ATE229019T1 - N-4-(heteroarylmethyl)phenyl- heteroarylaminderivate - Google Patents

N-4-(heteroarylmethyl)phenyl- heteroarylaminderivate

Info

Publication number
ATE229019T1
ATE229019T1 AT97930378T AT97930378T ATE229019T1 AT E229019 T1 ATE229019 T1 AT E229019T1 AT 97930378 T AT97930378 T AT 97930378T AT 97930378 T AT97930378 T AT 97930378T AT E229019 T1 ATE229019 T1 AT E229019T1
Authority
AT
Austria
Prior art keywords
heteroarylmethyl
phenyl
heteroarylamine derivatives
heteroarylamine
derivatives
Prior art date
Application number
AT97930378T
Other languages
English (en)
Inventor
Marc Gaston Venet
Dominique Jean-Pierre Mabire
Jean Fernand Armand Lacrampe
Gerard Charles Sanz
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE229019T1 publication Critical patent/ATE229019T1/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT97930378T 1996-06-27 1997-06-19 N-4-(heteroarylmethyl)phenyl- heteroarylaminderivate ATE229019T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96201781 1996-06-27
PCT/EP1997/003248 WO1997049704A1 (en) 1996-06-27 1997-06-19 N-[4-(heteroarylmethyl)phenyl]-heteroarylamines

Publications (1)

Publication Number Publication Date
ATE229019T1 true ATE229019T1 (de) 2002-12-15

Family

ID=8224119

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97930378T ATE229019T1 (de) 1996-06-27 1997-06-19 N-4-(heteroarylmethyl)phenyl- heteroarylaminderivate

Country Status (32)

Country Link
US (5) US6124330A (de)
EP (1) EP0907650B1 (de)
JP (1) JP3404749B2 (de)
KR (1) KR100365312B1 (de)
CN (1) CN1102593C (de)
AR (1) AR007626A1 (de)
AT (1) ATE229019T1 (de)
AU (1) AU711575B2 (de)
BG (1) BG63545B1 (de)
BR (1) BR9710002A (de)
CA (1) CA2258165C (de)
CZ (1) CZ297769B6 (de)
DE (1) DE69717627T2 (de)
DK (1) DK0907650T3 (de)
EE (1) EE03688B1 (de)
ES (1) ES2188957T3 (de)
HU (1) HU223093B1 (de)
ID (1) ID17275A (de)
IL (1) IL127740A (de)
MY (1) MY116917A (de)
NO (1) NO312102B1 (de)
NZ (1) NZ333382A (de)
PL (1) PL201704B1 (de)
PT (1) PT907650E (de)
RU (1) RU2190611C2 (de)
SI (1) SI0907650T1 (de)
SK (1) SK282769B6 (de)
TR (1) TR199802709T2 (de)
TW (1) TW490464B (de)
UA (1) UA53649C2 (de)
WO (1) WO1997049704A1 (de)
ZA (1) ZA975698B (de)

