ATE463576T1 - Aggregat-freie harnsäureoxidase zur herstellung von nicht-immunogenen polymer-konjugaten - Google Patents
Aggregat-freie harnsäureoxidase zur herstellung von nicht-immunogenen polymer-konjugatenInfo
- Publication number
- ATE463576T1 ATE463576T1 AT01923265T AT01923265T ATE463576T1 AT E463576 T1 ATE463576 T1 AT E463576T1 AT 01923265 T AT01923265 T AT 01923265T AT 01923265 T AT01923265 T AT 01923265T AT E463576 T1 ATE463576 T1 AT E463576T1
- Authority
- AT
- Austria
- Prior art keywords
- aggregate
- production
- uric acid
- acid oxidase
- polymer conjugates
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title abstract 2
- 102000004316 Oxidoreductases Human genes 0.000 title 1
- 108090000854 Oxidoreductases Proteins 0.000 title 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 title 1
- 229940116269 uric acid Drugs 0.000 title 1
- 108010092464 Urate Oxidase Proteins 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 208000017667 Chronic Disease Diseases 0.000 abstract 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000000717 retained effect Effects 0.000 abstract 1
- 229940005267 urate oxidase Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
- C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/501,730 US6783965B1 (en) | 2000-02-10 | 2000-02-10 | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
| PCT/US2001/040069 WO2001059078A2 (en) | 2000-02-10 | 2001-02-07 | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE463576T1 true ATE463576T1 (de) | 2010-04-15 |
Family
ID=23994789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01923265T ATE463576T1 (de) | 2000-02-10 | 2001-02-07 | Aggregat-freie harnsäureoxidase zur herstellung von nicht-immunogenen polymer-konjugaten |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US6783965B1 (de) |
| EP (3) | EP2196538B1 (de) |
| JP (2) | JP5165826B2 (de) |
| KR (3) | KR100884724B1 (de) |
| CN (2) | CN101735991B (de) |
| AT (1) | ATE463576T1 (de) |
| AU (3) | AU4997501A (de) |
| BE (1) | BE2013C045I2 (de) |
| BR (1) | BRPI0108386B8 (de) |
| CA (1) | CA2398679C (de) |
| CY (3) | CY1110142T1 (de) |
| CZ (1) | CZ304864B6 (de) |
| DE (1) | DE60141742D1 (de) |
| DK (3) | DK1254237T3 (de) |
| ES (2) | ES2343105T3 (de) |
| FR (1) | FR13C0036I2 (de) |
| HU (1) | HU227127B1 (de) |
| IL (3) | IL151065A0 (de) |
| LU (1) | LU92237I2 (de) |
| MX (1) | MXPA02007545A (de) |
| NZ (1) | NZ520434A (de) |
| PL (1) | PL208064B1 (de) |
| PT (2) | PT2305819E (de) |
| RU (3) | RU2352354C2 (de) |
| TW (2) | TWI322184B (de) |
| WO (1) | WO2001059078A2 (de) |
| ZA (1) | ZA200207206B (de) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| EP1100542B1 (de) * | 1998-08-06 | 2005-06-22 | Mountain View Pharmaceuticals, Inc. | Peg-uricase konjugate und verwendung davon |
| US6783965B1 (en) * | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
| PL207369B1 (pl) | 1998-08-06 | 2010-12-31 | Univ Duke | Zrekombinowane białko urykazy, wyizolowane i oczyszczone cząsteczki kwasu nukleinowego, wektory, komórki gospodarza, sposoby zwiększania dostępności nieszkodliwych miejsc przyłączenia PEG do białka urykazy |
| PT2316475T (pt) * | 1998-08-06 | 2017-12-21 | Univ Duke | Uricase tetramérica isolada |
| US20060188971A1 (en) * | 1998-08-06 | 2006-08-24 | Duke University | Urate oxidase |
| CA2450985A1 (en) | 2001-06-28 | 2003-01-09 | Mountain View Pharmaceuticals, Inc. | Polymer stabilized proteinases |
| US6913915B2 (en) | 2001-08-02 | 2005-07-05 | Phoenix Pharmacologics, Inc. | PEG-modified uricase |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| ATE477020T1 (de) | 2002-06-07 | 2010-08-15 | Dyax Corp | Prevention und verringerung von ischemia |
