WO2002024902A1 - Method of synthesizing polynucleotide - Google Patents

Method of synthesizing polynucleotide Download PDF

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Publication number
WO2002024902A1
WO2002024902A1 PCT/JP2001/008142 JP0108142W WO0224902A1 WO 2002024902 A1 WO2002024902 A1 WO 2002024902A1 JP 0108142 W JP0108142 W JP 0108142W WO 0224902 A1 WO0224902 A1 WO 0224902A1
Authority
WO
WIPO (PCT)
Prior art keywords
polynucleotide
isothermally
loop
template
synthesizing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2001/008142
Other languages
English (en)
French (fr)
Inventor
Kentaro Nagamine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eiken Chemical Co Ltd
Original Assignee
Eiken Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18768163&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2002024902(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to US10/380,930 priority Critical patent/US7374913B2/en
Priority to JP2002529496A priority patent/JP4918210B2/ja
Priority to EP01967728A priority patent/EP1327679B1/en
Priority to DE60139331T priority patent/DE60139331D1/de
Priority to AT01967728T priority patent/ATE437225T1/de
Application filed by Eiken Chemical Co Ltd filed Critical Eiken Chemical Co Ltd
Priority to AU2001288065A priority patent/AU2001288065A1/en
Priority to HK03107694.1A priority patent/HK1055445B/en
Publication of WO2002024902A1 publication Critical patent/WO2002024902A1/ja
Anticipated expiration legal-status Critical
Priority to US12/103,492 priority patent/US7851186B2/en
Priority to US12/103,506 priority patent/US7846695B2/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
PCT/JP2001/008142 2000-09-19 2001-09-19 Method of synthesizing polynucleotide Ceased WO2002024902A1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
HK03107694.1A HK1055445B (en) 2000-09-19 2001-09-19 Method of synthesizing polynucleotide
JP2002529496A JP4918210B2 (ja) 2000-09-19 2001-09-19 ポリヌクレオチドの合成方法
EP01967728A EP1327679B1 (en) 2000-09-19 2001-09-19 Method of synthesizing polynucleotide
DE60139331T DE60139331D1 (de) 2000-09-19 2001-09-19 Verfahren zur polynukleotidsynthese
AT01967728T ATE437225T1 (de) 2000-09-19 2001-09-19 Verfahren zur polynukleotidsynthese
US10/380,930 US7374913B2 (en) 2000-09-19 2001-09-19 Method for synthesizing polynucleotides
AU2001288065A AU2001288065A1 (en) 2000-09-19 2001-09-19 Method of synthesizing polynucleotide
US12/103,492 US7851186B2 (en) 2000-09-19 2008-04-15 Kit for synthesizing polynucleotides
US12/103,506 US7846695B2 (en) 2000-09-19 2008-04-15 Method for synthesizing polynucleotides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000-283862 2000-09-19
JP2000283862 2000-09-19

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US10380930 A-371-Of-International 2001-09-19
US12/103,506 Division US7846695B2 (en) 2000-09-19 2008-04-15 Method for synthesizing polynucleotides
US12/103,492 Division US7851186B2 (en) 2000-09-19 2008-04-15 Kit for synthesizing polynucleotides

Publications (1)

Publication Number Publication Date
WO2002024902A1 true WO2002024902A1 (en) 2002-03-28

Family

ID=18768163

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2001/008142 Ceased WO2002024902A1 (en) 2000-09-19 2001-09-19 Method of synthesizing polynucleotide

Country Status (9)

Country Link
US (3) US7374913B2 (ja)
EP (2) EP1327679B1 (ja)
JP (2) JP4918210B2 (ja)
CN (1) CN1222614C (ja)
AT (1) ATE437225T1 (ja)
AU (1) AU2001288065A1 (ja)
DE (1) DE60139331D1 (ja)
ES (2) ES2327712T3 (ja)
WO (1) WO2002024902A1 (ja)

Cited By (39)

