WO2001059078A2 - Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates - Google Patents

Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates Download PDF

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Publication number
WO2001059078A2
WO2001059078A2 PCT/US2001/040069 US0140069W WO0159078A2 WO 2001059078 A2 WO2001059078 A2 WO 2001059078A2 US 0140069 W US0140069 W US 0140069W WO 0159078 A2 WO0159078 A2 WO 0159078A2
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WO
WIPO (PCT)
Prior art keywords
uricase
polylethylene
peg
conjugate
glycol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/040069
Other languages
English (en)
French (fr)
Other versions
WO2001059078A3 (en
Inventor
Merry R. Sherman
Mark G. P. Saifer
L. David Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mountain View Pharmaceuticals Inc
Original Assignee
Mountain View Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DK01923265.1T priority Critical patent/DK1254237T3/da
Priority to IL15106501A priority patent/IL151065A0/xx
Priority to HU0204544A priority patent/HU227127B1/hu
Priority to KR1020087024272A priority patent/KR101054247B1/ko
Priority to JP2001558218A priority patent/JP5165826B2/ja
Priority to BRPI0108386A priority patent/BRPI0108386B8/pt
Priority to DE60141742T priority patent/DE60141742D1/de
Priority to NZ520434A priority patent/NZ520434A/en
Priority to CA2398679A priority patent/CA2398679C/en
Priority to HK03109064.9A priority patent/HK1056742B/xx
Priority to MXPA02007545A priority patent/MXPA02007545A/es
Priority to EP01923265A priority patent/EP1254237B1/en
Priority to ES01923265T priority patent/ES2343105T3/es
Application filed by Mountain View Pharmaceuticals Inc filed Critical Mountain View Pharmaceuticals Inc
Priority to AT01923265T priority patent/ATE463576T1/de
Priority to AU2001249975A priority patent/AU2001249975B2/en
Priority to AU4997501A priority patent/AU4997501A/xx
Publication of WO2001059078A2 publication Critical patent/WO2001059078A2/en
Publication of WO2001059078A3 publication Critical patent/WO2001059078A3/en
Priority to IL151065A priority patent/IL151065A/en
Anticipated expiration legal-status Critical
Priority to AU2006203252A priority patent/AU2006203252B8/en
Priority to IL193365A priority patent/IL193365A/en
Priority to BE2013C045C priority patent/BE2013C045I2/fr
Priority to CY2013028C priority patent/CY2013028I2/el
Priority to FR13C0036C priority patent/FR13C0036I2/fr
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
    • C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PCT/US2001/040069 2000-02-10 2001-02-07 Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates Ceased WO2001059078A2 (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
ES01923265T ES2343105T3 (es) 2000-02-10 2001-02-07 Urato oxidasa sin agregados para la preparacion de conjugados polimericos inmunogenicos.
HU0204544A HU227127B1 (en) 2000-02-10 2001-02-07 Purified urate oxidases, process for preparation thereof and uricase conjugates
KR1020087024272A KR101054247B1 (ko) 2000-02-10 2001-02-07 정제된 요산산화효소 제제 및 이를 포함한 조성물, 그리고 그 정제법
JP2001558218A JP5165826B2 (ja) 2000-02-10 2001-02-07 非免疫原性ポリマー結合体の調製のための凝集体非含有尿酸オキシダーゼ
BRPI0108386A BRPI0108386B8 (pt) 2000-02-10 2001-02-07 conjugado de uricase, composição farmacêutica e método para a purificação de uricase
DE60141742T DE60141742D1 (de) 2000-02-10 2001-02-07 Aggregat-freie harnsäureoxidase zur herstellung von nicht-immunogenen polymer-konjugaten
NZ520434A NZ520434A (en) 2000-02-10 2001-02-07 Urate oxidase free of aggregates larger than octamers, for preparation of non-immunogenic polymer conjugates
CA2398679A CA2398679C (en) 2000-02-10 2001-02-07 Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
IL15106501A IL151065A0 (en) 2000-02-10 2001-02-07 Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
MXPA02007545A MXPA02007545A (es) 2000-02-10 2001-02-07 Urato oxidasa libre de agregados, para preparacion de conjugado de polimero no-inmunogenicos.
AT01923265T ATE463576T1 (de) 2000-02-10 2001-02-07 Aggregat-freie harnsäureoxidase zur herstellung von nicht-immunogenen polymer-konjugaten
DK01923265.1T DK1254237T3 (da) 2000-02-10 2001-02-07 Aggregatfri uratoxidase til fremstilling af ikke-immunogene polymerkonjugater
HK03109064.9A HK1056742B (en) 2000-02-10 2001-02-07 Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
EP01923265A EP1254237B1 (en) 2000-02-10 2001-02-07 Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
AU2001249975A AU2001249975B2 (en) 2000-02-10 2001-02-07 Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
AU4997501A AU4997501A (en) 2000-02-10 2001-02-07 Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
IL151065A IL151065A (en) 2000-02-10 2002-08-05 Orate oxidase is free of aggregates for making non-immunogenic polymer couplings
AU2006203252A AU2006203252B8 (en) 2000-02-10 2006-07-31 Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
IL193365A IL193365A (en) 2000-02-10 2008-08-11 Orate oxidases free of aggregates, their polymer couplings and their prepared preparations
BE2013C045C BE2013C045I2 (enExample) 2000-02-10 2013-07-03
CY2013028C CY2013028I2 (el) 2000-02-10 2013-07-04 Ουρικη οξειδαση ελευθερη συσσωματωματων για την παρασκευη μη ανοσογονων συζευγματων με πολυμερες
FR13C0036C FR13C0036I2 (fr) 2000-02-10 2013-07-04 Urate oxidase exempte d'agregats destinee a la preparation de polymeres conjugues non-immunogenes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/501,730 US6783965B1 (en) 2000-02-10 2000-02-10 Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
US09/501,730 2000-02-10