| US8129330B2 (en) * | 2002-09-30 | 2012-03-06 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
| US20040062748A1 (en) | 2002-09-30 | 2004-04-01 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
| MXPA05006944A (es) * | 2002-12-26 | 2005-12-14 | Mountain View Pharmaceuticals | Conjugados polimericos de interferon-beta cion potencia biologica aumentada. |
| NZ543935A (en) * | 2003-05-12 | 2008-06-30 | Affymax Inc | Peptides that bind to the erythropoietin receptor |
| NZ543934A (en) * | 2003-05-12 | 2008-06-30 | Affymax Inc | Novel spacer moiety for poly (ethylene glycol)-modified peptide-based compounds |
| ATE478093T1 (de) * | 2003-05-12 | 2010-09-15 | Affymax Inc | Neue poly(ethylenglycol) modifizierte erythropoietinagonisten und deren verwendungen |
| WO2005021557A2 (en) * | 2003-08-29 | 2005-03-10 | Dyax Corp. | Poly-pegylated protease inhibitors |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| WO2006060148A2 (en) * | 2004-11-11 | 2006-06-08 | Affymax, Inc. | Novel peptides that bind to the erythropoietin receptor |
| WO2006062685A2 (en) * | 2004-11-11 | 2006-06-15 | Affymax, Inc. | Novel peptides that bind to the erythropoietin receptor |
| EP1868652A2 (de) * | 2005-04-05 | 2007-12-26 | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. | Verfahren zur abschirmung von funktionalen stellen oder epitopen auf proteinen |
| HU229626B1 (hu) | 2005-04-11 | 2014-03-28 | Savient Pharmaceuticals | Urát oxidáz változat és alkalmazása |
| EP1871874B1 (de) | 2005-04-11 | 2015-04-08 | Crealta Pharmaceuticals LLC | Varianten der uricase und deren verwendung |
| TWI418564B (zh) * | 2005-04-11 | 2013-12-11 | Savient Pharmaceuticals Inc | 利用陽離子界面活性劑之蛋白質純化 |
| US8148123B2 (en) * | 2005-04-11 | 2012-04-03 | Savient Pharmaceuticals, Inc. | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
| US20080159976A1 (en) * | 2005-04-11 | 2008-07-03 | Jacob Hartman | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
| JP2008545665A (ja) * | 2005-05-23 | 2008-12-18 | ユニベルシテ ドゥ ジュネーブ | 高体温による処置のための注入可能な超常磁性ナノ粒子および高体温インプラントを形成するための使用 |
| US7919461B2 (en) | 2005-06-03 | 2011-04-05 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
| US7550433B2 (en) * | 2005-06-03 | 2009-06-23 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
| US8324159B2 (en) * | 2005-06-03 | 2012-12-04 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
| PL2013225T3 (pl) * | 2006-04-12 | 2015-06-30 | Crealta Pharmaceuticals Llc | Oczyszczanie białek z zastosowaniem kationowego środka powierzchniowo czynnego |
| US20090075887A1 (en) * | 2007-08-21 | 2009-03-19 | Genzyme Corporation | Treatment with Kallikrein Inhibitors |
| EP2385843A4 (de) | 2009-01-06 | 2013-02-27 | Dyax Corp | Behandlung von mukositis mit kallikrein-hemmern |
| RU2535038C2 (ru) | 2009-06-25 | 2014-12-10 | Криэлта Фармасьютикалз ЭлЭлСи | Способы и наборы для прогнозирования риска инфузионных реакций и опосредованной антителами потери ответа при терапии пэгилированной уриказой с помощью мониторинга содержания мочевой кислоты в сыворотке крови |
| EP4011917A1 (de) | 2010-01-06 | 2022-06-15 | Takeda Pharmaceutical Company Limited | Plasmakallikreinbindende proteine |
| US8940861B2 (en) | 2010-04-08 | 2015-01-27 | Georgia Tech Research Corporation | Variants of ancestral uricases and uses thereof |
| AU2012204202A1 (en) | 2011-01-06 | 2013-07-11 | Dyax Corp. | Plasma kallikrein binding proteins |
| CN102827073A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
