HUP9904131A3 - Mercaptoalkylpeptidyl compounds having an imidazole substituent and their use as inhibitors of matrix metalloproteinases (mmp) and/or tomour necrosis factor (tnf) - Google Patents
Mercaptoalkylpeptidyl compounds having an imidazole substituent and their use as inhibitors of matrix metalloproteinases (mmp) and/or tomour necrosis factor (tnf)Info
- Publication number
- HUP9904131A3 HUP9904131A3 HU9904131A HUP9904131A HUP9904131A3 HU P9904131 A3 HUP9904131 A3 HU P9904131A3 HU 9904131 A HU9904131 A HU 9904131A HU P9904131 A HUP9904131 A HU P9904131A HU P9904131 A3 HUP9904131 A3 HU P9904131A3
- Authority
- HU
- Hungary
- Prior art keywords
- tomour
- mmp
- tnf
- inhibitors
- necrosis factor
- Prior art date
Links
- 102000002274 Matrix Metalloproteinases Human genes 0.000 title 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 125000002883 imidazolyl group Chemical group 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000017074 necrotic cell death Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9523828.3A GB9523828D0 (en) | 1995-11-22 | 1995-11-22 | Compounds |
GBGB9607121.2A GB9607121D0 (en) | 1996-04-04 | 1996-04-04 | Compounds |
PCT/GB1996/002892 WO1997019075A1 (en) | 1995-11-22 | 1996-11-22 | Mercaptoalkylpeptidyl compounds having an imidazole substituent and their use as inhibitors of matrix metalloproteinases (mmp) and/or tumour necrosis factor (tnf) |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP9904131A2 HUP9904131A2 (hu) | 2000-06-28 |
HUP9904131A3 true HUP9904131A3 (en) | 2002-04-29 |
Family
ID=26308152
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9904131A HUP9904131A3 (en) | 1995-11-22 | 1996-11-22 | Mercaptoalkylpeptidyl compounds having an imidazole substituent and their use as inhibitors of matrix metalloproteinases (mmp) and/or tomour necrosis factor (tnf) |
Country Status (19)
Country | Link |
---|---|
US (1) | US6048841A (hu) |
EP (1) | EP0874842B1 (hu) |
JP (1) | JP2000500482A (hu) |
KR (1) | KR19990067687A (hu) |
CN (1) | CN1072667C (hu) |
AT (1) | ATE215946T1 (hu) |
AU (1) | AU711907B2 (hu) |
BR (1) | BR9611636A (hu) |
CA (1) | CA2229438C (hu) |
CZ (1) | CZ291337B6 (hu) |
DE (1) | DE69620639T2 (hu) |
ES (1) | ES2172690T3 (hu) |
HU (1) | HUP9904131A3 (hu) |
IL (1) | IL123431A (hu) |
MX (1) | MX9804052A (hu) |
NO (1) | NO982290D0 (hu) |
NZ (1) | NZ322565A (hu) |
PL (1) | PL326710A1 (hu) |
WO (1) | WO1997019075A1 (hu) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6673927B2 (en) | 1996-02-16 | 2004-01-06 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Farnesyl transferase inhibitors |
US6953788B1 (en) | 1996-09-19 | 2005-10-11 | Aventis Pharmaceuticals Inc. | 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase |
RU2201931C2 (ru) | 1996-11-20 | 2003-04-10 | Биомежер Инкорпорэйтед | Ингибиторы фарнезилтрансферазы и способы ингибирования фарнезилтрансферазы |
CN100494182C (zh) * | 2000-05-12 | 2009-06-03 | 基酶有限公司 | 肿瘤坏死α因子信号的调节因子 |
CA2409035A1 (en) | 2000-05-15 | 2001-11-22 | Darwin Discovery Limited | Hydroxamic acid derivatives |
SE0100902D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
SE0100903D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
SE0103710D0 (sv) * | 2001-11-07 | 2001-11-07 | Astrazeneca Ab | Compounds |
ES2262996T3 (es) * | 2002-01-07 | 2006-12-01 | Eisai Co., Ltd. | Deazapurinas y sus usos. |
SE0202539D0 (sv) | 2002-08-27 | 2002-08-27 | Astrazeneca Ab | Compounds |
GB0221246D0 (en) * | 2002-09-13 | 2002-10-23 | Astrazeneca Ab | Compounds |
ATE493980T1 (de) * | 2002-11-21 | 2011-01-15 | Genzyme Corp | Verwendung eines diamidderivats zur verhinderung der chronischen transplantatabstossung |
WO2004047826A1 (en) * | 2002-11-21 | 2004-06-10 | Genzyme Corporation | Combination of diamide derivatives and immunosuppressive agents for induction of immune tolerance |
