UY29116A1 - Un procedimiento de fabricacion de compuestos imidazolicos, sus sales y sus pseudopolimorfos - Google Patents
Un procedimiento de fabricacion de compuestos imidazolicos, sus sales y sus pseudopolimorfosInfo
- Publication number
- UY29116A1 UY29116A1 UY29116A UY29116A UY29116A1 UY 29116 A1 UY29116 A1 UY 29116A1 UY 29116 A UY29116 A UY 29116A UY 29116 A UY29116 A UY 29116A UY 29116 A1 UY29116 A1 UY 29116A1
- Authority
- UY
- Uruguay
- Prior art keywords
- pseudopolimorphes
- salts
- procedure
- manufacture
- imidazolic
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- HAAITRDZHUANGT-UHFFFAOYSA-N 1-[2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric acid Chemical compound O[N+]([O-])=O.ClC1=CC(Cl)=CC=C1C(OCC=1C2=CC=CC(Cl)=C2SC=1)CN1C=NC=C1 HAAITRDZHUANGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 abstract 1
- OFKWTWJUANJQNU-UHFFFAOYSA-N 3-(bromomethyl)-7-chloro-1-benzothiophene Chemical compound ClC1=CC=CC2=C1SC=C2CBr OFKWTWJUANJQNU-UHFFFAOYSA-N 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229910017604 nitric acid Inorganic materials 0.000 abstract 1
- DZLFLBLQUQXARW-UHFFFAOYSA-N tetrabutylammonium Chemical compound CCCC[N+](CCCC)(CCCC)CCCC DZLFLBLQUQXARW-UHFFFAOYSA-N 0.000 abstract 1
- 238000006276 transfer reaction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Plant Pathology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Catalysts (AREA)
Abstract
El procedimiento de fabricación de la presente invención consiste en la reacción por trasferencia defase de 1-(2,4-diclorofenil)-2-(1H-imidazol-I-il) con 3-bromometil-7-clorobenzo(b)tiofeno catalizada por sulfato ácido de tetrabutilamonio en tolueno y e presencia de hidróxido sódico. Por tratamiento del producto resultante con ácido nítrico en medio acuoso se obtiene el sertaconazol mononitrato monohidrato, el cual por calentamiento posterior proporciona el sertaconazol mononitrato.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200402183A ES2249991B1 (es) | 2004-09-13 | 2004-09-13 | Procedimiento de fabricacion de compuestos imidazolicos, sus sales y sus pseudopolimorfos. |
Publications (1)
Publication Number | Publication Date |
---|---|
UY29116A1 true UY29116A1 (es) | 2005-11-30 |
Family
ID=35295386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY29116A UY29116A1 (es) | 2004-09-13 | 2005-09-13 | Un procedimiento de fabricacion de compuestos imidazolicos, sus sales y sus pseudopolimorfos |
Country Status (24)
Country | Link |
---|---|
US (1) | US7829726B2 (es) |
EP (1) | EP1788876B1 (es) |
JP (1) | JP4866355B2 (es) |
KR (1) | KR100861436B1 (es) |
CN (1) | CN100579966C (es) |
AR (1) | AR053093A1 (es) |
AT (1) | ATE431076T1 (es) |
AU (1) | AU2005284331B2 (es) |
BR (1) | BRPI0515254A (es) |
CA (1) | CA2577253C (es) |
DE (1) | DE602005014491D1 (es) |
DK (1) | DK1788876T3 (es) |
ES (1) | ES2249991B1 (es) |
HK (1) | HK1104765A1 (es) |
MX (1) | MX2007002924A (es) |
NO (1) | NO337950B1 (es) |
PA (1) | PA8645401A1 (es) |
PE (1) | PE20060690A1 (es) |
PL (1) | PL1788876T3 (es) |
PT (1) | PT1788876E (es) |
RU (1) | RU2357965C2 (es) |
TW (1) | TWI357813B (es) |
UY (1) | UY29116A1 (es) |
