AR007626A1 - N-[4-(heteroaril-metil)fenil]-heteroarilaminas, composicion que las contiene, proceso para preparar dicha composicion y proceso para preparar dichos compuestos - Google Patents

N-[4-(heteroaril-metil)fenil]-heteroarilaminas, composicion que las contiene, proceso para preparar dicha composicion y proceso para preparar dichos compuestos

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Publication number
AR007626A1
AR007626A1 ARP970102822A ARP970102822A AR007626A1 AR 007626 A1 AR007626 A1 AR 007626A1 AR P970102822 A ARP970102822 A AR P970102822A AR P970102822 A ARP970102822 A AR P970102822A AR 007626 A1 AR007626 A1 AR 007626A1
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AR
Argentina
Prior art keywords
alkyl
aryl
amino
substituted
compounds
Prior art date
Application number
ARP970102822A
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English (en)
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Janssen Pharmaceutica Nv
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Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AR007626A1 publication Critical patent/AR007626A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

N-[4-(heteroaril-metil)fenil]-heteroarilaminas de la fórmula (I), los N-óxidos, las sales de adición farmacéuticamente aceptables y sus formasestereoquímicamente isoméricas donde R1 es hidrógeno, hidroxi, aril o alquil de C1-6; R2 eshidróge no, alquilo de C1-12, cicloalquilo de C3-7, alquenilode C2-8, arilo, pirrolidinilo opcionalmente sustituido con alquilo de C1-4 o alcoxicarbonilo de C1-4, o alquilo de C1-12 sustituido con uno o dossustituyentes seleccionados decicloalquilo de C3 -7, hidroxi, alquiloxi de C1-4, ciano, amino- y di(alquilo C1-4)amino, mono- y di(aril-amino,arilalquil C1-4amino, (alquil C1-4)(arilalquil C1-4)amino, pirrolidinil, piperidinal, piperazinil opcionalmente sustituidocon alquil C1-4, morfo linil,perhidro-azepinil, carboxi, alquil C1-4oxicarbonil, aminocarbonil, mono- y di(alquilC1-4)aminocarbonil, aril, ariloxi y ariltio; R3 es hidrógeno,alquilC1-6, arilo o alquil C1-6sustituidos con aril; Het es unheterociclo no saturado se leccionado de imidazolil, triazolil, tetrazolil y piridinil,cada uno de dichos heterociclos no saturados pueden opcionalmente ser sustituidos con amino, mercapto, alquilo C1-6, C1-6 alquiltio o aril; Y Aestádefinido en la memoria descript iva. Procesos para su preparación, composiciones que comprenden a dichos compuestos, su proceso de preparación, así comotambién a su uso como medicamento. Los compuestos de fórmula (I) son inhibidoresdel metabolismo del ácido retinoico.
ARP970102822A 1996-06-27 1997-06-26 N-[4-(heteroaril-metil)fenil]-heteroarilaminas, composicion que las contiene, proceso para preparar dicha composicion y proceso para preparar dichos compuestos AR007626A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96201781 1996-06-27

Publications (1)

Publication Number Publication Date
AR007626A1 true AR007626A1 (es) 1999-11-10

Family

ID=8224119

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970102822A AR007626A1 (es) 1996-06-27 1997-06-26 N-[4-(heteroaril-metil)fenil]-heteroarilaminas, composicion que las contiene, proceso para preparar dicha composicion y proceso para preparar dichos compuestos

Country Status (33)

Country Link
US (5) US6124330A (es)
EP (1) EP0907650B1 (es)
JP (1) JP3404749B2 (es)
KR (1) KR100365312B1 (es)
CN (1) CN1102593C (es)
AR (1) AR007626A1 (es)
AT (1) ATE229019T1 (es)
AU (1) AU711575B2 (es)
BG (1) BG63545B1 (es)
BR (1) BR9710002A (es)
CA (1) CA2258165C (es)
CZ (1) CZ297769B6 (es)
DE (1) DE69717627T2 (es)
DK (1) DK0907650T3 (es)
EE (1) EE03688B1 (es)
ES (1) ES2188957T3 (es)
HK (1) HK1018458A1 (es)
HU (1) HU223093B1 (es)
ID (1) ID17275A (es)
IL (1) IL127740A (es)
MY (1) MY116917A (es)
NO (1) NO312102B1 (es)
NZ (1) NZ333382A (es)
PL (1) PL201704B1 (es)
PT (1) PT907650E (es)
RU (1) RU2190611C2 (es)
SI (1) SI0907650T1 (es)
SK (1) SK282769B6 (es)
TR (1) TR199802709T2 (es)
TW (1) TW490464B (es)
UA (1) UA53649C2 (es)
WO (1) WO1997049704A1 (es)
ZA (1) ZA975698B (es)