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WO2003097878A1 (en) 2002-05-21 2003-11-27 Sysmex Corporation Nucleic acid amplification primers for detecting cytokeratins and examination method with the use of the primers
WO2005001097A1 (ja) 2003-06-27 2005-01-06 Eiken Kagaku Kabushiki Kaisha Ｓａｒｓコロナウイルスの検出法
WO2005035789A1 (ja) * 2003-10-08 2005-04-21 Sapporo Breweries Limited アリサイクロバチラス属菌検出用プライマー
WO2005063977A1 (ja) * 2003-12-25 2005-07-14 Riken 核酸の増幅法およびこれを利用した変異核酸の検出法
WO2006035712A1 (ja) * 2004-09-30 2006-04-06 Sysmex Corporation Ｒｂｃｓ－１ａ遺伝子を検出するための核酸増幅用プライマ及び前記遺伝子を内部標準物質として用いる核酸の定量方法
WO2006049061A1 (ja) 2004-11-01 2006-05-11 Eiken Kagaku Kabushiki Kaisha Ｈ５型又はｈ７型トリインフルエンザウイルスの検出方法
WO2006098428A1 (ja) * 2005-03-17 2006-09-21 Kabushiki Kaisha Dnaform プライマーダイマーからの非特異的増幅を減少させる方法
WO2006117676A2 (en) 2005-04-29 2006-11-09 Millipore Corporation Method for the detection and characterization of microorganisms on a filter
WO2007069331A1 (ja) * 2005-12-16 2007-06-21 Eiken Kagaku Kabushiki Kaisha ヒト免疫不全ウイルス１型の検出方法
EP1564301A4 (en) * 2002-10-29 2007-07-11 Riken PROCESS FOR NUCLEIC ACID AMPLIFICATION
EP1820865A1 (en) 2006-01-27 2007-08-22 Sysmex Corporation Primer and primer set for amplification of CEA nucleic acid, and methods for assisting cancer diagnosis
EP1970453A2 (en) 2007-03-09 2008-09-17 Riken Primer, primer set, and nucleic acid amplification method and mutation detection method using the same
EP1988178A2 (en) 2007-04-26 2008-11-05 Kabushiki Kaisha Toshiba Nucleotide primer set and nucleotide probe for detecting genotype of serum amyloid A1(SAA1)
WO2009054510A1 (ja) 2007-10-25 2009-04-30 Riken 等温増幅方法およびそれに用いるｄｎａポリメラーゼ
EP2107113A1 (en) 2002-02-20 2009-10-07 Sysmex Corporation Primers for nucleic acid amplification in detecting housekeeping gene mRNA and test method using these primers
WO2009145314A1 (ja) 2008-05-29 2009-12-03 花王株式会社 パエシロマイセス バリオッティの検出方法
WO2009145279A1 (ja) 2008-05-28 2009-12-03 花王株式会社 耐熱性菌類の検出方法
US7728119B2 (en) 2007-03-28 2010-06-01 Kabushiki Kaisha Toshiba Nucleotide primer set and nucleotide probe for detecting genotype of methylene tetrahydrofolate reductase (MTHFR)
WO2010061922A1 (ja) 2008-11-27 2010-06-03 独立行政法人理化学研究所 新規ＭｕｔＳタンパク質およびそれを用いた変異の判定方法
