WO2005009958A1 - Ppar active compounds - Google Patents
Ppar active compounds Download PDFInfo
- Publication number
- WO2005009958A1 WO2005009958A1 PCT/US2004/023234 US2004023234W WO2005009958A1 WO 2005009958 A1 WO2005009958 A1 WO 2005009958A1 US 2004023234 W US2004023234 W US 2004023234W WO 2005009958 A1 WO2005009958 A1 WO 2005009958A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- optionally substituted
- compound
- binding
- ppar
- heteroaryb
- Prior art date
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- 0 CC1=C(C=C*S=C)C(*)=**1* Chemical compound CC1=C(C=C*S=C)C(*)=**1* 0.000 description 11
- NMKDVQKLFXIACC-UHFFFAOYSA-N CC(C)c(cc1)ccc1[S]([n](cc(CCC(O)=O)c1c2)c1ccc2OC)(=O)#[O] Chemical compound CC(C)c(cc1)ccc1[S]([n](cc(CCC(O)=O)c1c2)c1ccc2OC)(=O)#[O] NMKDVQKLFXIACC-UHFFFAOYSA-N 0.000 description 1
- BESCSCXVUPNWEI-UHFFFAOYSA-N CCNC([n](cc(CCCl)c1c2)c1ccc2OC)=S Chemical compound CCNC([n](cc(CCCl)c1c2)c1ccc2OC)=S BESCSCXVUPNWEI-UHFFFAOYSA-N 0.000 description 1
- DORZZVLKQLKUSC-UHFFFAOYSA-N CCc1c(c(C=O)c[nH]2)c2ccc1 Chemical compound CCc1c(c(C=O)c[nH]2)c2ccc1 DORZZVLKQLKUSC-UHFFFAOYSA-N 0.000 description 1
- VKDZFCJHFXFXAM-KADMYINMSA-N COC(/C=C/C(c(cccc1)c1N)=N)=O Chemical compound COC(/C=C/C(c(cccc1)c1N)=N)=O VKDZFCJHFXFXAM-KADMYINMSA-N 0.000 description 1
- ZLSZCJIWILJKMR-UHFFFAOYSA-N COc(cc1)cc2c1[nH]cc2CCC(O)=O Chemical compound COc(cc1)cc2c1[nH]cc2CCC(O)=O ZLSZCJIWILJKMR-UHFFFAOYSA-N 0.000 description 1
- GDWRWBCCOZWYNX-QBFSEMIESA-N COc(cc1)cc2c1[n](/C=C(/CC=C1)\C=C1Cl)cc2CCC(O)=O Chemical compound COc(cc1)cc2c1[n](/C=C(/CC=C1)\C=C1Cl)cc2CCC(O)=O GDWRWBCCOZWYNX-QBFSEMIESA-N 0.000 description 1
- XUNSZADDFLWFOL-UHFFFAOYSA-N COc(cc1)ccc1S(=O)=O Chemical compound COc(cc1)ccc1S(=O)=O XUNSZADDFLWFOL-UHFFFAOYSA-N 0.000 description 1
- NBDLWHIPPSAGOS-UHFFFAOYSA-N COc(cc1C(CC(O)=O)C2)ccc1N2S(c1ccccc1)(=O)=O Chemical compound COc(cc1C(CC(O)=O)C2)ccc1N2S(c1ccccc1)(=O)=O NBDLWHIPPSAGOS-UHFFFAOYSA-N 0.000 description 1
- BIWLYQBNISMACS-UHFFFAOYSA-N COc(cc1c(CCC(O)=O)c2)ccc1[n]2C(Nc1ccccc1)=O Chemical compound COc(cc1c(CCC(O)=O)c2)ccc1[n]2C(Nc1ccccc1)=O BIWLYQBNISMACS-UHFFFAOYSA-N 0.000 description 1
- BEEKCBKRQDZBSX-UHFFFAOYSA-N COc(cc1c(CCCl)c2)ccc1[n]2OS(c1ccc(C(F)(F)F)cc1)=O Chemical compound COc(cc1c(CCCl)c2)ccc1[n]2OS(c1ccc(C(F)(F)F)cc1)=O BEEKCBKRQDZBSX-UHFFFAOYSA-N 0.000 description 1
- DTHGMYGYAPTNGG-UHFFFAOYSA-N COc(cc1c(CCCl)c2)ccc1[n]2O[S+2](c1cc(Cl)ccc1)=O Chemical compound COc(cc1c(CCCl)c2)ccc1[n]2O[S+2](c1cc(Cl)ccc1)=O DTHGMYGYAPTNGG-UHFFFAOYSA-N 0.000 description 1
- QSNMCLKISUKAHU-UHFFFAOYSA-N COc1ncc(CCN2)c2c1 Chemical compound COc1ncc(CCN2)c2c1 QSNMCLKISUKAHU-UHFFFAOYSA-N 0.000 description 1
