WO2005003100A2 - 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis - Google Patents
4-arylamino-quinazolines as activators of caspases and inducers of apoptosis Download PDFInfo
- Publication number
- WO2005003100A2 WO2005003100A2 PCT/US2004/021631 US2004021631W WO2005003100A2 WO 2005003100 A2 WO2005003100 A2 WO 2005003100A2 US 2004021631 W US2004021631 W US 2004021631W WO 2005003100 A2 WO2005003100 A2 WO 2005003100A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- methyl
- independently
- halo
- phenyl
- Prior art date
Links
- 0 *Nc1ncnc2ccccc12 Chemical compound *Nc1ncnc2ccccc12 0.000 description 10
- APCWBVSQRDHZEO-UHFFFAOYSA-N C(C1)C1C1C2C1CCCC2 Chemical compound C(C1)C1C1C2C1CCCC2 APCWBVSQRDHZEO-UHFFFAOYSA-N 0.000 description 1
- VCZKCHJSRJBHEL-UHFFFAOYSA-N CC(CCCN)C1CC1 Chemical compound CC(CCCN)C1CC1 VCZKCHJSRJBHEL-UHFFFAOYSA-N 0.000 description 1
- GHJBFYKMWVRJFY-UHFFFAOYSA-N CN(c(cc1)ccc1OC)c(c1c2)nc(N(C)c(cc3)ccc3OC)nc1ccc2Cl Chemical compound CN(c(cc1)ccc1OC)c(c1c2)nc(N(C)c(cc3)ccc3OC)nc1ccc2Cl GHJBFYKMWVRJFY-UHFFFAOYSA-N 0.000 description 1
- JFXDIXYFXDOZIT-UHFFFAOYSA-N CNc(cc1)ccc1OC Chemical compound CNc(cc1)ccc1OC JFXDIXYFXDOZIT-UHFFFAOYSA-N 0.000 description 1
- ASZWKYNXHHCDEF-TXEJJXNPSA-N C[C@H](CC1)CC[C@H]1N(C)c1nc(Cl)nc2ccccc12 Chemical compound C[C@H](CC1)CC[C@H]1N(C)c1nc(Cl)nc2ccccc12 ASZWKYNXHHCDEF-TXEJJXNPSA-N 0.000 description 1
- NYBNGJROQHEOAB-UHFFFAOYSA-N Cc1nc(ccc(N=[N+]=N)c2)c2c(N(C)c(cc2)ccc2OC)n1 Chemical compound Cc1nc(ccc(N=[N+]=N)c2)c2c(N(C)c(cc2)ccc2OC)n1 NYBNGJROQHEOAB-UHFFFAOYSA-N 0.000 description 1
- SNHCRNMVYDHVDT-UHFFFAOYSA-N Cc1nc(cccc2)c2c(N(C)c(cc2)ccc2OC)n1 Chemical compound Cc1nc(cccc2)c2c(N(C)c(cc2)ccc2OC)n1 SNHCRNMVYDHVDT-UHFFFAOYSA-N 0.000 description 1
- WJGOQGIQVKMFFP-UHFFFAOYSA-N Cc1nc(cccc2)c2c(N(C)c(cn2)ncc2OC)n1 Chemical compound Cc1nc(cccc2)c2c(N(C)c(cn2)ncc2OC)n1 WJGOQGIQVKMFFP-UHFFFAOYSA-N 0.000 description 1
- COSPAHRPFSSQPX-UHFFFAOYSA-N Cc1nc(cccc2)c2c(N(C)c(nc2)ncc2OC)n1 Chemical compound Cc1nc(cccc2)c2c(N(C)c(nc2)ncc2OC)n1 COSPAHRPFSSQPX-UHFFFAOYSA-N 0.000 description 1
- YBTQUKLEFZVCQY-UHFFFAOYSA-N Cc1nc2ccccc2c(Nc(cc2)ccc2OC(F)F)n1 Chemical compound Cc1nc2ccccc2c(Nc(cc2)ccc2OC(F)F)n1 YBTQUKLEFZVCQY-UHFFFAOYSA-N 0.000 description 1
- UWMKIAJGXUIFCL-UHFFFAOYSA-N Clc1nc(cccc2)c2c(Nc2ccncc2)n1 Chemical compound Clc1nc(cccc2)c2c(Nc2ccncc2)n1 UWMKIAJGXUIFCL-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cephalosporin Compounds (AREA)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006517854A JP5129957B2 (ja) | 2003-07-03 | 2004-07-06 | カスパーゼの活性化因子およびアポトーシスの誘発因子としての4−アリールアミノ−キナゾリン |
NZ544472A NZ544472A (en) | 2003-07-03 | 2004-07-06 | Compounds and therapeutical use thereof |
CN2004800242058A CN1984660B (zh) | 2003-07-03 | 2004-07-06 | 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉 |
EP04785803A EP1660092A2 (en) | 2003-07-03 | 2004-07-06 | 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis |
CA002531327A CA2531327A1 (en) | 2003-07-03 | 2004-07-06 | Compounds and therapeutical use thereof |
AU2004253967A AU2004253967B2 (en) | 2003-07-03 | 2004-07-06 | 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48432503P | 2003-07-03 | 2003-07-03 | |
US60/484,325 | 2003-07-03 | ||
US49300603P | 2003-08-07 | 2003-08-07 | |
US60/493,006 | 2003-08-07 | ||
US55755604P | 2004-03-29 | 2004-03-29 | |
US60/557,556 | 2004-03-29 | ||
US57128804P | 2004-05-14 | 2004-05-14 | |
US60/571,288 | 2004-05-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005003100A2 true WO2005003100A2 (en) | 2005-01-13 |
WO2005003100A3 WO2005003100A3 (en) | 2005-05-12 |
Family
ID=33568832
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/021631 WO2005003100A2 (en) | 2003-07-03 | 2004-07-06 | 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis |
Country Status (9)
Cited By (34)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2005115362A1 (en) | 2004-05-15 | 2005-12-08 | Vertex Pharmaceuticals Incorporated | Treating seizures using ice inhibitors |