US7803544B2 (en) 2006-01-20 2010-09-28 Kabushiki Kaisha Toshiba Method of detecting amplification product or target nucleic acid
US7919611B2 (en) 2007-03-28 2011-04-05 Kabushiki Kaisha Toshiba Nucleotide primer set and nucleotide probe for detecting genotype of N-acetyltransferase-2 (NAT2)
JP2012085652A (ja) * 2000-09-19 2012-05-10 Eiken Chemical Co Ltd ポリヌクレオチドの合成方法
WO2013035875A1 (ja) 2011-09-08 2013-03-14 独立行政法人理化学研究所 プライマーセット及びそれを用いた標的核酸配列の増幅方法並びに変異核酸の検出方法
WO2013065574A1 (ja) 2011-10-31 2013-05-10 栄研化学株式会社 標的核酸の検出法
EP2784508A2 (en) 2008-12-25 2014-10-01 Universal Bio Research Co., Ltd. Biologically-relevant substance assay system
WO2016011280A1 (en) 2014-07-16 2016-01-21 Tangen Biosciences, Inc. Isothermal methods for amplifying nucleic acid samples
WO2016098892A1 (ja) * 2014-12-19 2016-06-23 国立大学法人 長崎大学 ザイールエボラウイルス検出用プライマーセット、アッセイキットおよび増幅方法
CN107406845A (zh) * 2014-12-19 2017-11-28 国立大学法人长崎大学 扎伊尔埃博拉病毒检测用引物对、检测试剂盒及扩增方法
WO2017212904A1 (ja) * 2016-06-06 2017-12-14 国立大学法人 宮崎大学 複数のプライマーセットを組み合わせたｌａｍｐ法を用いたアフリカ豚コレラウイルスの迅速検出法
WO2019163672A1 (ja) 2018-02-22 2019-08-29 佐藤製薬株式会社 白癬菌の遺伝子をｌａｍｐ法により検出するためのプライマーセット及びそれを含むキット並びにそれらを用いて白癬菌を検出する方法
CN110878367A (zh) * 2019-12-05 2020-03-13 华南农业大学 一种可检测snp的新型cpa方法、引物组和试剂盒
WO2021172370A1 (ja) 2020-02-27 2021-09-02 栄研化学株式会社 一本鎖ｒｎａウイルスを検出する方法
WO2021177372A1 (ja) 2020-03-05 2021-09-10 栄研化学株式会社 コロナウイルス（ＳＡＲＳ－ＣｏＶ－２）の検出方法
WO2021224355A1 (en) 2020-05-05 2021-11-11 Genomtec Sa Diagnostic primers, kits and methods for viral detection
WO2021252836A1 (en) 2020-06-12 2021-12-16 Sherlock Biosciences Crispr-based sars-cov-2 detection
WO2022029449A1 (en) 2020-08-07 2022-02-10 Oxford Nanopore Technologies Limited Methods of identifying nucleic acid barcodes
WO2022173710A1 (en) 2021-02-09 2022-08-18 Sherlock Biosciences, Inc. Nucleic acid amplification using promoter primers
US11559801B2 (en) 2014-11-03 2023-01-24 Tangen Biosciences, Inc. Apparatus and method for cell, spore, or virus capture and disruption
US12325883B2 (en) 2019-01-15 2025-06-10 Neogen Food Safety Us Holdco Corporation Loop-mediated isothermal amplification primers for Shiga toxin-producing E. coli (STEC) detection

