WO2002051421A2 - Gelzusammensetzung und transskrotale applikation einer zusammensetzung zur behandlung von hypogonadismus - Google Patents
Gelzusammensetzung und transskrotale applikation einer zusammensetzung zur behandlung von hypogonadismus Download PDFInfo
- Publication number
- WO2002051421A2 WO2002051421A2 PCT/EP2001/015123 EP0115123W WO02051421A2 WO 2002051421 A2 WO2002051421 A2 WO 2002051421A2 EP 0115123 W EP0115123 W EP 0115123W WO 02051421 A2 WO02051421 A2 WO 02051421A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- testosterone
- composition
- gel
- gel composition
- hypogonadism
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Abstract
Description
Claims
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/451,482 US20040044086A1 (en) | 2000-12-22 | 2001-12-20 | Gel composition and trans-scrotal application of a composition for the treatment of hypogonadism |
DE20121209U DE20121209U1 (de) | 2000-12-22 | 2001-12-20 | Gelzusammensetzung zur Behandlung von Hypogonadismus |
EEP200300305A EE05318B1 (et) | 2000-12-22 | 2001-12-20 | Geelkompositsioon ja kompositsiooni transskrotaalne kasutamine hpogonadismi raviks |
DE50112206T DE50112206D1 (de) | 2000-12-22 | 2001-12-20 | Gelzusammensetzung auf alkoholischer basis zur behandlung von hypogonadismus durch transskrotale applikation |
EP01985426A EP1347764B1 (de) | 2000-12-22 | 2001-12-20 | Gelzusammensetzung auf alkoholischer basis zur behandlung von hypogonadismus durch transskrotale applikation |
HU0600234A HUP0600234A3 (en) | 2000-12-22 | 2001-12-20 | Gel composition containing at least one steroid and trans-scrotal application of the composition for the treatment of hypogonadism |
PL366101A PL206702B1 (pl) | 2000-12-22 | 2001-12-20 | Zastosowanie kompozycji żelowej do leczenia hipogonadyzmu |
SI200130714T SI1347764T1 (sl) | 2000-12-22 | 2001-12-20 | Gelni sestavek na alkoholni osnovi za zdravljenje hipogonadizma s trans-skrotalno aplikacijo |
DK01985426T DK1347764T3 (da) | 2000-12-22 | 2001-12-20 | Gelpræparat på alkoholisk basis til behandling af hypogonadisme ved transskrotal applikation |
SK793-2003A SK7932003A3 (en) | 2000-12-22 | 2001-12-20 | Gel composition and trans-scrotal application of a composition for the treatment of hypogonadism |
CA002432534A CA2432534C (en) | 2000-12-22 | 2001-12-20 | Gel composition and trans-scrotal application of a composition for the treatment of hypogonadism |
HR20030510A HRP20030510A2 (en) | 2000-12-22 | 2003-06-20 | Gel composition and trans-scrotal application of acomposition for the treatment of hypogonadism |
CY20071100660T CY1106595T1 (el) | 2000-12-22 | 2007-05-16 | Συνθεση πηγματος και εφαρμογη μεσω του οσχεου μιας συνθεσεως δια την θεραπευτικη αγωγη του υπογοναδισμου |
US12/795,348 US20100317631A1 (en) | 2000-12-22 | 2010-06-07 | Gel Composition and Transcrotal Application of a Composition for the Treatment of Hypogonadism |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10064205.5 | 2000-12-22 | ||
DE10064205 | 2000-12-22 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/795,348 Continuation US20100317631A1 (en) | 2000-12-22 | 2010-06-07 | Gel Composition and Transcrotal Application of a Composition for the Treatment of Hypogonadism |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002051421A2 true WO2002051421A2 (de) | 2002-07-04 |
WO2002051421A3 WO2002051421A3 (de) | 2002-11-07 |
Family
ID=7668398
