Classifications

• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
  • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
  • B29C43/00—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor
  • B29C43/003—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor characterised by the choice of material
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
  • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
  • B29C43/00—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor
  • B29C43/02—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor of articles of definite length, i.e. discrete articles
  • B29C43/04—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor of articles of definite length, i.e. discrete articles using movable moulds
  • B29C43/06—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor of articles of definite length, i.e. discrete articles using movable moulds continuously movable in one direction, e.g. mounted on chains, belts
  • B29C43/08—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor of articles of definite length, i.e. discrete articles using movable moulds continuously movable in one direction, e.g. mounted on chains, belts with circular movement, e.g. mounted on rolls, turntables
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B30—PRESSES
  • B30B—PRESSES IN GENERAL
  • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
  • B30B11/34—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses for coating articles, e.g. tablets
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
  • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
  • B29C43/00—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor
  • B29C43/32—Component parts, details or accessories; Auxiliary operations
  • B29C43/34—Feeding the material to the mould or the compression means
  • B29C2043/3466—Feeding the material to the mould or the compression means using rotating supports, e.g. turntables or drums
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
  • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
  • B29C43/00—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor
  • B29C43/32—Component parts, details or accessories; Auxiliary operations
  • B29C43/36—Moulds for making articles of definite length, i.e. discrete articles
  • B29C43/361—Moulds for making articles of definite length, i.e. discrete articles with pressing members independently movable of the parts for opening or closing the mould, e.g. movable pistons
  • B29C2043/3615—Forming elements, e.g. mandrels or rams or stampers or pistons or plungers or punching devices
  • B29C2043/3618—Forming elements, e.g. mandrels or rams or stampers or pistons or plungers or punching devices plurality of counteracting elements

Definitions

• the invention relates to a Man.telkern press for the production of coated tablets according to the preamble of claim 1.
• a jacket core press pre-pressed cores are provided with a coating made of pressed powder, the coating having to be carried out symmetrically to the core. This is particularly important in the case of tablets, for example those with a sustained-release effect, since the coating layer first takes up at different thicknesses when the tablet is taken the thinnest point is resolved, whereby the desired retarding effect occurs prematurely.
• a jacket core press for the production of coated tablets of the generic type is known from GB-PS 858.538. This has considerable disadvantages with regard to the transfer of the cores from a core supply tube via an annular disc into the dies of the die tables.
• the cores fall out of the core supply tube onto the annular disc of the transfer device and are taken over by fork-shaped receiving elements which transfer the cores into receiving openings of the transfer heads.
• Stamps with short extensions are guided in them, the stamps being mounted in the transfer heads by means of upper ring cams which can be raised and lowered.
• the lower extensions of the punches press on the cores which are guided on the circular disk by means of the transfer device until the transfer heads are brought into register with the dies of the die table.
• the cores fall into the dies under the effect of the stamp. Before this, the lower punch guided in the die is lowered and the die is filled with the lower layer of powder material used to form the casing. The lower stamp is then further lowered by a small amount.
• the centrifugal force acting on the core which increases with the square of the rotational speed, has the further disadvantage that the core, which may have just been introduced centrally into the die, slips outwards on the lower layer of the powder material, so that the centering of the Core within the coated core tablet is not possible.
• a disadvantage of the known jacket core press is, on the one hand, that the cores rub on the circular disc, which is a fixed component which has segment-like incisions in order to be able to accommodate two die tables, and, on the other hand, that the cores are essentially underneath Effect of its own weight from the transfer heads fall into the dies, which means that a relatively slow rotational speed of the jacket core press is necessary.
• the invention is therefore based on the object to provide a jacket core press for producing coated tablets of the generic type, with which a exact centering and positioning of the cores in the matrices filled with an underlayer of powder material is possible.
• the device for receiving and transferring the cores on the underside of the lifting and lowering core stamp comprises gripping devices which pick up the cores in the receiving station and into the transfer area into the Press the bottom layer of the powder material formed within the assigned die centered.
• the undersides of the core punches themselves engage in the matrices, which enables the core to be centered precisely within the lower layer of the powder material in the die.
• the centering takes place by pressing the core into the powder material by means of the transfer heads which can be raised and lowered vertically and which are provided with gripping devices. This prevents the core built into the die from shifting within the lower layer of the powder material under the action of the centrifugal force which occurs at high speeds of rotation of the die table.