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US8445664B2 (en) * 1998-06-24 2013-05-21 Enzo Diagnostics, Inc. Kits for amplifying and detecting nucleic acid sequences
US8956850B2 (en) * 2008-06-05 2015-02-17 Butamax Advanced Biofuels Llc Enhanced pyruvate to acetolactate conversion in yeast
CN101605911A (zh) * 2007-01-17 2009-12-16 梅里第安生物科学公司 有效用于核酸的环-介导的等温扩增(lamp)的稳定试剂和试剂盒
JPWO2009119331A1 (ja) * 2008-03-28 2011-07-21 シスメックス株式会社 サイトケラチン７のｍＲＮＡの検出用プライマを含む試薬
GB0910302D0 (en) * 2009-06-15 2009-07-29 Lumora Ltd Nucleic acid amplification
WO2014085687A1 (en) 2012-11-28 2014-06-05 Abwiz Bio, Inc. Preparation of gene-specific templates for the use in single primer amplification
WO2014151177A1 (en) 2013-03-15 2014-09-25 3M Innovative Properties Company Sample concentrator and method of use
JP2016538882A (ja) 2013-10-30 2016-12-15 グリーン ライフ バイオテック，エルエルシー カンキツグリーニング病のための病因定量システム及び治療方法
MY193444A (en) 2015-03-30 2022-10-13 Greenlight Biosciences Inc Cell-free production of ribonucleic acid
WO2018209092A1 (en) * 2017-05-10 2018-11-15 Board Of Regents, The University Of Texas System Methods and devices related to amplifying nucleic acid at a variety of temperatures
CN109658982B (zh) * 2018-12-25 2020-06-19 人和未来生物科技（长沙）有限公司 一种用于基因测序的引物设计方法及系统
EP3911757A2 (en) * 2019-01-14 2021-11-24 Camena Bioscience Limited Compositions and methods for template-free geometric enzymatic nucleic acid synthesis
SG10201910254YA (en) 2019-11-04 2021-06-29 Denka Company Ltd Nucleic Acid Detection Method Using Lamp And Probe Detection
US11377683B2 (en) 2020-03-13 2022-07-05 Uh-Oh Labs Inc. Looped primer and loop-de-loop method for detecting target nucleic acid
CN112553300A (zh) * 2020-10-15 2021-03-26 德歌生物技术(山东)有限公司 引物设计方法、引物及等温扩增核酸片段的方法
EP3992300A1 (en) 2020-10-30 2022-05-04 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk Onderzoek TNO Sample pre-treatment for isothermal amplification
WO2022155246A1 (en) 2021-01-12 2022-07-21 Definitive Biotechnologies Llc Device and method for detecting nucleic acids in biological samples
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CN118434883A (zh) 2021-12-24 2024-08-02 豪夫迈·罗氏有限公司 Lamp扩增产物的改进检测
WO2025009968A1 (en) 2023-07-03 2025-01-09 Erasmus University Medical Center Rotterdam Methods for specific quantitation of the inducible hiv reservoir
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JP2012085652A (ja) * 2000-09-19 2012-05-10 Eiken Chemical Co Ltd ポリヌクレオチドの合成方法
EP2107113A1 (en) 2002-02-20 2009-10-07 Sysmex Corporation Primers for nucleic acid amplification in detecting housekeeping gene mRNA and test method using these primers
US8198052B2 (en) 2002-02-20 2012-06-12 Sysmex Corporation Primers for nucleic acid amplification in detecting β-actin and test method using these primers
WO2003097878A1 (en) 2002-05-21 2003-11-27 Sysmex Corporation Nucleic acid amplification primers for detecting cytokeratins and examination method with the use of the primers
US8076080B2 (en) 2002-05-21 2011-12-13 Sysmex Corporation Nucleic acid amplification primers for detecting cytokeratins and examination method with the use of the primers
EP1564301A4 (en) * 2002-10-29 2007-07-11 Riken PROCESS FOR NUCLEIC ACID AMPLIFICATION
US7803579B2 (en) 2002-10-29 2010-09-28 Riken Process for amplifying nucleic acid
JP4603979B2 (ja) * 2003-06-27 2010-12-22 栄研化学株式会社 Ｓａｒｓコロナウイルスの検出法
JPWO2005001097A1 (ja) * 2003-06-27 2006-10-19 栄研化学株式会社 Ｓａｒｓコロナウイルスの検出法
CN1813064B (zh) * 2003-06-27 2011-11-02 荣研化学株式会社 检测sars冠状病毒的方法
