczu oraz ekstrakt wytworzony tym sposobem |
DE502004005850T DE502004005850D1 (de) | 2003-09-19 | 2004-09-10 | Verfahren zur herstellung eines lagerstabilen extraktes aus efeublättern, sowie ein nach diesem verfahren hergestellter extrakt |
EA200600489A EA009805B1 (ru) | 2003-09-19 | 2004-09-10 | Способ получения стабильного при хранении экстракта из листьев плюща, а также полученный этим способом экстракт |
MXPA06002946A MXPA06002946A (es) | 2003-09-19 | 2004-09-10 | Metodo para preparar un extracto de hojas de hiedra estable al almacenamiento y un extracto preparado de acuerdo a ese metodo. |
EP04765026A EP1663269B1 (de) | 2003-09-19 | 2004-09-10 | Verfahren zur herstellung eines lagerstabilen extraktes aus efeublättern, sowie ein nach diesem verfahren hergestellter extrakt |
UAA200604149A UA83683C2 (uk) | 2003-09-19 | 2004-10-09 | Спосіб одержання стабільного при зберіганні екстракту з листя плюща, екстракт, його застосування та лікарський засіб |
US11/267,518 US7802376B2 (en) | 2003-09-19 | 2005-11-04 | Apparatus for treating particulate material |
HK07103775.8A HK1096868A1 (en) | 2003-09-19 | 2007-04-11 | Method for the production of a storage-resistant ivy leaf extract, and extract produced according to said method |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10345342A DE10345342A1 (de) | 2003-09-19 | 2003-09-19 | Verfahren zur Herstellung eines lagerstabilen Extraktes aus Efeublättern, sowie ein nach diesem Verfahren hergestellter Extrakt |
DE10345342.3 | 2003-09-19 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/267,518 Continuation US7802376B2 (en) | 2003-09-19 | 2005-11-04 | Apparatus for treating particulate material |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2005037299A1 true WO2005037299A1 (de) | 2005-04-28 |
Family
ID=34399064
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2004/010093 WO2005037299A1 (de) | 2003-09-19 | 2004-09-10 | Verfahren zur herstellung eines lagerstabilen extraktes aus efeublättern, sowie ein nach diesem verfahren hergestellter extrakt |
Country Status (19)
Country | Link |
---|---|
US (1) | US7802376B2 (de) |
EP (1) | EP1663269B1 (de) |
JP (1) | JP4773963B2 (de) |
KR (1) | KR100839884B1 (de) |
CN (1) | CN100584346C (de) |
AT (1) | ATE382361T1 (de) |
BR (1) | BRPI0414535B8 (de) |
CY (1) | CY1107296T1 (de) |
DE (2) | DE10345342A1 (de) |
DK (1) | DK1663269T3 (de) |
EA (1) | EA009805B1 (de) |
ES (1) | ES2298802T3 (de) |
HK (1) | HK1096868A1 (de) |
MX (1) | MXPA06002946A (de) |
PL (1) | PL1663269T3 (de) |
PT (1) | PT1663269E (de) |
SI (1) | SI1663269T1 (de) |
UA (1) | UA83683C2 (de) |
WO (1) | WO2005037299A1 (de) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016009001A1 (en) | 2014-07-17 | 2016-01-21 | Hexal Ag | Orodispersible film |
CN114805466A (zh) * | 2022-04-15 | 2022-07-29 | 湖南朗林生物资源股份有限公司 | 一种常春藤提取物的制备方法 |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10345342A1 (de) * | 2003-09-19 | 2005-04-28 | Engelhard Arzneimittel Gmbh | Verfahren zur Herstellung eines lagerstabilen Extraktes aus Efeublättern, sowie ein nach diesem Verfahren hergestellter Extrakt |
DE102005028168B3 (de) * | 2005-06-17 | 2007-01-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Einrichtung zur Führung eines Gases für Vorrichtungen zum Behandeln körnigen Gutes durch Trocknen, Filmcoaten oder Beschichten, insbesondere Zulufteinheit und Vorrichtung mit einer derartigen Einrichtung |
RU2461388C1 (ru) | 2008-06-13 | 2012-09-20 | Ахн-Гоок Фармасьютикал Ко., Лтд. | Экстракт coptidis rhizoma и его новое применение в лечении респираторного заболевания |
US8807070B2 (en) * | 2008-08-07 | 2014-08-19 | Vector Corporation | Rotor processor for dry powders |
CN102721265B (zh) * | 2012-06-28 | 2014-10-15 | 罗泽云 | 物料干燥方法及其干燥系统 |
US8931717B2 (en) | 2012-10-03 | 2015-01-13 | Control Components, Inc. | Nozzle design for high temperature attemperators |
US8955773B2 (en) | 2012-10-03 | 2015-02-17 | Control Components, Inc. | Nozzle design for high temperature attemperators |
ES2643867T3 (es) | 2012-11-01 | 2017-11-24 | Janak Ramanlal Shah | Sistema de concentración controlada y recuperación de sólidos |
CN103588832B (zh) * | 2013-11-26 | 2017-01-04 | 陕西嘉禾生物科技股份有限公司 | 从常春藤叶中分离常春藤苷c及苷元的方法 |