• the cores can be pressed into the tablet to be manufactured with an accuracy of - 0.10 mm, so that the wall thickness of the jacket layer surrounding the core can be formed uniformly around the core.
• An essential prerequisite for the precise function of the jacket core press is the diameter of the subcircuits of essentially the same size / of the die table and the transfer device, since in this case the peripheral speeds on the subcircuits are of the same size.
• FIG. 2 shows an enlarged vertical section through a partial area of the die table and a partial area of the transfer device of the jacket core press in the first embodiment according to FIG. 1,
• FIG. 3 shows an enlarged illustration through a partial area of the transfer device and a receiving device of the jacket core press in the first embodiment according to FIG. 1,
• Own 4 shows a top view of the jacket core press in a basic illustration
• FIG. 6 shows a top view of the jacket core press in the second embodiment according to FIG. 5 in a basic illustration
• Embodiment of the jacket core press when receiving a core shows an enlarged detail section through the transfer device of the jacket core press in the second embodiment before the introduction of a core into a die of the die table,
• Fig. 12 is a view of a partially coated shell core tablet.
• the jacket core press shown in FIGS. 1 to 4 in the first embodiment which is used for the production of coated tablets 143 (FIG. 12), comprises a rotary-driven die table 1 with dies 3 arranged on a pitch circle 2, a transfer device 4, which transfers an axis 6 parallel to the axis 5 of the die table 1 is driven in rotation, and a receiving device 60 for feeding cores 9 to transfer heads 8 which are mounted at the free end of radial arms 7 arranged in the transfer device 4.
• the transfer device 4 consists of a around the axis 6 rotatable rotor 10, on the circumference of which a plurality of horizontal guide pistons 11 are radially movably mounted, which form the radial arms 7.
• 20 guide pistons 11 are provided, each with a transfer head 8, as is shown in plan view in FIG. 4.
• a radial bore 12 is provided within the rotor 10, into which a slide bearing bush 13, 14 is inserted near the axis 6 and on the outer circumference, which are used to guide one guide piston 11 with a circular cross section.
• the rotor 10 is provided from the bottom with a circumferential groove 15, the top of which is provided with a contact plate 16 against which a guide plate 17 bears, which is fixed on the top of the guide piston 11.
• the guide piston 11 is rotatably guided radially.
• the guide piston 11 is radially penetrated by a cam pin 18, which lies within the circumferential groove 15 and which engages at its lower end by means of support rollers 19, 20 in a groove cam 21 of a groove cam disk 22, which rotates with a rotary cam fixed column 23 is firmly connected, which in turn receives the drive shaft 24 for the rotor 10 of the transfer device 4 by means of needle bearings 25.
• the two support rollers 19, 20 each engage on the radially outer or radially inner side of the groove curve 21, as shown in FIG. 2.
• the groove curve 21 runs - as shown in FIG. 4 - concentrically over its essential area to the axis 6 of the transfer device 4. Only in the receiving and transfer area of the cores 9 does the groove curve approach the axis 6, as will be described later.
• the rotor 10 of the transfer device 4 is supported in axial direction on two slide rails 26, 27, which are embedded in the top of the grooved cam 22.
• the transfer heads 8 are arranged on the free, outer ends of the guide pistons 11. These consist of a guide bush 30, which is inserted into a bore of the guide piston 11 parallel to the axis 6, of a core punch 31, which is guided in the guide bush 30, of two guide disks 32, 33, which form the guide bush
• the core punch 31 has a circumferential collar 35 approximately in its longitudinal center plane, which slides in the guide bush 30, whereas the upper stamp part of the core punch 31 is guided by a guide ring 36.
• a compression spring 37 which presses the unloaded core punch 31 upward, is supported on the underside of the circumferential collar 35. The other end of the compression spring 37 is supported on the bottom of a gap space formed within the guide bush 30.
• a blind hole 38 runs, which opens at the lower end of the core punch 31 and a suction pipe 39 for sucking cores 9 to the underside of the core punch
• a bore 40 extends through the guide piston 11 and is connected via axial and radial connecting bores 41, 42 to the blind bore 38 in the core punch 31 forming the suction tube 39.
• the bore 40 also traverses the cam pin 15, as shown in FIG. 2.
• the bore 40 opens at the inner end of the radial bore 12 for the guide piston 11.
• a bore 43 opens, which runs parallel to the axis 6 and passes through a bushing 44, which is inserted into a vacuum disc 45 and into the rotor 10 .