US20040259744A1 (en) * | 2003-12-19 | 2004-12-23 | Meidong Yang | Skin and hair cleansers containing sulfur |
SE0401762D0 (sv) * | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Novel compounds |
US7648992B2 (en) | 2004-07-05 | 2010-01-19 | Astrazeneca Ab | Hydantoin derivatives for the treatment of obstructive airway diseases |
SE0403086D0 (sv) * | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Compounds |
SE0403085D0 (sv) * | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Novel componds |
TW200831488A (en) * | 2006-11-29 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
PL227790B1 (pl) | 2015-08-13 | 2018-01-31 | Slaski Univ Medyczny W Katowicach | Fosfoniany acetylenowych pochodnych betuliny o działaniu przeciwnowotworowym, sposób ich wytwarzania i zastosowanie. |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69309047T2 (de) * | 1992-04-07 | 1997-09-11 | British Biotech Pharm | Hydroxamsäure enthaltende collagenase-inhibitoren und cytokinaktivitätsinhibitoren |
GB9215665D0 (en) * | 1992-07-23 | 1992-09-09 | British Bio Technology | Compounds |
GB9323165D0 (en) * | 1993-11-10 | 1994-01-05 | Chiros Ltd | Compounds |
GB9404046D0 (en) * | 1994-03-03 | 1994-04-20 | Smithkline Beecham Corp | Novel compounds |
MX9702487A (es) * | 1994-10-05 | 1998-04-30 | Darwin Discovery Ltd | Compuestos peptidilo y su uso terapeutico como inhibidores de las metaloproteasas. |
-
1996
- 1996-11-22 NZ NZ322565A patent/NZ322565A/xx unknown
- 1996-11-22 ES ES96939208T patent/ES2172690T3/es not_active Expired - Lifetime
- 1996-11-22 DE DE69620639T patent/DE69620639T2/de not_active Expired - Fee Related
- 1996-11-22 IL IL12343196A patent/IL123431A/en not_active IP Right Cessation
- 1996-11-22 JP JP9519522A patent/JP2000500482A/ja not_active Ceased
- 1996-11-22 CZ CZ19981455A patent/CZ291337B6/cs not_active IP Right Cessation
- 1996-11-22 AU AU76343/96A patent/AU711907B2/en not_active Ceased
- 1996-11-22 US US08/755,071 patent/US6048841A/en not_active Expired - Fee Related
- 1996-11-22 CA CA002229438A patent/CA2229438C/en not_active Expired - Fee Related
- 1996-11-22 KR KR1019980703717A patent/KR19990067687A/ko not_active Application Discontinuation
- 1996-11-22 AT AT96939208T patent/ATE215946T1/de not_active IP Right Cessation
- 1996-11-22 EP EP96939208A patent/EP0874842B1/en not_active Expired - Lifetime
- 1996-11-22 BR BR9611636-6A patent/BR9611636A/pt unknown
- 1996-11-22 CN CN96198507A patent/CN1072667C/zh not_active Expired - Fee Related
- 1996-11-22 WO PCT/GB1996/002892 patent/WO1997019075A1/en not_active Application Discontinuation
- 1996-11-22 PL PL96326710A patent/PL326710A1/xx unknown
- 1996-11-22 HU HU9904131A patent/HUP9904131A3/hu unknown
-
1998
- 1998-05-20 NO NO982290A patent/NO982290D0/no not_active Application Discontinuation
- 1998-05-21 MX MX9804052A patent/MX9804052A/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR19990067687A (ko) | 1999-08-25 |
DE69620639T2 (de) | 2002-10-17 |
HUP9904131A2 (hu) | 2000-06-28 |
EP0874842B1 (en) | 2002-04-10 |
NO982290L (no) | 1998-05-20 |
CN1202895A (zh) | 1998-12-23 |
EP0874842A1 (en) | 1998-11-04 |
IL123431A0 (en) | 1998-09-24 |
DE69620639D1 (de) | 2002-05-16 |
CA2229438C (en) | 2006-01-17 |
JP2000500482A (ja) | 2000-01-18 |
AU7634396A (en) | 1997-06-11 |
CZ291337B6 (cs) | 2003-02-12 |
AU711907B2 (en) | 1999-10-21 |
MX9804052A (es) | 1998-09-30 |
PL326710A1 (en) | 1998-10-26 |
CN1072667C (zh) | 2001-10-10 |
IL123431A (en) | 2001-05-20 |
ATE215946T1 (de) | 2002-04-15 |
NO982290D0 (no) | 1998-05-20 |
NZ322565A (en) | 1999-11-29 |
ES2172690T3 (es) | 2002-10-01 |
WO1997019075A1 (en) | 1997-05-29 |
CA2229438A1 (en) | 1997-05-29 |
CZ145598A3 (cs) | 1998-08-12 |
US6048841A (en) | 2000-04-11 |
BR9611636A (pt) | 1999-12-28 |
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