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DE19951701A1 (de) 1999-10-27 2001-05-03 Aventis Pharma Gmbh Verwendung von 2-Imidazolyl-substituierten Carbinolen zur Herstellung eines Medikaments zur Behandlung oder Prophylaxe von durch ischämischen Zuständen bewirkten Krankheiten
US7780687B2 (en) * 2002-04-17 2010-08-24 Tyco Healthcare Group Lp Method and apparatus for anastomosis including expandable anchor
ATE503483T1 (de) 2002-10-30 2011-04-15 Merck Sharp & Dohme Hemmer der akt aktivität
CA2522430A1 (en) 2003-04-24 2004-11-11 Merck & Co., Inc. Inhibitors of akt activity
US7618975B2 (en) * 2003-07-03 2009-11-17 Myriad Pharmaceuticals, Inc. 4-arylamino-quinazolines and analogs as activators of caspases and inducers of apoptosis and the use thereof
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
DE10337942A1 (de) * 2003-08-18 2005-03-17 Merck Patent Gmbh Aminobenzimidazolderivate
AU2005290008A1 (en) * 2004-09-24 2006-04-06 Allergan, Inc. 4-(heteroaryl-methyl and substituted heteroaryl-methyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists
KR20070063016A (ko) * 2004-09-24 2007-06-18 알러간, 인코포레이티드 알파2 아드레날린성 아고니스트로서 작용하는 4-(축합시클릭메틸)-이미다졸-2-티온
CA2581579A1 (en) 2004-09-24 2006-04-06 Allergan, Inc. 4-(phenylmethyl and substituted phenylmethyl)-imidazole-2-thiones acting as specific alpha2 adrenergic agonists
BRPI0516217A (pt) * 2004-09-28 2008-08-26 Allergan Inc compostos de 4-benzil-1,3-diidro-imidazol-2-tionas não-substituìdos e substituìdos que atuam como agonistas especìficos ou seletivos alfa2-adrenérgicos e métodos de utilização dos mesmos
US8258145B2 (en) * 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
CA2592900A1 (en) 2005-01-03 2006-07-13 Myriad Genetics Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
US7547782B2 (en) * 2005-09-30 2009-06-16 Bristol-Myers Squibb Company Met kinase inhibitors
MX2008009215A (es) * 2006-01-17 2008-12-10 Barrier Therapeutics Inc Tratamiento de trastornos inflamatorios con compuestos de triazol.
AU2007311026B2 (en) 2006-10-17 2012-05-17 Stiefel Laboratories, Inc. Talarazole metabolites
WO2009050258A1 (en) * 2007-10-18 2009-04-23 Dompé S.p.A. (r)-4-(heteroaryl) phenylethyl derivatives and pharmaceutical compositions containing them
GB0811091D0 (en) * 2008-06-17 2008-07-23 Cancer Rec Tech Ltd CYP26 Inhibitors
EP2576544A4 (de) 2010-06-01 2013-09-11 Angion Biomedica Corp Zytochrom-p450-hemmer und verwendungen davon
US10414760B2 (en) 2016-11-29 2019-09-17 Angion Biomedica Corp. Cytochrome P450 inhibitors and uses thereof
KR101108577B1 (ko) * 2010-07-28 2012-01-30 국제엘렉트릭코리아 주식회사 테이프 히터
EP3357915A1 (de) 2010-11-19 2018-08-08 Ligand Pharmaceuticals Inc. Heterocyclische amine mit anti-inflammatorischer wirkung
WO2013028771A1 (en) 2011-08-23 2013-02-28 Leong Hwei Xian Reversing intestinal inflammation by inhibiting retinoic acid metabolism
DK3180335T3 (da) 2014-08-11 2021-08-09 Angion Biomedica Corp Cytokrom-p450-inhibitorer og anvendelser deraf
EP3240778A4 (de) 2014-12-31 2018-07-11 Angion Biomedica Corp. Verfahren und mittel zur behandlung von krankheiten
US10807983B2 (en) 2015-03-16 2020-10-20 Ligand Pharmaceuticals, Inc. Imidazo-fused heterocycles and uses thereof
CN106632051A (zh) * 2016-12-15 2017-05-10 青岛辰达生物科技有限公司 一种盐酸右美托咪定中间体的合成方法
CN106588779A (zh) * 2016-12-15 2017-04-26 青岛辰达生物科技有限公司 一种合成盐酸右美托咪定中间体的方法
CN106588780A (zh) * 2016-12-15 2017-04-26 青岛辰达生物科技有限公司 一种盐酸右美托咪定中间体的制备工艺
KR20210055340A (ko) 2019-11-07 2021-05-17 정화종 화물 커버
CN115462347B (zh) * 2021-08-13 2024-07-16 广州市妇女儿童医疗中心 视黄酸代谢通路在先天性巨结肠疾病中的应用

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Also Published As

Publication number Publication date
IL127740A (en) 2001-09-13
IL127740A0 (en) 1999-10-28
SK178198A3 (en) 2000-05-16
AU3435697A (en) 1998-01-14
MY116917A (en) 2004-04-30
US20050113378A1 (en) 2005-05-26
RU2190611C2 (ru) 2002-10-10
SI0907650T1 (en) 2003-06-30
SK282769B6 (sk) 2002-12-03
HUP9902138A2 (hu) 1999-10-28
HU223093B1 (hu) 2004-03-29
PL330816A1 (en) 1999-06-07
BG103013A (en) 1999-09-30
US20070088062A1 (en) 2007-04-19
CZ297769B6 (cs) 2007-03-28
HK1018458A1 (en) 1999-12-24
ES2188957T3 (es) 2003-07-01
EP0907650A1 (de) 1999-04-14
KR100365312B1 (ko) 2003-03-06
PL201704B1 (pl) 2009-04-30
AU711575B2 (en) 1999-10-14
UA53649C2 (uk) 2003-02-17
NZ333382A (en) 2000-05-26
CN1102593C (zh) 2003-03-05
CN1223654A (zh) 1999-07-21
EP0907650B1 (de) 2002-12-04
US7378433B2 (en) 2008-05-27
NO986017D0 (no) 1998-12-21
EE9800437A (et) 1999-06-15
HUP9902138A3 (en) 2001-10-29
DK0907650T3 (da) 2003-03-10
CA2258165A1 (en) 1997-12-31
CZ423198A3 (cs) 1999-05-12
BR9710002A (pt) 1999-08-10
AR007626A1 (es) 1999-11-10
KR20000016196A (ko) 2000-03-25
ID17275A (id) 1997-12-18
EE03688B1 (et) 2002-04-15
US6833375B2 (en) 2004-12-21
TR199802709T2 (xx) 1999-02-22
US6486187B1 (en) 2002-11-26
US7205312B2 (en) 2007-04-17
DE69717627D1 (de) 2003-01-16
NO986017L (no) 1999-02-19
WO1997049704A1 (en) 1997-12-31
PT907650E (pt) 2003-04-30
CA2258165C (en) 2009-03-03
JP2000503670A (ja) 2000-03-28
US6124330A (en) 2000-09-26
US20030176419A1 (en) 2003-09-18
JP3404749B2 (ja) 2003-05-12
NO312102B1 (no) 2002-03-18
TW490464B (en) 2002-06-11
BG63545B1 (bg) 2002-04-30
ZA975698B (en) 1999-01-20
DE69717627T2 (de) 2003-09-18

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