DE69509875D1 - Nipecotinsäurederivate als antithrombische verbindungen - Google Patents

Nipecotinsäurederivate als antithrombische verbindungen

Info

Publication number
DE69509875D1
DE69509875D1 DE69509875T DE69509875T DE69509875D1 DE 69509875 D1 DE69509875 D1 DE 69509875D1 DE 69509875 T DE69509875 T DE 69509875T DE 69509875 T DE69509875 T DE 69509875T DE 69509875 D1 DE69509875 D1 DE 69509875D1
Authority
DE
Germany
Prior art keywords
compounds
antithrombic
acid derivatives
nipecotic acid
nipecotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69509875T
Other languages
English (en)
Other versions
DE69509875T2 (de
Inventor
Mary Beavers
Patricia Andrade-Gordon
William Hoekstra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Application granted granted Critical
Publication of DE69509875D1 publication Critical patent/DE69509875D1/de
Publication of DE69509875T2 publication Critical patent/DE69509875T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69509875T 1994-03-16 1995-03-14 Nipecotinsäurederivate als antithrombische verbindungen Expired - Fee Related DE69509875T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21377294A 1994-03-16 1994-03-16
US36489694A 1994-12-27 1994-12-27
PCT/US1995/003145 WO1995025091A2 (en) 1994-03-16 1995-03-14 Nipecotic acid derivatives as antithrombic compounds

Publications (2)

Publication Number Publication Date
DE69509875D1 true DE69509875D1 (de) 1999-07-01
DE69509875T2 DE69509875T2 (de) 1999-12-09

Family

ID=26908383

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69509875T Expired - Fee Related DE69509875T2 (de) 1994-03-16 1995-03-14 Nipecotinsäurederivate als antithrombische verbindungen

Country Status (20)

Country Link
US (1) US5770575A (de)
EP (1) EP0746545B1 (de)
JP (1) JPH09510453A (de)
KR (1) KR100328287B1 (de)
CN (1) CN1083834C (de)
AT (1) ATE180470T1 (de)
AU (1) AU703397B2 (de)
CA (1) CA2163027A1 (de)
DE (1) DE69509875T2 (de)
DK (1) DK0746545T3 (de)
ES (1) ES2131313T3 (de)
FI (1) FI113763B (de)
GR (1) GR3030566T3 (de)
HU (1) HUT74871A (de)
MX (1) MX9504800A (de)
NO (1) NO304885B1 (de)
NZ (1) NZ283209A (de)
RU (1) RU2135470C1 (de)
TW (1) TW318179B (de)
WO (1) WO1995025091A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2161155C2 (ru) * 1993-09-22 2000-12-27 Фудзисава Фармасьютикал Ко., Лтд Производные n-(3-пиперидинилкарбонил)-бета-аланина в качестве антагонистов фактора активации тромбоцитов (фат), способ получения, фармацевтическая композиция и способ лечения
CA2215106A1 (en) * 1995-03-17 1996-09-26 Fujisawa Pharmaceutical Co., Ltd. N-acylpiperidinylcarbonylaminocarboxylic acids and their use as glycoprotein iib/iiia antagonists and fibrinogen-blood platelets binding inhibitors
WO1997033869A1 (en) * 1996-03-13 1997-09-18 Fujisawa Pharmaceutical Co., Ltd. N-[(r)-1-{3-(4-piperidyl)propionyl-3-piperidylcarbonyl]-2(s)-acetylamino-beta-alanine as fibrinogen receptor antagonist
EP1988078B1 (de) * 1996-05-01 2012-10-17 Ortho-McNeil Pharmaceutical, Inc. Carboxamid-Derivate aus Pyrrolidin, Piperidin und Hexahydroazepin für die Behandlung von Thrombosestörungen
SI0923555T1 (en) * 1996-05-01 2005-10-31 Ortho-Mcneil Pharmaceutical, Inc. Carboxamide derivatives of pyrrolidine, piperidine and hexahydroazepine for the treatment of thrombosis disorders
DE19741235A1 (de) * 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US6066651A (en) * 1997-10-29 2000-05-23 Ortho-Mcneil Pharmaceutical, Inc. Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders
US6020347A (en) * 1997-11-18 2000-02-01 Merck & Co., Inc. 4-substituted-4-piperidine carboxamide derivatives
AU1415099A (en) * 1997-11-18 1999-06-07 Merck & Co., Inc. 4-substituted-4-piperidine carboxamide derivatives
WO2000056730A1 (en) * 1999-03-22 2000-09-28 Ortho-Mcneil Pharmaceutical, Inc. PROCESS FOR PREPARING [S-(R*,S*)] -β -[[[1-[1-OXO-3- (4-PIPERIDINYL) PROPYL] -3-PIPERIDINYL] CARBONYL] AMINO] -3- PYRIDINEPROPANOIC ACID AND DERIVATIVES
AUPQ570100A0 (en) * 2000-02-17 2000-03-09 Fujisawa Pharmaceutical Co., Ltd. Beta-alanine derivatives and their use as receptor antagonists
WO2005079863A1 (ja) 2004-02-25 2005-09-01 Astellas Pharma Inc. 血栓造影剤
EP3184149A1 (de) * 2015-12-23 2017-06-28 Julius-Maximilians-Universität Würzburg Lösliches glycoprotein v zur behandlung von thrombose-erkrankungen
CN109734655B (zh) * 2019-03-11 2020-06-02 都创(上海)医药科技有限公司 一种fkbp配体的同型二聚体合成工艺

