WO2000051629A1 - Preparations stabilisees a longue conservation - Google Patents
Preparations stabilisees a longue conservation Download PDFInfo
- Publication number
- WO2000051629A1 WO2000051629A1 PCT/JP2000/001160 JP0001160W WO0051629A1 WO 2000051629 A1 WO2000051629 A1 WO 2000051629A1 JP 0001160 W JP0001160 W JP 0001160W WO 0051629 A1 WO0051629 A1 WO 0051629A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- csf
- methionine
- amino acids
- month
- preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Signal Processing For Digital Recording And Reproducing (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Amplifiers (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/914,641 US6908610B1 (en) | 1999-03-01 | 2000-02-29 | Long-term stabilized formulations |
CA2381229A CA2381229C (en) | 1999-03-01 | 2000-02-29 | Stabilized g-csf preparations |
AU26954/00A AU772604B2 (en) | 1999-03-01 | 2000-02-29 | Long-term stabilized formulations |
DE60028037T DE60028037T2 (de) | 1999-03-01 | 2000-02-29 | LANGFRISTIG STABILISIERTE G-CSF PRäPARATE |
JP2000602295A JP4607336B2 (ja) | 1999-03-01 | 2000-02-29 | 長期安定化製剤 |
EP00905397A EP1197221B1 (en) | 1999-03-01 | 2000-02-29 | G-csf preparations stabilized over long time |
HK02107149.3A HK1045652A1 (zh) | 1999-03-01 | 2002-09-27 | 長期穩定的製劑 |
HK02107478.4A HK1046239B (zh) | 1999-03-01 | 2002-10-16 | 長期穩定的g-csf製劑 |
CY20061101080T CY1105528T1 (el) | 1999-03-01 | 2006-08-02 | Παρασκευaσματα σταθεροποιημeνα για μακρo διaστημα |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11/52314 | 1999-03-01 | ||
JP11052314A JP2000247903A (ja) | 1999-03-01 | 1999-03-01 | 長期安定化製剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000051629A1 true WO2000051629A1 (fr) | 2000-09-08 |
Family
ID=12911333
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2000/001160 WO2000051629A1 (fr) | 1999-03-01 | 2000-02-29 | Preparations stabilisees a longue conservation |
Country Status (16)
Country | Link |
---|---|
US (1) | US6908610B1 (ja) |
EP (2) | EP1700605B1 (ja) |
JP (2) | JP2000247903A (ja) |
KR (2) | KR100731559B1 (ja) |
CN (3) | CN1879875B (ja) |
AT (1) | ATE326233T1 (ja) |
AU (1) | AU772604B2 (ja) |
CA (1) | CA2381229C (ja) |
CY (1) | CY1105528T1 (ja) |
DE (1) | DE60028037T2 (ja) |
DK (1) | DK1197221T3 (ja) |
ES (1) | ES2263450T3 (ja) |
HK (3) | HK1045652A1 (ja) |
PT (1) | PT1197221E (ja) |
TW (1) | TWI232749B (ja) |
WO (1) | WO2000051629A1 (ja) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001048117A1 (fr) * | 1999-12-24 | 2001-07-05 | Otsuka Pharmaceutical Co., Ltd. | Compositions seches contenant un acide amine hydrophobe |
WO2002017957A1 (fr) * | 2000-09-01 | 2002-03-07 | Chugai Seiyaku Kabushiki Kaisha | Preparations de solutions stabilisees sur une longue periode de temps |
