WO1998008876B1 - Esters de l'acide hyaluronique, fils et biomateriaux les contenant, et leur utilisation en chirurgie - Google Patents
Esters de l'acide hyaluronique, fils et biomateriaux les contenant, et leur utilisation en chirurgieInfo
- Publication number
- WO1998008876B1 WO1998008876B1 PCT/EP1997/004684 EP9704684W WO9808876B1 WO 1998008876 B1 WO1998008876 B1 WO 1998008876B1 EP 9704684 W EP9704684 W EP 9704684W WO 9808876 B1 WO9808876 B1 WO 9808876B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- anyone
- esterified
- hyaluronic acid
- alcohol
- carboxylic functions
- Prior art date
Links
- MAKUBRYLFHZREJ-JWBQXVCJSA-M sodium;(2S,3S,4R,5R,6R)-3-[(2S,3R,5S,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylate Chemical class [Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@H](O)[C@H]1O MAKUBRYLFHZREJ-JWBQXVCJSA-M 0.000 title claims abstract 10
- 238000001356 surgical procedure Methods 0.000 title claims abstract 5
- 239000000560 biocompatible material Substances 0.000 title claims 2
- 238000006065 biodegradation reaction Methods 0.000 claims abstract 14
- 150000002148 esters Chemical class 0.000 claims abstract 12
- 229920002674 hyaluronan Polymers 0.000 claims abstract 9
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract 9
- -1 aliphatic alcohols Chemical class 0.000 claims abstract 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 12
- 235000019445 benzyl alcohol Nutrition 0.000 claims 4
- 125000004432 carbon atoms Chemical group C* 0.000 claims 4
- 150000001298 alcohols Chemical class 0.000 claims 3
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 2
- 150000001342 alkaline earth metals Chemical class 0.000 claims 2
- 125000001204 arachidyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 2
- 229910052708 sodium Inorganic materials 0.000 claims 2
- 239000011734 sodium Substances 0.000 claims 2
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N Docosanol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 125000002511 behenyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 238000002316 cosmetic surgery Methods 0.000 claims 1
- 229960000735 docosanol Drugs 0.000 claims 1
- 238000005886 esterification reaction Methods 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 238000002682 general surgery Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000004745 nonwoven fabric Substances 0.000 claims 1
- 125000004429 atoms Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Abstract
L'invention concerne des esters de l'acide hyaluronique, dans lesquels une première partie des fonctions carboxy est estérifiée par un alcool araliphatique et une seconde partie par des alcools aliphatiques purs à longue chaîne comportant 10 à 22 atomes de carbone. Les fonctions carboxy restant éventuellement non estérifiées, s'il y en a, sont salifiées. L'invention concerne également des fils biodégradables constitués par lesdits esters, ainsi que leur utilisation dans le domaine de la médecine et de la chirurgie.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97940137A EP0922060B1 (fr) | 1996-08-29 | 1997-08-28 | Esters de l'acide hyaluronique, fils et biomateriaux les contenant, et leur utilisation en chirurgie |
| DE69716745T DE69716745T2 (de) | 1996-08-29 | 1997-08-28 | Ester von hyaluronsäure, sie enthaltende faden und biomaterialen, ihre verwendung in der chirurgie |
| AT97940137T ATE226961T1 (de) | 1996-08-29 | 1997-08-28 | Ester von hyaluronsäure, sie enthaltende faden und biomaterialen, ihre verwendung in der chirurgie |
| CA002264085A CA2264085C (fr) | 1996-08-29 | 1997-08-28 | Esters de l'acide hyaluronique, fils et biomateriaux les contenant, et leur utilisation en chirurgie |
| JP51129098A JP4221734B2 (ja) | 1996-08-29 | 1997-08-28 | ヒアルロン酸エステル、これを含有する糸および生体適合材料、ならびに外科手術におけるその使用 |
| AU42080/97A AU722586B2 (en) | 1996-08-29 | 1997-08-28 | Hyaluronic acid esters, threads and biomaterials containing them, and their use in surgery |
| US09/236,958 US20010008937A1 (en) | 1996-08-29 | 1999-01-25 | Threads containing hyaluronic acid esters and their use in surgery |