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AU2003223672A1 (en) * 2002-04-17 2003-11-03 Tyco Healthcare Group Lp Method and apparatus for anastomosis including an expandable anchor
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WO2004096130A2 (en) 2003-04-24 2004-11-11 Merck & Co., Inc. Inhibitors of akt activity
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MX2007003094A (es) * 2004-09-24 2007-06-07 Allergan Inc 4-(metilo ciclico condensado)-imidazol-2-tionas como agonistas alfa2 adrenergicos.
JP2008514601A (ja) 2004-09-24 2008-05-08 アラーガン、インコーポレイテッド 特異的α2アドレナリン作動剤としての4−(フェニルメチルおよび置換フェニルメチル)−イミダゾール−2−チオン
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KR101108577B1 (ko) * 2010-07-28 2012-01-30 국제엘렉트릭코리아 주식회사 테이프 히터
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HUE055262T2 (hu) 2014-08-11 2021-11-29 Angion Biomedica Corp Citokróm P450 inhibitorok és ezek alkalmazásai
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JP2000503670A (ja) 2000-03-28
ES2188957T3 (es) 2003-07-01
TW490464B (en) 2002-06-11
UA53649C2 (uk) 2003-02-17
AU3435697A (en) 1998-01-14
SI0907650T1 (en) 2003-06-30
CZ423198A3 (cs) 1999-05-12
MY116917A (en) 2004-04-30
EP0907650B1 (en) 2002-12-04
US20030176419A1 (en) 2003-09-18
ATE229019T1 (de) 2002-12-15
KR100365312B1 (ko) 2003-03-06
BG63545B1 (bg) 2002-04-30
HU223093B1 (hu) 2004-03-29
SK178198A3 (en) 2000-05-16
BR9710002A (pt) 1999-08-10
EE03688B1 (et) 2002-04-15
CN1102593C (zh) 2003-03-05
JP3404749B2 (ja) 2003-05-12
US6486187B1 (en) 2002-11-26
DK0907650T3 (da) 2003-03-10
CN1223654A (zh) 1999-07-21
CA2258165A1 (en) 1997-12-31
PL201704B1 (pl) 2009-04-30
IL127740A (en) 2001-09-13
PT907650E (pt) 2003-04-30
NO986017D0 (no) 1998-12-21
BG103013A (en) 1999-09-30
HUP9902138A3 (en) 2001-10-29
CA2258165C (en) 2009-03-03
TR199802709T2 (xx) 1999-02-22
SK282769B6 (sk) 2002-12-03
AU711575B2 (en) 1999-10-14
RU2190611C2 (ru) 2002-10-10
EE9800437A (et) 1999-06-15
WO1997049704A1 (en) 1997-12-31
HK1018458A1 (en) 1999-12-24
NO312102B1 (no) 2002-03-18
PL330816A1 (en) 1999-06-07
ID17275A (id) 1997-12-18
ZA975698B (en) 1999-01-20
US7378433B2 (en) 2008-05-27
US20070088062A1 (en) 2007-04-19
EP0907650A1 (en) 1999-04-14
US6833375B2 (en) 2004-12-21
KR20000016196A (ko) 2000-03-25
NO986017L (no) 1999-02-19
US6124330A (en) 2000-09-26
IL127740A0 (en) 1999-10-28
DE69717627D1 (de) 2003-01-16
US20050113378A1 (en) 2005-05-26
HUP9902138A2 (hu) 1999-10-28
CZ297769B6 (cs) 2007-03-28
DE69717627T2 (de) 2003-09-18
US7205312B2 (en) 2007-04-17
NZ333382A (en) 2000-05-26

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