AR053093A1 - Procedimiento de fabricacion de sertaconazol mononitrato, sertaconazol mononitrato y sertaconazol mononitrato monohidrato obtenidos con dicho proceso - Google Patents
Procedimiento de fabricacion de sertaconazol mononitrato, sertaconazol mononitrato y sertaconazol mononitrato monohidrato obtenidos con dicho procesoInfo
- Publication number
- AR053093A1 AR053093A1 ARP050103793A ARP050103793A AR053093A1 AR 053093 A1 AR053093 A1 AR 053093A1 AR P050103793 A ARP050103793 A AR P050103793A AR P050103793 A ARP050103793 A AR P050103793A AR 053093 A1 AR053093 A1 AR 053093A1
- Authority
- AR
- Argentina
- Prior art keywords
- mixture
- water
- mononitrate
- sertaconazole
- sertaconazol
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agronomy & Crop Science (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Catalysts (AREA)
Abstract
Se revela un procedimiento de fabricacion de Sertaconazol mononitrato (1), caracterizado porque comprende: (a) la reaccion de 1-(2,4-diclorofenil)-2-(1 J-imidazol-1-il)-etanol (II) con 3-bromometil-7-cloro venzo[b]tiofeno(III) en presencia de sulfato ácido de tetrabutilamonio(IV, Z = HO4S) e hidroxido sodico en tolueno a 30-45°C, seguido de adicion de agua, enfriamiento de la mezcla a una temperatura de la masa de 0-15°C y filtracion, lavado del solido obtenido con agua y tolueno, y reflujo de la base libre de Sertaconazol así obtenida en etanol absoluto hasta disolucion completa, seguido de calentamiento de la masa a 60-80°C y adicion de agua, nuevo enfriamiento a 5-15°C , filtracion del solido formado y lavado con una mezcla de etanol y agua, redisolucion de la base libre de Sertaconazol puro obtenida en etanol absoluto a 70-80, enfriamiento de la mezcla a una temperatura de la masa de 65 - 75°C y adicion posterior de una solucion que contiene ácido nítrico al 60% en agua, manteniéndose la temperatura durante 10-20 minutos, ajustando el pH por debajo de 2 enfriando la mezcla a 5 - 15 y manteniendo dicha temperatura durante 30 minutos a 2 horas, seguido de filtracion y lavado para rendir el Sertaconazol mononitrato monohidrato (V); y (b) disolviendo el Sertaconazol mononitrato monohidrato en una mezcla de etanol y agua calentando la masa a 75 - 80°C, anadiendo la mezcla sobre una solucion acuosa de ácido nítrico enfriado a 5- 15°C, filtrando, secando a 60 - 70°C tamizando y finalmente secando a 80 - 90°C. También se revela el compuesto obtenido. El Sertaconazol es un antifungico ampliamente utilizado en el tratamiento de las infecciones producidas por hongos y levaduras en el hombre y los animales
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200402183A ES2249991B1 (es) | 2004-09-13 | 2004-09-13 | Procedimiento de fabricacion de compuestos imidazolicos, sus sales y sus pseudopolimorfos. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR053093A1 true AR053093A1 (es) | 2007-04-25 |
Family
ID=35295386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050103793A AR053093A1 (es) | 2004-09-13 | 2005-09-12 | Procedimiento de fabricacion de sertaconazol mononitrato, sertaconazol mononitrato y sertaconazol mononitrato monohidrato obtenidos con dicho proceso |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7829726B2 (es) |
| EP (1) | EP1788876B1 (es) |
| JP (1) | JP4866355B2 (es) |
| KR (1) | KR100861436B1 (es) |
| CN (1) | CN100579966C (es) |
| AR (1) | AR053093A1 (es) |
| AT (1) | ATE431076T1 (es) |
| AU (1) | AU2005284331B2 (es) |
| BR (1) | BRPI0515254A (es) |
| CA (1) | CA2577253C (es) |
| DE (1) | DE602005014491D1 (es) |
| DK (1) | DK1788876T3 (es) |