US10288280B2 (en) | 2014-08-04 | 2019-05-14 | Cci Italy Srl | Dual cone spray nozzle assembly for high temperature attemperators |
CN105943671A (zh) * | 2016-06-20 | 2016-09-21 | 陆川县银湖橘红种植专业合作社 | 一种从橘红中提取有效成分的方法 |
USD938503S1 (en) * | 2019-08-21 | 2021-12-14 | Rapid Granulator Ab | Ripper for granulating machine |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2051575A (en) * | 1979-07-05 | 1981-01-21 | Synthelabo | Pharmaceutical compositions containing climbing ivy extracts |
Family Cites Families (166)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2452858A (en) * | 1948-11-02 | Method of and apparatus for | ||
US1547171A (en) * | 1924-07-03 | 1925-07-28 | Ross B Linton | Bounce-ball game apparatus |
US2046525A (en) * | 1929-03-01 | 1936-07-07 | William J Miller | Method of and apparatus for producing pottery ware |
US2264523A (en) * | 1938-08-08 | 1941-12-02 | Binks Manufaucturing Company | Means for distributing humidity in printing presses |
US2304857A (en) * | 1940-03-25 | 1942-12-15 | Saylor Beall Mfg Co | Nozzle |
US2303280A (en) * | 1940-09-09 | 1942-11-24 | Alexander F Jenkins | Spray gun |
US2366926A (en) * | 1942-01-05 | 1945-01-09 | Carborundum Co | Coating and treating material |
US2416923A (en) * | 1943-08-30 | 1947-03-04 | Alexander Milburn Company | Spray gun |
US2680652A (en) * | 1946-02-15 | 1954-06-08 | Babcock & Wilcox Co | Atomizer |
US2613112A (en) * | 1947-04-30 | 1952-10-07 | Babcock & Wilcox Co | Atomizer |
US2607193A (en) * | 1947-10-25 | 1952-08-19 | Curtiss Wright Corp | Annular combustion chamber with multiple notched fuel nozzles |
US2624624A (en) * | 1948-11-26 | 1953-01-06 | Karlsruhe Augsburg Iweka | Sprayer nozzle |
US2610092A (en) * | 1950-10-26 | 1952-09-09 | Spray Engineering Co | Spray discharge nozzle |
US2770583A (en) * | 1952-07-05 | 1956-11-13 | Socony Mobil Oil Co Inc | Method and apparatus for the conversion of liquid hydrocarbons in the presence of a granular contact material |
US2971250A (en) * | 1952-12-19 | 1961-02-14 | Spraying Systems Co | Spray nozzle with contoured orifice and method of contouring the orifice |
US2792259A (en) * | 1953-07-03 | 1957-05-14 | Int Harvester Co | Fuel injector for internal combustion engines |
US3908933A (en) * | 1956-06-26 | 1975-09-30 | Us Navy | Guided missile |
US2953457A (en) * | 1957-06-24 | 1960-09-20 | Sanna Dairies Inc | Method for drying food materials |
US2893871A (en) * | 1958-11-12 | 1959-07-07 | Blaw Knox Co | Agglomeration process and apparatus |
US3276844A (en) * | 1961-11-28 | 1966-10-04 | United Staltes Rubber Company | Process control by surface tension measurement |
US3508308A (en) * | 1962-07-06 | 1970-04-28 | Du Pont | Jet-treatment process for producing nonpatterned and line-entangled nonwoven fabrics |
US3493462A (en) * | 1962-07-06 | 1970-02-03 | Du Pont | Nonpatterned,nonwoven fabric |
US3237870A (en) * | 1962-09-13 | 1966-03-01 | Rosemount Eng Co Ltd | Spray nozzle having a forward surface on which liquid films |
US3292868A (en) * | 1962-09-13 | 1966-12-20 | Aero Spray Inc | Spray nozzle |
US3187944A (en) * | 1962-10-09 | 1965-06-08 | Arthur J Stock | Gravimetric feeder and method of filling voids therein or in other pressure vessels |
FR92033E (fr) * | 1967-03-22 | 1968-09-13 | Sames Mach Electrostat | Appareil nouveau et perfectionné pour le poudrage électrostatique d'objets |
US3174283A (en) * | 1963-06-28 | 1965-03-23 | Crocco Luigi | Expendable barrier |
US3998714A (en) * | 1964-04-23 | 1976-12-21 | Tii Corporation | System for pollution suppression |
US4035296A (en) * | 1964-04-23 | 1977-07-12 | Tii Corporation | System for pollution suppression |
US4045347A (en) * | 1964-04-23 | 1977-08-30 | Tii Corporation | System for pollution suppression |
US4035301A (en) * | 1964-04-23 | 1977-07-12 | Tii Corporation | System for pollution suppression |
US3278125A (en) * | 1964-07-24 | 1966-10-11 | Texaco Inc | Oil burner structure |
US3309027A (en) * | 1964-12-18 | 1967-03-14 | American Radiator & Standard | Oil burner |
US3328894A (en) * | 1965-01-15 | 1967-07-04 | Hupp Corp | Coffee roasting apparatus |