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
TW201303B (de) * 1990-07-05 1993-03-01 Hoffmann La Roche
MX9100517A (es) * 1990-08-06 1992-04-01 Smith Kline French Lab Compuestos
DE69222433D1 (de) * 1991-11-22 1997-10-30 Yeda Res & Dev Nicht-peptidische surrogate der arg-gly-asp sequenz und entsprechende pharmazeutische zusammensetzungen
US5219867A (en) * 1991-12-16 1993-06-15 Research Corporation Technologies, Inc. Platelet aggregation inhibitory agents
EP0945504A3 (de) * 1992-12-11 1999-12-08 The University Of Florida Stoffe und verfahren zur Schädlingskontrolle
US5559209A (en) * 1993-02-18 1996-09-24 The General Hospital Corporation Regulator regions of G proteins

Also Published As

Publication number Publication date
US5770575A (en) 1998-06-23
FI955498A (fi) 1996-01-15
AU2119195A (en) 1995-10-03
JPH09510453A (ja) 1997-10-21
NO954609D0 (no) 1995-11-15
DK0746545T3 (da) 1999-11-08
RU2135470C1 (ru) 1999-08-27
DE69509875T2 (de) 1999-12-09
EP0746545B1 (de) 1999-05-26
NO954609L (no) 1996-01-05
FI955498A0 (fi) 1995-11-15
ATE180470T1 (de) 1999-06-15
KR100328287B1 (ko) 2002-10-11
TW318179B (en) 1997-10-21
ES2131313T3 (es) 1999-07-16
WO1995025091A2 (en) 1995-09-21
EP0746545A1 (de) 1996-12-11
CN1128022A (zh) 1996-07-31
NZ283209A (en) 1998-04-27
CA2163027A1 (en) 1995-09-21
NO304885B1 (no) 1999-03-01
AU703397B2 (en) 1999-03-25
MX9504800A (es) 1997-05-31
FI113763B (fi) 2004-06-15
HU9503270D0 (en) 1996-05-28
WO1995025091A3 (en) 1995-10-12
HUT74871A (en) 1997-02-28
CN1083834C (zh) 2002-05-01
GR3030566T3 (en) 1999-10-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: BOEHMERT & BOEHMERT, 28209 BREMEN

8339 Ceased/non-payment of the annual fee