MX9804052A - Compuestos de mercaptoalquilpeptidilo que tienen un substituyente de imidazol y su uso como inhibidores de metaloproteinasas (mmp) y/o factor de necrosis tumoral (tnf). - Google Patents

Compuestos de mercaptoalquilpeptidilo que tienen un substituyente de imidazol y su uso como inhibidores de metaloproteinasas (mmp) y/o factor de necrosis tumoral (tnf).

Info

Publication number
MX9804052A
MX9804052A MX9804052A MX9804052A MX9804052A MX 9804052 A MX9804052 A MX 9804052A MX 9804052 A MX9804052 A MX 9804052A MX 9804052 A MX9804052 A MX 9804052A MX 9804052 A MX9804052 A MX 9804052A
Authority
MX
Mexico
Prior art keywords
alkyl
aryl
heteroaryl
necrosis factor
tumour necrosis
Prior art date
Application number
MX9804052A
Other languages
English (en)
Inventor
Andrew Douglas Baxter
John Gary Montana
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9523828.3A external-priority patent/GB9523828D0/en
Priority claimed from GBGB9607121.2A external-priority patent/GB9607121D0/en
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Publication of MX9804052A publication Critical patent/MX9804052A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Compuestos de peptidilos que tienen un substituyente de imidazol de la formula general (I), en donde R1 es un alquilo de C1-6, alquenilo de C2-6, (alquilo de C1-6) arilo, arilo, alquilheteroarilo de C1-6, heteroarilo o grupo alquil-AR9 de C1-6 donde A es O, NR9 o S(O)m, donde m=0-2, y R9 es H, alquilo de C1-4, arilo, heteroarilo, (alquilo de C1-6) arilo, o (alquilo de C1-4)arilo o (alquilo de C1-4)heteroarilo; si A=NR9 los grupos R9 pueden ser iguales o diferentes; R2 es hidrogeno o un grupo alquilo de C1-6; R3 es un grupo [Alq]nR6 donde Alq es un alquilo de C1-6 o un grupo alquenilo de C2-6 y n es cero o 1; X es NR9, O o S; Y es n o CR4; R4 y R5 son iguales o diferentes y son R9, COR13, alquilo-R13 de C1-3 o alquilo -COR13 de C1-3; R7 hidrogeno o R10CO donde R10 es alquilo de C1-4, alquilarilo de C1-4, alquilheteroarilo de C1-4, cicloalquilo (C3-6), alquil (de C1-4)cicloalquilo(C3-6), alquenilo de C2-6, alquenilarilo de C2-6, arilo o heteroarilo; R8 es arilo (opcionalmente substituido con R11), heteroarilo (opcionalmente substituido con R11), alquilo de C1-4 (opcionalmente substituido con R11), etc, tienen utilidad terapéutica vía su efecto inhibitorio sobre metaloproteinasa y factor de necrosis tumoral.
MX9804052A 1995-11-22 1998-05-21 Compuestos de mercaptoalquilpeptidilo que tienen un substituyente de imidazol y su uso como inhibidores de metaloproteinasas (mmp) y/o factor de necrosis tumoral (tnf). MX9804052A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9523828.3A GB9523828D0 (en) 1995-11-22 1995-11-22 Compounds
GBGB9607121.2A GB9607121D0 (en) 1996-04-04 1996-04-04 Compounds

Publications (1)

Publication Number Publication Date
MX9804052A true MX9804052A (es) 1998-09-30

Family

ID=26308152

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9804052A MX9804052A (es) 1995-11-22 1998-05-21 Compuestos de mercaptoalquilpeptidilo que tienen un substituyente de imidazol y su uso como inhibidores de metaloproteinasas (mmp) y/o factor de necrosis tumoral (tnf).

Country Status (19)