WO (1) | WO2006029812A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0922851A2 (pt) * | 2008-12-09 | 2015-12-29 | Ferrer Int | polimorfo ii de um compsoto antifúngico |
US10437922B2 (en) * | 2015-12-03 | 2019-10-08 | Workday, Inc. | Spreadsheet with unit based conversions |
CN113501814A (zh) * | 2021-07-30 | 2021-10-15 | 海南海神同洲制药有限公司 | 一种硝酸舍他康唑的纯化方法 |
CN113501815A (zh) * | 2021-07-30 | 2021-10-15 | 海南海神同洲制药有限公司 | 一种硝酸舍他康唑晶型的制备方法 |
CN113816947A (zh) * | 2021-08-25 | 2021-12-21 | 海南海神同洲制药有限公司 | 一种硝酸舍他康唑的重结晶方法 |
CN113735843B (zh) * | 2021-09-07 | 2023-05-26 | 海南海神同洲制药有限公司 | 一种低熔点硝酸舍他康唑的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5135943A (en) * | 1984-02-02 | 1992-08-04 | Ferrer Internacional S.A. | 1H-imidazole derivative compounds and pharmaceutical compositions containing the same |
ES8504779A1 (es) | 1984-02-02 | 1985-05-01 | Ferrer Int | Procedimiento de obtencion de nuevos derivados de 1h-imidazol |
CA1250586A (en) * | 1984-02-02 | 1989-02-28 | Manuel Raga | 1h-imidazole derivatives and process for their production |
WO1996020939A1 (es) * | 1995-01-04 | 1996-07-11 | Ferrer Internacional, S.A. | POLYMORFOS B Y C DE MONONITRATO DE 1-[2,4-DICLORO-β-[(7-CLOROBENZO[b]TIEN-3-IL)METOXI]FENETIL]IMIDAZOL |
CN1191250C (zh) * | 2001-09-26 | 2005-03-02 | 河北省药物研究所 | 一种硝酸舍他康唑的合成方法 |
ES2203316B1 (es) * | 2002-02-11 | 2005-03-01 | Ferrer Internacional, S.A. | R-(-)-1-(2-(7-cloro-benzo(b)tiofen-3-il-metoxi)-2-(2,4-dicloro-fenil)-etil)1h-imidazol. |
-
2004
- 2004-09-13 ES ES200402183A patent/ES2249991B1/es not_active Expired - Fee Related
-
2005
- 2005-09-09 PE PE2005001048A patent/PE20060690A1/es active IP Right Grant
- 2005-09-12 PA PA20058645401A patent/PA8645401A1/es unknown
- 2005-09-12 AR ARP050103793A patent/AR053093A1/es not_active Application Discontinuation
- 2005-09-13 JP JP2007530670A patent/JP4866355B2/ja active Active
- 2005-09-13 KR KR1020077005698A patent/KR100861436B1/ko active IP Right Grant
- 2005-09-13 AU AU2005284331A patent/AU2005284331B2/en active Active
- 2005-09-13 DE DE602005014491T patent/DE602005014491D1/de active Active
- 2005-09-13 DK DK05786030T patent/DK1788876T3/da active
- 2005-09-13 UY UY29116A patent/UY29116A1/es unknown
- 2005-09-13 WO PCT/EP2005/009825 patent/WO2006029812A1/en active Application Filing
- 2005-09-13 AT AT05786030T patent/ATE431076T1/de active
- 2005-09-13 PT PT05786030T patent/PT1788876E/pt unknown
- 2005-09-13 CN CN200580030628A patent/CN100579966C/zh active Active
- 2005-09-13 US US11/662,256 patent/US7829726B2/en active Active
- 2005-09-13 TW TW094131394A patent/TWI357813B/zh active
- 2005-09-13 MX MX2007002924A patent/MX2007002924A/es active IP Right Grant
- 2005-09-13 RU RU2007113922/04A patent/RU2357965C2/ru active
- 2005-09-13 PL PL05786030T patent/PL1788876T3/pl unknown
- 2005-09-13 EP EP05786030A patent/EP1788876B1/en active Active
- 2005-09-13 BR BRPI0515254-2A patent/BRPI0515254A/pt not_active IP Right Cessation
- 2005-09-13 CA CA2577253A patent/CA2577253C/en active Active
-
2007
- 2007-04-04 NO NO20071818A patent/NO337950B1/no unknown
- 2007-11-30 HK HK07113084.3A patent/HK1104765A1/xx unknown
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