| US09/941,055 US6632802B2 (en) | 1996-08-29 | 2001-08-28 | Hyaluronic acid esters, threads and biomaterials containing them, and their use in surgery |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96PD000207A IT1287698B1 (it) | 1996-08-29 | 1996-08-29 | Fili da sutura essenzialmente costituiti da derivati esterei dello acido ialuronico |
| ITPD96A000207 | 1996-08-29 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US09/236,958 Continuation-In-Part US20010008937A1 (en) | 1996-08-29 | 1999-01-25 | Threads containing hyaluronic acid esters and their use in surgery |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1998008876A1 WO1998008876A1 (fr) | 1998-03-05 |
| WO1998008876B1 true WO1998008876B1 (fr) | 1998-05-07 |
Family
ID=11391508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP1997/004684 WO1998008876A1 (fr) | 1996-08-29 | 1997-08-28 | Esters de l'acide hyaluronique, fils et biomateriaux les contenant, et leur utilisation en chirurgie |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20010008937A1 (fr) |
| EP (1) | EP0922060B1 (fr) |
| JP (1) | JP4221734B2 (fr) |
| AT (1) | ATE226961T1 (fr) |
| AU (1) | AU722586B2 (fr) |
| CA (1) | CA2264085C (fr) |
| DE (1) | DE69716745T2 (fr) |
| ES (1) | ES2185991T3 (fr) |
| IT (1) | IT1287698B1 (fr) |
| WO (1) | WO1998008876A1 (fr) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6632802B2 (en) * | 1996-08-29 | 2003-10-14 | Fidia Advanced Biopolymers S.R.L. | Hyaluronic acid esters, threads and biomaterials containing them, and their use in surgery |
| IT1294797B1 (it) | 1997-07-28 | 1999-04-15 | Fidia Advanced Biopolymers Srl | Uso dei derivati dell'acido ialuronico nella preparazione di biomateriali aventi attivita' emostatica fisica e tamponante |
| IT1306643B1 (it) | 1999-04-08 | 2001-10-02 | Fidia Advanced Biopolymers Srl | Processo per la preparazione dei composti autoreticolati dell'acidoialuronico e dei suoi derivati ottenibili mediante la tecnica |
| IT1306644B1 (it) | 1999-04-08 | 2001-10-02 | Fidia Advanced Biopolymers Srl | Strutture tridimensionali comprendenti derivati dell'acido ialuronicoottenibili mediante la tecnica antisolvente supercritico. |
| DE10226396B4 (de) * | 2002-06-13 | 2004-12-09 | Siemens Ag | Modulares Kommunikationsgerät |
| WO2004046200A1 (fr) | 2002-11-21 | 2004-06-03 | Chugai Seiyaku Kabushiki Kaisha | Excipient pour medicament a liberation retardee |
| DE202006008868U1 (de) * | 2006-06-06 | 2006-08-03 | Sefar Ag | Gewebe, insbesondere für textile Bauten und/oder Abdeckungen |
| US20110130473A1 (en) | 2007-11-13 | 2011-06-02 | Bio-Technology General (Israel) Ltd. | Dilute filtration sterilization process for viscoelastic biopolymers |
| JP5676858B2 (ja) | 2008-06-19 | 2015-02-25 | キヤノン株式会社 | 記録装置 |
| CA2735173C (fr) * | 2008-09-02 | 2017-01-10 | Tautona Group Lp | Fils d'acide hyaluronique et/ou derives de ceux-ci, procedes de fabrication de ceux-ci et utilisations de ceux-ci |
| HUE049678T2 (hu) | 2008-12-02 | 2020-10-28 | Allergan Inc | Injekciós eszköz |
| CZ302503B6 (cs) | 2009-12-11 | 2011-06-22 | Contipro C A.S. | Zpusob prípravy derivátu kyseliny hyaluronové oxidovaného v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd a zpusob jeho modifikace |
| CZ302504B6 (cs) | 2009-12-11 | 2011-06-22 | Contipro C A.S. | Derivát kyseliny hyaluronové oxidovaný v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd, zpusob jeho prípravy a zpusob jeho modifikace |
| CZ20101001A3 (cs) | 2010-12-31 | 2012-02-08 | Cpn S.R.O. | Hyaluronová vlákna, zpusob jejich prípravy a použití |
| CZ2012136A3 (cs) | 2012-02-28 | 2013-06-05 | Contipro Biotech S.R.O. | Deriváty na bázi kyseliny hyaluronové schopné tvorit hydrogely, zpusob jejich prípravy, hydrogely na bázi techto derivátu, zpusob jejich prípravy a pouzití |
| CZ304512B6 (cs) | 2012-08-08 | 2014-06-11 | Contipro Biotech S.R.O. | Derivát kyseliny hyaluronové, způsob jeho přípravy, způsob jeho modifikace a použití |
| CZ304654B6 (cs) | 2012-11-27 | 2014-08-20 | Contipro Biotech S.R.O. | Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití |
| CZ304303B6 (cs) | 2012-11-27 | 2014-02-19 | Contipro Biotech S.R.O. | Vlákna založená na hydrofobizovaném hyaluronanu, způsob jejich přípravy a použití, textilie na jejich bázi a použití |