Publications (2)

Publication Number Publication Date
WO2001059078A2 true WO2001059078A2 (en) 2001-08-16
WO2001059078A3 WO2001059078A3 (en) 2002-03-07

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/040069 Ceased WO2001059078A2 (en) 2000-02-10 2001-02-07 Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates

Country Status (27)

Country Link
US (3) US6783965B1 (enExample)
EP (3) EP2305819B1 (enExample)
JP (2) JP5165826B2 (enExample)
KR (3) KR20070092329A (enExample)
CN (2) CN101735991B (enExample)
AT (1) ATE463576T1 (enExample)
AU (3) AU4997501A (enExample)
BE (1) BE2013C045I2 (enExample)
BR (1) BRPI0108386B8 (enExample)
CA (1) CA2398679C (enExample)
CY (3) CY1110142T1 (enExample)
CZ (1) CZ304864B6 (enExample)
DE (1) DE60141742D1 (enExample)
DK (3) DK1254237T3 (enExample)
ES (2) ES2343105T3 (enExample)
FR (1) FR13C0036I2 (enExample)
HU (1) HU227127B1 (enExample)
IL (3) IL151065A0 (enExample)
LU (1) LU92237I2 (enExample)
MX (1) MXPA02007545A (enExample)
NZ (1) NZ520434A (enExample)
PL (1) PL208064B1 (enExample)
PT (2) PT1254237E (enExample)
RU (3) RU2352354C2 (enExample)
TW (2) TW200914617A (enExample)
WO (1) WO2001059078A2 (enExample)
ZA (1) ZA200207206B (enExample)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6576235B1 (en) 1998-08-06 2003-06-10 Mountain View Pharmaceuticals, Inc. PEG-urate oxidase conjugates and use thereof
WO2004030617A2 (en) 2002-09-30 2004-04-15 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
US7056713B1 (en) 1998-08-06 2006-06-06 Duke University Urate oxidase
WO2006110819A2 (en) 2005-04-11 2006-10-19 Savient Pharmaceuticals, Inc. Variant forms of urate oxidase and use thereof
US7229810B2 (en) 2001-06-28 2007-06-12 Mountain View Pharmaceuticals, Inc. Polymer conjugates of proteinases
US7528104B2 (en) 2003-05-12 2009-05-05 Affymax, Inc. Peptides that bind to the erythropoietin receptor
US7550433B2 (en) 2005-06-03 2009-06-23 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
US7811800B2 (en) 2005-04-11 2010-10-12 Savient Pharmaceuticals, Inc. Variant form of urate oxidase and use thereof
US7919118B2 (en) 2003-05-12 2011-04-05 Affymax, Inc. Spacer moiety for poly (ethylene glycol) modified peptide based compounds
US7927852B2 (en) 1998-08-06 2011-04-19 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
US8129330B2 (en) 2002-09-30 2012-03-06 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
US9534013B2 (en) 2006-04-12 2017-01-03 Horizon Pharma Rheumatology Llc Purification of proteins with cationic surfactant
US10139399B2 (en) 2009-06-25 2018-11-27 Horizon Pharma Rheumatology Llc Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during PEGylated uricase therapy
US10883087B2 (en) 2015-05-15 2021-01-05 Medimmune, Llc Uricase sequences and methods of treatment
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers
US12465631B2 (en) 2019-01-30 2025-11-11 Horizon Therapeutics Usa, Inc. Reducing immunogenicity to pegloticase
US12496331B2 (en) 2016-11-11 2025-12-16 Horizon Therapeutics Usa, Inc. Combination therapies of prednisone and uricase molecules and uses thereof

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US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
US20060188971A1 (en) * 1998-08-06 2006-08-24 Duke University Urate oxidase
RU2278680C2 (ru) * 1998-08-06 2006-06-27 Маунтэн Вью Фармасьютикэлз, Инк. Способ изолирования тетрамерной формы уриказы и уриказа, полученная данным способом
US6913915B2 (en) * 2001-08-02 2005-07-05 Phoenix Pharmacologics, Inc. PEG-modified uricase
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
PT1941867E (pt) 2002-06-07 2012-02-16 Dyax Corp Polipeptídeo contendo um domínio kunitz modificado
EP1667708B9 (en) * 2002-12-26 2012-10-31 Mountain View Pharmaceuticals, Inc. POLYETHYLENE GLYCOL CONJUGATES OF INTERFERON-BETA-1b WITH ENHANCED IN VITRO BIOLOGICAL POTENCY
EA010016B1 (ru) * 2003-05-12 2008-06-30 Афимакс, Инк. Новые модифицированные полиэтиленгликолем соединения и их применение
PT1663281E (pt) * 2003-08-29 2014-03-17 Dyax Corp Inibidores de proteases poli-peguilados
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
WO2006062685A2 (en) * 2004-11-11 2006-06-15 Affymax, Inc. Novel peptides that bind to the erythropoietin receptor
AU2005310189A1 (en) * 2004-11-11 2006-06-08 Affymax, Inc. Novel peptides that bind to the erythropoietin receptor
EP2279756A2 (en) * 2005-04-05 2011-02-02 Instituto di Ricerche di Biologia Molecolare p Angeletti S.P.A. Method for shielding functional sites or epitopes on proteins
TWI418564B (zh) * 2005-04-11 2013-12-11 Savient Pharmaceuticals Inc 利用陽離子界面活性劑之蛋白質純化
US20080159976A1 (en) * 2005-04-11 2008-07-03 Jacob Hartman Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
US20090081122A1 (en) * 2005-05-23 2009-03-26 Universite De Geneve Injectable superparamagnetic nanoparticles for treatment by hyperthermia and use for forming an hyperthermic implant
US8324159B2 (en) * 2005-06-03 2012-12-04 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
US7919461B2 (en) 2005-06-03 2011-04-05 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
US20090075887A1 (en) * 2007-08-21 2009-03-19 Genzyme Corporation Treatment with Kallikrein Inhibitors
JP2013516389A (ja) 2009-01-06 2013-05-13 ダイアックス コーポレーション カリクレイン阻害剤による粘膜炎治療
HRP20181419T1 (hr) 2010-01-06 2018-11-16 Dyax Corp. Plazma kalikrein vezni proteini
WO2011127393A2 (en) 2010-04-08 2011-10-13 Georgia Tech Research Corporation Variants of ancestral uricases and uses thereof
IL269565B2 (en) 2011-01-06 2024-06-01 Dyax Corp Plasma kallikrein binding proteins
CN102827073A (zh) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
US9474779B2 (en) 2012-01-19 2016-10-25 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their methods of use
CA2913476A1 (en) * 2013-06-07 2014-12-11 Allena Pharmaceuticals, Inc. Compositions, methods, and devices for dialysis
AU2014287121B2 (en) 2013-07-11 2018-11-15 Agios Pharmaceuticals, Inc. 2,4- or 4,6-diaminopyrimidine compounds as IDH2 mutants inhibitors for the treatment of cancer
WO2015003360A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
US9579324B2 (en) 2013-07-11 2017-02-28 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
WO2015003355A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
US20150031627A1 (en) 2013-07-25 2015-01-29 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
EA036325B1 (ru) 2014-03-14 2020-10-27 Аджиос Фармасьютикалз, Инк. Фармацевтическая композиция на основе твердой дисперсии ингибитора idh1
KR102555955B1 (ko) 2014-03-27 2023-07-18 다케다 파머수티컬 컴패니 리미티드 당뇨병성 황반 부종의 치료를 위한 조성물 및 방법
UA123401C2 (uk) 2015-10-15 2021-03-31 Аджиос Фармасьютікалз, Інк. Комбінована терапія для лікування злоякісних пухлин
ES2897959T3 (es) 2015-10-15 2022-03-03 Servier Lab Terapia de combinación para tratar neoplasias malignas
WO2017100679A1 (en) 2015-12-11 2017-06-15 Dyax Corp. Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
AU2018297309A1 (en) 2017-07-07 2020-01-30 Allena Pharmaceuticals, Inc. Recombinant uricase enzyme
US20190309269A1 (en) 2018-03-20 2019-10-10 Rubius Therapeutics, Inc. Therapeutic cell systems and methods for treating hyperuricemia and gout
US10980788B2 (en) 2018-06-08 2021-04-20 Agios Pharmaceuticals, Inc. Therapy for treating malignancies
CN109055260B (zh) * 2018-08-08 2021-11-09 淮海工学院 弯曲芽孢杆菌alkaAU及产尿酸氧化酶方法、产品与应用
US12121566B2 (en) 2019-01-30 2024-10-22 Horizon Therapeutics Usa, Inc. Methods for treating gout
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