WO2004019966A1 (ja) * | 2002-08-27 | 2004-03-11 | Chugai Seiyaku Kabushiki Kaisha | タンパク質溶液製剤の安定化方法 |
JP2005511520A (ja) * | 2001-10-05 | 2005-04-28 | ビスカム・アーゲー | 組換え炭水化物結合ポリペプチドの安定型凍結乾燥生薬製剤 |
JP2005527470A (ja) * | 2001-08-30 | 2005-09-15 | キリン−アムジエン・インコーポレーテツド | Hsa非含有組成物中のnesp/epoの安定化剤としてのl−メチオニン |
JP2006515321A (ja) * | 2002-08-16 | 2006-05-25 | ブラッコ インターナショナル ビー.ヴイ. | シンカリド製剤 |
US7202208B2 (en) * | 2000-05-15 | 2007-04-10 | Hoffman-La Roche Inc. | Erythropoietin composition |
JP2007536215A (ja) * | 2004-03-10 | 2007-12-13 | ビオシューティカルズ アールツナイミテル アクチェンゲゼルシャフト | 液体エリスロポエチン製剤 |
EP1260230A4 (en) * | 2000-02-29 | 2008-08-06 | Chugai Pharmaceutical Co Ltd | LONG-TERM STABILIZED PREPARATIONS |
US8617568B2 (en) | 2007-07-10 | 2013-12-31 | Medy-Tox, Inc. | Pharmaceutical liquid composition of botulinum toxin with improved stability |
WO2015076285A1 (ja) * | 2013-11-21 | 2015-05-28 | 協和メデックス株式会社 | 血清又は血漿中の低密度リポ蛋白の凍結乾燥による変性抑制剤及び変性抑制方法 |
JP2019073543A (ja) * | 2017-09-22 | 2019-05-16 | 旭化成ファーマ株式会社 | 安定性に優れるテリパラチド含有液状医薬組成物 |
Families Citing this family (64)
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US8703126B2 (en) | 2000-10-12 | 2014-04-22 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
EP1324776B2 (en) | 2000-10-12 | 2018-03-21 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
AU2002351756A1 (en) | 2001-12-21 | 2003-07-15 | Novo Nordisk Health Care Ag | Liquid composition of factor vii polypeptides |
KR20040065278A (ko) * | 2001-12-21 | 2004-07-21 | 노보 노르디스크 에이/에스 | 변경된 인자 ⅶ 폴리펩티드의 액체 조성물 |
ATE477810T1 (de) * | 2002-02-28 | 2010-09-15 | Nipro Corp | Stabilisierte albumin-zubereitungen |
US20040009918A1 (en) * | 2002-05-03 | 2004-01-15 | Hanne Nedergaard | Stabilised solid compositions of modified factor VII |
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EP1598074B1 (en) | 2003-02-28 | 2019-01-02 | Chugai Seiyaku Kabushiki Kaisha | Stabilized protein-containing formulations |
CA2518327A1 (en) * | 2003-03-18 | 2004-09-30 | Novo Nordisk Health Care Ag | Liquid, aqueous, pharmaceutical compositions of factor vii polypeptides |
US7897734B2 (en) * | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
ES2349779T5 (es) * | 2003-04-04 | 2013-11-26 | Genentech, Inc. | Formulaciones de anticuerpos y de proteínas a concentración elevada |
AU2004241698A1 (en) * | 2003-05-23 | 2004-12-02 | Novo Nordisk Health Care Ag | Protein stabilization in solution |
JP5306597B2 (ja) * | 2003-07-01 | 2013-10-02 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 第vii因子ポリペプチドの液体水性薬学的組成物 |
FR2857267B1 (fr) * | 2003-07-09 | 2006-03-10 | Lab Francais Du Fractionnement | Formulation stabilisante et solubilisante pour les proteines cryoprecipitables. |
DE10333317A1 (de) * | 2003-07-22 | 2005-02-17 | Biotecon Therapeutics Gmbh | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
ES2574581T3 (es) * | 2003-08-14 | 2016-06-20 | Novo Nordisk Health Care Ag | Composición farmacéutica líquida acuosa de polipéptidos de tipo Factor VII |
EP1685160A1 (en) * | 2003-11-10 | 2006-08-02 | Arriva-Prometic Inc. | Dry recombinant human alpha 1-antitrypsin formulation |
PT1684719E (pt) * | 2003-11-14 | 2012-02-03 | Baxter Int | Composições de alfa-1-antitripsina e métodos de tratamento utilizando estas composições |
TR201809670T4 (tr) * | 2003-12-19 | 2018-07-23 | Novo Nordisk Healthcare Ag | Faktör VII polipeptitlerinin stabilize edilmiş kompozisyonları. |
JP2005310840A (ja) | 2004-04-16 | 2005-11-04 | Toshiba Corp | 磁気ランダムアクセスメモリ |
US20060293243A1 (en) * | 2005-06-17 | 2006-12-28 | Navneet Puri | Stable, buffered, pharmaceutical compositions including motilin-like peptides |
US7534753B2 (en) * | 2006-01-12 | 2009-05-19 | Air Products And Chemicals, Inc. | pH buffered aqueous cleaning composition and method for removing photoresist residue |
TW200806317A (en) * | 2006-03-20 | 2008-02-01 | Wyeth Corp | Methods for reducing protein aggregation |
EP1997505A4 (en) * | 2006-03-22 | 2013-02-13 | Chugai Pharmaceutical Co Ltd | PREPARATION OF ERYTHROPOIETIN SOLUTION |
SI2142174T1 (sl) * | 2007-04-05 | 2011-04-29 | Sandoz Ag | Stabilne vodne G-CSF formulacije |
US20080286471A1 (en) * | 2007-05-18 | 2008-11-20 | Doubleday Marc D | Protective gel for an electrical connection |
JP5513380B2 (ja) * | 2007-06-25 | 2014-06-04 | アムジエン・インコーポレーテツド | 肝細胞増殖因子に対する特異的結合剤の組成物 |
PE20091174A1 (es) * | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
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US11110063B2 (en) | 2017-08-25 | 2021-09-07 | MAIA Pharmaceuticals, Inc. | Storage stable sincalide formulations |
CN109627300B (zh) * | 2019-02-18 | 2022-08-05 | 浙江新银象生物工程有限公司 | Nisin溶液稳定剂开发及应用 |
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WO2001048117A1 (fr) * | 1999-12-24 | 2001-07-05 | Otsuka Pharmaceutical Co., Ltd. | Compositions seches contenant un acide amine hydrophobe |
EP1260230A4 (en) * | 2000-02-29 | 2008-08-06 | Chugai Pharmaceutical Co Ltd | LONG-TERM STABILIZED PREPARATIONS |
US7202208B2 (en) * | 2000-05-15 | 2007-04-10 | Hoffman-La Roche Inc. | Erythropoietin composition |
WO2002017957A1 (fr) * | 2000-09-01 | 2002-03-07 | Chugai Seiyaku Kabushiki Kaisha | Preparations de solutions stabilisees sur une longue periode de temps |
US7998929B2 (en) | 2000-09-01 | 2011-08-16 | Chugai Seikyaku Kabushiki Kaisha | Solution preparations stabilized over long time |
JP2005527470A (ja) * | 2001-08-30 | 2005-09-15 | キリン−アムジエン・インコーポレーテツド | Hsa非含有組成物中のnesp/epoの安定化剤としてのl−メチオニン |
JP2005511520A (ja) * | 2001-10-05 | 2005-04-28 | ビスカム・アーゲー | 組換え炭水化物結合ポリペプチドの安定型凍結乾燥生薬製剤 |
JP4751993B2 (ja) * | 2002-08-16 | 2011-08-17 | ブラッコ スイス エス.エー. | シンカリド製剤 |
JP2006515321A (ja) * | 2002-08-16 | 2006-05-25 | ブラッコ インターナショナル ビー.ヴイ. | シンカリド製剤 |
JP4489591B2 (ja) * | 2002-08-27 | 2010-06-23 | 中外製薬株式会社 | タンパク質溶液製剤の安定化方法 |
JPWO2004019966A1 (ja) * | 2002-08-27 | 2005-12-15 | 中外製薬株式会社 | タンパク質溶液製剤の安定化方法 |
WO2004019966A1 (ja) * | 2002-08-27 | 2004-03-11 | Chugai Seiyaku Kabushiki Kaisha | タンパク質溶液製剤の安定化方法 |
JP2007536215A (ja) * | 2004-03-10 | 2007-12-13 | ビオシューティカルズ アールツナイミテル アクチェンゲゼルシャフト | 液体エリスロポエチン製剤 |
US7767644B2 (en) * | 2004-03-10 | 2010-08-03 | Bioceuticals Arzneimittel Ag | Erythropoietin liquid formulation |
JP4887281B2 (ja) * | 2004-03-10 | 2012-02-29 | ビオシューティカルズ アールツナイミテル アクチェンゲゼルシャフト | 液体エリスロポエチン製剤 |
US8617568B2 (en) | 2007-07-10 | 2013-12-31 | Medy-Tox, Inc. | Pharmaceutical liquid composition of botulinum toxin with improved stability |
US9220780B2 (en) | 2007-07-10 | 2015-12-29 | Medy-Tox Inc. | Pharmaceutical liquid composition of botulinum toxin with improved stability |
WO2015076285A1 (ja) * | 2013-11-21 | 2015-05-28 | 協和メデックス株式会社 | 血清又は血漿中の低密度リポ蛋白の凍結乾燥による変性抑制剤及び変性抑制方法 |
JPWO2015076285A1 (ja) * | 2013-11-21 | 2017-03-16 | 協和メデックス株式会社 | 血清又は血漿中の低密度リポ蛋白の凍結乾燥による変性抑制剤及び変性抑制方法 |
JP2019073543A (ja) * | 2017-09-22 | 2019-05-16 | 旭化成ファーマ株式会社 | 安定性に優れるテリパラチド含有液状医薬組成物 |
JP2019089865A (ja) * | 2017-09-22 | 2019-06-13 | 旭化成ファーマ株式会社 | 安定性に優れるテリパラチド含有液状医薬組成物 |
Also Published As
Publication number | Publication date |
---|---|
KR20050099637A (ko) | 2005-10-14 |
KR100656125B1 (ko) | 2006-12-12 |
EP1197221A4 (en) | 2003-01-29 |
DE60028037D1 (de) | 2006-06-22 |
ATE326233T1 (de) | 2006-06-15 |
JP2000247903A (ja) | 2000-09-12 |
TWI232749B (en) | 2005-05-21 |
KR20010102469A (ko) | 2001-11-15 |
CA2381229A1 (en) | 2000-09-08 |
EP1197221A1 (en) | 2002-04-17 |
CN101537173A (zh) | 2009-09-23 |
HK1046239A1 (en) | 2003-01-03 |
HK1098963A1 (en) | 2007-08-03 |
KR100731559B1 (ko) | 2007-06-22 |
HK1045652A1 (zh) | 2002-12-06 |
CY1105528T1 (el) | 2010-07-28 |
CN1879875A (zh) | 2006-12-20 |
AU772604B2 (en) | 2004-05-06 |
US6908610B1 (en) | 2005-06-21 |
DK1197221T3 (da) | 2006-11-13 |
EP1700605A3 (en) | 2007-06-13 |
AU2695400A (en) | 2000-09-21 |
CN1342087A (zh) | 2002-03-27 |
PT1197221E (pt) | 2006-08-31 |
DE60028037T2 (de) | 2006-12-21 |
ES2263450T3 (es) | 2006-12-16 |
CN1879875B (zh) | 2010-08-25 |
JP4607336B2 (ja) | 2011-01-05 |
HK1046239B (zh) | 2006-08-18 |
EP1700605B1 (en) | 2014-04-30 |
EP1197221B1 (en) | 2006-05-17 |
CA2381229C (en) | 2010-10-26 |
EP1700605A2 (en) | 2006-09-13 |
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