WO2005001097A1 (ja) 2003-06-27 2005-01-06 Eiken Kagaku Kabushiki Kaisha Ｓａｒｓコロナウイルスの検出法
US7595163B2 (en) 2003-06-27 2009-09-29 Eiken Kagaku Kabushiki Kaisha Method for detecting SARS coronavirus
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US7595381B2 (en) 2003-06-27 2009-09-29 Eiken Kagaku Kabushiki Kaisha Method for detecting SARS coronavirus
WO2005035789A1 (ja) * 2003-10-08 2005-04-21 Sapporo Breweries Limited アリサイクロバチラス属菌検出用プライマー
AU2004280430B2 (en) * 2003-10-08 2008-03-13 Eiken Chemical Co., Ltd. Primer for detecting Alicyclobacillus
EP2415878A1 (en) 2003-12-25 2012-02-08 Riken Method of amplifying nucleic acid and method of detecting mutated nucleic acid using the same
WO2005063977A1 (ja) * 2003-12-25 2005-07-14 Riken 核酸の増幅法およびこれを利用した変異核酸の検出法
US8206902B2 (en) 2003-12-25 2012-06-26 Riken Method of amplifying nucleic acid and method of detecting mutated nucleic acid using the same
JP3897805B2 (ja) * 2003-12-25 2007-03-28 独立行政法人理化学研究所 核酸の増幅法およびこれを利用した変異核酸の検出法
WO2006035712A1 (ja) * 2004-09-30 2006-04-06 Sysmex Corporation Ｒｂｃｓ－１ａ遺伝子を検出するための核酸増幅用プライマ及び前記遺伝子を内部標準物質として用いる核酸の定量方法
WO2006049061A1 (ja) 2004-11-01 2006-05-11 Eiken Kagaku Kabushiki Kaisha Ｈ５型又はｈ７型トリインフルエンザウイルスの検出方法
EP2388340A1 (en) 2004-11-01 2011-11-23 Eiken Kagaku Kabushiki Kaisha Method of detecting H5 or H7 avian influenza virus
WO2006098428A1 (ja) * 2005-03-17 2006-09-21 Kabushiki Kaisha Dnaform プライマーダイマーからの非特異的増幅を減少させる方法
WO2006117676A2 (en) 2005-04-29 2006-11-09 Millipore Corporation Method for the detection and characterization of microorganisms on a filter
WO2007069331A1 (ja) * 2005-12-16 2007-06-21 Eiken Kagaku Kabushiki Kaisha ヒト免疫不全ウイルス１型の検出方法
US7803544B2 (en) 2006-01-20 2010-09-28 Kabushiki Kaisha Toshiba Method of detecting amplification product or target nucleic acid
US7951541B2 (en) 2006-01-20 2011-05-31 Kabushiki Kaisha Toshiba Assay kit for use in method of detecting a target nucleic acid
EP1820865A1 (en) 2006-01-27 2007-08-22 Sysmex Corporation Primer and primer set for amplification of CEA nucleic acid, and methods for assisting cancer diagnosis
EP1970453A2 (en) 2007-03-09 2008-09-17 Riken Primer, primer set, and nucleic acid amplification method and mutation detection method using the same
US7728119B2 (en) 2007-03-28 2010-06-01 Kabushiki Kaisha Toshiba Nucleotide primer set and nucleotide probe for detecting genotype of methylene tetrahydrofolate reductase (MTHFR)
US7919611B2 (en) 2007-03-28 2011-04-05 Kabushiki Kaisha Toshiba Nucleotide primer set and nucleotide probe for detecting genotype of N-acetyltransferase-2 (NAT2)
EP1988178A2 (en) 2007-04-26 2008-11-05 Kabushiki Kaisha Toshiba Nucleotide primer set and nucleotide probe for detecting genotype of serum amyloid A1(SAA1)
WO2009054510A1 (ja) 2007-10-25 2009-04-30 Riken 等温増幅方法およびそれに用いるｄｎａポリメラーゼ
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US7374913B2 (en) 2008-05-20
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CN1222614C (zh) 2005-10-12
US20080213842A1 (en) 2008-09-04
CN1474870A (zh) 2004-02-11
ES2390242T3 (es) 2012-11-07
ATE437225T1 (de) 2009-08-15
EP2031058A1 (en) 2009-03-04
EP1327679A1 (en) 2003-07-16
EP1327679B1 (en) 2009-07-22
EP1327679A4 (en) 2005-06-01
US20080213790A1 (en) 2008-09-04
HK1055445A1 (en) 2004-01-09
AU2001288065A1 (en) 2002-04-02
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ES2327712T3 (es) 2009-11-03
US7851186B2 (en) 2010-12-14
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US7846695B2 (en) 2010-12-07
US20040038253A1 (en) 2004-02-26

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