BR9611636A - Compostos de mercaptoalquilpeptidila que apresentam um substituinte imdazol e seu uso como inibidores de metaloproteinases de matriz (mmp) e/ou como fator de necrose de tumores (tnf). - Google Patents
Compostos de mercaptoalquilpeptidila que apresentam um substituinte imdazol e seu uso como inibidores de metaloproteinases de matriz (mmp) e/ou como fator de necrose de tumores (tnf).Info
- Publication number
- BR9611636A BR9611636A BR9611636-6A BR9611636A BR9611636A BR 9611636 A BR9611636 A BR 9611636A BR 9611636 A BR9611636 A BR 9611636A BR 9611636 A BR9611636 A BR 9611636A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- aryl
- heteroaryl
- necrosis factor
- tumor necrosis
- Prior art date
Links
- 108060008682 Tumor Necrosis Factor Proteins 0.000 title abstract 4
- 102000003390 tumor necrosis factor Human genes 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000002274 Matrix Metalloproteinases Human genes 0.000 title 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 13
- 125000003118 aryl group Chemical group 0.000 abstract 7
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000005213 alkyl heteroaryl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical compound C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 1
- 102000005741 Metalloproteases Human genes 0.000 abstract 1
- 108010006035 Metalloproteases Proteins 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001151 peptidyl group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Patente de Invenção: <B>"COMPOSTOS DE MERCAPTOALQUILPEPTIDILA QUE APRESENTAM UM SUBSTITUINTE IMIDAZOL E SEU USO COMO INIBIDORES DE METALOPROTEINASES DE MATRIZ (MMP) E/OU COMO FATOR DE NECROSE DE TUMORES (TNF)''<D>. Esta invenção refere-se a compostos de peptidila que apresentam um substituinte de imidazol de fórmula geral (I), onde R^ 1^ é um alquila de C~ 1-6~, alquenila de C~ 2-6~, (alquila de C~ 1-6~)arila, arila, alquil-heteroarila de C~ 1-6~, heteroarila ou alquila de C~ 1-6~-grupo AR^ 9^ onde A é O, NR^ 9^ ou S(O)~ m~, onde m = 0-2, e R^ 9^ é H, alquila de C~ 1-4~, arila, heteroarila, (alquila de C~ 1-4~)arila ou (alquila de C~ 1-4~)arila ou (alquila de C~ 1-4~)heteroarila; se A=NR^ 9^, os grupos R^ 9^ poderão ser iguais ou diferentes; R^ 2^ é hidrogênio ou um grupo alquila de C~ 1-6~; R^ 3^ é um grupo [Alk]~ n~R^ 6^ onde Alk é um grupo alquila de C~ 1-6~ ou alquenila de C~ 2-6~ e n é zero ou 1; X é NR^ 9^, O ou S; Y é N ou CR^ 4^; R^ 4^ e R^ 5^ são iguais ou diferentes e são R^ 9^, COR^ 13^, alquila de C~ 1-3~-R^ 13^ ou alquila de C~ 1-3~-COR^ 13^; R^ 7^ é hidrogênio ou R^ 10^CO onde R^ 10^ é alquila de C~ 1-4~, alquilarila de C~ 1-4~, alquil-heteroarila de C~ 1-4~, cicloalquila de (C~ 3-6~), alquila de C~ 1-4~-cicloalquila de (C~ 3-6~), alquenila de C~ 2-6~, alquenilarila de C~ 2-6~, arila ou heteroarila; R^ 8^ é arila (opcionalmente substituída por R^ 11^), heteroarila (opcionalmente substituída por R^ 11^), alquila de C~ 1-4~ (opcionalmente substituída por R^ 11^) etc, compostos estes que têm utilidade terapêutica via seu efeito inibidor sobre metaloproteinases e como fator de necrose de tumores.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9523828.3A GB9523828D0 (en) | 1995-11-22 | 1995-11-22 | Compounds |