| ES2875060T3 (es) | 2013-06-07 | 2021-11-08 | Allena Pharmaceuticals Inc | Composiciones y dispositivos para diálisis |
| WO2015003355A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| WO2015006591A1 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | 2,4- or 4,6-diaminopyrimidine compounds as idh2 mutants inhibitors for the treatment of cancer |
| US20150031627A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| UA121211C2 (uk) | 2014-03-14 | 2020-04-27 | Аджіос Фармасьютикалз, Інк. | Фармацевтична композиція, що містить тверду дисперсію, та спосіб лікування гострої мієлогенної/мієлоїдної лейкемії (гмл) |
| KR20230109785A (ko) | 2014-03-27 | 2023-07-20 | 다케다 파머수티컬 컴패니 리미티드 | 당뇨병성 황반 부종의 치료를 위한 조성물 및 방법 |
| EP3294322A4 (de) | 2015-05-15 | 2018-12-12 | Medimmune, LLC | Verbesserte uricasesequenzen und behandlungsverfahren |
| DK3362066T3 (da) | 2015-10-15 | 2021-11-22 | Les Laboratoires Servier Sas | Kombinationsterapi til behandling af maligniteter |
| MD3362065T2 (ro) | 2015-10-15 | 2024-08-31 | Servier Lab | Terapie combinată care conține ivosidenib, citarabină și daunorubicina sau idarubicina pentru tratarea leucemiei acute mielogene |
| IL311156A (en) | 2015-12-11 | 2024-04-01 | Takeda Pharmaceuticals Co | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
| CN110234340A (zh) | 2016-11-11 | 2019-09-13 | 好利恩风湿病制药有限责任公司 | 泼尼松和尿酸酶分子的组合疗法及其用途 |
| US20200308534A1 (en) | 2017-07-07 | 2020-10-01 | Allena Pharmaceuticals, Inc. | Recombinant uricase enzyme |
| WO2019183292A1 (en) | 2018-03-20 | 2019-09-26 | Rubius Therapeutics, Inc. | Therapeutic cell systems and methods for treating hyperuricemia and gout |
| US10980788B2 (en) | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
| CN109055260B (zh) * | 2018-08-08 | 2021-11-09 | 淮海工学院 | 弯曲芽孢杆菌alkaAU及产尿酸氧化酶方法、产品与应用 |
| WO2020160325A1 (en) | 2019-01-30 | 2020-08-06 | Horizon Pharma Rheumatology Llc | Reducing immunogenicity to pegloticase |
| WO2020160322A1 (en) | 2019-01-30 | 2020-08-06 | Horizon Pharma Rheumatology Llc | Tolerization reduces intolerance to pegloticase and prolongs the urate lowering effect (triple) |
| KR102785972B1 (ko) * | 2019-05-10 | 2025-03-24 | 피이지-바이오 바이오팜 컴퍼니 리미티드 (총칭) | 폴리에틸렌 글리콜로 변형된 요산 산화효소 |
| AU2021324665A1 (en) | 2020-08-10 | 2023-04-13 | Horizon Therapeutics Usa, Inc. | Methods of treating gout |
| CN114181917B (zh) * | 2022-02-14 | 2022-06-03 | 潍坊华卓生物科技有限公司 | 一种改造尿酸酶、基因序列、制备方法及应用 |
| CN117051026A (zh) * | 2022-05-06 | 2023-11-14 | 江苏恰瑞生物科技有限公司 | 一种特异性尿酸结合物固定化树脂及其制备方法和应用 |
| US12269875B2 (en) | 2023-08-03 | 2025-04-08 | Jeff R. Peterson | Gout flare prevention methods using IL-1BETA blockers |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE279486C (de) | ||||
| FR6301M (de) * | 1967-03-29 | 1968-09-09 | ||
| US3616231A (en) | 1968-11-14 | 1971-10-26 | Boehringer Mannheim Gmbh | Process for the production of uricase |
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS5599189A (en) | 1979-01-22 | 1980-07-28 | Mihama Hisaharu | Modified uricase free from antigenicity and its preparation |
| JPS55135590A (en) | 1979-04-05 | 1980-10-22 | Mihama Hisaharu | Modified asparaginase and uricase and their preparation |
| CH651308A5 (de) | 1980-07-01 | 1985-09-13 | Hoffmann La Roche | Interferone und deren herstellung. |
| JPS57192435A (en) | 1981-05-20 | 1982-11-26 | Toyobo Co Ltd | Modified polypeptide |
| DE3126759A1 (de) | 1981-07-07 | 1983-01-27 | Boehringer Mannheim Gmbh, 6800 Mannheim | Loesliche leber-uricase, verfahren zu ihrer herstellung und verwendung |