Country Link
US (1) US6048841A (es)
EP (1) EP0874842B1 (es)
JP (1) JP2000500482A (es)
KR (1) KR19990067687A (es)
CN (1) CN1072667C (es)
AT (1) ATE215946T1 (es)
AU (1) AU711907B2 (es)
BR (1) BR9611636A (es)
CA (1) CA2229438C (es)
CZ (1) CZ291337B6 (es)
DE (1) DE69620639T2 (es)
ES (1) ES2172690T3 (es)
HU (1) HUP9904131A3 (es)
IL (1) IL123431A (es)
MX (1) MX9804052A (es)
NO (1) NO982290L (es)
NZ (1) NZ322565A (es)
PL (1) PL326710A1 (es)
WO (1) WO1997019075A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6673927B2 (en) * 1996-02-16 2004-01-06 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Farnesyl transferase inhibitors
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
RU2201931C2 (ru) 1996-11-20 2003-04-10 Биомежер Инкорпорэйтед Ингибиторы фарнезилтрансферазы и способы ингибирования фарнезилтрансферазы
CA2408408C (en) 2000-05-12 2013-07-09 Genzyme Corporation Modulators of tnf- alpha signaling
ES2208595T3 (es) 2000-05-15 2004-06-16 Darwin Discovery Limited Derivados del acido hidroxamico.
SE0100902D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
SE0100903D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
SE0103710D0 (sv) * 2001-11-07 2001-11-07 Astrazeneca Ab Compounds
IL162884A0 (en) * 2002-01-07 2005-11-20 Eisai Co Ltd Deazapurines and uses thereof
SE0202539D0 (sv) * 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
GB0221246D0 (en) * 2002-09-13 2002-10-23 Astrazeneca Ab Compounds
WO2004047826A1 (en) * 2002-11-21 2004-06-10 Genzyme Corporation Combination of diamide derivatives and immunosuppressive agents for induction of immune tolerance
PT1567138E (pt) * 2002-11-21 2011-04-11 Genzyme Corp Utilização de derivados de diamida para inibição de rejeição crónica de transplante
US20040259744A1 (en) * 2003-12-19 2004-12-23 Meidong Yang Skin and hair cleansers containing sulfur
SE0401762D0 (sv) * 2004-07-05 2004-07-05 Astrazeneca Ab Novel compounds
US7648992B2 (en) 2004-07-05 2010-01-19 Astrazeneca Ab Hydantoin derivatives for the treatment of obstructive airway diseases
SE0403085D0 (sv) * 2004-12-17 2004-12-17 Astrazeneca Ab Novel componds
SE0403086D0 (sv) * 2004-12-17 2004-12-17 Astrazeneca Ab Compounds
TW200831488A (en) * 2006-11-29 2008-08-01 Astrazeneca Ab Novel compounds
PL227790B1 (pl) 2015-08-13 2018-01-31 Slaski Univ Medyczny W Katowicach Fosfoniany acetylenowych pochodnych betuliny o działaniu przeciwnowotworowym, sposób ich wytwarzania i zastosowanie.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69309047T2 (de) * 1992-04-07 1997-09-11 British Biotech Pharm Hydroxamsäure enthaltende collagenase-inhibitoren und cytokinaktivitätsinhibitoren
GB9215665D0 (en) * 1992-07-23 1992-09-09 British Bio Technology Compounds
GB9323165D0 (en) * 1993-11-10 1994-01-05 Chiros Ltd Compounds
GB9404046D0 (en) * 1994-03-03 1994-04-20 Smithkline Beecham Corp Novel compounds
HUT77282A (hu) * 1994-10-05 1998-03-30 Darwin Discovery Limited Peptidvegyületek és gyógyászati alkalmazásuk metalloproteáz inhibitorokként

Also Published As

Publication number Publication date
CZ145598A3 (cs) 1998-08-12
CZ291337B6 (cs) 2003-02-12
EP0874842B1 (en) 2002-04-10
IL123431A (en) 2001-05-20
DE69620639D1 (de) 2002-05-16
CA2229438C (en) 2006-01-17
ATE215946T1 (de) 2002-04-15
CN1072667C (zh) 2001-10-10
US6048841A (en) 2000-04-11
HUP9904131A2 (hu) 2000-06-28
DE69620639T2 (de) 2002-10-17
CA2229438A1 (en) 1997-05-29
NO982290D0 (no) 1998-05-20
CN1202895A (zh) 1998-12-23
NZ322565A (en) 1999-11-29
EP0874842A1 (en) 1998-11-04
HUP9904131A3 (en) 2002-04-29
WO1997019075A1 (en) 1997-05-29
BR9611636A (pt) 1999-12-28
PL326710A1 (en) 1998-10-26
IL123431A0 (en) 1998-09-24
AU7634396A (en) 1997-06-11
NO982290L (no) 1998-05-20
ES2172690T3 (es) 2002-10-01
AU711907B2 (en) 1999-10-21
JP2000500482A (ja) 2000-01-18
KR19990067687A (ko) 1999-08-25

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