• a compression spring 46 which is arranged in a gap surrounding the bush 44, presses the vacuum disk 45 against the surface of a recess 47 within the groove cam disc 22.
• a groove-like vacuum chamber 48 is formed within the recess 47, which is formed over a circumferential part. area of the grooved cam 22 runs, as shown in Fig. 4 and will be explained later.
• a bore 49 runs from the groove-like vacuum chamber 48 to a vacuum supply line 50. All of the bores and components which are designated by the reference numerals 38 to 50 form in their entirety a vacuum device 29 for the controlled supply of a vacuum which is at the free end of the suction pipe 39 Core stamp 31 is used to grip a core 9.
• the matrix table 1 which is equipped with a large number of matrices 3, is provided with an upper and a lower guide disk 51, 52, in which upper punches 53 and lower punches 54 are guided concentrically to the axes of the matrices 3 and are not guided by them
• the curves shown are controlled and compress the powder material 144 filled into the matrices 3 to coat the cores 9 to form the jacket core tablets 143.
• the upper punches 53 in the first embodiment of the jacket core press serve to press the core punch 31 when inserting a core 9 into a die 3 and, against the action of the compression spring 37, to press a core 9 into the submerged powder layer formed on the lower punch 54 within the die 3 .
• a head guide ring 55 is arranged between the upper guide disk 51 and the die table 1, which is connected to the die table 1 in a rotationally fixed manner and on the part circle 2 of the die table 3 with a semicircular head Receiving troughs 56 is provided, which are aligned coaxially to the dies 3 and in which the correspondingly circular head parts 57 of the transfer heads 8 of the guide pistons 11 engage in a rotating and sliding manner. It is provided that the pitch circle on which the axes of the transfer heads 8 of the radial arms 7 or guide pistons 11 move in their radially extended position ⁇ and the pitch circle 2 of the dies 3 of the die table 1 overlap at least by the distance between two dies 3, as shown in more detail in FIG. 4. Here, the transfer heads 8 are guided in the overlap area of the partial circles on the partial circle 2 of the die table 1, as will be explained in more detail later.
• the receiving device 60 diametrically opposite the die table 1 via the transfer device 4 comprises a head guide ring 61 which. corresponding to the head guide ring 55 of the die table 1 is provided with semicircular head receiving recesses 56, in which the head-shaped guide sleeves 57 of the transfer heads 8 engage in a rotationally sliding manner.
• the guide disk 61 is firmly connected to a receiving disk 62 for the cores 9, which has twenty receiving nests 63 for the cores 9.
• These receiving nests 63 consist of an outer guide bush 64 which is screwed firmly into an axial bore of the receiving washer 62, a hollow outer punch 65 which is guided in the guide bush 64, and an inner punch 66 which in turn is guided in the outer punch 65.
• an inner and an outer compression spring 67, 68 are arranged, which act on the inner punch 66 and the outer punch 65, respectively.
• the lower part of the inner punch 66 is guided in a guide plate 69, which together with the guide bush 64 in the Receiving disc 62 is screwed.
• a stroke curve 70 is screwed on the underside in the area of the receiving device for the cores 9, on which the inner punches 66 for receiving a core 9 are guided into a transfer head 8.
• the outer and inner punches 65, 66 are located below the surface of the receiving disk 62 under the action of the springs 67, 68.
• the inner die 66 moves onto the stroke curve 7.0, the inner die 66 is first raised slightly, so that the core 9 located thereon is raised somewhat above the upper edge of the outer die 66. Only then is the outer punch 65 also raised, delayed by the interposed inner spring 68.
• the associated transfer head 8 comes under the action of the cam pin 18 engaging in the groove curve 21 with its support rollers 19, 20 and the associated guide piston 11 in a path which corresponds exactly to the pitch circle 71 of the receiving nests 63, so that over one a core stamp / 31 is brought into congruence with the outer and inner stamp 65, 66, as shown in FIG.
• the core 9 is removed from the underside of the core stamp 11 Effect of the vacuum which is built up within the suction pipe 39 is taken and continued in the direction of rotation of the transfer device 4 during the lowering of the outer and inner punches 65, 66.
• the transfer of the core 9 from the transfer head 8 to the associated die 3 of the die table 1 then takes place in that after a rotation of the rotor 10 of the transfer device 4 of approximately 180 °, the transfer head 8 is controlled by the one guided in the groove curve 21 Curved pin 18 is brought into a curved path that corresponds to the pitch circle 2 of the dies 3 of the die table 1.
