UY33775A - Inhibidores macrocíclicos de virus flaviviridae, composiciones farmacéuticas que los comprenden y sus usos - Google Patents
Inhibidores macrocíclicos de virus flaviviridae, composiciones farmacéuticas que los comprenden y sus usosInfo
- Publication number
- UY33775A UY33775A UY0001033775A UY33775A UY33775A UY 33775 A UY33775 A UY 33775A UY 0001033775 A UY0001033775 A UY 0001033775A UY 33775 A UY33775 A UY 33775A UY 33775 A UY33775 A UY 33775A
- Authority
- UY
- Uruguay
- Prior art keywords
- understand
- pharmaceutical compositions
- macrocyclic inhibitors
- virus flaviviridae
- compounds
- Prior art date
Links
- 241000710781 Flaviviridae Species 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000005176 Hepatitis C Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 208000010710 hepatitis C virus infection Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42207110P | 2010-12-10 | 2010-12-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY33775A true UY33775A (es) | 2012-07-31 |
Family
ID=45464097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY0001033775A UY33775A (es) | 2010-12-10 | 2011-12-07 | Inhibidores macrocíclicos de virus flaviviridae, composiciones farmacéuticas que los comprenden y sus usos |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8513184B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2649076B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5847193B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20140031841A (cg-RX-API-DMAC7.html) |
| CN (1) | CN103403009B (cg-RX-API-DMAC7.html) |
| AR (1) | AR084217A1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2011338262B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112013014063A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2819824A1 (cg-RX-API-DMAC7.html) |
| EA (1) | EA026114B1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2536321T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL226739A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2013006475A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ612159A (cg-RX-API-DMAC7.html) |
| PL (1) | PL2649076T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2649076E (cg-RX-API-DMAC7.html) |
| SI (1) | SI2649076T1 (cg-RX-API-DMAC7.html) |
| TW (1) | TWI520966B (cg-RX-API-DMAC7.html) |
| UY (1) | UY33775A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012078915A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (74)
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|---|---|---|---|---|
| PL2859009T3 (pl) * | 2012-06-08 | 2018-03-30 | Gilead Sciences, Inc. | Makrocykliczne inhibitory wirusów flaviviridae |
| AR091279A1 (es) * | 2012-06-08 | 2015-01-21 | Gilead Sciences Inc | Inhibidores macrociclicos de virus flaviviridae |
| HK1211285A1 (en) | 2012-06-08 | 2016-05-20 | 吉利德科学公司 | Macrocyclic inhibitors of flaviviridae viruses |
| ES2724460T3 (es) * | 2013-12-23 | 2019-09-11 | Gilead Pharmasset Llc | Síntesis de un tripéptido que inhíbe el NS3 del virus de VHC macrocíclico |
| KR20190125537A (ko) | 2014-09-16 | 2019-11-06 | 길리애드 사이언시즈, 인코포레이티드 | 톨-유사 수용체 조정제의 고체 형태 |
| CN107427529A (zh) | 2014-12-26 | 2017-12-01 | 埃莫里大学 | N4‑羟基胞苷和衍生物及与其相关的抗病毒用途 |
| PH12021551982A1 (en) | 2015-03-04 | 2022-09-05 | Gilead Sciences Inc | Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds |
| US20210292327A1 (en) | 2015-08-26 | 2021-09-23 | Gilead Sciences, Inc. | Deuterated toll-like receptor modulators |
| EP3455219A4 (en) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | AMINE-RELATED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
| EP3454862B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| WO2017197055A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| WO2017197046A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
| MX2018014377A (es) | 2016-05-27 | 2019-03-14 | Gilead Sciences Inc | Metodos para tratar infecciones por virus de hepatitis b usando inhibidores de proteina no estructural 5a (ns5a), proteina no estructural 5b (ns5b) o proteina no estructural 3 (ns3). |
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2011
- 2011-12-07 AR ARP110104596A patent/AR084217A1/es unknown
- 2011-12-07 UY UY0001033775A patent/UY33775A/es not_active Application Discontinuation
- 2011-12-08 AU AU2011338262A patent/AU2011338262B2/en not_active Ceased
- 2011-12-08 ES ES11805697.7T patent/ES2536321T3/es active Active
- 2011-12-08 MX MX2013006475A patent/MX2013006475A/es active IP Right Grant
- 2011-12-08 PT PT118056977T patent/PT2649076E/pt unknown
- 2011-12-08 CA CA2819824A patent/CA2819824A1/en not_active Abandoned
- 2011-12-08 EA EA201390822A patent/EA026114B1/ru not_active IP Right Cessation
- 2011-12-08 JP JP2013543356A patent/JP5847193B2/ja not_active Expired - Fee Related
- 2011-12-08 EP EP11805697.7A patent/EP2649076B1/en active Active
- 2011-12-08 NZ NZ612159A patent/NZ612159A/en not_active IP Right Cessation
- 2011-12-08 WO PCT/US2011/064009 patent/WO2012078915A1/en not_active Ceased
- 2011-12-08 US US13/315,069 patent/US8513184B2/en not_active Expired - Fee Related
- 2011-12-08 PL PL11805697T patent/PL2649076T3/pl unknown
- 2011-12-08 BR BR112013014063A patent/BR112013014063A2/pt not_active IP Right Cessation
- 2011-12-08 CN CN201180066396.4A patent/CN103403009B/zh not_active Expired - Fee Related
- 2011-12-08 SI SI201130434T patent/SI2649076T1/sl unknown
- 2011-12-08 KR KR1020137017607A patent/KR20140031841A/ko not_active Abandoned
- 2011-12-09 TW TW100145540A patent/TWI520966B/zh not_active IP Right Cessation
-
2013
- 2013-06-04 IL IL226739A patent/IL226739A/en active IP Right Grant
- 2013-07-15 US US13/942,501 patent/US8933015B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AR084217A1 (es) | 2013-05-02 |
| CN103403009B (zh) | 2016-01-13 |
| US8933015B2 (en) | 2015-01-13 |
| NZ612159A (en) | 2015-07-31 |
| AU2011338262B2 (en) | 2016-12-15 |
| EP2649076B1 (en) | 2015-03-04 |
| CA2819824A1 (en) | 2012-06-14 |
| WO2012078915A1 (en) | 2012-06-14 |
| IL226739A (en) | 2017-05-29 |
| JP2014503516A (ja) | 2014-02-13 |
| EP2649076A1 (en) | 2013-10-16 |
| KR20140031841A (ko) | 2014-03-13 |
| EA201390822A1 (ru) | 2013-12-30 |
| HK1191000A1 (en) | 2014-07-18 |
| SI2649076T1 (sl) | 2015-07-31 |
| EA026114B1 (ru) | 2017-03-31 |
| PL2649076T3 (pl) | 2015-08-31 |
| AU2011338262A1 (en) | 2013-07-11 |
| TW201307355A (zh) | 2013-02-16 |
| TWI520966B (zh) | 2016-02-11 |
| ES2536321T3 (es) | 2015-05-22 |
| JP5847193B2 (ja) | 2016-01-20 |
| US8513184B2 (en) | 2013-08-20 |
| MX2013006475A (es) | 2013-11-01 |
| US20140023616A1 (en) | 2014-01-23 |
| BR112013014063A2 (pt) | 2016-09-13 |
| CN103403009A (zh) | 2013-11-20 |
| PT2649076E (pt) | 2015-06-02 |
| US20130022573A1 (en) | 2013-01-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 109 | Application deemed to be withdrawn |
Effective date: 20200904 |