WO2003055594A2 - Materiaux supports optiquement actifs, leur procede de prepartion et leurs utilisations - Google Patents
Materiaux supports optiquement actifs, leur procede de prepartion et leurs utilisations Download PDFInfo
- Publication number
- WO2003055594A2 WO2003055594A2 PCT/FR2002/004391 FR0204391W WO03055594A2 WO 2003055594 A2 WO2003055594 A2 WO 2003055594A2 FR 0204391 W FR0204391 W FR 0204391W WO 03055594 A2 WO03055594 A2 WO 03055594A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- poly
- optically active
- support material
- material according
- ethylene
- Prior art date
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- 239000000463 material Substances 0.000 title claims abstract description 41
- 238000000034 method Methods 0.000 title claims abstract description 16
- AKZWRTCWNXHHFR-PDIZUQLASA-N [(3S)-oxolan-3-yl] N-[(2S,3S)-4-[(5S)-5-benzyl-3-[(2R)-2-carbamoyloxy-2,3-dihydro-1H-inden-1-yl]-4-oxo-3H-pyrrol-5-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamate Chemical compound NC(=O)O[C@@H]1Cc2ccccc2C1C1C=N[C@](C[C@H](O)[C@H](Cc2ccccc2)NC(=O)O[C@H]2CCOC2)(Cc2ccccc2)C1=O AKZWRTCWNXHHFR-PDIZUQLASA-N 0.000 claims abstract description 72
- 150000002148 esters Chemical class 0.000 claims abstract description 57
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 48
- 239000005017 polysaccharide Substances 0.000 claims abstract description 48
- 150000004676 glycans Chemical class 0.000 claims abstract description 47
- 239000007787 solid Substances 0.000 claims abstract description 46
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 38
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 35
- 239000011707 mineral Substances 0.000 claims abstract description 35
- 229920001542 oligosaccharide Polymers 0.000 claims abstract description 34
- -1 oligosaccharide ester Chemical class 0.000 claims abstract description 34
- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 12
- 150000002482 oligosaccharides Chemical class 0.000 claims description 32
- 235000010755 mineral Nutrition 0.000 claims description 31
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- 239000000725 suspension Substances 0.000 claims description 20
- MYRTYDVEIRVNKP-UHFFFAOYSA-N divinylbenzene Substances C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 claims description 18
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- 239000000203 mixture Substances 0.000 claims description 14
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- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 claims description 9
- 239000000391 magnesium silicate Substances 0.000 claims description 9
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- 235000019792 magnesium silicate Nutrition 0.000 claims description 9
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 8
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- 239000000470 constituent Substances 0.000 claims description 8
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- CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 6
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 claims description 6
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 6
- 238000004587 chromatography analysis Methods 0.000 claims description 6
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- 238000006116 polymerization reaction Methods 0.000 claims description 6
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- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 235000012245 magnesium oxide Nutrition 0.000 claims description 5
- 229920000131 polyvinylidene Polymers 0.000 claims description 5
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 claims description 5
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- 229920002125 Sokalan® Polymers 0.000 claims description 4
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- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 4
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 claims description 4
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 claims description 4
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 4
- 239000000395 magnesium oxide Substances 0.000 claims description 4
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 4
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- 229910052718 tin Inorganic materials 0.000 claims description 4
- 239000010936 titanium Substances 0.000 claims description 4
- 229910052719 titanium Inorganic materials 0.000 claims description 4
- 229910052726 zirconium Inorganic materials 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 239000000010 aprotic solvent Substances 0.000 claims description 3
- 239000000460 chlorine Substances 0.000 claims description 3
- 238000004132 cross linking Methods 0.000 claims description 3
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims description 3
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims description 3
- 229920000620 organic polymer Polymers 0.000 claims description 3
- ROLAGNYPWIVYTG-UHFFFAOYSA-N 1,2-bis(4-methoxyphenyl)ethanamine;hydrochloride Chemical compound Cl.C1=CC(OC)=CC=C1CC(N)C1=CC=C(OC)C=C1 ROLAGNYPWIVYTG-UHFFFAOYSA-N 0.000 claims description 2
- UWFRVQVNYNPBEF-UHFFFAOYSA-N 1-(2,4-dimethylphenyl)propan-1-one Chemical compound CCC(=O)C1=CC=C(C)C=C1C UWFRVQVNYNPBEF-UHFFFAOYSA-N 0.000 claims description 2
- WGGLDBIZIQMEGH-UHFFFAOYSA-N 1-bromo-4-ethenylbenzene Chemical compound BrC1=CC=C(C=C)C=C1 WGGLDBIZIQMEGH-UHFFFAOYSA-N 0.000 claims description 2
- KUIZKZHDMPERHR-UHFFFAOYSA-N 1-phenylprop-2-en-1-one Chemical compound C=CC(=O)C1=CC=CC=C1 KUIZKZHDMPERHR-UHFFFAOYSA-N 0.000 claims description 2
- QWVCIORZLNBIIC-UHFFFAOYSA-N 2,3-dibromopropan-1-ol Chemical compound OCC(Br)CBr QWVCIORZLNBIIC-UHFFFAOYSA-N 0.000 claims description 2
- OEPOKWHJYJXUGD-UHFFFAOYSA-N 2-(3-phenylmethoxyphenyl)-1,3-thiazole-4-carbaldehyde Chemical compound O=CC1=CSC(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=N1 OEPOKWHJYJXUGD-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 claims description 2
- 125000005999 2-bromoethyl group Chemical group 0.000 claims description 2
- WSQZNZLOZXSBHA-UHFFFAOYSA-N 3,8-dioxabicyclo[8.2.2]tetradeca-1(12),10,13-triene-2,9-dione Chemical compound O=C1OCCCCOC(=O)C2=CC=C1C=C2 WSQZNZLOZXSBHA-UHFFFAOYSA-N 0.000 claims description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 2
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- 239000005995 Aluminium silicate Substances 0.000 claims description 2
- DJHGAFSJWGLOIV-UHFFFAOYSA-K Arsenate3- Chemical class [O-][As]([O-])([O-])=O DJHGAFSJWGLOIV-UHFFFAOYSA-K 0.000 claims description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
- 229920002284 Cellulose triacetate Polymers 0.000 claims description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 2
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- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 2
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- NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 claims description 2
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Definitions
- optically active support materials constituted by one or more esters and / or one or more carbamates and / or one or more mixed ester and carbamate compounds of polysaccharide or oligosaccharide, and an organic support and / or mineral.
- the invention also relates to their preparation process and their uses for the optical enrichment of chiral molecules, and more particularly for the separation of enantiomers by liquid, supercritical, gas or gas / liquid chromatography.
- the support materials of the invention When used in a chromatographic process, the support materials of the invention, also called enantioselective chromatographic support materials, constitute unichiral stationary phases, or “PSCs”, also called enantioselective, or optically active stationary phases, and the the technique used is then called chiral or enantioselective chromatography.
- PSCs unichiral stationary phases
- enantioselective chromatographic support materials constitute unichiral stationary phases, or “PSCs”, also called enantioselective, or optically active stationary phases, and the technique used is then called chiral or enantioselective chromatography.
- Enantioselective chromatography has experienced considerable growth during the last twenty armies, both for analytical applications, but also for the preparation on an industrial scale, of unichiral or optically active pharmaceutical molecules of high enantiomeric purity.
- ester and carbamate derivatives of polysaccharides although very broad in terms of chromatographic resolution of molecules of extremely varied chemical structures, is limited by the fact that said ester and carbamate derivatives of polysaccharides are physically deposited and / or linked by covalent bond to silica.
- silica and more particularly silica gels, which are soluble in basic aqueous media and in the presence of fluoride ions.
- EP957358 describes stationary chiral phases whose performance is improved by the presence of a remaining quantity of solvent for deposition on the solid support.
- the Depositing Company has found, quite surprisingly and unexpectedly, that the chemical nature of the support on which a polysaccharide ester or carbamate derivative is placed in order to form an enantioselective chromatographic support material, or PSC, has a direct influence on the enantioselectivity factor of the PSC thus constituted.
- ester derivative or more ester derivatives, or else from one or more carbamate derivatives, or alternatively from one or more mixed ester and carbamate derivatives d oligosaccharide or polysaccharide, to have a whole range of different PSCs, made from support materials of different chemical nature, and having a different enantioselectivity factor with respect to the same racemic molecule, or else d '' a same mixture of enantiomers to separate.
- the invention therefore relates to an optically active support material constituted by one or more ester derivatives, and / or by one or more carbamate derivatives, and / or by one or more mixed ester and carbamate derivatives of polysaccharides or oligosaccharides, and by a solid support of organic and / or mineral origin, said solid support not being able to be chosen from the group comprising silica gel, alumina, magnesia, titanium oxide, glass, kaolin , silicates, chromium oxide, boron oxide, zirconia, clay, polyvinyl alcohols, carbon, polyamide, polystyrene, polyacrylate and polyacrylamide.
- the solid support is of organic origin, it is an organic polymer chosen from the group comprising in particular poly (substituted styrenes), polyolefins, polyvinyl ethers, polyalkylvinyl ketones, polyalkynes, polyisocyanates, polyisonitriles, polyoxiranes, polythiiranes, polyaziridines, polyesters, polythioesters, polyurethanes, polyureas, polysulfonamides, phenol / fomaldehyde, polyacenaphthylene, poly (acrylamide-co-acrylic acid), poly- (acrylamide-co-diallyl dimethyl ammonium chloride) resins ), poly- (2- acrylamido-2-methyl-1-propane sulfonic acid), poly- (2-acrylamido-2-methyl-1- propane sulfonic acid -co-acrylonitrile), poly (2-acrylamido-2 acid -methyl-l- sulfonic
- polyacrylonitrile poly (acrylonitrile-co-butadiene), poly (acrylonitrile-co-butadiene-co-acrylic acid), poly (acrylonitrile-co-butadiene-co-styrene), poly (acrylonitrile-co-methacrylonitrile), poly (acrylonitrile-co-methylacrylate), poly- (acrylonitrile-co-vinylidenechloride-co-methylmethacrylate), poly (allylamine), poly (amide-imide), polyaniline, poly (aspartic acid), poly (azelaic anhydride), polyaziridine, poly (benzyl methacrylate), poly (bisphenol A carbonate), poly (bisphenol A-co-epichlorohydrin), poly (4-bromostyrene), poly (l-butene), poly (tert-butyl acrylate-co-ethylacrylate-co- methacrylic acid), poly (1,4-butylene
- polymer is used interchangeably for polymers and copolymers.
- the solid support is of organic and mineral origin, it can be chosen from all types of existing organic and mineral-based composite materials, such as, for example, silica / dextran or hydroxyapatite / agarose composites.
- the solid support is of mineral origin, it is chosen from the group comprising magnesium silicate, zeolites, diatomaceous earths, phosphates such as calcium, zirconium, titanium, hafiiium, germanium phosphates , tin or lead, arsenates such as titanium, zirconium or tin arsenates, ceramics such as titanium oxide / magnesium oxide, alumina / silicon oxide, zirconia / silicon oxide, apatites like fiuoroapatite or hydroxyapatite.
- magnesium silicate such as calcium, zirconium, titanium, hafiiium, germanium phosphates , tin or lead
- arsenates such as titanium, zirconium or tin arsenates
- ceramics such as titanium oxide / magnesium oxide, alumina / silicon oxide, zirconia / silicon oxide, apatites like fiuoroapatite or hydroxyapatite.
- the supports whether of organic or mineral origin, or both of organic and mineral origin (composite) can be in the form of particles having a diameter of 1 ⁇ m to 10 mm and pores having a diameter from 1 to 4000 ⁇ .
- ester or carbamate derivatives or the mixed ester and carbamate derivatives of polysaccharides and oligosaccharides used in the constitution of the optically active support material according to the invention have the following general formula: PS - (OZ) n (I)
- PS represents a polysaccharide or an oligosaccharide having at least 6 sugar units
- n varies from 12 to 30,000, each OZ group being able to represent independently of each other OH, -OC (O) -NH-R or -OC (O) - R, with R representing an alkyl, aryl, alkylaryl or arylalkyl group having 1 to 40 carbon atoms, optionally substituted by at least one heteroatom chosen from the group comprising in particular sulfur, nitrogen, oxygen, phosphorus, chlorine, fluorine, bromine, iodine and silicon.
- R is chosen from the group comprising phenyl, tolyl, 3,5-dimethylphenyl, 4-chlorophenyl, 3,5-dichlorophenyl and 4-tertio butylphenyl.
- PS when in formula (I) PS represents a polysaccharide, it is chosen from the group comprising in particular cellulose, amylose, starch, chitosan, having an average degree of polymerization of 20 to 10,000 .
- PS represents an oligosaccharide
- this is preferably chosen from the group comprising ⁇ , ⁇ and ⁇ -cyclodextrins.
- the optically active support material according to the invention comprises 2 to 70% by weight of the ester or carbamate derivative or of the mixed ester derivative and polysaccharide and oligosaccharide carbamate, and 30 to 98% by weight of said solid support.
- the ester derivative (s), and / or the carbamate derivative (s), and / or the mixed ester and carbamate derivative (s) of polysaccharide or oligosaccharide are not linked by a covalent bond to the support d organic and / or mineral origin and are not chemically linked to each other, that is to say are not crosslinked.
- the support of organic origin is one of the polymers mentioned above and can also be polyamide or a polyvinyl alcohol.
- the support is of mineral origin, in this first embodiment, it is as described above and can also be chromium oxide, boron oxide, aluminum silicate, clay and carbon.
- the enantioselective supports in accordance with this first embodiment are prepared by physical deposition of the ester or carbamate derivative or of the mixed ester and carbamate derivative of polysaccharide or oligosaccharide on the solid support of organic and / or mineral origin.
- This physical deposition can be done in two different ways, namely: evaporation of a suspension, produced from the solid support and from a solution of said ester and / or carbamate derivative of polysaccharide or oligosaccharide, at ordinary pressure or under vacuum, at room temperature or by heating,
- the invention also relates to a process for the preparation of the optically active support material in accordance with the first embodiment described above which presents the successive stages consisting in: dissolving a compound of formula (I) in a polar organic protic or aprotic solvent, adding to the solution obtained a solid support according to the invention and perfectly homogenize the suspension obtained, evaporate the solvent at ordinary pressure and / or under vacuum, at a temperature ranging from room temperature to approximately 100 ° C., or else gently add to the suspension obtained in the preceding step a non-solvent for the compound of formula (I), dry at room temperature or by heating, at ordinary pressure or under vacuum the optically active support material obtained.
- the preferred organic solvents of the ester and / or carbamate derivatives of polysaccharide or oligosaccharide are tetrahydrofuran, 1,4-dioxane, pyridine, and the preferred non-solvents are heptane, hexane and alkanes in general , alcohol and water.
- the compound of general formula (I) is dissolved preferably in a protic solvent, so as not to dissolve or excessively swell the part organic polymer, on the other hand, when the support is of mineral origin, the compound of formula (I) is dissolved either in a polar organic protic or aprotic solvent.
- the ester derivative (s) and / or the carbamate derivative (s) and / or the mixed ester and carbamate derivative (s) of polysaccharide or oligosaccharide are linked by a covalent chemical bond to a support of organic and / or mineral origin, the solid support having optionally been chemically modified beforehand with a bifunctional agent.
- the solid support is chemically modified beforehand if it does not contain groups capable of forming covalent bonds with the derivative ester or carbamate or the mixed ester and carbamate derivative of polysaccharide or oligosaccharide.
- the support of organic origin is one of the polymers mentioned above and can also be polyamide or a polyvinyl alcohol.
- the support is of mineral origin, in this second embodiment, it is as described above and can also be clay or carbon.
- the enantioselective supports in accordance with this second embodiment are prepared using a method as described above which further comprises, before or after the drying step, a reaction step consisting in creating a covalent bond between the solid support and the ester and / or carbamate derivative or the mixed ester and carbamate derivative, as described in "Journal of Chromatography A, 839, 15-21, 1999".
- ester derivative (s) and / or the carbamate derivative (s) and / or the mixed ester and carbamate derivative (s) of polysaccharide or the oligosaccharide are not linked by a covalent bond to the original support organic and / or mineral but are chemically linked to each other, that is to say are crosslinked.
- the support of organic origin is one of the polymers mentioned above and can also be polyamide.
- the support is of mineral origin, in this third embodiment, it is as described above and can also be aluminum silicate, chromium oxide or boron oxide.
- the enantioselective supports in accordance with this third embodiment are prepared using a process comprising the steps consisting in physically depositing the compounds of formula (I) on a solid support which is inert with respect to it. ci, that is to say a solid support which does not contain reactive functions making it possible to create a covalent bond with the compound of formula (I) as described in connection with the first embodiment, then with polymerize the compounds of formula (I) with one another, optionally using bi- or polyfunctional crosslinking agents.
- the crosslinking step can be carried out using bifunctional agents as indicated in US patents 6,342,592, EP0985681 and US5,302,633.
- the ester derivative (s) and / or the carbamate derivative (s) and / or the mixed ester and carbamate derivative (s) of polysaccharide or oligosaccharide are linked by a covalent chemical bond to the support of organic origin and / or mineral and are also chemically bonded to each other, that is to say crosslinked
- the support is of mineral origin
- it is as described above and can also be the aluminum silicate, chromium oxide or boron oxide.
- the enantioselective supports in accordance with this fourth embodiment are prepared using a method as described in connection with the first embodiment which further comprises a step of forming a covalent bond, a step of crosslinking which are performed in any order before or after the drying step.
- ester derivative (s) and / or the carbamate derivative (s) and / or the mixed ester and carbamate derivative (s) of polysaccharide or oligosaccharide are fixed by covalent bond to the solid support of organic and mineral origin, as described for example in the "Journal of chromatography A, 839,
- the invention also relates to the use of an optically active support material, for removing from a mixture of at least two constituents, chosen from the group comprising organic, mineral or organo-mineral molecules, at least part of one of these constituents, or to separate the said constituents by a chromatographic method. It also relates to the use of the optically active support material, to remove from a mixture of at least two enantiomers, chosen from the group comprising organic, inorganic or organomineral molecules, at least part of one of these constituents , to enrich the mixture with one of the enantiomers and thus obtain the other enriched enantiomer, that is to say of a rotary power greater than that of the initial mixture.
- the invention also relates to the use of the optically active support material, for separating enantiomers by a chromatographic method.
- the invention is illustrated by the following examples which are not limiting.
- Examples I to VI illustrate the first embodiment of the enantioselective supports in accordance with the invention.
- EXAMPLE I a / Preparation of a tris-2,3,6- (3,5-dimethylphenyl carbamate cellulose
- microcrystalline cellulose (average degree of polymerization n of 100), 75 ml of pyridine and 38 ml of heptane are placed in a reactor. Agitation and heating at reflux make it possible to dehydrate the cellulose by azeotropic entrainment. 8.15 g of 3,5-dimethylphenylisocyanate and 0.05 g of dimethylaminopyridine are added and the medium is brought to reflux for 24 hours.
- a polyamide support marketed by Merck under the reference 32
- CDMPC tetrahydrofuran
- the THF is then slowly evaporated at ordinary pressure and then under vacuum until a perfectly dry and homogeneous powder is obtained.
- the column is inserted into an HPLC system and the entire system is then balanced under the following conditions: temperature 20 ° C., elution rate 1 ml / min, detection wavelength 254 nm, variable eluting mobile phase ( see table of results), quantity of racemic mixture injected: 1 ⁇ g, 25 ⁇ l injection loop, ethanol injection solvent.
- elution rate 1 ml / min
- detection wavelength 254 nm
- variable eluting mobile phase see table of results
- quantity of racemic mixture injected 1 ⁇ g, 25 ⁇ l injection loop, ethanol injection solvent.
- microcrystalline cellulose (average degree of polymerization n of 100), 75 ml of pyridine and 38 ml of heptane are placed in a reactor. Agitation and heating at reflux make it possible to dehydrate the cellulose by azeotropic entrainment. 10.42 g of 3,5-dichlorophenylisocyanate and 0.05 g of dimethylaminopyridine are added and the medium is brought to reflux for 24 hours.
- the solution is cooled and then poured onto 100 ml of methanol.
- the precipitate is washed with 300 ml of methanol and then dried under vacuum at 50 ° C.
- Biosepra is dried at 150 ° C under vacuum.
- CDMPCs prepared in step a / of Example I, are then dissolved in 40 ml of tetrahydrofuran or THF. 3 g of previously dried titanium support are added to the previous solution and the suspension obtained is perfectly homogenized with stirring.
- the solid is dried at ordinary pressure and then under vacuum until a perfectly dry and homogeneous powder is obtained.
- PSCs were prepared from cellulose tris-2,3,6- (3,5-dimethylphenyl) carbamate, or CDMPC, which was synthesized as in step a / of Example I and various references solid supports.
- the solid supports used are magnesium silicate and titanium oxide. They are of chromatographic quality and consist of irregular particles of 5 to 15 ⁇ m having a pore diameter varying from 200 to 2000 ⁇ .
- the cellulose carbamate derivative obtained, or CDMPC was physically deposited by evaporation from a tetrahydrofuran solution, at a content of 15% by weight relative to the support.
- each enantioselective chromatographic support material obtained was conditioned in a chromatographic column of dimensions 100 ⁇ 4.6 mm (length ⁇ internal diameter).
- PSCs were prepared from cellulose tris-2,3,6- (3,5-dimethylphenyl) carbarnate, or CDMPC, which was synthesized as in step a / of Example I and from different supports solid.
- the solid supports used are silica gel, magnesium silicate and zeolite.
- Silica gel consists of irregular particles of 5 to 15 ⁇ m having a pore diameter varying from 200 to 2000 ⁇ .
- the magnesium silicate used is Florisil (Supelco / Aldrich catalog reference 288705) sieved between 5 and 10 ⁇ m.
- the zeolite comes from FLUKA (reference 9606).
- the cellulose carbamate derivative obtained, or CDMPC was physically deposited by evaporation from a tetrahydrofuran solution, at a content of 15% by weight relative to the support silica gel and magnesium silicate and at a content of 5 % by weight relative to the zeolite support.
- each enantioselective chromatographic support material obtained was conditioned in a chromatographic column of dimensions 250 x 4.6 mm (length x internal diameter).
- Example V The procedure is the same as in Example V, except that a solid support is used, a polystyrene / divinylbenzene from the company Purolite (5 ⁇ m / 2000 ⁇ ).
- test conditions are identical to those described above and the eluting mobile phase consists of a heptane / isopropanol 90/10 mixture:
- EXAMPLE VII Enantioselective solid support in accordance with the fourth embodiment of the invention a / Preparation of a mixed tris-2 amyloidosis. 3, 6- (3, 5-dimethylphenylcarbamate and 4-vinylbenzoate).
- zeolite from FLUKA, reference 9606 are dehydrated by azeotropic entrainment at reflux in 50 ml of toluene. 3 g of ⁇ -mercaptopropyltrimethoxysilane are added all at once and the reaction suspension is brought to reflux for 72 hours. The suspension is filtered and the solid is washed with 2 x 50 ml of toluene. After drying at 60 ° C. under vacuum, 6.25 g of mercaptopropyl derivative zeolite are obtained.
- the solid is taken up in 20 ml of tetrahydrofuran and 80 ml of heptane and 2 ml of ethanedithiol are added as well as 10 mg of AIBN (azo-bis-isobutyronitrile). The suspension is brought to reflux for 10 minutes.
- AIBN azo-bis-isobutyronitrile
- the precipitate is filtered and then washed with 3 x 20 ml of boiling tretrahydrofuran then 3 x 20 ml of heptane.
- the solid is then suspended in 30 ml of heptane and is then conditioned in a chromatographic column of 100 mm x 4.6 mm (length x diameter).
- the column is conditioned in heptane / isopropanol 90/10 at a flow rate of 1 ml / mm and the detection is carried out at 254 nm. 10 ⁇ g of racemic solutes are injected.
- the enantioselectivity of the separation is calculated after measurement of the chromatographic parameters and the calculation of the selectivity factor ⁇ .
- magnesium silicate (reference 288705, absorbent Florisil from the company SUPELCO) are dehydrated by azeotropic entrainment at reflux in 50 ml of toluene.
- the column obtained is conditioned in pure chloroform.
- the eluting phase and pure chloroform which is percolated through the column at a flow rate of 1 ml / min.
- the enantioselectivity of the separation is calculated after measurement of chromatographic parameters and calculation of the selectivity factor ⁇ .
- EXAMPLE IX Enantioselective support in accordance with the second embodiment of the invention a / Preparation of a mixed tris-2 amyloidosis. 3, 6- (3, 5-dimethylphenylcarbamate and 4-vinylbenzoate. 2.5 g of amylose (average degree of polymerization of 100), 75 ml of pyridine and 38 ml of heptane are placed in a reactor. amylose is dehydrated by azeotropic entrainment, the suspension medium is cooled, then 6 g of 3,5-dimethylphenyl isocyanate and 3 g of 4-vinylbenzoyl chloride are successively added.