• the core stamp 31 of the transfer head 8 with the core 9 held under vacuum on the underside of the core stamp 9 is above the associated die 3, the core stamp 31 is pressed into the die 3 under the effect of the upper stamp 53, the core 9 in the powder layer already in the die 3 is pressed in exactly in the center.
• the vacuum is abruptly released by means of a ventilation chamber 72, whereupon the core punch 31 releases the core 9.
• the control of the guide pistons 11 and of the transfer heads 8 with core punches 31 attached to them takes place essentially by means of the groove curve 21 and the cam bolts 18 engaging in them. Only for the accurate registration of the core punches 31 on the one hand the outer / inner punch 65, 66 of the receiving unit 60 and, on the other hand, with the dies 3 of the die table 1, the transfer heads 8 come with their guide sleeves 57 into engagement with the head guide rings 55 of the die table 1 or 61 of the receiving unit 60.
• the jacket core press in the second embodiment shown in FIGS. 5 to 11 correspondingly comprises a rotary-driven die table 1 with dies 3 arranged on the pitch circle 2 and a transfer device 4 which rotates about an axis 6 parallel to the axis 5 of the die table 1 is rotationally driven and provided with radial arms 7, in the head hurry 140 radially movable transfer heads 8 are mounted, which can be brought into register with the dies 3 for the transfer of the cores 9.
• the transfer device 4 consists of a rotor 110 rotatably mounted about the axis 6, on the circumference of which a plurality of vertical cylinder piston units 111 are arranged, the cylinders 112 of which are screwed to the rotor 110.
• the piston rods 113 of the vertical cylinder-piston units 111 carry at their free ends, via clamping pieces 146 screwed to them, the cylinders 114 of horizontal cylinder-piston units 115 held by these clamping pieces, the cylinders 114 being slidably supported via spacers 116 on a centering piece 117, which is concentric with the axis 6 of the transfer device 4 is mounted on an axial extension 118 of the rotor 110.
• the centering piece 117 is preferably made of bronze.
• the head parts 140 with the transfer heads 8 inserted are screwed onto the free ends of the piston rods 119 of the horizontal cylinder-piston units 115.
• the free ends of the screwed head parts 140 are also rounded off in a semicircle, as shown in FIG. 10, the center of the circle lying exactly in the axes of the transfer heads 8.
• the cylinders 112 of the vertical cylinder piston units 111 are supplied with compressed air via lines 120 and the cylinders 114 of the horizontal cylinder piston units 115 via lines 121.
• the lines 120, 121 are connected in a manner not shown to control valves which are led to a control device. In this way, the piston rods 113 and 119 can be moved up and down or extended and retracted independently of one another.
• the rotor 110 of the transfer device 4 is provided with an annular disk 123 located outside the vertical cylinder piston units 111 in the range of motion of the transfer heads 8 and which carries receiving nests 124 assigned to the radial arms 7.
• the receiving nests 124 lie in the range of movement of the transfer heads 8 and serve to receive the cores 9, which are fed from a feed device (not shown in more detail) on the side of the transfer device 4 remote from the die table 1.
• the transfer heads 8 have a circular cross section made of solid metal material and are provided with a collar 125 directed radially outwards somewhat below their central transverse axis.
• the transfer heads 8 are inserted into bores 126 which are parallel to the axis 6 of the transfer device 4 and whose diameter is somewhat larger than the diameter of the collar 125.
• the bores are provided at the upper end with annular flanges 127 which guide the transfer heads 8.
• a compression spring 128 is inserted, which holds each transfer head 8 in its radially outward position.
• each transfer head 8 In the underside of each transfer head 8, an axially and centrally extending blind bore 129 is made, which is connected to a transverse bore 130 which opens into the annular space 131 receiving the compression spring 128. A radial bore 132 extends from this, into which the vacuum line 122 opens via a connecting piece 133. Since the sliding fit of the transfer head 8 made of round solid material between the material of the head part 140 on the one hand and the material of the circular flange 127 on the other hand is largely gastight, the vertically extending bore 129 within each transfer head 8 can be used as a suction pipe serve to suck in the cores 9 on the underside of the transfer heads 8 under the action of an unpressurized pressure to be built up by means of the line 122.
• the die table 1 which is equipped with a large number of dies 3, is provided with an upper and a lower guide disk 134, 135, which are guided by the upper punches 136 and lower punches 137, which are guided concentrically to the axes of the dies 3, and which are not guided in more detail by curves shown are controlled and compress the powder material 144 filled into the matrices 3 to coat the cores 9 to form the jacket core tablets 143.
• a head guide ring 138 is arranged, which rotatably firmly connected to the die table 1 and which is provided on the pitch circle 2 of the die table 1 with semicircular head receiving recesses 139 which are aligned coaxially with the dies 3 and in which the correspondingly semicircular head parts 140 of the radial arms 7 engage in a rotating and sliding manner.
• the pitch circle 141 on which the axes of the transfer heads 8 of the radial arms 7 move in their radially extended position, and the pitch circle 2 of the dies 3 of the die table 1 overlap at least by the distance between two dies 3, as it is shown in more detail in Fig. 10.
• the transfer heads 8 are guided in the overlap area 145 of the partial circles 2, 141 on the partial circle 2 of the matrix table 1, as will be explained in more detail below.
• the cores 9 to be provided with a sheathing 142 are fed to the receiving nests 124 of the annular disc 123 of the transfer device 4 from a guide device (not shown in more detail).
• the radial arm 7 moves downward under the action of the vertical cylinder-piston unit 111, the transfer head 8 being pressed into the head part 140 against the action of the compression spring 128.
• the transfer head 8 already provided on its underside with the contour of the core 9 to be taken over takes over the core 9 from the receiving nest 124 under the effect of the vacuum suction vacuum built up by means of the suction tube 129.
• the radial arm 7 is now raised by means of the vertical cylinder piston unit 111, the transfer head 8 being moved out of the
• Ersaizb ⁇ ati Headboard 140 extends downwards. Subsequently, the transfer head 8 is moved radially outwards under the action of the horizontal cylinder-piston unit 115, as shown in FIG. 8. The transfer head 8 now rotates on its pitch circle 141. As soon as the transfer head 8 reaches the associated die 3 of the die table 1, the head part 140 of the radial arm 7 arrives in a head receiving recess 139 of the head guide ring 138. This guides the transfer head 8 over the distance of two Adjacent matrices 3 exactly along the pitch circle 2 of the die table 1 until the second intersection of the pitch circles 2,141 is reached.
• the lower layer 144 of the powder material for the casing 142 of the tablet 143 to be pressed has been introduced on the lower punch 137.
• the core 9 is placed in this lower layer 144 by means of the transfer head
• the tablet 143 is then completed by further lowering the lower punch 137 into the die 3, then introducing an upper layer of the powder material into the die 3 and final pressing of the tablet 143 by means of the upper punch 136 dipping into the die 3.
• the finished jacket core tablet 143 is shown in Fig. 12.
• the transfer device 4 is assigned a rotationally fixed guide curve 150, which is arranged in the overlap area of the partial circles 2, 141 parallel to the partial circle 2 of the matrix table 1.
• 7 rollers 151 are arranged on the radial arms, which are guided along the guide curve 150.
• An essential prerequisite for the precise function of the jacket core press of both embodiments is the same circumferential speeds of the dies 3 and the transfer heads 8 and the same distances between the dies 3 and the transfer heads 8 in the overlap region 145 on the tendons connecting them.

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• Engineering & Computer Science (AREA)
• Mechanical Engineering (AREA)
• Medicinal Preparation (AREA)
• Powder Metallurgy (AREA)
• Medical Preparation Storing Or Oral Administration Devices (AREA)

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• 1987
  • 1987-06-07 US US07/466,260 patent/US5088915A/en not_active Expired - Lifetime
• 1988
  • 1988-06-08 DE DE3819821A patent/DE3819821A1/de active Granted
• 1989
  • 1989-06-07 ES ES89110253T patent/ES2022739B3/es not_active Expired - Lifetime
  • 1989-06-07 WO PCT/DE1989/000375 patent/WO1989011968A1/de not_active Ceased
  • 1989-06-07 DE DE8989110253T patent/DE58900110D1/de not_active Expired - Lifetime
  • 1989-06-07 EP EP89110253A patent/EP0349777B1/de not_active Expired - Lifetime
  • 1989-06-07 JP JP1506099A patent/JPH0822478B2/ja not_active Expired - Fee Related
• 1990
  • 1990-02-07 DK DK032590A patent/DK165909C/da not_active IP Right Cessation

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