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2001/015123 WO2002051421A2 (de) | 2000-12-22 | 2001-12-20 | Gelzusammensetzung und transskrotale applikation einer zusammensetzung zur behandlung von hypogonadismus |
Country Status (17)
Country | Link |
---|---|
US (2) | US20040044086A1 (de) |
EP (1) | EP1347764B1 (de) |
AT (1) | ATE356626T1 (de) |
CA (1) | CA2432534C (de) |
CY (1) | CY1106595T1 (de) |
CZ (1) | CZ20031761A3 (de) |
DE (2) | DE50112206D1 (de) |
DK (1) | DK1347764T3 (de) |
EE (1) | EE05318B1 (de) |
ES (1) | ES2283446T3 (de) |
HR (1) | HRP20030510A2 (de) |
HU (1) | HUP0600234A3 (de) |
PL (1) | PL206702B1 (de) |
PT (1) | PT1347764E (de) |
SI (1) | SI1347764T1 (de) |
SK (1) | SK7932003A3 (de) |
WO (1) | WO2002051421A2 (de) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1634583A1 (de) * | 2004-09-09 | 2006-03-15 | Laboratoires Besins International | Testosterongele enthaltend Propylenglykol als Resorptionsverstärker |
EA013430B1 (ru) * | 2004-09-09 | 2010-04-30 | Лаборатуар Безен Энтернасьональ | Тестостероновые гели, включающие пропиленгликоль в качестве усилителя проницаемости |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040092494A9 (en) * | 2000-08-30 | 2004-05-13 | Dudley Robert E. | Method of increasing testosterone and related steroid concentrations in women |
US20040002482A1 (en) * | 2000-08-30 | 2004-01-01 | Dudley Robert E. | Androgen pharmaceutical composition and method for treating depression |
US6503894B1 (en) * | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
MY139721A (en) * | 2002-04-19 | 2009-10-30 | Cpex Pharmaceuticals Inc | Pharmaceutical composition |
US20070088012A1 (en) * | 2005-04-08 | 2007-04-19 | Woun Seo | Method of treating or preventing type-2 diabetes |
EP1937276B1 (de) | 2005-10-12 | 2012-11-21 | Unimed Pharmaceuticals, LLC | Verbessertes testosterongel und anwendungsverfahren dafür |
US9757388B2 (en) | 2011-05-13 | 2017-09-12 | Acerus Pharmaceuticals Srl | Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels |
US20130045958A1 (en) | 2011-05-13 | 2013-02-21 | Trimel Pharmaceuticals Corporation | Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
US20130040923A1 (en) | 2011-05-13 | 2013-02-14 | Trimel Pharmaceuticals Corporation | Intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
US11744838B2 (en) | 2013-03-15 | 2023-09-05 | Acerus Biopharma Inc. | Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0043738A2 (de) * | 1980-07-09 | 1982-01-13 | THE PROCTER & GAMBLE COMPANY | Topische pharmazeutische Präparate mit Tiefenwirkung |
US4867982A (en) * | 1986-01-13 | 1989-09-19 | Alza Corporation | Transdermal drug delivery device |
WO1997041865A1 (de) * | 1996-05-02 | 1997-11-13 | Azupharma Gmbh | Topische penile androgen-applikation zur behandlung der erektilen dysfunktion |
WO1997043989A1 (en) * | 1996-05-22 | 1997-11-27 | Diversified Pharmaceuticals, Inc. | Compositions, methods and devices for the transdermal delivery of drugs |
US5776923A (en) * | 1993-01-19 | 1998-07-07 | Endorecherche, Inc. | Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone |
WO1999024041A1 (en) * | 1997-11-10 | 1999-05-20 | Cellegy Pharmaceuticals, Inc. | Penetration enhancing and irritation reducing systems |
DE19803193C1 (de) * | 1998-01-28 | 1999-07-15 | August Wolff Gmbh & Co Arzneim | Pharmazeutische Zusammensetzung mit Lecithin und alpha-Bisabolol als Penetrationsbeschleuniger |
US5968919A (en) * | 1997-10-16 | 1999-10-19 | Macrochem Corporation | Hormone replacement therapy drug formulations for topical application to the skin |
WO2002011768A1 (en) * | 2000-08-03 | 2002-02-14 | Antares Pharma Ipl Ag | Novel composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3860712A (en) * | 1973-04-16 | 1975-01-14 | Sterling Drug Inc | Composition and method for treatment of acne or seborrhea |
CA1249968A (en) * | 1984-04-05 | 1989-02-14 | Kazuo Kigasawa | Ointment base |
DK3994A (da) * | 1994-01-10 | 1995-07-11 | Frank Nielsen | CDopbevaringssystem hvor CDcoverne monteres på en skinne |
US6503894B1 (en) * | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
US20040072810A1 (en) * | 2001-11-07 | 2004-04-15 | Besins International Belgique | Pharmaceutical composition in the form of a gel or a solution based on dihydrotestosterone, process for preparing it and uses thereof |
DK1317921T3 (da) * | 2001-12-07 | 2009-12-21 | Besins Mfg Belgium | Farmaceutisk sammensætning i form af en gel eller oplösning med dihydrotestosteron, fremgangsmåde til fremstilling og anvendelser heraf |
-
2001
- 2001-12-20 CZ CZ20031761A patent/CZ20031761A3/cs unknown
- 2001-12-20 WO PCT/EP2001/015123 patent/WO2002051421A2/de active IP Right Grant
- 2001-12-20 EP EP01985426A patent/EP1347764B1/de not_active Expired - Lifetime
- 2001-12-20 SI SI200130714T patent/SI1347764T1/sl unknown
- 2001-12-20 DK DK01985426T patent/DK1347764T3/da active
- 2001-12-20 DE DE50112206T patent/DE50112206D1/de not_active Expired - Lifetime
- 2001-12-20 ES ES01985426T patent/ES2283446T3/es not_active Expired - Lifetime
- 2001-12-20 SK SK793-2003A patent/SK7932003A3/sk unknown
- 2001-12-20 US US10/451,482 patent/US20040044086A1/en not_active Abandoned
- 2001-12-20 EE EEP200300305A patent/EE05318B1/xx not_active IP Right Cessation
- 2001-12-20 CA CA002432534A patent/CA2432534C/en not_active Expired - Fee Related
- 2001-12-20 PT PT01985426T patent/PT1347764E/pt unknown
- 2001-12-20 HU HU0600234A patent/HUP0600234A3/hu unknown
- 2001-12-20 DE DE20121209U patent/DE20121209U1/de not_active Expired - Lifetime
- 2001-12-20 PL PL366101A patent/PL206702B1/pl not_active IP Right Cessation
- 2001-12-20 AT AT01985426T patent/ATE356626T1/de not_active IP Right Cessation
-
2003
- 2003-06-20 HR HR20030510A patent/HRP20030510A2/hr not_active Application Discontinuation
-
2007
- 2007-05-16 CY CY20071100660T patent/CY1106595T1/el unknown
-
2010
- 2010-06-07 US US12/795,348 patent/US20100317631A1/en not_active Abandoned
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0043738A2 (de) * | 1980-07-09 | 1982-01-13 | THE PROCTER & GAMBLE COMPANY | Topische pharmazeutische Präparate mit Tiefenwirkung |
US4867982A (en) * | 1986-01-13 | 1989-09-19 | Alza Corporation | Transdermal drug delivery device |
US5776923A (en) * | 1993-01-19 | 1998-07-07 | Endorecherche, Inc. | Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone |
WO1997041865A1 (de) * | 1996-05-02 | 1997-11-13 | Azupharma Gmbh | Topische penile androgen-applikation zur behandlung der erektilen dysfunktion |
WO1997043989A1 (en) * | 1996-05-22 | 1997-11-27 | Diversified Pharmaceuticals, Inc. | Compositions, methods and devices for the transdermal delivery of drugs |
US5968919A (en) * | 1997-10-16 | 1999-10-19 | Macrochem Corporation | Hormone replacement therapy drug formulations for topical application to the skin |
WO1999024041A1 (en) * | 1997-11-10 | 1999-05-20 | Cellegy Pharmaceuticals, Inc. | Penetration enhancing and irritation reducing systems |