| CZ2012843A3 (cs) | 2012-11-27 | 2014-02-05 | Contipro Biotech S.R.O. | Nekonečná vlákna na bázi hyaluronanu, selektivně oxidovaného v poloze 6 N-acetyl-D-glukosaminové části, jejich příprava, použití, nitě, střiže, příze, textilie a způsob jejich úpravy |
| RU2520599C1 (ru) * | 2013-02-21 | 2014-06-27 | Общество с ограниченной ответственностью "ДЖИ-Групп" | Способ эндоскопической биопластики гастродуоденальных язв комплексным биопластическим материалом |
| US20140350518A1 (en) | 2013-05-23 | 2014-11-27 | Allergan, Inc. | Syringe extrusion accessory |
| ES2791290T3 (es) | 2014-01-27 | 2020-11-03 | Allergan Holdings France S A S | Dispositivo de administración de sustancias |
| CZ2014150A3 (cs) | 2014-03-11 | 2015-05-20 | Contipro Biotech S.R.O. | Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití |
| US10029048B2 (en) | 2014-05-13 | 2018-07-24 | Allergan, Inc. | High force injection devices |
| CZ2014451A3 (cs) | 2014-06-30 | 2016-01-13 | Contipro Pharma A.S. | Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití |
| US10226585B2 (en) | 2014-10-01 | 2019-03-12 | Allergan, Inc. | Devices for injection and dosing |
| CZ309295B6 (cs) | 2015-03-09 | 2022-08-10 | Contipro A.S. | Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití |
| US10433928B2 (en) | 2015-03-10 | 2019-10-08 | Allergan Pharmaceuticals Holdings (Ireland) Unlimited Company | Multiple needle injector |
| CZ2015398A3 (cs) | 2015-06-15 | 2017-02-08 | Contipro A.S. | Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin |
| CZ306662B6 (cs) | 2015-06-26 | 2017-04-26 | Contipro A.S. | Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití |
| CZ2015710A3 (cs) | 2015-10-09 | 2016-12-14 | Contipro A.S. | Nekonečná vlákna typu jádro-obal zahrnující kombinaci nativního a C11-C18 acylovaného hyaluronanu nebo C11-C18 acylovaných hyaluronanů, způsob jejich přípravy a použití, střiž, příze a textilie z těchto vláken a jejich použití |
| RU2709154C1 (ru) | 2016-04-08 | 2019-12-16 | Аллерган, Инк. | Аспирационно-инъекционное устройство |
| CZ308106B6 (cs) | 2016-06-27 | 2020-01-08 | Contipro A.S. | Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití |
| US10709444B2 (en) | 2017-01-24 | 2020-07-14 | Allergan Industrie Sas | Thread insertion devices |
| US10820900B2 (en) | 2017-01-24 | 2020-11-03 | Allergan Industrie Sas | Thread insertion devices |
| US10258447B2 (en) | 2017-01-24 | 2019-04-16 | Allergan Industrie Sas | Thread insertion devices |
| US10595977B2 (en) | 2017-01-24 | 2020-03-24 | Allergan Industrie, Sas | Thread insertion devices |
| US10265151B2 (en) | 2017-01-24 | 2019-04-23 | Allergan Industrie Sas | Thread insertion devices |
| USD867582S1 (en) | 2017-03-24 | 2019-11-19 | Allergan, Inc. | Syringe device |
| WO2020016820A1 (fr) | 2018-07-18 | 2020-01-23 | Bio-Technology General (Israel) Ltd. | Procédé de filtration stérile d'un liquide non newtonien et agencement pour celle-ci, et formulation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
| JPH0625306A (ja) * | 1992-04-21 | 1994-02-01 | Shiseido Co Ltd | 溶媒不溶化ヒアルロン酸及びその製造方法 |
| IT1268955B1 (it) * | 1994-03-11 | 1997-03-18 | Fidia Advanced Biopolymers Srl | Esteri attivi di polisaccaridi carbossilici |
| ES2244975T3 (es) * | 1995-08-29 | 2005-12-16 | Fidia Advanced Biopolymers S.R.L. | Biomateriales para la prevencion de adherencias postquirurgicas, formados por derivados de acido hialuronico. |
-
1996
- 1996-08-29 IT IT96PD000207A patent/IT1287698B1/it active IP Right Grant
-
1997
- 1997-08-28 JP JP51129098A patent/JP4221734B2/ja not_active Expired - Fee Related
- 1997-08-28 AU AU42080/97A patent/AU722586B2/en not_active Ceased
- 1997-08-28 WO PCT/EP1997/004684 patent/WO1998008876A1/fr active IP Right Grant
- 1997-08-28 EP EP97940137A patent/EP0922060B1/fr not_active Expired - Lifetime
- 1997-08-28 ES ES97940137T patent/ES2185991T3/es not_active Expired - Lifetime
- 1997-08-28 AT AT97940137T patent/ATE226961T1/de not_active IP Right Cessation
- 1997-08-28 CA CA002264085A patent/CA2264085C/fr not_active Expired - Fee Related
- 1997-08-28 DE DE69716745T patent/DE69716745T2/de not_active Expired - Lifetime
-
1999
- 1999-01-25 US US09/236,958 patent/US20010008937A1/en not_active Abandoned
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