| GBGB9607121.2A GB9607121D0 (en) | 1996-04-04 | 1996-04-04 | Compounds |
| PCT/GB1996/002892 WO1997019075A1 (en) | 1995-11-22 | 1996-11-22 | Mercaptoalkylpeptidyl compounds having an imidazole substituent and their use as inhibitors of matrix metalloproteinases (mmp) and/or tumour necrosis factor (tnf) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9611636A true BR9611636A (pt) | 1999-12-28 |
Family
ID=26308152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9611636-6A BR9611636A (pt) | 1995-11-22 | 1996-11-22 | Compostos de mercaptoalquilpeptidila que apresentam um substituinte imdazol e seu uso como inibidores de metaloproteinases de matriz (mmp) e/ou como fator de necrose de tumores (tnf). |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6048841A (pt) |
| EP (1) | EP0874842B1 (pt) |
| JP (1) | JP2000500482A (pt) |
| KR (1) | KR19990067687A (pt) |
| CN (1) | CN1072667C (pt) |
| AT (1) | ATE215946T1 (pt) |
| AU (1) | AU711907B2 (pt) |
| BR (1) | BR9611636A (pt) |
| CA (1) | CA2229438C (pt) |
| CZ (1) | CZ291337B6 (pt) |
| DE (1) | DE69620639T2 (pt) |
| ES (1) | ES2172690T3 (pt) |
| HU (1) | HUP9904131A3 (pt) |
| IL (1) | IL123431A (pt) |
| MX (1) | MX9804052A (pt) |
| NO (1) | NO982290L (pt) |
| NZ (1) | NZ322565A (pt) |
| PL (1) | PL326710A1 (pt) |
| WO (1) | WO1997019075A1 (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6673927B2 (en) | 1996-02-16 | 2004-01-06 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Farnesyl transferase inhibitors |
| US6953788B1 (en) | 1996-09-19 | 2005-10-11 | Aventis Pharmaceuticals Inc. | 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase |
| RU2201931C2 (ru) | 1996-11-20 | 2003-04-10 | Биомежер Инкорпорэйтед | Ингибиторы фарнезилтрансферазы и способы ингибирования фарнезилтрансферазы |
| EP1294699B1 (en) | 2000-05-12 | 2016-04-13 | Genzyme Corporation | Modulators of tnf- alpha signalling |
| US6809100B2 (en) | 2000-05-15 | 2004-10-26 | Darwin Discovery Ltd. | Hydroxamic acid derivatives |
| SE0100903D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| SE0100902D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| SE0103710D0 (sv) * | 2001-11-07 | 2001-11-07 | Astrazeneca Ab | Compounds |
| NZ533958A (en) * | 2002-01-07 | 2007-09-28 | Eisai Co Ltd | Deazapurines and uses thereof |
| SE0202539D0 (sv) | 2002-08-27 | 2002-08-27 | Astrazeneca Ab | Compounds |
| GB0221246D0 (en) * | 2002-09-13 | 2002-10-23 | Astrazeneca Ab | Compounds |
| DE60335652D1 (de) * | 2002-11-21 | 2011-02-17 | Genzyme Corp | Verwendung eines diamidderivats zur verhinderung der chronischen transplantatabstossung |
| JP4914008B2 (ja) * | 2002-11-21 | 2012-04-11 | ジェンザイム・コーポレーション | 免疫寛容を誘導するためのジアミド誘導体と免疫抑制剤との組み合わせ |
| US20040259744A1 (en) * | 2003-12-19 | 2004-12-23 | Meidong Yang | Skin and hair cleansers containing sulfur |
| US7648992B2 (en) | 2004-07-05 | 2010-01-19 | Astrazeneca Ab | Hydantoin derivatives for the treatment of obstructive airway diseases |
| SE0401762D0 (sv) * | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Novel compounds |
| SE0403086D0 (sv) * | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Compounds |
| SE0403085D0 (sv) * | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Novel componds |