DE19803193C1 (de) * | 1998-01-28 | 1999-07-15 | August Wolff Gmbh & Co Arzneim | Pharmazeutische Zusammensetzung mit Lecithin und alpha-Bisabolol als Penetrationsbeschleuniger |
WO2002011768A1 (en) * | 2000-08-03 | 2002-02-14 | Antares Pharma Ipl Ag | Novel composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels |
Non-Patent Citations (5)
Title |
---|
"Dictonnaire Vidal" 1982 XP002205868 Seite 967, Spalte 1 * |
FINDLAY J C ET AL: "TREATMENT OF PRIMARY HYPOGONADISM IN MEN BY THE TRANSDERMAL ADMINISTRATION OF TESTOSTERONE" JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Bd. 68, Nr. 2, 1989, Seiten 369-373, XP001088685 ISSN: 0021-972X * |
KIM E D ET AL: "Papaverine topical gel for treatment of erectile dysfunction." THE JOURNAL OF UROLOGY. UNITED STATES FEB 1995, Bd. 153, Nr. 2, Februar 1995 (1995-02), Seiten 361-365, XP001084767 ISSN: 0022-5347 * |
LIN S S ET AL: "Transdermal testosterone delivery: Comparison between scrotal and nonscrotal delivery systems" PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, (AUG 1999) VOL. 4, NO. 3, PP. 405-414. PUBLISHER: MARCEL DEKKER INC, 270 MADISON AVE, NEW YORK, NY 10016. ISSN: 1083-7450., XP001084425 RUTGERS STATE UNIV, COLL PHARM, CONTROLLED DRUG DELIVERY RES CTR, POB 10406, NEW BRUNSWICK, NJ 08906 (Reprint);RUTGERS STATE UNIV, COLL PHARM, CONTROLLED DRUG DELIVERY RES CTR, NEW BRUNSWICK, NJ 08906 * |
ODAME I ET AL: "Early diagnosis and management of 5 alpha-reductase deficiency." ARCHIVES OF DISEASE IN CHILDHOOD. ENGLAND JUN 1992, Bd. 67, Nr. 6, Juni 1992 (1992-06), Seiten 720-723, XP001088867 ISSN: 1468-2044 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1634583A1 (de) * | 2004-09-09 | 2006-03-15 | Laboratoires Besins International | Testosterongele enthaltend Propylenglykol als Resorptionsverstärker |
WO2006027278A1 (en) | 2004-09-09 | 2006-03-16 | Laboratoires Besins International | Testosterone gels comprising propylene glycol as penetration enhancer |
EA013430B1 (ru) * | 2004-09-09 | 2010-04-30 | Лаборатуар Безен Энтернасьональ | Тестостероновые гели, включающие пропиленгликоль в качестве усилителя проницаемости |
EP2957279A1 (de) * | 2004-09-09 | 2015-12-23 | Besins Healthcare Luxembourg SARL | Testosterongele mit propylen-glycol als penetrationsverbesserer |
NO341780B1 (no) * | 2004-09-09 | 2018-01-22 | Besins Healthcare Lu Sarl | Testosterongeler omfattende polypropylenglykol og isopropylmyristat som gjennomtrengningsforsterker |
Also Published As
Publication number | Publication date |
---|---|
SK7932003A3 (en) | 2003-11-04 |
WO2002051421A3 (de) | 2002-11-07 |
CY1106595T1 (el) | 2012-01-25 |
EE200300305A (et) | 2003-12-15 |
PT1347764E (pt) | 2007-06-01 |
PL206702B1 (pl) | 2010-09-30 |
EP1347764A2 (de) | 2003-10-01 |
US20040044086A1 (en) | 2004-03-04 |
DE50112206D1 (de) | 2007-04-26 |
DE20121209U1 (de) | 2002-06-20 |
CA2432534A1 (en) | 2002-07-04 |
ATE356626T1 (de) | 2007-04-15 |
US20100317631A1 (en) | 2010-12-16 |
CZ20031761A3 (cs) | 2004-01-14 |
CA2432534C (en) | 2009-09-22 |
PL366101A1 (en) | 2005-01-24 |
HUP0600234A2 (en) | 2006-07-28 |
SI1347764T1 (sl) | 2007-06-30 |
EE05318B1 (et) | 2010-08-16 |
HRP20030510A2 (en) | 2005-04-30 |
DK1347764T3 (da) | 2007-07-23 |
EP1347764B1 (de) | 2007-03-14 |
HUP0600234A3 (en) | 2011-04-28 |
ES2283446T3 (es) | 2007-11-01 |
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