| ES (1) | ES2249991B1 (es) |
| HK (1) | HK1104765A1 (es) |
| MX (1) | MX2007002924A (es) |
| NO (1) | NO337950B1 (es) |
| PA (1) | PA8645401A1 (es) |
| PE (1) | PE20060690A1 (es) |
| PL (1) | PL1788876T3 (es) |
| PT (1) | PT1788876E (es) |
| RU (1) | RU2357965C2 (es) |
| TW (1) | TWI357813B (es) |
| UY (1) | UY29116A1 (es) |
| WO (1) | WO2006029812A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010066756A1 (en) * | 2008-12-09 | 2010-06-17 | Ferrer Internacional, S.A. | Polymorph ii of an antifungal compound |
| US10437922B2 (en) * | 2015-12-03 | 2019-10-08 | Workday, Inc. | Spreadsheet with unit based conversions |
| CN113501814A (zh) * | 2021-07-30 | 2021-10-15 | 海南海神同洲制药有限公司 | 一种硝酸舍他康唑的纯化方法 |
| CN113501815A (zh) * | 2021-07-30 | 2021-10-15 | 海南海神同洲制药有限公司 | 一种硝酸舍他康唑晶型的制备方法 |
| CN113816947A (zh) * | 2021-08-25 | 2021-12-21 | 海南海神同洲制药有限公司 | 一种硝酸舍他康唑的重结晶方法 |
| CN113735843B (zh) * | 2021-09-07 | 2023-05-26 | 海南海神同洲制药有限公司 | 一种低熔点硝酸舍他康唑的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1250586A (en) | 1984-02-02 | 1989-02-28 | Manuel Raga | 1h-imidazole derivatives and process for their production |
| ES8504779A1 (es) * | 1984-02-02 | 1985-05-01 | Ferrer Int | Procedimiento de obtencion de nuevos derivados de 1h-imidazol |
| US5135943A (en) * | 1984-02-02 | 1992-08-04 | Ferrer Internacional S.A. | 1H-imidazole derivative compounds and pharmaceutical compositions containing the same |
| ES2120720T3 (es) * | 1995-01-04 | 1998-11-01 | Ferrer Int | Procedimiento de obtencion de los polimeros b y c de mononitrato de 1-(2,4-dicloro-beta-((7-clorobenzo(b)tien-3-il)metoxi)fenetil)imidazol. |
| CN1191250C (zh) * | 2001-09-26 | 2005-03-02 | 河北省药物研究所 | 一种硝酸舍他康唑的合成方法 |
| ES2203316B1 (es) * | 2002-02-11 | 2005-03-01 | Ferrer Internacional, S.A. | R-(-)-1-(2-(7-cloro-benzo(b)tiofen-3-il-metoxi)-2-(2,4-dicloro-fenil)-etil)1h-imidazol. |
-
2004
- 2004-09-13 ES ES200402183A patent/ES2249991B1/es active Active
-
2005
- 2005-09-09 PE PE2005001048A patent/PE20060690A1/es active IP Right Grant
- 2005-09-12 AR ARP050103793A patent/AR053093A1/es not_active Application Discontinuation
- 2005-09-12 PA PA20058645401A patent/PA8645401A1/es unknown
- 2005-09-13 UY UY29116A patent/UY29116A1/es unknown
- 2005-09-13 BR BRPI0515254-2A patent/BRPI0515254A/pt not_active IP Right Cessation
- 2005-09-13 US US11/662,256 patent/US7829726B2/en active Active
- 2005-09-13 CN CN200580030628A patent/CN100579966C/zh active Active
- 2005-09-13 EP EP05786030A patent/EP1788876B1/en active Active
- 2005-09-13 AT AT05786030T patent/ATE431076T1/de active
- 2005-09-13 DK DK05786030T patent/DK1788876T3/da active
- 2005-09-13 KR KR1020077005698A patent/KR100861436B1/ko active IP Right Grant
- 2005-09-13 DE DE602005014491T patent/DE602005014491D1/de active Active
- 2005-09-13 AU AU2005284331A patent/AU2005284331B2/en active Active
- 2005-09-13 MX MX2007002924A patent/MX2007002924A/es active IP Right Grant
- 2005-09-13 PL PL05786030T patent/PL1788876T3/pl unknown
- 2005-09-13 CA CA2577253A patent/CA2577253C/en active Active
- 2005-09-13 PT PT05786030T patent/PT1788876E/pt unknown
- 2005-09-13 TW TW094131394A patent/TWI357813B/zh active
- 2005-09-13 JP JP2007530670A patent/JP4866355B2/ja active Active
- 2005-09-13 WO PCT/EP2005/009825 patent/WO2006029812A1/en active Application Filing
- 2005-09-13 RU RU2007113922/04A patent/RU2357965C2/ru active
-
2007
- 2007-04-04 NO NO20071818A patent/NO337950B1/no unknown
- 2007-11-30 HK HK07113084.3A patent/HK1104765A1/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal | ||
| FB | Suspension of granting procedure |