| TW200831488A (en) * | 2006-11-29 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
| PL227790B1 (pl) | 2015-08-13 | 2018-01-31 | Slaski Univ Medyczny W Katowicach | Fosfoniany acetylenowych pochodnych betuliny o działaniu przeciwnowotworowym, sposób ich wytwarzania i zastosowanie. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993020047A1 (en) * | 1992-04-07 | 1993-10-14 | British Bio-Technology Limited | Hydroxamic acid based collagenase and cytokine inhibitors |
| GB9215665D0 (en) * | 1992-07-23 | 1992-09-09 | British Bio Technology | Compounds |
| GB9323165D0 (en) * | 1993-11-10 | 1994-01-05 | Chiros Ltd | Compounds |
| GB9404046D0 (en) * | 1994-03-03 | 1994-04-20 | Smithkline Beecham Corp | Novel compounds |
| JP3787605B2 (ja) * | 1994-10-05 | 2006-06-21 | ダーウィン・ディスカバリー・リミテッド | ペプチジル化合物および金属プロテアーゼのインヒビターとしてのその治療的使用 |
-
1996
- 1996-11-22 EP EP96939208A patent/EP0874842B1/en not_active Expired - Lifetime
- 1996-11-22 WO PCT/GB1996/002892 patent/WO1997019075A1/en not_active Application Discontinuation
- 1996-11-22 CA CA002229438A patent/CA2229438C/en not_active Expired - Fee Related
- 1996-11-22 KR KR1019980703717A patent/KR19990067687A/ko not_active Application Discontinuation
- 1996-11-22 DE DE69620639T patent/DE69620639T2/de not_active Expired - Fee Related
- 1996-11-22 CZ CZ19981455A patent/CZ291337B6/cs not_active IP Right Cessation
- 1996-11-22 NZ NZ322565A patent/NZ322565A/xx unknown
- 1996-11-22 CN CN96198507A patent/CN1072667C/zh not_active Expired - Fee Related
- 1996-11-22 US US08/755,071 patent/US6048841A/en not_active Expired - Fee Related
- 1996-11-22 JP JP9519522A patent/JP2000500482A/ja not_active Ceased
- 1996-11-22 AT AT96939208T patent/ATE215946T1/de not_active IP Right Cessation
- 1996-11-22 ES ES96939208T patent/ES2172690T3/es not_active Expired - Lifetime
- 1996-11-22 PL PL96326710A patent/PL326710A1/xx unknown
- 1996-11-22 IL IL12343196A patent/IL123431A/en not_active IP Right Cessation
- 1996-11-22 HU HU9904131A patent/HUP9904131A3/hu unknown
- 1996-11-22 BR BR9611636-6A patent/BR9611636A/pt unknown
- 1996-11-22 AU AU76343/96A patent/AU711907B2/en not_active Ceased
-
1998
- 1998-05-20 NO NO982290A patent/NO982290L/no not_active Application Discontinuation
- 1998-05-21 MX MX9804052A patent/MX9804052A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU711907B2 (en) | 1999-10-21 |
| WO1997019075A1 (en) | 1997-05-29 |
| JP2000500482A (ja) | 2000-01-18 |
| CA2229438C (en) | 2006-01-17 |
| MX9804052A (es) | 1998-09-30 |
| HUP9904131A3 (en) | 2002-04-29 |
| IL123431A0 (en) | 1998-09-24 |
| US6048841A (en) | 2000-04-11 |
| DE69620639T2 (de) | 2002-10-17 |
| KR19990067687A (ko) | 1999-08-25 |
| PL326710A1 (en) | 1998-10-26 |
| ES2172690T3 (es) | 2002-10-01 |
| ATE215946T1 (de) | 2002-04-15 |
| DE69620639D1 (de) | 2002-05-16 |
| NZ322565A (en) | 1999-11-29 |
| CZ291337B6 (cs) | 2003-02-12 |
| EP0874842B1 (en) | 2002-04-10 |
| CA2229438A1 (en) | 1997-05-29 |
| CN1202895A (zh) | 1998-12-23 |
| CZ145598A3 (cs) | 1998-08-12 |
| NO982290D0 (no) | 1998-05-20 |
| CN1072667C (zh) | 2001-10-10 |
| EP0874842A1 (en) | 1998-11-04 |
| AU7634396A (en) | 1997-06-11 |
| NO982290L (no) | 1998-05-20 |
| IL123431A (en) | 2001-05-20 |
| HUP9904131A2 (hu) | 2000-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A,8A E 9A ANUIDADES. |