WO2007011618A1 (en) * | 2005-07-15 | 2007-01-25 | Schering Corporation | Quinazoline derivatives useful in cancer treatment |
EP1833511A2 (en) * | 2005-01-03 | 2007-09-19 | Myriad Genetics, Inc. | Method of treating brain cancer |
EP1833482A2 (en) * | 2005-01-03 | 2007-09-19 | Myriad Genetics, Inc. | Compounds and therapeutical use thereof |
EP1890677A2 (en) * | 2005-06-16 | 2008-02-27 | Myriad Genetics, Inc. | Pharmaceutical compositions and use thereof |
JP2008526734A (ja) * | 2004-12-31 | 2008-07-24 | エスケー ケミカルズ カンパニー リミテッド | 糖尿及び肥満治療予防に有効なキナゾリン誘導体 |
WO2008157500A1 (en) * | 2007-06-17 | 2008-12-24 | Kalypsys, Inc. | Aminoquinazoline cannabinoid receptor modulators for treatment of disease |
JP2009521460A (ja) * | 2005-12-21 | 2009-06-04 | アボット・ラボラトリーズ | 抗ウイルス化合物 |
JP2009521479A (ja) * | 2005-12-21 | 2009-06-04 | アボット・ラボラトリーズ | 抗ウイルス化合物 |
JP2009533405A (ja) * | 2006-04-14 | 2009-09-17 | アストラゼネカ アクチボラグ | Csf−1rキナーゼ阻害剤としての4−アニリノキノリン−3−カルボキサミド |
EP2144887A1 (en) * | 2007-04-10 | 2010-01-20 | Myriad Pharmaceuticals, Inc. | Dosages and methods for the treatment of cancer |
EP2144888A1 (en) * | 2007-04-10 | 2010-01-20 | Myriad Pharmaceuticals, Inc. | Methods for treating cancer |
EP2144504A1 (en) * | 2007-04-10 | 2010-01-20 | Myriad Pharmaceuticals, Inc. | Method of treating brain cancer |
EP2144886A1 (en) * | 2007-04-10 | 2010-01-20 | Myriad Pharmaceuticals, Inc. | Method of treating melanoma |
US7767670B2 (en) | 2003-11-13 | 2010-08-03 | Ambit Biosciences Corporation | Substituted 3-carboxamido isoxazoles as kinase modulators |
WO2010112124A1 (en) | 2009-04-02 | 2010-10-07 | Merck Patent Gmbh | Autotaxin inhibitors |
EP2295054A1 (en) | 2004-05-27 | 2011-03-16 | Vertex Pharmaceuticals Incorporated | Ice inhibitors for the treatment of autoinflammatory diseases |
US7915411B2 (en) | 2005-12-21 | 2011-03-29 | Abbott Laboratories | Anti-viral compounds |
CN102088854A (zh) * | 2008-07-11 | 2011-06-08 | 美瑞德生物工程公司 | 作为细胞毒素剂的药物化合物及其使用方法 |
WO2011069335A1 (zh) * | 2009-12-08 | 2011-06-16 | 中国人民解放军军事医学科学院野战输血研究所 | 一类吡啶化合物在制备rna干涉增强剂中的应用 |
WO2011151423A1 (en) | 2010-06-04 | 2011-12-08 | Exonhit S.A. | Substituted isoquinolines and their use as tubulin polymerization inhibitors |
US8236950B2 (en) | 2006-12-20 | 2012-08-07 | Abbott Laboratories | Anti-viral compounds |
US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
US8575184B2 (en) | 2009-09-03 | 2013-11-05 | Bristol-Myers Squibb Company | Quinazolines as potassium ion channel inhibitors |
CN104130200A (zh) * | 2014-07-01 | 2014-11-05 | 中山大学 | 一种2-取代苯基-4-芳胺基喹唑啉衍生物及其制备方法和应用 |
US9116157B2 (en) | 2010-11-05 | 2015-08-25 | Brandeis University | Ice-cleaved alpha-synuclein as a biomarker |
CN108239071A (zh) * | 2016-12-27 | 2018-07-03 | 沈阳药科大学 | 酰胺及硫代酰胺类衍生物及其制备方法和应用 |
US11661422B2 (en) | 2020-08-27 | 2023-05-30 | Incyte Corporation | Tricyclic urea compounds as JAK2 V617F inhibitors |
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AU2012225735B2 (en) | 2011-03-04 | 2016-03-10 | Glaxosmithkline Intellectual Property Development Limited | Amino-quinolines as kinase inhibitors |
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JP2012207044A (ja) | 2012-10-25 |
JP2007524637A (ja) | 2007-08-30 |
CN1984660A (zh) | 2007-06-20 |
CN1984660B (zh) | 2010-12-15 |
US20070249601A1 (en) | 2007-10-25 |
AU2004253967B2 (en) | 2010-02-18 |
AU2004253967A8 (en) | 2010-02-04 |
KR20060052775A (ko) | 2006-05-19 |
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US20080039479A1 (en) | 2008-02-14 |
US20070244113A1 (en) | 2007-10-18 |
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US20080032974A1 (en) | 2008-02-07 |
AU2004253967A1 (en) | 2005-01-13 |
US20170050937A1 (en) | 2017-02-23 |
US20050137213A1 (en) | 2005-06-23 |
US7618975B2 (en) | 2009-11-17 |
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US20070208044A1 (en) | 2007-09-06 |
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