- WXHMONUQDSWYOO-UHFFFAOYSA-N COc1ncc(c(C=O)c[nH]2)c2c1 Chemical compound COc1ncc(c(C=O)c[nH]2)c2c1 WXHMONUQDSWYOO-UHFFFAOYSA-N 0.000 description 1
- NJYHZMQGTQOAJJ-UHFFFAOYSA-N COc1ncc(cc[nH]2)c2c1 Chemical compound COc1ncc(cc[nH]2)c2c1 NJYHZMQGTQOAJJ-UHFFFAOYSA-N 0.000 description 1
- WHUNFIXNERWADS-UHFFFAOYSA-N Nc1ccccc1C(C=O)=N Chemical compound Nc1ccccc1C(C=O)=N WHUNFIXNERWADS-UHFFFAOYSA-N 0.000 description 1
- DJGNUBADRQIDNQ-UHFFFAOYSA-N O=Cc1c[nH]c(cc2)c1cc2OCc1ccccc1 Chemical compound O=Cc1c[nH]c(cc2)c1cc2OCc1ccccc1 DJGNUBADRQIDNQ-UHFFFAOYSA-N 0.000 description 1
- JOPGNUKHKKAPQR-UHFFFAOYSA-N O=S(c1ccccc1)([n](cc(CCCl)c1c2)c1ccc2Br)=O Chemical compound O=S(c1ccccc1)([n](cc(CCCl)c1c2)c1ccc2Br)=O JOPGNUKHKKAPQR-UHFFFAOYSA-N 0.000 description 1
- LNZDOMBAPNJFOK-LZCJLJQNSA-N OC(/C=C/C(C1)c2cc(O)ccc2N1S(c(cc1Cl)ccc1Cl)(=O)=O)=O Chemical compound OC(/C=C/C(C1)c2cc(O)ccc2N1S(c(cc1Cl)ccc1Cl)(=O)=O)=O LNZDOMBAPNJFOK-LZCJLJQNSA-N 0.000 description 1
- WVDDGKGOMKODPV-UHFFFAOYSA-N OCc1ccccc1 Chemical compound OCc1ccccc1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 1
- FEPBITJSIHRMRT-UHFFFAOYSA-N Oc(cc1)ccc1S(O)(=O)=O Chemical compound Oc(cc1)ccc1S(O)(=O)=O FEPBITJSIHRMRT-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
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- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
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- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020067001015A KR101415503B1 (ko) | 2003-07-17 | 2004-07-16 | Ppar 활성 화합물 |
BRPI0412684-0A BRPI0412684A (pt) | 2003-07-17 | 2004-07-16 | compostos ppar-ativos |
KR1020137002335A KR20130023381A (ko) | 2003-07-17 | 2004-07-16 | Ppar 활성 화합물 |
AU2004259738A AU2004259738B2 (en) | 2003-07-17 | 2004-07-16 | PPAR active compounds |
DK04778641.3T DK1648867T3 (da) | 2003-07-17 | 2004-07-16 | Ppar-aktive forbindelser |
SI200432116T SI1648867T1 (sl) | 2003-07-17 | 2004-07-16 | Ppar aktivne spojine |
EP04778641.3A EP1648867B1 (en) | 2003-07-17 | 2004-07-16 | Ppar active compounds |
NZ545326A NZ545326A (en) | 2003-07-17 | 2004-07-16 | PPAR active compounds |
CA002532403A CA2532403A1 (en) | 2003-07-17 | 2004-07-16 | Ppar active compounds |
UAA200600453A UA88767C2 (uk) | 2003-07-17 | 2004-07-16 | Ppar активні сполуки |
JP2006520413A JP4845730B2 (ja) | 2003-07-17 | 2004-07-16 | Ppar活性化合物 |
IL173079A IL173079A (en) | 2003-07-17 | 2006-01-11 | Ppar active compounds, pharmaceutical compositions comprising them and uses thereof for preparing medicaments |
EC6288A ECSP066288A (es) | 2003-07-17 | 2006-01-16 | Compuestos activos de ppar |
NO20060385A NO20060385L (no) | 2003-07-17 | 2006-01-24 | Ppar-Aktive forbindelser |
HK06108153.0A HK1086010A1 (en) | 2003-07-17 | 2006-07-21 | Ppar active compounds |
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