- the solid is taken up in 20 ml of tetrahydrofuran and 80 ml of heptane and 10 mg of AIBN (azo-bis-isobutyronitrile) are added. The suspension is brought to reflux for 10 minutes. The precipitate is filtered and then washed with 3 x 20 ml of boiling tretrahydrofuran then 3 x 20 ml of heptane. The solid is then suspended in 30 ml of heptane and is then conditioned in a chromatographic column of 100 mm x 4.6 mm (length x diameter). The column is conditioned in pure chloroform at a flow rate of 1 ml / mm and the detection is carried out at 254 nm. 10 ⁇ g of racemic solutes are injected. The enantioselectivity of the separation is calculated after measurement of the chromatographic parameters and the calculation of the selectivity factor ⁇ .
- AIBN azo-bis-isobutyronitrile
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KR10-2004-7010247A KR20040078656A (ko) | 2001-12-27 | 2002-12-17 | 광학 활성 지지체 물질, 제조방법 및 용도 |
JP2003556165A JP2005513492A (ja) | 2001-12-27 | 2002-12-17 | 光学活性支持体材料、それらの調製方法及びそれらの使用 |
EP02805798A EP1458475A2 (fr) | 2001-12-27 | 2002-12-17 | Materiaux supports optiquement actifs, leur procede de prepartion et leurs utilisations |
AU2002364659A AU2002364659B2 (en) | 2001-12-27 | 2002-12-17 | Optically active support materials, method for preparing same and uses thereof |
US10/876,777 US7597804B2 (en) | 2001-12-27 | 2004-06-28 | Optically active support materials, their method of preparation and their uses |
NO20043125A NO20043125L (no) | 2001-12-27 | 2004-07-21 | Optisk aktive baerematerialer, fremgangsmate for fremstilling og anvendelse derav |
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- 2001-12-27 FR FR0116933A patent/FR2834227A1/fr not_active Withdrawn
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- 2002-12-17 EP EP02805798A patent/EP1458475A2/fr not_active Ceased
- 2002-12-17 AU AU2002364659A patent/AU2002364659B2/en not_active Ceased
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- 2002-12-17 KR KR10-2004-7010247A patent/KR20040078656A/ko active IP Right Grant
- 2002-12-17 WO PCT/FR2002/004391 patent/WO2003055594A2/fr active Application Filing
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2004
- 2004-06-28 US US10/876,777 patent/US7597804B2/en not_active Expired - Fee Related
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Cited By (7)
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CN102205770A (zh) * | 2011-03-16 | 2011-10-05 | 陈广耀 | 将平面图片中的影像做成立体实物的方法 |
EP3330704A4 (fr) * | 2015-07-31 | 2018-08-08 | Daicel Corporation | Phase stationnaire pour chromatographie à fluide supercritique |
US11014019B2 (en) | 2015-07-31 | 2021-05-25 | Daicel Corporation | Stationary phase for supercritical fluid chromatography |
CN107376656A (zh) * | 2017-07-13 | 2017-11-24 | 杭州水处理技术研究开发中心有限公司 | 一种基于墨鱼骨纳米粒子改性的高通量反渗透膜的制备方法 |
CN112121776A (zh) * | 2020-09-18 | 2020-12-25 | 董晓明 | 一种用于去除印染废水中锑的吸附剂及其制备方法和应用 |
CN112778437A (zh) * | 2020-12-31 | 2021-05-11 | 北京科华微电子材料有限公司 | 一种天然多糖改性树脂及其制备方法和应用、光刻胶 |
CN112778437B (zh) * | 2020-12-31 | 2022-07-15 | 北京科华微电子材料有限公司 | 一种天然多糖改性树脂及其制备方法和应用、光刻胶 |
Also Published As
Publication number | Publication date |
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NO20043125L (no) | 2004-09-27 |
JP2005513492A (ja) | 2005-05-12 |
EP1458475A2 (fr) | 2004-09-22 |
US7597804B2 (en) | 2009-10-06 |
US20050209100A1 (en) | 2005-09-22 |
CN1617762A (zh) | 2005-05-18 |
FR2834227A1 (fr) | 2003-07-04 |
KR20040078656A (ko) | 2004-09-10 |
AU2002364659B2 (en) | 2008-02-28 |
WO2003055594A3 (fr) | 2003-12-24 |
AU2002364659A1 (en) | 2003-07-15 |
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