US3382129A (en) * | 1965-04-13 | 1968-05-07 | Goodyear Aerospace Corp | Apparatus for forming fiber reinforced resinous material |
US3343814A (en) * | 1965-06-01 | 1967-09-26 | Bahre Metallwerk K G Fa | Device for coating chips with glue |
US3401888A (en) * | 1965-10-22 | 1968-09-17 | Sutter Arthur | Snow nozzle |
US3425634A (en) * | 1966-07-20 | 1969-02-04 | American Air Filter Co | Multifuel burner nozzle |
JPS4830411B1 (de) * | 1966-08-20 | 1973-09-20 | ||
ES378353A1 (es) * | 1969-04-18 | 1973-02-01 | Beges A G | Una maquina automatica, gobernada por un regulador de pro- grama, destinada a limpiar ropa. |
US3696780A (en) * | 1969-11-25 | 1972-10-10 | Gen Electric | Apparatus for applying powered coating material to an article |
US3866567A (en) * | 1969-11-25 | 1975-02-18 | Gen Electric | Masking apparatus for use in coating an article of manufacture |
US3939238A (en) * | 1970-06-23 | 1976-02-17 | Crowe-Gulde, Inc. | Method for manufacture of facing bricks with sharply delineated portions of different color and texture |
US3732086A (en) * | 1970-12-28 | 1973-05-08 | C Heyne | Method and apparatus for recovering discrete gobs of molten glass |
US3936577A (en) * | 1971-12-15 | 1976-02-03 | E. I. Du Pont De Nemours & Company | Method for concomitant particulate diamond deposition in electroless plating, and the product thereof |
USRE29285E (en) * | 1973-03-15 | 1977-06-28 | E. I. Du Pont De Nemours And Company | Method for concomitant particulate diamond deposition in electroless plating, and the product thereof |
USRE33767E (en) * | 1971-12-15 | 1991-12-10 | Surface Technology, Inc. | Method for concomitant particulate diamond deposition in electroless plating, and the product thereof |
US3799716A (en) * | 1972-06-23 | 1974-03-26 | Crowe Gulde Inc | Apparatus for manufacture of coated bricks |
DE2315882C3 (de) * | 1973-03-30 | 1975-10-23 | Glatt, Werner, 7859 Haltingen | Trocknungsvorrichtung für eine Dragiertrommel |
US3856036A (en) * | 1973-11-02 | 1974-12-24 | Whirlpool Co | Siphon break and diverter for an appliance |
DE3806539A1 (de) * | 1988-03-01 | 1989-09-14 | Herbert Huettlin | Wirbelschichtapparatur, insbes. zum granulieren pulverfoermiger substanz |
US3923253A (en) * | 1974-05-21 | 1975-12-02 | Grefco | Spraying nozzle |
US4015366A (en) * | 1975-04-11 | 1977-04-05 | Advanced Decision Handling, Inc. | Highly automated agricultural production system |
USRE31023E (en) * | 1975-04-11 | 1982-09-07 | Advanced Decision Handling, Inc. | Highly automated agricultural production system |
US4204955A (en) * | 1975-09-24 | 1980-05-27 | Armstrong Edward T | System for pollution suppression |
DE2649796C2 (de) * | 1976-10-29 | 1978-10-26 | Herbert 7853 Steinen Huettlin | Schlauchkupplung |
US4184220A (en) * | 1978-12-20 | 1980-01-22 | Coyle Thomas M | Conduit cleaner |
DE2912780A1 (de) * | 1979-03-30 | 1980-10-09 | Herbert Huettlin | Siebboden fuer wirbelschichtapparaturen |
DE2932803C2 (de) * | 1979-08-13 | 1986-12-04 | Herbert 7853 Steinen Hüttlin | Wirbelschichtapparatur |
DE3002210C2 (de) * | 1980-01-22 | 1982-02-18 | Herbert 7853 Steinen Hüttlin | Pumpe oder Gebläse, insbesondere für Heizungs- und Klimaanlagen |
US4358057A (en) * | 1980-05-27 | 1982-11-09 | Ethyl Products Company | Fluid dispenser method and apparatus |
US4313569A (en) * | 1980-05-27 | 1982-02-02 | Ethyl Products Company | Fluid dispenser method and apparatus |
DE3130166C1 (de) * | 1981-07-30 | 1982-11-11 | Herbert 7853 Steinen Hüttlin | Dragiertrommel |
DE3146536A1 (de) * | 1981-11-24 | 1983-06-01 | Herbert 7853 Steinen Hüttlin | Einrichtung zum behandlen koernigen gutes durch trocknen, filmcoaten oder beschichten |
US4434049A (en) * | 1982-03-17 | 1984-02-28 | Dean Robert R | Residual oil feed process for fluid catalyst cracking |
US4456181A (en) * | 1982-04-19 | 1984-06-26 | Bete Fog Nozzle, Inc. | Gas liquid mixing nozzle |
DE3234911A1 (de) * | 1982-09-21 | 1984-03-22 | Herbert 7853 Steinen Hüttlin | Fliessbettapparatur |
NL8400470A (nl) * | 1983-02-28 | 1984-09-17 | Condair Ag | Inrichting en werkwijze voor het afscheiden van vreemde stoffen uit een gasstroom. |
US4657773A (en) * | 1984-03-15 | 1987-04-14 | Gebruder Buhler Ag | Process and an apparatus for dressing seed |
US4645520A (en) * | 1984-07-20 | 1987-02-24 | Huettlin Herbert | Filter assembly for dust removal from gases, especially in fluidized bed apparatus |
DE3520718A1 (de) * | 1985-06-10 | 1986-12-11 | Herbert 7853 Steinen Hüttlin | Fliessbettapparatur |
DE3530744A1 (de) * | 1985-08-28 | 1987-03-05 | Herbert Huettlin | Fliessbettapparatur |
DE3608885A1 (de) * | 1986-03-17 | 1987-09-24 | Herbert Huettlin | Vorrichtung zum granulieren, pelletieren, dragieren und/oder trocknen rieselfaehigen gutes |
DE8708312U1 (de) * | 1987-06-12 | 1987-07-30 | Behr Industrieanlagen GmbH & Co, 74379 Ingersheim | Einrichtung zum Vernebeln flüssiger Farbe |
US4815660A (en) * | 1987-06-16 | 1989-03-28 | Nordson Corporation | Method and apparatus for spraying hot melt adhesive elongated fibers in spiral patterns by two or more side-by-side spray devices |
DE3806543A1 (de) * | 1988-03-01 | 1989-09-14 | Herbert Huettlin | Wirbelschichtapparatur, insbes. zum granulieren pulverfoermiger substanz |
US4934595A (en) * | 1988-08-19 | 1990-06-19 | Plastic Flamecoat Systems, Inc. | Method and aparatus for spray coating |
US4952325A (en) * | 1988-09-26 | 1990-08-28 | Gaston County Dyeing Machine Co. | Apparatus and method for cleaning filtered accumulation from an annular filter |
US4969602A (en) * | 1988-11-07 | 1990-11-13 | Nordson Corporation | Nozzle attachment for an adhesive dispensing device |
US5087349A (en) * | 1988-11-18 | 1992-02-11 | Stone & Webster Engineering Corporation | Process for selectively maximizing product production in fluidized catalytic cracking of hydrocarbons |
DE3839723C1 (de) * | 1988-11-24 | 1989-07-20 | Herbert 7853 Steinen De Huettlin | |
US4953365A (en) * | 1989-06-28 | 1990-09-04 | Liquid Carbonic Corporation | Helical conveyor freezer |
US4934651A (en) * | 1989-10-31 | 1990-06-19 | Dema Engineering Company | Magnetically operated valve and timer assembly |
US4989790A (en) * | 1989-12-26 | 1991-02-05 | Afa Products, Inc. | Nozzle cap, spring valve and body assembly |
DE4000572C1 (de) * | 1990-01-10 | 1991-02-21 | Herbert 7853 Steinen De Huettlin | |
US5215253A (en) * | 1990-08-30 | 1993-06-01 | Nordson Corporation | Method and apparatus for forming and dispersing single and multiple phase coating material containing fluid diluent |
DE4030086C1 (de) * | 1990-09-21 | 1991-12-12 | Herbert 7853 Steinen De Huettlin | |
GB9101812D0 (en) * | 1991-01-28 | 1991-03-13 | Morgan Crucible Co | Dispensing of fluids |
US5158235A (en) * | 1991-02-19 | 1992-10-27 | Elwood Hydraulics Company, Inc. | Turbulence-quelling fluid-flow controller and method |
DE4110127A1 (de) * | 1991-03-27 | 1992-10-01 | Herbert Huettlin | Duesenbaugruppe zum verspruehen von fluessigkeiten |
DE4118433C2 (de) * | 1991-06-05 | 1994-12-01 | Herbert Huettlin | Fließbettapparatur zum Behandeln partikelförmigen Gutes |
DE4123176C1 (de) * | 1991-07-12 | 1992-08-27 | Herbert 7853 Steinen De Huettlin | |
US5282573A (en) * | 1991-09-16 | 1994-02-01 | Plastic Flamecoat Systems, Inc. | Spray coating system and method |
US5228600A (en) * | 1992-02-24 | 1993-07-20 | Afa Products Inc. | Child resistant nozzle for trigger sprayer |
US5615696A (en) * | 1992-07-24 | 1997-04-01 | Lawler; Oliver W. | Apparatus for treating pipe |
EP0628644B1 (de) * | 1993-05-27 | 2003-04-02 | Applied Materials, Inc. | Verbesserungen betreffend Substrathalter geeignet für den Gebrauch in Vorrichtungen für die chemische Abscheidung aus der Dampfphase |
US5400966A (en) * | 1993-08-05 | 1995-03-28 | Holimont, Inc. | Machine for making artificial snow and method |
DE4430307A1 (de) * | 1994-08-26 | 1996-02-29 | Bayer Ag | Verfahren und Vorrichtung zur gleichzeitigen Dispergierung und Zerstäubung von mindestens zwei Flüssigkeiten |
JPH08238079A (ja) * | 1995-03-03 | 1996-09-17 | Sanki Shoji Kk | プルーン葉茶とその飲料及び抽出液乾固物 |
US5727739A (en) * | 1995-03-03 | 1998-03-17 | Spraying Systems Co. | Nozzle with quick disconnect spray tip |
JP3470211B2 (ja) * | 1995-03-30 | 2003-11-25 | 小林製薬株式会社 | 杜仲茶の製造方法 |
DE19608349A1 (de) * | 1996-03-05 | 1997-09-11 | Abb Research Ltd | Druckzerstäuberdüse |
DE19639503C1 (de) * | 1996-09-26 | 1998-01-15 | Herbert Huettlin | Schwenkkolbenmaschine |
