MX9504800A - Derivados de acido nipecotico como compuestos antitromboticos. - Google Patents

Derivados de acido nipecotico como compuestos antitromboticos.

Info

Publication number
MX9504800A
MX9504800A MX9504800A MX9504800A MX9504800A MX 9504800 A MX9504800 A MX 9504800A MX 9504800 A MX9504800 A MX 9504800A MX 9504800 A MX9504800 A MX 9504800A MX 9504800 A MX9504800 A MX 9504800A
Authority
MX
Mexico
Prior art keywords
compounds
antithrombic
acid derivatives
nipecotic acid
nipecotic
Prior art date
Application number
MX9504800A
Other languages
English (en)
Inventor
Mary Pat Beavers
Patricia Andrade-Gordon
William J Hoekstra
Original Assignee
Johnson & Johnson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson & Johnson filed Critical Johnson & Johnson
Publication of MX9504800A publication Critical patent/MX9504800A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invencion se refiere a compuestos de la siguiente formula I: (Ver Formula); en donde X1 y X2 son iguales o diferentes y se seleccionan de H2 u O. Preferiblemente, cada uno de X1 y X2 es O; Y es (CH2)m, CH(NHCOR3)(CH2)m, o CH(NH2)CH2)m; A es NHR1, C(NH)NH2 o un anillo de cicloalquilo que contiene un nitrogeno en el mismo, dicho anillo se selecciona de cualquiera de piperidin-2-ilo, piperidin-3-ilo, piperidin-4-ilo, pirrolidin-2-ilo y pirrolidin-3-ilo; muy preferiblemente, el anillo se selecciona de cualquiera de piperidin-2-ilo, piperidin-3-ilo o piperidin-4-ilo; Z es (CH2)n o CH(CO2R4)CH2)n; preferiblemente Z es (CH2)2; R1 es H, alquilo o CH(NH)NH2; muy preferiblemente, R1 es H o alquilo; preferiblemente, R1 es hidrogeno; R2 es H o alquilo; preferiblemente, R2 es hidrogeno; R3 es alcoxi o alquilo. Preferiblemente R3 es t-butoxi o metilo; muy preferiblemente R3 es t-butoxi; R4 es alquilo o arilalquilo tal como bencilo; preferiblemente, R4 es metilo; R6 es H, alquilo o arilalquilo tal como bencilo, cuando R6 es diferente de H, está en su forma de profármaco; m es un entero de 0, 1, 2 o 3; n es el entero de 0, 1 o 2, o el enantiomero o la sal farmaceuticamente aceptable del mismo.
MX9504800A 1994-03-16 1995-03-14 Derivados de acido nipecotico como compuestos antitromboticos. MX9504800A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21377294A 1994-03-16 1994-03-16
US36489694A 1994-12-27 1994-12-27
PCT/US1995/003145 WO1995025091A2 (en) 1994-03-16 1995-03-14 Nipecotic acid derivatives as antithrombic compounds

Publications (1)

Publication Number Publication Date
MX9504800A true MX9504800A (es) 1997-05-31

Family

ID=26908383

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9504800A MX9504800A (es) 1994-03-16 1995-03-14 Derivados de acido nipecotico como compuestos antitromboticos.

Country Status (20)