| JP2524586B2 (ja) * | 1985-06-26 | 1996-08-14 | シタス コーポレイション | ポリマ−接合を利用する医薬組成物用蛋白質の可溶化 |
| US4917888A (en) | 1985-06-26 | 1990-04-17 | Cetus Corporation | Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US4847079A (en) * | 1985-07-29 | 1989-07-11 | Schering Corporation | Biologically stable interferon compositions comprising thimerosal |
| DD279486A1 (de) | 1986-03-10 | 1990-06-06 | Akad Wissenschaften Ddr | Verfahren zur aktivierung von hydroxylgruppenhaltigen polymeren verbindungen |
| JPS6255079A (ja) * | 1986-04-23 | 1987-03-10 | Mihama Hisaharu | 修飾ウリカ−ゼ |
| JPH085506B2 (ja) * | 1986-08-25 | 1996-01-24 | 日東製器株式会社 | 缶容器 |
| DD279489A1 (de) | 1986-12-11 | 1990-06-06 | Leuna Werke Veb | Verfahren zur herstellung optisch transparenter epoxidharzformmassen |
| US5080891A (en) * | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| US4847325A (en) | 1988-01-20 | 1989-07-11 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
| US5955336A (en) * | 1988-08-17 | 1999-09-21 | Toyo Boseki Kabushiki Kaisha | DNA sequence for uricase and manufacturing process of uricase |
| US5349052A (en) | 1988-10-20 | 1994-09-20 | Royal Free Hospital School Of Medicine | Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor |
| US5324844A (en) | 1989-04-19 | 1994-06-28 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| US5122614A (en) * | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| NZ234453A (en) * | 1989-07-13 | 1993-01-27 | Sanofi Sa | Recombinant dna encoding urate oxidase, and vector, host, protein and pharmaceutical compositions associated therewith |
| US5382518A (en) | 1989-07-13 | 1995-01-17 | Sanofi | Urate oxidase activity protein, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells |
| US5286637A (en) | 1989-08-07 | 1994-02-15 | Debiopharm, S.A. | Biologically active drug polymer derivatives and method for preparing same |
| JPH03148298A (ja) | 1989-11-01 | 1991-06-25 | Sumitomo Pharmaceut Co Ltd | 修飾ペプチドおよびその製造方法 |
| SU1730145A1 (ru) * | 1990-05-04 | 1992-04-30 | Всесоюзный научно-исследовательский институт текстильно-галантерейной промышленности | Способ стабилизации уриказы |
| US5766897A (en) * | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| US5653974A (en) | 1990-10-18 | 1997-08-05 | Board Of Regents,The University Of Texas System | Preparation and characterization of liposomal formulations of tumor necrosis factor |
| CA2106079C (en) * | 1991-03-15 | 2000-04-25 | Robert C. Thompson | Pegylation of polypeptides |
| ES2284226T3 (es) | 1991-07-02 | 2007-11-01 | Nektar Therapeutics | Dispositivo para proporcionar medicamentos en aerosol. |
| WO1994019007A1 (en) | 1993-02-16 | 1994-09-01 | Enzon, Inc. | Ribosome inactivating protein compositions having reduced antigenicity |
| WO1994023740A1 (en) * | 1993-04-22 | 1994-10-27 | Celtrix Pharmaceuticals, Inc. | Conjugates of growth factor and bone resorption inhibitor |
| WO1995000162A1 (en) | 1993-06-21 | 1995-01-05 | Enzon, Inc. | Site specific synthesis of conjugated peptides |
| IT1265101B1 (it) * | 1993-07-23 | 1996-10-30 | Erba Carlo Spa | Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico |
| US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| KR960705579A (ko) * | 1993-11-10 | 1996-11-08 | 에릭에스. 딕커 | 개선된 인터페론 중합체 결합체(Improved interferon polymer conjugates) |
| US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| AU697440B2 (en) * | 1994-12-07 | 1998-10-08 | Novozymes A/S | Polypeptide with reduced allergenicity |
| US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| TW426523B (en) * | 1995-04-06 | 2001-03-21 | Hoffmann La Roche | Interferon solution |
| FR2733914B1 (fr) * | 1995-05-11 | 1997-08-01 | Sanofi Sa | Composition de liquide stable contenant de l'urate oxydase et composition lyophilisee pour sa preparation |
| US5853974A (en) | 1995-06-07 | 1998-12-29 | Chiron Corporation | Enhancement of alkaline phosphatase with SDS in chemiluminescent substrates |
| JPH09154581A (ja) | 1995-12-05 | 1997-06-17 | Asahi Chem Ind Co Ltd | ウリカーゼを生産する実質上純粋な微生物 |
| WO1998031383A1 (en) | 1997-01-15 | 1998-07-23 | Phoenix Pharmacologics, Inc. | Modified tumor necrosis factor |
| IL139609A (en) * | 1998-06-01 | 2006-06-11 | Genentech Inc | Separation of polypeptides monomers |
| PT2316475T (pt) * | 1998-08-06 | 2017-12-21 | Univ Duke | Uricase tetramérica isolada |
| PL207369B1 (pl) | 1998-08-06 | 2010-12-31 | Univ Duke | Zrekombinowane białko urykazy, wyizolowane i oczyszczone cząsteczki kwasu nukleinowego, wektory, komórki gospodarza, sposoby zwiększania dostępności nieszkodliwych miejsc przyłączenia PEG do białka urykazy |
| EP1100542B1 (de) | 1998-08-06 | 2005-06-22 | Mountain View Pharmaceuticals, Inc. | Peg-uricase konjugate und verwendung davon |
| US6783965B1 (en) * | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
| US6425448B1 (en) | 2001-01-30 | 2002-07-30 | Cdx Gas, L.L.P. | Method and system for accessing subterranean zones from a limited surface area |
| US6913915B2 (en) * | 2001-08-02 | 2005-07-05 | Phoenix Pharmacologics, Inc. | PEG-modified uricase |
| WO2014187953A1 (en) | 2013-05-24 | 2014-11-27 | Zentrum Mikroelektronik Dresden Ag | Non pwm digital dc-dc converter |
-
2000
- 2000-02-10 US US09/501,730 patent/US6783965B1/en not_active Expired - Lifetime
-
2001
- 2001-02-06 TW TW090102540A patent/TWI322184B/zh not_active IP Right Cessation
- 2001-02-06 TW TW097145974A patent/TW200914617A/zh unknown
- 2001-02-07 EP EP10158016.5A patent/EP2196538B1/de not_active Expired - Lifetime
- 2001-02-07 NZ NZ520434A patent/NZ520434A/en not_active IP Right Cessation
- 2001-02-07 KR KR1020027010189A patent/KR100884724B1/ko not_active Expired - Lifetime
- 2001-02-07 DE DE60141742T patent/DE60141742D1/de not_active Expired - Lifetime
- 2001-02-07 DK DK01923265.1T patent/DK1254237T3/da active
- 2001-02-07 CZ CZ2002-2982A patent/CZ304864B6/cs not_active IP Right Cessation
- 2001-02-07 CN CN2009101278530A patent/CN101735991B/zh not_active Expired - Lifetime
- 2001-02-07 DK DK10158016.5T patent/DK2196538T3/en active
- 2001-02-07 WO PCT/US2001/040069 patent/WO2001059078A2/en not_active Ceased
- 2001-02-07 DK DK10180428.4T patent/DK2305819T3/en active
- 2001-02-07 KR KR1020087024272A patent/KR101054247B1/ko not_active Expired - Lifetime
- 2001-02-07 HU HU0204544A patent/HU227127B1/hu active Protection Beyond IP Right Term
- 2001-02-07 CA CA2398679A patent/CA2398679C/en not_active Expired - Lifetime
- 2001-02-07 KR KR1020077018682A patent/KR20070092329A/ko not_active Ceased
- 2001-02-07 PT PT101804284T patent/PT2305819E/pt unknown
- 2001-02-07 MX MXPA02007545A patent/MXPA02007545A/es active IP Right Grant
- 2001-02-07 PT PT01923265T patent/PT1254237E/pt unknown
- 2001-02-07 ES ES01923265T patent/ES2343105T3/es not_active Expired - Lifetime
- 2001-02-07 RU RU2006107110/13A patent/RU2352354C2/ru active
- 2001-02-07 EP EP01923265A patent/EP1254237B1/de not_active Expired - Lifetime
- 2001-02-07 BR BRPI0108386A patent/BRPI0108386B8/pt not_active Application Discontinuation
- 2001-02-07 EP EP10180428.4A patent/EP2305819B1/de not_active Expired - Lifetime
- 2001-02-07 IL IL15106501A patent/IL151065A0/xx unknown
- 2001-02-07 ES ES10180428.4T patent/ES2524153T3/es not_active Expired - Lifetime
- 2001-02-07 CN CNB018077501A patent/CN100491532C/zh not_active Expired - Lifetime
- 2001-02-07 AU AU4997501A patent/AU4997501A/xx active Pending
- 2001-02-07 AT AT01923265T patent/ATE463576T1/de active
- 2001-02-07 JP JP2001558218A patent/JP5165826B2/ja not_active Expired - Lifetime
- 2001-02-07 PL PL358539A patent/PL208064B1/pl unknown
- 2001-02-07 AU AU2001249975A patent/AU2001249975B2/en not_active Revoked
- 2001-02-07 RU RU2002120486/13A patent/RU2281954C2/ru not_active IP Right Cessation
-
2002
- 2002-08-05 IL IL151065A patent/IL151065A/en active Protection Beyond IP Right Term
- 2002-09-09 ZA ZA200207206A patent/ZA200207206B/en unknown
-
2007
- 2007-08-03 US US11/882,750 patent/US7927852B2/en not_active Expired - Fee Related
-
2008
- 2008-08-11 IL IL193365A patent/IL193365A/en active IP Right Grant
-
2009
- 2009-02-06 RU RU2009104003/10A patent/RU2557318C9/ru active
- 2009-09-02 AU AU2009212900A patent/AU2009212900B2/en not_active Expired
-
2010
- 2010-06-29 CY CY20101100597T patent/CY1110142T1/el unknown
-
2011
- 2011-04-12 JP JP2011088663A patent/JP5341945B2/ja not_active Expired - Lifetime
- 2011-04-13 US US13/085,793 patent/US8921064B2/en not_active Expired - Fee Related
-
2013
- 2013-07-03 LU LU92237C patent/LU92237I2/fr unknown
- 2013-07-03 BE BE2013C045C patent/BE2013C045I2/fr unknown
- 2013-07-04 CY CY2013028C patent/CY2013028I2/el unknown
- 2013-07-04 FR FR13C0036C patent/FR13C0036I2/fr active Active
-
2015
- 2015-02-09 CY CY20151100129T patent/CY1117264T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE463576T1 (de) | Aggregat-freie harnsäureoxidase zur herstellung von nicht-immunogenen polymer-konjugaten | |
| BE2013C033I2 (de) | ||
| PT1075281E (pt) | Conjugados poliol-ifn-beta | |
| DK1037657T3 (da) | Alfainterferon-polymerkonjugat med foröget biologisk aktivitet og fremgangsmåder til fremstilling heraf | |
| RU94006023A (ru) | Физиологически активная композиция на основе лиофилизированных модифицированных полиалкилен оксидом комплексов белка и полипептида с циклодекстрином и способ ее получения | |
| DK1100880T3 (da) | Urat oxidase | |
| DE59904569D1 (de) | Therapeutikum zur unterdrückung von schnarchgeräuschen | |
| WO1998046257A8 (en) | Compositions comprising conjugates of stable, active, human ob protein with antibody fc chain and methods | |
| BR0213298A (pt) | formulações com alta concentração de proteìna e processo de fabricação | |
| DE69505804D1 (de) | Afamin: ein menschliches serum albumin ähnliches protein | |
| ATE126523T1 (de) | Saccharid-modifizierte, wasserlösliche proteine. | |
| Zhang et al. | Synthesis of silk fibroin‐insulin bioconjugates and their characterization and activities in vivo | |
| WO1997015668A3 (en) | Methods and compositions comprising glut-2 and glut-2 chimeras | |
| Weil et al. | Interferon structure: facts and speculation | |
| Yuecel et al. | Increased susceptibility to oxidative stress in lens tissues of sulfur dioxide exposed rats | |
| DE50008782D1 (de) | VERFAHREN ZUR HERSTELLUNG VON WESPENGIFT-ALLERGENEN MIT VERMINDERTER IgE-REAKTIVITÄT | |
| DE60223232D1 (de) | Mucinpeptid mit immunstärkenden eigenschaften | |
| NN | Effect of some physiological changes on the binding of tenoxicam to human serum albumin | |
| TH52654A (th) | แอนตี-แอนจิโอจินิก เปปไทด์ ที่มีอายุยาวนาน | |
| UA25289C2 (uk) | Спосіб приготування горілки "імператорська" |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1254237 Country of ref document: EP |