US6769969B1 (en) * | 1997-03-06 | 2004-08-03 | Keltech Engineering, Inc. | Raised island abrasive, method of use and lapping apparatus |
US5947377A (en) * | 1997-07-11 | 1999-09-07 | Nordson Corporation | Electrostatic rotary atomizing spray device with improved atomizer cup |
US5934569A (en) * | 1997-09-03 | 1999-08-10 | Bete Fog Nozzle, Inc. | Fluid nozzle having a swirl unit and orifice plate, and means for facilitating assembly thereof |
US6129290A (en) * | 1997-11-06 | 2000-10-10 | Nikkanen; John P. | Snow maker |
DE19749072C1 (de) * | 1997-11-06 | 1999-06-10 | Herbert Huettlin | Mehrstoffzerstäuberdüse |
US6161769A (en) * | 1997-12-16 | 2000-12-19 | Boyne Usa, Inc. | Adjustable snow making tower |
DE19819980B4 (de) * | 1998-05-05 | 2004-02-05 | Hüttlin, Herbert | Filtereinrichtung für eine Prozeßapparatur |
DE19838540C2 (de) * | 1998-08-25 | 2001-07-26 | Herbert Huettlin | Verfahren zum Behandeln eines partikelförmigen Guts mit einem Überzugsmedium sowie Vorrichtung zur Durchführung eines derartigen Verfahrens |
US20020044898A1 (en) * | 1998-10-22 | 2002-04-18 | Sermed Industries, Inc. | Instrument securing device for a sterilizer |
AU1319800A (en) * | 1998-10-22 | 2000-05-08 | Sermed Industries Inc. | A cartridge for holding a first and second fluid |
US6521180B2 (en) * | 1998-10-22 | 2003-02-18 | Sermed Industries, Inc. | Method of sterilization |
FR2788231B1 (fr) * | 1999-01-11 | 2001-03-09 | Itw Surfaces & Finitions | Tete de pulverisation d'un produit tel que de la peinture |
DE19901110C2 (de) * | 1999-01-14 | 2002-06-06 | Herbert Huettlin | Schwenkkolbenmaschine |
DE19904147C2 (de) * | 1999-02-03 | 2001-05-10 | Herbert Huettlin | Vorrichtung zum Behandeln von partikelförmigem Gut |
US6311473B1 (en) * | 1999-03-25 | 2001-11-06 | Parker-Hannifin Corporation | Stable pre-mixer for lean burn composition |
US6550696B2 (en) * | 2000-02-28 | 2003-04-22 | Adel B. Mansour | Integrated fuel injection and mixing system with impingement cooling face |
US6533954B2 (en) * | 2000-02-28 | 2003-03-18 | Parker-Hannifin Corporation | Integrated fluid injection air mixing system |
US7011154B2 (en) * | 2000-04-24 | 2006-03-14 | Shell Oil Company | In situ recovery from a kerogen and liquid hydrocarbon containing formation |
US6649384B2 (en) * | 2000-07-05 | 2003-11-18 | Islet Technology, Inc. | System and method for encapsulating biological material by applying electrostatic charge to capsules |
US20030038192A1 (en) * | 2000-10-05 | 2003-02-27 | Shutic Jeffrey R. | Quick change powder coating spray system |
US7325750B2 (en) * | 2000-10-05 | 2008-02-05 | Nordson Corporation | Powder coating system with improved overspray collection |
US6730167B2 (en) * | 2000-10-05 | 2004-05-04 | Nordson Corporation | Powder coating spray booth with a powder extraction system |
US7014670B2 (en) * | 2000-10-05 | 2006-03-21 | Nordson Corporation | Controlling cyclone efficiency with a vacuum interface |
JP3846680B2 (ja) * | 2000-10-26 | 2006-11-15 | 共栄化学工業株式会社 | 化粧料 |
DE10112168A1 (de) * | 2001-03-12 | 2002-10-02 | Bionorica Arzneimittel Ag | Trockenextrakt mit einstellbarem Gehalt an lipophilen und hydrophilen Substanzen und Verfahren zur Herstellung desselben |
DE10112562B4 (de) * | 2001-03-15 | 2005-02-17 | Düsen-Schlick GmbH | Aussenmischdüse |
GB2373984B (en) * | 2001-04-06 | 2003-08-13 | G E Baker | Method and apparatus for feeding pigs |
WO2002086276A2 (en) * | 2001-04-24 | 2002-10-31 | Shell Internationale Research Maatschappij B.V. | Method for in situ recovery from a tar sands formation and a blending agent produced by such a method |
US6782947B2 (en) * | 2001-04-24 | 2004-08-31 | Shell Oil Company | In situ thermal processing of a relatively impermeable formation to increase permeability of the formation |
US6915850B2 (en) * | 2001-04-24 | 2005-07-12 | Shell Oil Company | In situ thermal processing of an oil shale formation having permeable and impermeable sections |
WO2002085821A2 (en) * | 2001-04-24 | 2002-10-31 | Shell International Research Maatschappij B.V. | In situ recovery from a relatively permeable formation containing heavy hydrocarbons |
DE10129166C1 (de) * | 2001-06-12 | 2003-01-16 | Herbert Huettlin | Vorrichtung zum Behandeln von partikelförmigem Gut |
US20050178851A1 (en) * | 2001-06-25 | 2005-08-18 | Nordson Corporation | Quick change powder coating spray system |
US7104319B2 (en) * | 2001-10-24 | 2006-09-12 | Shell Oil Company | In situ thermal processing of a heavy oil diatomite formation |
US7077199B2 (en) * | 2001-10-24 | 2006-07-18 | Shell Oil Company | In situ thermal processing of an oil reservoir formation |
US6969123B2 (en) * | 2001-10-24 | 2005-11-29 | Shell Oil Company | Upgrading and mining of coal |
CN100540843C (zh) * | 2001-10-24 | 2009-09-16 | 国际壳牌研究有限公司 | 利用自然分布型燃烧器对含烃岩层进行就地热处理的方法 |
US7090013B2 (en) * | 2001-10-24 | 2006-08-15 | Shell Oil Company | In situ thermal processing of a hydrocarbon containing formation to produce heated fluids |
US7165615B2 (en) * | 2001-10-24 | 2007-01-23 | Shell Oil Company | In situ recovery from a hydrocarbon containing formation using conductor-in-conduit heat sources with an electrically conductive material in the overburden |
US6536683B1 (en) * | 2002-05-14 | 2003-03-25 | Spraying Systems Co. | Spray apparatus with multiple pressurizable tank liquid supply system |
US6718770B2 (en) * | 2002-06-04 | 2004-04-13 | General Electric Company | Fuel injector laminated fuel strip |
DE10248116B3 (de) * | 2002-10-07 | 2004-04-15 | Hüttlin, Herbert, Dr.h.c. | Vorrichtung zum Behandeln von partikelförmigem Gut mit einer Höhenverstellvorrichtung |
US7021562B2 (en) * | 2002-11-15 | 2006-04-04 | Parker-Hannifin Corp. | Macrolaminate direct injection nozzle |
US6898926B2 (en) * | 2003-01-31 | 2005-05-31 | General Electric Company | Cooled purging fuel injectors |
DE10309989A1 (de) * | 2003-02-28 | 2004-09-16 | Hüttlin, Herbert, Dr.h.c. | Tunnelförmige Vorrichtung zum Behandeln von partikelförmigem Gut |
US6746001B1 (en) * | 2003-02-28 | 2004-06-08 | Control Components, Inc. | Desuperheater nozzle |
US6898938B2 (en) * | 2003-04-24 | 2005-05-31 | General Electric Company | Differential pressure induced purging fuel injector with asymmetric cyclone |
US7213383B2 (en) * | 2003-05-09 | 2007-05-08 | Intellipack | Bag forming system edge seal |
US7341632B2 (en) * | 2003-05-09 | 2008-03-11 | Intellipack | Dispensing system with means for easy access of dispenser components and method of using same |
US7331542B2 (en) * | 2003-05-09 | 2008-02-19 | Intellipack | Film unwind system with hinged spindle and electronic control of web tension |
US7156260B2 (en) * | 2003-05-09 | 2007-01-02 | Intellipack | Mixing module drive mechanism and dispensing system with same |
US7386969B2 (en) * | 2003-05-09 | 2008-06-17 | Intellipack | Exterior configuration of a foam-in-bag dispenser assembly |
US7552847B2 (en) * | 2003-05-09 | 2009-06-30 | Intellipack | Dispenser mixing module and method of assembling and using same |
US7182221B2 (en) * | 2003-05-09 | 2007-02-27 | Intellipack | Dispensing system and method of manufacturing and using same with a dispenser tip management |
US7028483B2 (en) * | 2003-07-14 | 2006-04-18 | Parker-Hannifin Corporation | Macrolaminate radial injector |
US20050126476A1 (en) * | 2003-11-05 | 2005-06-16 | Nordson Corporation | Improved particulate material application system |
DE10345342A1 (de) * | 2003-09-19 | 2005-04-28 | Engelhard Arzneimittel Gmbh | Verfahren zur Herstellung eines lagerstabilen Extraktes aus Efeublättern, sowie ein nach diesem Verfahren hergestellter Extrakt |
DE10361566B4 (de) * | 2003-12-23 | 2006-09-07 | Hüttlin, Herbert, Dr. h.c. | Schwenkkolbenmaschine |
DE102004029466A1 (de) * | 2004-06-18 | 2006-01-05 | Leybold Optics Gmbh | Medieninjektor |
DE202005003791U1 (de) * | 2005-02-28 | 2006-07-06 | Hüttlin, Herbert, Dr. h.c. | Apparatur zur Behandlung von partikelförmigem Gut |
US7738694B2 (en) * | 2006-03-23 | 2010-06-15 | Pratt & Whitney Canada Corp. | Calibration of optical patternator spray parameter measurements |
US20070242871A1 (en) * | 2006-03-23 | 2007-10-18 | Pratt & Whitney Canada Corp. | Method of computing spray parameters from optical patternation |
US8268136B2 (en) * | 2007-12-20 | 2012-09-18 | McCutchen, Co. | Electrohydraulic and shear cavitation radial counterflow liquid processor |
-
2003
- 2003-09-19 DE DE10345342A patent/DE10345342A1/de not_active Withdrawn
-
2004
- 2004-09-10 EA EA200600489A patent/EA009805B1/ru not_active IP Right Cessation
- 2004-09-10 EP EP04765026A patent/EP1663269B1/de not_active Expired - Lifetime
- 2004-09-10 JP JP2006526564A patent/JP4773963B2/ja not_active Expired - Fee Related
- 2004-09-10 PT PT04765026T patent/PT1663269E/pt unknown
- 2004-09-10 DE DE502004005850T patent/DE502004005850D1/de not_active Expired - Lifetime
- 2004-09-10 BR BRPI0414535A patent/BRPI0414535B8/pt not_active IP Right Cessation
- 2004-09-10 AT AT04765026T patent/ATE382361T1/de active
- 2004-09-10 CN CN200480026543A patent/CN100584346C/zh not_active Expired - Fee Related
- 2004-09-10 ES ES04765026T patent/ES2298802T3/es not_active Expired - Lifetime
- 2004-09-10 MX MXPA06002946A patent/MXPA06002946A/es active IP Right Grant
- 2004-09-10 PL PL04765026T patent/PL1663269T3/pl unknown
- 2004-09-10 KR KR1020067005188A patent/KR100839884B1/ko active IP Right Grant
- 2004-09-10 SI SI200430632T patent/SI1663269T1/sl unknown
- 2004-09-10 DK DK04765026T patent/DK1663269T3/da active
- 2004-09-10 WO PCT/EP2004/010093 patent/WO2005037299A1/de active IP Right Grant
- 2004-10-09 UA UAA200604149A patent/UA83683C2/uk unknown
-
2005
- 2005-11-04 US US11/267,518 patent/US7802376B2/en active Active
-
2007
- 2007-04-11 HK HK07103775.8A patent/HK1096868A1/xx not_active IP Right Cessation
-
2008
- 2008-03-07 CY CY20081100262T patent/CY1107296T1/el unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2051575A (en) * | 1979-07-05 | 1981-01-21 | Synthelabo | Pharmaceutical compositions containing climbing ivy extracts |
Non-Patent Citations (5)
Title |
---|
ALTERNATIVE MEDICINE REVIEW : A JOURNAL OF CLINICAL THERAPEUTIC. AUG 2000, vol. 5, no. 4, August 2000 (2000-08-01), pages 372 - 375, ISSN: 1089-5159 * |
DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; 1986, WAGNER H ET AL: "Extracts of Hedera helix leaves: HPLC analysis", XP001204524, Database accession no. EMB-1987018570 * |
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; August 2000 (2000-08-01), "Green tea.", XP002311065, Database accession no. NLM10956382 * |
DEUTSCHE APOTHEKER ZEITUNG 1986 GERMANY, vol. 126, no. 48, 1986, pages 2613 - 2617 * |
ELIAS R ET AL: "INFLUENCE OF THE DRYING'S PROCESS AND THE ALCOHOLIC DEGREE ON THE EXTRACTION OF HEDERASAPONIN C AND ÄALPHAÜ HEDERIN FROM THE LEACES OF HEDERA HELIX L INFLUENCE DU PROCEDE DE SECHAGE ET DU DEGRE ALCOOLIQUE SUR L'EXTRACTION DE L'HEDERASAPONINE C ET DE L'ALPHA-HEDERINE A PARTIR DES FEUILLES DE HEDERA H", JOURNAL DE PHARMACIE DE BELGIQUE, MASSON, PARIS, FR, vol. 46, no. 3, 1991, pages 177 - 181, XP009033524, ISSN: 0047-2166 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016009001A1 (en) | 2014-07-17 | 2016-01-21 | Hexal Ag | Orodispersible film |
US10335443B2 (en) | 2014-07-17 | 2019-07-02 | Hexal Ag | Orodispersible film |
CN114805466A (zh) * | 2022-04-15 | 2022-07-29 | 湖南朗林生物资源股份有限公司 | 一种常春藤提取物的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN100584346C (zh) | 2010-01-27 |
DE502004005850D1 (de) | 2008-02-14 |
EA009805B1 (ru) | 2008-04-28 |
EA200600489A1 (ru) | 2006-10-27 |
MXPA06002946A (es) | 2006-06-14 |
KR20060037465A (ko) | 2006-05-03 |
ATE382361T1 (de) | 2008-01-15 |
BRPI0414535A (pt) | 2006-11-07 |
BRPI0414535B1 (pt) | 2019-10-15 |
KR100839884B1 (ko) | 2008-06-19 |
EP1663269B1 (de) | 2008-01-02 |
ES2298802T3 (es) | 2008-05-16 |
DE10345342A1 (de) | 2005-04-28 |
US20060112589A1 (en) | 2006-06-01 |
CN1852724A (zh) | 2006-10-25 |
CY1107296T1 (el) | 2012-11-21 |
PL1663269T3 (pl) | 2008-05-30 |
DK1663269T3 (da) | 2008-03-10 |
BRPI0414535B8 (pt) | 2021-05-25 |
UA83683C2 (uk) | 2008-08-11 |
JP2007505848A (ja) | 2007-03-15 |
US7802376B2 (en) | 2010-09-28 |
PT1663269E (pt) | 2008-01-23 |
JP4773963B2 (ja) | 2011-09-14 |
SI1663269T1 (sl) | 2008-06-30 |
HK1096868A1 (en) | 2007-06-15 |
EP1663269A1 (de) | 2006-06-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69218764T2 (de) | Pharmazeutische zubereitungen fuer die behandlung von hautschaedigungen | |
EP1267900B1 (de) | Emulsion enthaltend einen triterpen-haltigen pflanzenextrakt, verfahren zur herstellung der emulsion sowie zur gewinnung des pflanzenextraktes | |