Country Link
US (1) US5770575A (es)
EP (1) EP0746545B1 (es)
JP (1) JPH09510453A (es)
KR (1) KR100328287B1 (es)
CN (1) CN1083834C (es)
AT (1) ATE180470T1 (es)
AU (1) AU703397B2 (es)
CA (1) CA2163027A1 (es)
DE (1) DE69509875T2 (es)
DK (1) DK0746545T3 (es)
ES (1) ES2131313T3 (es)
FI (1) FI113763B (es)
GR (1) GR3030566T3 (es)
HU (1) HUT74871A (es)
MX (1) MX9504800A (es)
NO (1) NO304885B1 (es)
NZ (1) NZ283209A (es)
RU (1) RU2135470C1 (es)
TW (1) TW318179B (es)
WO (1) WO1995025091A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995008536A1 (en) * 1993-09-22 1995-03-30 Fujisawa Pharmaceutical Co., Ltd. N-(3-piperidinylcarbonyl)-beta-alanine derivatives as paf antagonists
IL117495A (en) * 1995-03-17 2002-05-23 Fujisawa Pharmaceutical Co History of b-alanine, the process for their preparation and the pharmaceutical preparations containing them
KR19990087694A (ko) * 1996-03-13 1999-12-27 후지야마 아키라 피브리노겐 수용체 길항제로서의 N-[(R)-１-{３-(４-피페리딜)프로피오닐-３-피페리딜카보닐]-２(S)-아세틸아미노-β-알라닌
DK0923555T3 (da) * 1996-05-01 2005-08-15 Ortho Mcneil Pharm Inc pyrrolidin, piperidin og hexahydroazepin til behandling af trombotiske lidelser
EP1184374B1 (en) * 1996-05-01 2009-01-28 Ortho-McNeil Pharmaceutical, Inc. Carboxamide derivatives of pyrrolidine, piperidine and hexahydroazepine for the treatment of thrombosis disorders
DE19741235A1 (de) * 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US6066651A (en) * 1997-10-29 2000-05-23 Ortho-Mcneil Pharmaceutical, Inc. Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders
AU1415099A (en) * 1997-11-18 1999-06-07 Merck & Co., Inc. 4-substituted-4-piperidine carboxamide derivatives
US6020347A (en) * 1997-11-18 2000-02-01 Merck & Co., Inc. 4-substituted-4-piperidine carboxamide derivatives
ES2199805T3 (es) * 1999-03-22 2004-03-01 Ortho-Mcneil Pharmaceutical, Inc. Procedimiento para la preparacion de acido (s-(r*s*))-beta-(((1-(1-oxo-3-4-piperidinil)propil)-3-piperidinil)carbonil)amino)-3-piridinoproanoico y derivados.
AUPQ570100A0 (en) * 2000-02-17 2000-03-09 Fujisawa Pharmaceutical Co., Ltd. Beta-alanine derivatives and their use as receptor antagonists
EP2404899A1 (en) 2004-02-25 2012-01-11 Astellas Pharma Inc. Contrast medium for thrombus detection
EP3184149A1 (en) * 2015-12-23 2017-06-28 Julius-Maximilians-Universität Würzburg Soluble glycoprotein v for treating thrombotic diseases
CN109734655B (zh) * 2019-03-11 2020-06-02 都创(上海)医药科技有限公司 一种fkbp配体的同型二聚体合成工艺

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
TW201303B (es) * 1990-07-05 1993-03-01 Hoffmann La Roche
IE912760A1 (en) * 1990-08-06 1992-02-12 Smith Kline French Lab Compounds
ATE158589T1 (de) * 1991-11-22 1997-10-15 Yeda Res & Dev Nicht-peptidische surrogate der arg-gly-asp sequenz und entsprechende pharmazeutische zusammensetzungen
US5219867A (en) * 1991-12-16 1993-06-15 Research Corporation Technologies, Inc. Platelet aggregation inhibitory agents
WO1994013698A1 (en) * 1992-12-11 1994-06-23 University Of Florida Materials and methods for control of pests
US5559209A (en) * 1993-02-18 1996-09-24 The General Hospital Corporation Regulator regions of G proteins

Also Published As

Publication number Publication date
AU2119195A (en) 1995-10-03
ES2131313T3 (es) 1999-07-16
NO304885B1 (no) 1999-03-01
WO1995025091A3 (en) 1995-10-12
KR100328287B1 (ko) 2002-10-11
FI955498A (fi) 1996-01-15
HU9503270D0 (en) 1996-05-28
DE69509875D1 (de) 1999-07-01
DE69509875T2 (de) 1999-12-09
EP0746545B1 (en) 1999-05-26
WO1995025091A2 (en) 1995-09-21
JPH09510453A (ja) 1997-10-21
FI955498A0 (fi) 1995-11-15
EP0746545A1 (en) 1996-12-11
HUT74871A (en) 1997-02-28
CN1128022A (zh) 1996-07-31
NO954609L (no) 1996-01-05
CN1083834C (zh) 2002-05-01
TW318179B (en) 1997-10-21
CA2163027A1 (en) 1995-09-21
NZ283209A (en) 1998-04-27
FI113763B (fi) 2004-06-15
DK0746545T3 (da) 1999-11-08
RU2135470C1 (ru) 1999-08-27
NO954609D0 (no) 1995-11-15
AU703397B2 (en) 1999-03-25
US5770575A (en) 1998-06-23
ATE180470T1 (de) 1999-06-15
GR3030566T3 (en) 1999-10-29

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees