PT1197221E - Preparacoes de g-csf estabilizadas a longo prazo. - Google Patents
Preparacoes de g-csf estabilizadas a longo prazo.Info
- Publication number
- PT1197221E PT1197221E PT00905397T PT00905397T PT1197221E PT 1197221 E PT1197221 E PT 1197221E PT 00905397 T PT00905397 T PT 00905397T PT 00905397 T PT00905397 T PT 00905397T PT 1197221 E PT1197221 E PT 1197221E
- Authority
- PT
- Portugal
- Prior art keywords
- csf
- long
- residual ratio
- testing
- preparations
- Prior art date
Links
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 title abstract 7
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 title abstract 7
- 230000007774 longterm Effects 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000012931 lyophilized formulation Substances 0.000 abstract 1
- 229930182817 methionine Natural products 0.000 abstract 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Fodder In General (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Amplifiers (AREA)
- Signal Processing For Digital Recording And Reproducing (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11052314A JP2000247903A (ja) | 1999-03-01 | 1999-03-01 | 長期安定化製剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1197221E true PT1197221E (pt) | 2006-08-31 |
Family
ID=12911333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT00905397T PT1197221E (pt) | 1999-03-01 | 2000-02-29 | Preparacoes de g-csf estabilizadas a longo prazo. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6908610B1 (pt) |
| EP (2) | EP1197221B1 (pt) |
| JP (2) | JP2000247903A (pt) |
| KR (2) | KR100731559B1 (pt) |
| CN (3) | CN1879875B (pt) |
| AT (1) | ATE326233T1 (pt) |
| AU (1) | AU772604B2 (pt) |
| CA (1) | CA2381229C (pt) |
| CY (1) | CY1105528T1 (pt) |
| DE (1) | DE60028037T2 (pt) |
| DK (1) | DK1197221T3 (pt) |
| ES (1) | ES2263450T3 (pt) |
| HK (3) | HK1045652A1 (pt) |
| PT (1) | PT1197221E (pt) |
| TW (1) | TWI232749B (pt) |
| WO (1) | WO2000051629A1 (pt) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2395438C (en) * | 1999-12-24 | 2009-10-13 | Otsuka Pharmaceutical Co., Ltd. | Dry compositions containing hydrophobic amino acid |
| JP4683810B2 (ja) | 2000-02-29 | 2011-05-18 | 中外製薬株式会社 | 長期安定化製剤 |
| BRPI0110914B8 (pt) * | 2000-05-15 | 2021-05-25 | Hoffmann La Roche | 'composição farmacêutica líquida, processo para preparação da mesma e uso de uma composicão farmacêutica' |
| AU8260701A (en) * | 2000-09-01 | 2002-03-13 | Chugai Pharmaceutical Co Ltd | Solution preparations stabilized over long time |
| DE60139944D1 (de) | 2000-10-12 | 2009-10-29 | Genentech Inc | Niederviskose konzentrierte proteinformulierungen |
| US8703126B2 (en) | 2000-10-12 | 2014-04-22 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
| US20030104996A1 (en) * | 2001-08-30 | 2003-06-05 | Tiansheng Li | L-methionine as a stabilizer for NESP/EPO in HSA-free formulations |
| DE10149030A1 (de) * | 2001-10-05 | 2003-04-10 | Viscum Ag | Stabile galenische gefriergetrocknete Arzneimittelzubereitung von rViscumin |
| KR20040065278A (ko) * | 2001-12-21 | 2004-07-21 | 노보 노르디스크 에이/에스 | 변경된 인자 ⅶ 폴리펩티드의 액체 조성물 |
| IL162239A0 (en) | 2001-12-21 | 2005-11-20 | Novo Nordisk Healthcare Ag | Liquid composition of factor vii polypeptides |
| CN1330370C (zh) * | 2002-02-28 | 2007-08-08 | 尼普洛株式会社 | 稳定的白蛋白制剂 |
| US20040009918A1 (en) * | 2002-05-03 | 2004-01-15 | Hanne Nedergaard | Stabilised solid compositions of modified factor VII |
| EP2283856B1 (en) | 2002-06-21 | 2017-09-20 | Novo Nordisk Health Care AG | Stabilised solid compositions of factor VIIa polypeptides |
| US6803046B2 (en) * | 2002-08-16 | 2004-10-12 | Bracco International B.V. | Sincalide formulations |
| EP1541165A4 (en) * | 2002-08-27 | 2009-06-24 | Chugai Pharmaceutical Co Ltd | METHOD FOR STABILIZING PROTEIN PREPARATION |
| EP1598074B1 (en) * | 2003-02-28 | 2019-01-02 | Chugai Seiyaku Kabushiki Kaisha | Stabilized protein-containing formulations |
| MXPA05009914A (es) * | 2003-03-18 | 2006-01-09 | Novo Nordisk Healthcare Ag | Composiciones farmaceuticas acuosas, liquidas de polipeptidos del factor vii. |
| US7897734B2 (en) * | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
| PT1610820E (pt) * | 2003-04-04 | 2010-12-16 | Novartis Ag | Formulações de elevada concentração de anticorpos e proteínas |
| CA2525224A1 (en) * | 2003-05-23 | 2004-12-02 | Michael Bech Jensen | Protein stabilization in solution |
| ES2335994T3 (es) * | 2003-07-01 | 2010-04-07 | Novo Nordisk Health Care Ag | Composicion farmaceutica liquida, acuosa de polipeptidos factor vii. |
| FR2857267B1 (fr) * | 2003-07-09 | 2006-03-10 | Lab Francais Du Fractionnement | Formulation stabilisante et solubilisante pour les proteines cryoprecipitables. |
| DE10333317A1 (de) * | 2003-07-22 | 2005-02-17 | Biotecon Therapeutics Gmbh | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
| ES2574581T3 (es) | 2003-08-14 | 2016-06-20 | Novo Nordisk Health Care Ag | Composición farmacéutica líquida acuosa de polipéptidos de tipo Factor VII |
| AU2004288854B2 (en) * | 2003-11-10 | 2009-10-01 | Arriva-Pharmaceuticals, Inc. | Dry recombinant human alpha 1-antitrypsin formulation |
| ATE530165T1 (de) * | 2003-11-14 | 2011-11-15 | Baxter Int | Alpha1-antitrypsin-zusammensetzungen und behandlungsverfahren unter verwendung dieser zusammensetzungen |
| EP2298287B1 (en) * | 2003-12-19 | 2018-04-11 | Novo Nordisk Health Care AG | Stabilised compositions of factor VII polypeptides |
| DE202004020676U1 (de) * | 2004-03-10 | 2005-11-10 | Bioceuticals Arzneimittel Ag | Erythropoietin-Flüssigformulierung |
| JP2005310840A (ja) | 2004-04-16 | 2005-11-04 | Toshiba Corp | 磁気ランダムアクセスメモリ |
| US20060293243A1 (en) * | 2005-06-17 | 2006-12-28 | Navneet Puri | Stable, buffered, pharmaceutical compositions including motilin-like peptides |
| US7534753B2 (en) * | 2006-01-12 | 2009-05-19 | Air Products And Chemicals, Inc. | pH buffered aqueous cleaning composition and method for removing photoresist residue |
| TW200806317A (en) * | 2006-03-20 | 2008-02-01 | Wyeth Corp | Methods for reducing protein aggregation |
| WO2007108505A1 (ja) * | 2006-03-22 | 2007-09-27 | Chugai Seiyaku Kabushiki Kaisha | エリスロポエチン溶液製剤 |
| JP5349452B2 (ja) * | 2007-04-05 | 2013-11-20 | サンド アクチエンゲゼルシャフト | 安定な水性ｇ‐ｃｓｆ製剤 |
| US20080286471A1 (en) * | 2007-05-18 | 2008-11-20 | Doubleday Marc D | Protective gel for an electrical connection |
| US7951368B2 (en) * | 2007-06-25 | 2011-05-31 | Amgen Inc. | Compositions of specific binding agents to hepatocyte growth factor |
| EP2170400B1 (en) | 2007-07-10 | 2012-07-25 | Medy-Tox, INC. | Pharmaceutical liquid composition of botulinum toxin with improved stability |
| PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| EP2229407B1 (de) | 2008-01-09 | 2016-11-16 | Sanofi-Aventis Deutschland GmbH | Neue insulinderivate mit extrem verzögertem zeit- / wirkungsprofil |
| CN103599541A (zh) * | 2008-09-10 | 2014-02-26 | 弗·哈夫曼-拉罗切有限公司 | 用于防止蛋白质氧化降解的组合物和方法 |
| HUE037449T2 (hu) | 2008-10-17 | 2018-08-28 | Sanofi Aventis Deutschland | Egy inzulin és egy GLP-1 agonista kombinációja |
| BRPI1006519A2 (pt) | 2009-03-06 | 2016-08-09 | Genentech Inc | formulação de anticorpos |
| AR080669A1 (es) | 2009-11-13 | 2012-05-02 | Sanofi Aventis Deutschland | Composicion farmaceutica que comprende un agonista de glp-1, una insulina y metionina |
| WO2011058082A1 (de) | 2009-11-13 | 2011-05-19 | Sanofi-Aventis Deutschland Gmbh | Pharmazeutische zusammensetzung umfassend einen glp-1-agonisten und methionin |
| MA33989B1 (fr) * | 2010-01-15 | 2013-02-01 | Kirin Amgen Inc | Formulation d'anticorps et régimes thérapeutiques |
| TWI609698B (zh) | 2010-01-20 | 2018-01-01 | Chugai Pharmaceutical Co Ltd | 穩定化的含抗體溶液製劑 |
| EP2542257B1 (en) | 2010-03-01 | 2017-07-05 | Bayer Healthcare LLC | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
| EP2399572A1 (en) | 2010-06-22 | 2011-12-28 | Sandoz AG | Long-term storage of non-glycosylated recombinant human G-CSF |
| ES2606554T3 (es) | 2010-08-30 | 2017-03-24 | Sanofi-Aventis Deutschland Gmbh | Uso de AVE0010 para la fabricación de un medicamento para el tratamiento de la diabetes mellitus de tipo 2 |
| TWI480288B (zh) | 2010-09-23 | 2015-04-11 | Lilly Co Eli | 牛顆粒細胞群落刺激因子及其變體之調配物 |
| CN102028661B (zh) * | 2010-12-31 | 2012-05-23 | 山东新时代药业有限公司 | 聚乙二醇化重组人粒细胞集落刺激因子冻干粉针剂及其制备方法 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| BR112014004726A2 (pt) | 2011-08-29 | 2017-04-04 | Sanofi Aventis Deutschland | combinação farmacêutica para uso no controle glicêmico em pacientes de diabetes tipo 2 |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| WO2013142336A1 (en) * | 2012-03-21 | 2013-09-26 | Miller Leonard B | Combination therapy to improve joint, tendon, and ligament healing |
| US9592297B2 (en) | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
| US8613919B1 (en) | 2012-08-31 | 2013-12-24 | Bayer Healthcare, Llc | High concentration antibody and protein formulations |
| TWI780236B (zh) | 2013-02-04 | 2022-10-11 | 法商賽諾菲公司 | 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物 |
| WO2014142102A1 (ja) | 2013-03-12 | 2014-09-18 | 大日本住友製薬株式会社 | 液体水性組成物 |
| SG10201705525VA (en) * | 2013-03-13 | 2017-08-30 | Genentech Inc | Formulations with reduced oxidation |
| US20140314778A1 (en) | 2013-03-13 | 2014-10-23 | Genentech, Inc. | Formulations with reduced oxidation |
| SI2968467T1 (sl) * | 2013-03-13 | 2020-11-30 | F. Hoffmann-La Roche Ag | Pripravki z zmanjšano oksidacijo |
| WO2015076285A1 (ja) * | 2013-11-21 | 2015-05-28 | 協和メデックス株式会社 | 血清又は血漿中の低密度リポ蛋白の凍結乾燥による変性抑制剤及び変性抑制方法 |
| CN105899190B (zh) | 2014-01-09 | 2022-06-14 | 赛诺菲 | 门冬胰岛素的稳定化药物制剂 |
| AU2015205624A1 (en) | 2014-01-09 | 2016-07-14 | Sanofi | Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives |
| SG11201604708VA (en) | 2014-01-09 | 2016-07-28 | Sanofi Sa | Stabilized glycerol free pharmaceutical formulations of insulin analogues and/or insulin derivatives |
| PL3229828T3 (pl) | 2014-12-12 | 2023-07-31 | Sanofi-Aventis Deutschland Gmbh | Formulacja o ustalonym stosunku insuliny glargine/liksysenatydu |
| CN104524553B (zh) * | 2014-12-12 | 2015-07-29 | 薛传校 | 一种长效促排卵注射液 |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
| US11110063B2 (en) | 2017-08-25 | 2021-09-07 | MAIA Pharmaceuticals, Inc. | Storage stable sincalide formulations |
| WO2019059302A1 (ja) * | 2017-09-22 | 2019-03-28 | 旭化成ファーマ株式会社 | 安定性に優れるテリパラチド含有液状医薬組成物 |
| CN109627300B (zh) * | 2019-02-18 | 2022-08-05 | 浙江新银象生物工程有限公司 | Nisin溶液稳定剂开发及应用 |
| US20230190880A1 (en) * | 2020-03-30 | 2023-06-22 | Sichuan Luzhou Buchang Bio-Pharmaceutical Co., Ltd. | Formulations of Human Parathyroid Hormone (PTH) and Methods for Producing Same |
| WO2023066988A1 (en) | 2021-10-19 | 2023-04-27 | Sandoz Ag | Glass container with low aluminum content and gas overlay to prevent oxidation of sensitive therapeutic agents |
| CN115624187B (zh) * | 2022-12-08 | 2023-04-04 | 北京第一生物科技开发有限公司 | 牛脾肽粉在改善睡眠中的用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3228502A1 (de) | 1982-07-30 | 1984-02-02 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung des c1-inaktivators und seine verwendung |
| JP2577744B2 (ja) * | 1986-07-18 | 1997-02-05 | 中外製薬株式会社 | 安定な顆粒球コロニ−刺激因子含有製剤 |
| DE3729863A1 (de) * | 1987-09-05 | 1989-03-16 | Boehringer Mannheim Gmbh | Stabilisierte erythropoietin-lyophilisate |
| JP2974722B2 (ja) * | 1990-04-03 | 1999-11-10 | 帝国臓器製薬株式会社 | カルシトニン注射液 |
| US5272135A (en) | 1991-03-01 | 1993-12-21 | Chiron Ophthalmics, Inc. | Method for the stabilization of methionine-containing polypeptides |
| GB9120304D0 (en) | 1991-09-24 | 1991-11-06 | Erba Carlo Spa | Stable pharmaceutical compositions containing a granulocyte macrophage colony stimulating factor |
| US5192743A (en) | 1992-01-16 | 1993-03-09 | Genentech, Inc. | Reconstitutable lyophilized protein formulation |
| JPH05331071A (ja) * | 1992-01-17 | 1993-12-14 | Asahi Chem Ind Co Ltd | カルシトニン遺伝子関連ペプチド類の凍結乾燥組成物および安定化法 |
| IL107887A (en) * | 1992-12-08 | 2003-07-06 | Ambi Inc | Stabilized lanthionine containing bacteriocin compositions |
| DE4242863A1 (de) * | 1992-12-18 | 1994-06-23 | Boehringer Mannheim Gmbh | Stabile lyophilisierte pharmazeutische Zubereitungen von G-CSF |
| US5358708A (en) | 1993-01-29 | 1994-10-25 | Schering Corporation | Stabilization of protein formulations |
| US5780431A (en) * | 1996-09-20 | 1998-07-14 | Neurobiological Technologies, Inc. | Pharmaceutical formulations of corticotropin releasing factor having improved stability in liquid form |
| TW518235B (en) * | 1997-01-15 | 2003-01-21 | Akzo Nobel Nv | A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage |
| BRPI0017437B8 (pt) * | 1999-10-04 | 2021-05-25 | Chiron Corp | composição farmacêutica estabilizada contendo polipeptídeo il-2, método para aumentar estabilidade de interleucina-2 em uma composição farmacêutica, e uma forma seca da composição |
-
1999
- 1999-03-01 JP JP11052314A patent/JP2000247903A/ja active Pending
-
2000
- 2000-02-29 CN CN2006100923765A patent/CN1879875B/zh not_active Expired - Lifetime
- 2000-02-29 DE DE60028037T patent/DE60028037T2/de not_active Expired - Lifetime
- 2000-02-29 KR KR1020057017282A patent/KR100731559B1/ko active IP Right Grant
- 2000-02-29 KR KR1020017011145A patent/KR100656125B1/ko active IP Right Grant
- 2000-02-29 EP EP00905397A patent/EP1197221B1/en not_active Expired - Lifetime
- 2000-02-29 WO PCT/JP2000/001160 patent/WO2000051629A1/ja active IP Right Grant
- 2000-02-29 EP EP06010059.1A patent/EP1700605B1/en not_active Expired - Lifetime
- 2000-02-29 AT AT00905397T patent/ATE326233T1/de active
- 2000-02-29 CN CN00804421A patent/CN1342087A/zh active Pending
- 2000-02-29 JP JP2000602295A patent/JP4607336B2/ja not_active Expired - Lifetime
- 2000-02-29 PT PT00905397T patent/PT1197221E/pt unknown
- 2000-02-29 AU AU26954/00A patent/AU772604B2/en not_active Expired
- 2000-02-29 CA CA2381229A patent/CA2381229C/en not_active Expired - Lifetime
- 2000-02-29 CN CNA2009101329481A patent/CN101537173A/zh active Pending
- 2000-02-29 DK DK00905397T patent/DK1197221T3/da active
- 2000-02-29 US US09/914,641 patent/US6908610B1/en not_active Expired - Lifetime
- 2000-02-29 ES ES00905397T patent/ES2263450T3/es not_active Expired - Lifetime
- 2000-03-01 TW TW089103623A patent/TWI232749B/zh not_active IP Right Cessation
-
2002
- 2002-09-27 HK HK02107149.3A patent/HK1045652A1/zh unknown
- 2002-10-16 HK HK02107478.4A patent/HK1046239B/zh not_active IP Right Cessation
-
2006
- 2006-08-02 CY CY20061101080T patent/CY1105528T1/el unknown
-
2007
- 2007-06-15 HK HK07106471.8A patent/HK1098963A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2695400A (en) | 2000-09-21 |
| CA2381229A1 (en) | 2000-09-08 |
| KR100656125B1 (ko) | 2006-12-12 |
| ATE326233T1 (de) | 2006-06-15 |
| EP1197221A1 (en) | 2002-04-17 |
| HK1046239B (zh) | 2006-08-18 |
| KR20010102469A (ko) | 2001-11-15 |
| HK1046239A1 (en) | 2003-01-03 |
| EP1700605A2 (en) | 2006-09-13 |
| JP4607336B2 (ja) | 2011-01-05 |
| TWI232749B (en) | 2005-05-21 |
| KR100731559B1 (ko) | 2007-06-22 |
| HK1045652A1 (zh) | 2002-12-06 |
| CY1105528T1 (el) | 2010-07-28 |
| DE60028037T2 (de) | 2006-12-21 |
| CN1879875A (zh) | 2006-12-20 |
| ES2263450T3 (es) | 2006-12-16 |
| DE60028037D1 (de) | 2006-06-22 |
| EP1700605A3 (en) | 2007-06-13 |
| AU772604B2 (en) | 2004-05-06 |
| CN1879875B (zh) | 2010-08-25 |
| CN1342087A (zh) | 2002-03-27 |
| EP1197221B1 (en) | 2006-05-17 |
| DK1197221T3 (da) | 2006-11-13 |
| CA2381229C (en) | 2010-10-26 |
| KR20050099637A (ko) | 2005-10-14 |
| EP1700605B1 (en) | 2014-04-30 |
| US6908610B1 (en) | 2005-06-21 |
| CN101537173A (zh) | 2009-09-23 |
| HK1098963A1 (en) | 2007-08-03 |
| JP2000247903A (ja) | 2000-09-12 |
| EP1197221A4 (en) | 2003-01-29 |
| WO2000051629A1 (fr) | 2000-09-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT1197221E (pt) | Preparacoes de g-csf estabilizadas a longo prazo. | |
| NO883926D0 (no) | Fremgangsmaate for fremstilling av stabilisert humanproteinpreparat. | |
| GB2341801B (en) | Formulation | |
| IL95118A0 (en) | Polypeptide derivatives,their preparation and pharmaceutical compositions containing them | |
| DK2016950T3 (da) | Farmaceutisk sammensætning omfattende et exendin-4-peptid | |
| BR9908088A (pt) | Formulação farmacêutica de um composto de didemnin | |
| NZ320237A (en) | Stable pharmaceutical forms of administration containing parathormone | |
| AU7683296A (en) | Peptide conjugates derived from thymic hormones, their use as medicament and compositions containing them | |
| PT785795E (pt) | Composicao farmaceutica | |
| MX9203175A (es) | Composicion de implante que contiene un peptido, polipeptido o proteina biologicamente activa y procedimiento para su preparacion. | |
| ES2055607T3 (es) | Composiciones farmaceuticas estables que contienen un factor de crecimiento de fibroblastos. | |
| HRP20020071B1 (en) | Pharmaceutical composition and preparation thereof | |
| MY125597A (en) | Stable protein and nucleic acid formulations, using non-aqueus, anhydrous, aprotic, hydrophobic, non-polar vehicles with low reactivity | |
| IT1241459B (it) | Composizioni farmaceutiche per la somministrazione rettale di calcitonina | |
| MX9800309A (es) | Formulacion farmaceutica estabilizada que comprende una hormona del crecimiento y un peptido que comprende al menos un residuo de aminoacido basico y al menos un residuo de aminoacido acido. | |
| MX9702899A (es) | Compuestos y composiciones para suministrar agentes activos. |