EP1663269B1 (de) | Verfahren zur herstellung eines lagerstabilen extraktes aus efeublättern, sowie ein nach diesem verfahren hergestellter extrakt | |
DE4241487C2 (de) | Neue Extrakte von Cucurbita sp., Verfahren zu deren Herstellung und deren Verwendung in Arzneimitteln und in der Kosmetik | |
WO2003013562A1 (de) | Artischockenblätterextrakte | |
EP1608388B1 (de) | Verfahren zur herstellung eines extraktes aus efeublättern | |
DE102014202318B4 (de) | Verbessertes Verfahren zur Herstellung von Ginkgoextrakten | |
EP1843745A1 (de) | Dosierungsformen hydroxystilben-haltiger wirkstoffe zur behandlung klimakterischer beschwerden | |
WO1999032129A1 (de) | Extrakte aus blättern von ginkgo biloba mit vermindertem gehalt an 4'-o-methylpyridoxin und biflavonen | |
EP1852105B1 (de) | Verfahren zur Herstellung einer triterpensäurehaltigen wässrigen Lösung, triterpensäurehaltige wässrige Lösung und deren Verwendung | |
EP1663270B1 (de) | Verfahren zur herstellung eines extrakts aus efeublättern und nach diesem verfahren hergestellter extrakt | |
WO1997034565A2 (de) | Harpagosid-angereicherter extrakt aus harpagophytum procumbens und verfahren zu seiner herstellung | |
EP0683672B1 (de) | Extrakt aus blüten von salvia officinalis, verfahren zu dessen herstellung und dessen verwendung | |
EP0904092A1 (de) | Gereinigter extrakt von harpagophytum procumbens und/oder harpagophytum zeyheri dence, verfahren zu seiner herstellung und seine verwendung | |
DE19603788B4 (de) | Wirkstoffextrakt aus Teufelskrallenwurzel, diesen enthaltendes human- oder veterinärmedizinisches Präparat, Verfahren zur Herstellung eines hochkonzentrierten Extraktes aus Radix Harpagophyti oder Herba und Radix Scrophularia sowie dessen Verwendung | |
DE10112168A1 (de) | Trockenextrakt mit einstellbarem Gehalt an lipophilen und hydrophilen Substanzen und Verfahren zur Herstellung desselben | |
EP0508330B1 (de) | Verfahren zur Herstellung von Extrakten aus Rhizoma Petasitidis mit Kohlendioxid | |
WO1997023232A1 (de) | Verfahren zur schonenden keimreduzierung von pharmazeutischen zubereitungen | |
DE19818001C1 (de) | Verfahren zur schonenden Gewinnung von Extraktfraktionen aus Hypericum, diese enthaltende pharmazeutische Zubereitungen und Verwendung derselben | |
DE2246205A1 (de) | Verfahren zur gewinnung eines extrakts aus arnica montana | |
WO1995002410A1 (de) | Verfahren zur herstellung flüssiger pflanzenauszüge | |
DE19746284A1 (de) | Kosmetische und pharmazeutische Mittel auf Basis eines Kamillenextraktes | |
DE10066022B4 (de) | Pharmazeutische Zusammensetzung zur Behandlung der Neurodermitis | |
EP2138182A2 (de) | Verfahren zur Herstellung eines Arzneimittels auf pflanzlicher Basis | |
DE19651290A1 (de) | Harpagosid-angereicherter Extrakt aus Harpagophytum procumbens und Verfahren zu seiner Herstellung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 200480026543.5 Country of ref document: CN |
|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 11267518 Country of ref document: US |
|
WWE | Wipo information: entry into national phase |
Ref document number: 00491/KOLNP/2006 Country of ref document: IN Ref document number: 491/KOLNP/2006 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2004765026 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2006526564 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/2006/002946 Country of ref document: MX Ref document number: 1020067005188 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 200600489 Country of ref document: EA |
|
WWP | Wipo information: published in national office |
Ref document number: 1020067005188 Country of ref document: KR |
|
DPEN | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101) | ||
WWP | Wipo information: published in national office |
Ref document number: 11267518 Country of ref document: US |
|
WWP | Wipo information: published in national office |
Ref document number: 2004765026 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: PI0414535 Country of ref document: BR |
|
WWG | Wipo information: grant in national office |
Ref document number: 2004765026 Country of ref document: EP |